Clinical trials: Prehypertension
Obstructive Sleep Apnea
Cardiovascular Impact of Obstructive Sleep Apnea Treatment in Normotensive Patients
Recent evidences suggest that obstructive sleep apnea (OSA) can contribute to cardiovascular disease even in the absence of hypertension.
- Trial name
- OSA-NORMO (NCT00741520)
- Testing
- CPAP
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Prehypertension, Blood Pressure
The Effects of a Jump Rope Exercise Program on Vascular Health, Inflammatory Markers in Prehypertensive Adolescent Girls
The purpose of this study was to examine the impact of a 12-week jump rope exercise program on blood pressure, arterial stiffness, vasodilating and vasoconstricting factors, inflammatory markers, and body composition in…
- Conditions
- Prehypertension, Blood Pressure, Abdominal Obesity, Adiposity
- Trial name
- NCT03534427
- Testing
- Jump rope exercise intervention
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pusan National University
Prehypertension
Pranayama and Jacobson's Progressive Muscle Relaxation Technique in Pre-hypertensive Patients
Objective of our study is to determine the comparative effects of Pranayama and Jacobson's Relaxation Technique on cardiovascular parameters, stress and quality of life in Pre-hypertensive patients.
- Trial name
- PRANvsJPMR (NCT06656130)
- Testing
- Pranayama, Jacobson's progressive muscle relaxation technique
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Riphah International University
Prehypertension, Stage-1 Hypertension
Hypotensive Effects of Conventional Dairy Products: Role of Arterial Stiffness
Elevated systolic blood pressure is by far the largest single contributor to cardiovascular risks in middle-aged and older adults.
- Trial name
- NCT01577030
- Testing
- Non-fat dairy, Add 4 servings fruit
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Texas at Austin
Hypertension
The Effect of Grape Seed Extract on Blood Pressure in People With Pre-Hypertension
In this research study, the investigators are interested in learning how extracts from grape seeds can help those individuals with high blood pressure.
- Trial name
- GSE (NCT00979732)
- Testing
- grape seed extract
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Prehypertension, Hypertension
Efficacy of Nigella Sativa (Nisatol®) in Women With Borderline Blood Pressure Values or a Non-Dipper Blood Pressure Phenotype
This randomized placebo-controlled study evaluates the efficacy of Nigella sativa (Nisatol®) supplementation in women with borderline blood pressure values or a non-dipper blood pressure phenotype.
- Trial name
- NCT07494279
- Testing
- Nigella sativa (Nisatol®)
- Where
- Italy
- Volunteers
- 106 people
- Sponsor
- Liaquat University of Medical & Health Sciences
Blood Pressure, Endothelial Dysfunction
Neurovascular Effects of Empagliflozin
The goal of this clinical trial is to examine whether empagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, improves vascular and autonomic function in adults with prehypertension.
- Trial name
- NEURO-EMPA (NCT07799441)
- Testing
- Empagliflozin (EMPA)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kanokwan Bunsawat
Hypertension, Prehypertension
ReNEW Clinic Cohort Study
This is an ongoing, prospective cohort study of children and young adults who are evaluated in the Reversing the Negative Effects of Weight on the Heart (ReNEW) Clinic at Johns Hopkins University.
- Conditions
- Hypertension, Prehypertension, Obesity, Overweight
- Trial name
- ReNEW (NCT03816462)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Johns Hopkins University
Endothelial Dysfunction, High Blood Pressure
Inulin and Nitrate's Effects on Vascular Health and Gut Microbiome
Previous research has revealed that adults with pre-hypertensive and hypertensive blood pressure levels typically exhibit impaired vasodilation, which is a crucial aspect of blood vessel function, due to decreased nitric oxide…
- Conditions
- Endothelial Dysfunction, High Blood Pressure, Gut Microbiota Dysbiosis and Nutrition
- Trial name
- NCT06502535
- Testing
- Inulin, Potassium nitrate and inulin
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Exeter
Prediabetes, Prehypertension
Health Coaching to Effect Lifestyle Behaviour Change
A health coaching intervention in those with pre-disease (pre-hypertension or pre-diabetes) but without pre-existing cardiovascular disease will effectively help participants change their lifestyle behaviour and prevent or delay…
- Trial name
- HC (NCT01458496)
- Testing
- Health Coaching
- Where
- 2 sites in Canada
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Marshal Godwin
Prehypertension, Hypertension
Health Effects of a Nordic Diet Rich in Plant-based Foods and Fish
The purpose of this study is to investigate the effects of a Nordic diet rich in plant-based foods and fish on indicators of cardiovascular disease risk at two different levels of salt intake.
- Trial name
- NCT01412346
- Testing
- Effects of a Nordic diet rich in plant-based foods and fish
- Where
- Finland
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare
Hypertension, Prehypertension
Effects and Safety of Menthol on Blood Pressure and Metabolic Parameters in Prehypertensive and Mild Hypertensive Patients
Prehypertension and mild hypertension are associated with an increased risk of atherosclerosis and coronary artery disease, and often complicated with the metabolic disorder of glucose and lipid.
- Trial name
- ESMAB (NCT01408446)
- Testing
- Menthol
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Zhiming Zhu
Prehypertension, Hypertension, Stage I
A Prospective Study of B244 Delivered as a Topical Spray to Determine Safety and Efficacy in Subjects With Elevated Blood Pressure
The purpose of this study is to evaluate and compare the efficacy of B244 in treating patients with hypertension.
- Trial name
- NCT02998840
- Testing
- B244, Vehicle
- Where
- 10 sites in United States
- Volunteers
- 132 people
- Sponsor
- AOBiome LLC
Pre Hypertension
Combined Effects of Isometric Wall Squats and High Intensity Interval Training on Rate Pressure Product in Normotensive and Pre-hypertensive Sedentary Adults
Hypertension is leading yet preventable risk factor for cardiovascular disease and all-cause mortality worldwide. Prehypertension identifies those at high risk of developing HTN, prompting intervention to prevent or delay the…
- Trial name
- NCT06610006
- Testing
- High Intensity Interval Training (HIIT), Isometric Wall Squat
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Foundation University Islamabad
Hypertension
The Effect of Hibiscus Sabdariffa L. Tea on Blood Pressure
The goal of this study is to find out whether the plant compounds present in Hibiscus sabdariffa, a plant commonly used in herbal tea blends and other beverages, will have a beneficial effect on blood pressure in people with…
- Trial name
- NCT00175110
- Testing
- herbal therapy/botanical therapy (Hibiscus sabdariffa)
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Tufts University
Pre-hypertension, JNC 7 Stage I Hypertension
Center of Research Translation (CORT) Project 2
We propose a novel intervention for reducing BP that could have a preferential impact in patients with hyperuricemia and gout. There is a great need for new anti-hypertensives, particularly among those with gout.
- Trial name
- NCT02038179
- Testing
- Allopurinol
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Obesity, Pre-hypertension
Diet and Whole-body Vibration Training on Cardiovascular and Autonomic Function
Obesity is a major risk factor for premature arterial abnormalities including high blood pressure and increased stiffness. Previous studies have shown that weight loss via lifestyle modifications is associated with a decrease in…
- Conditions
- Obesity, Pre-hypertension, Hypertension
- Trial name
- NCT01741779
- Testing
- Whole Body Vibration Training, Hypocaloric diet, Whole body vibration training & diet
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Florida State University
Hypertension, Prehypertension
Use of Mobile Technology to Prevent Progression of Pre-hypertension in Latin American Urban Settings
Nearly half of the adult population in Latin American urban settings has abnormally high blood pressure. Although half of these subjects with high blood pressure are still in the pre-hypertensive stage (systolic blood pressure…
- Trial name
- NCT01295216
- Testing
- Mobile technology to promote lifestyle modification
- Where
- 3 sites in Argentina, Guatemala and 1 more
- Volunteers
- 637 people
- Sponsor
- Institute of Nutrition of Central America and Panama
Hypertension, Blood Pressure
Feasibility and Effectiveness of a Ring-type Blood Pressure Measurement Device
The goal of this clinical trial is to evaluate the feasibility and effectiveness of a ring-type blood pressure measurement device compared to a 24-hour ambulatory blood pressure monitoring device in patients with hypertension or…
- Conditions
- Hypertension, Blood Pressure, Systolic Hypertension, Diastolic Hypertension
- Trial name
- NCT06084065
- Testing
- CART-I Plus
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul National University Hospital
High Blood Pressure
Effect of Whey Protein on Blood Pressure
The purpose of this study is to determine if consumption of whey protein, compared with soy protein or a carbohydrate food decreases blood pressure along with reducing risk factors for heart disease.
- Trial name
- NCT00659672
- Testing
- Whey Protein, Soy Protein, Control (carbohydrate)
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- United States Department of Agriculture (USDA)