Clinical trials: Premature Babies
Preterm Infants, MCT Oil Massage
Medium-chain Triglyceride Oil Massage on Growth in Preterm
Aim: To explore the effect of medium-chain triglyceride (MCT) oil massage on growth in preterm infants. Methods: This randomized controlled trial was conducted in the newborn center of a regional hospital in Taiwan.
- Conditions
- Preterm Infants, MCT Oil Massage, Growth
- Trial name
- NCT04281563
- Testing
- massage with MCT oil (group 1)
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- Chiayi Christian Hospital
Surfactant Deficiency Syndrome Neonatal, Respiratory Distress Syndrome, Newborn
Fast Assessment of Surfactant Deficiency in Preterm Infants to Speed up Treatment
Recently the investigators have developed a point of care test (LS-test) to measure surfactant as lecithin in gastric aspirates from preterm infants.
- Conditions
- Surfactant Deficiency Syndrome Neonatal, Respiratory Distress Syndrome, Newborn, Bronchopulmonary Dysplasia
- Trial name
- FAST2 (NCT05638568)
- Testing
- LS test
- Where
- 4 sites in Denmark
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Respiratory Distress Syndrome in Premature Infant, Bronchopulmonary Dysplasia
Safety, Pk and Anti-inflammatory Effects of CC10 Protein in Premature Infants With Respiratory Distress Syndrome (RDS)
Bronchopulmonary Dysplasia (BPD) is a multi-factorial disease process that is the end result of an immature, surfactant deficient lung that has been exposed to hyperoxia, mechanical ventilation and infection.
- Trial name
- NCT01473264
- Testing
- recombinant human CC10 (rhCC10)
- Where
- 4 sites in United States
- Volunteers
- 22 people
- Sponsor
- Clarassance, Inc.
Infants in NICU Ventilated With HFV
Capnography in Infants Ventilated With High Frequency Ventilation
The investigators hypothesize that dEtCO2 measured by the Microstream® technique via a double-lumen ETT in infants ventilated with HFV would be feasible and adequately represent the arterial CO2 (PaCO2).
- Trial name
- NCT00859209
- Where
- Israel
- Volunteers
- 24 people
- Sponsor
- Bnai Zion Medical Center
The Focus of the Study is to Provide a Guideline on Osteopathic Approach in Treating Hospitalized Newborns.
Osteopathic Approach Into Neonatology Ward: the NE-O Model
Background Several studies have shown the effect of osteopathic manipulative treatment on neonatal care in reducing length of stay, gastrointestinal problems, clubfoot complications and improving cranial asymmetry of infants…
- Trial name
- NCT01902563
- Testing
- Osteopathic Manipulative Treatment
- Sponsor
- European Institute for Evidence Based Osteopathic Medicine
Premature Infant
A Study of Family-integrated Care for Reducing Uncertainty
To explore the intervention effect of family participatory nursing on the uncertainty of illness of parents of hospitalized premature infants, and to evaluate the uncertainty level of parents of premature infants in different…
- Trial name
- NCT04648787
- Testing
- family-integrated care, traditional nursing
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Children's Hospital of Fudan University
Premature Birth, Risk
The Effect of the Movement Imitation Therapy in Preterm (MIT-PB) in Motor Behavior's Quality.
This study aims to assess the effect of a parent-administered intervention program based on MIT-PB in preterm with abnormal general movements during the preterm period.
- Conditions
- Premature Birth, Risk, Early Intervention
- Trial name
- MIT-PB (NCT05319158)
- Testing
- MIT-PB, movement imitation therapy for preterm.
- Where
- 3 sites in Spain
- Volunteers
- 36 people
- Sponsor
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Apnea of Prematurity
A Comparison of Non-invasive Ventilation Methods Used to Prevent Endotracheal Intubation Due to Apnea in Very Low Birth Weight Infants
The purpose of this study is to determine whether nasal intermittent positive pressure ventilation (NIPPV) reduces the need for endotracheal intubation in very low birth weight infants with persistent apnea who fail nasal…
- Trial name
- NCT03298035
- Testing
- NCPAP as mode for apnea prevention, NIPPV as rescue mode for apnea prevention
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- The University of Texas Health Science Center, Houston
Necrotizing Enterocolitis of Newborn
The Intestinal Dysbacteriosis in the Pathogenesis of Necrotizing Enterocolitis
Study Description The goal of this observational study is to detect intestinal flora and the metabolic products in premature infants diagnosed as necrotizing enterocolitis. The main questions it aims to answer are: 1.
- Trial name
- NCT05619055
- Testing
- Routine treatment
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Zuohui Zhao
Hyalinosis, Hyaline Membrane Disease
Biomarker for Hyaline Fibromatosis Syndrome (BioHFS)
Development of a new MS-based biomarker for the early and sensitive diagnosis of Hyaline fibromatosis syndrome from the blood
- Conditions
- Hyalinosis, Hyaline Membrane Disease, Juvenile Hyaline Fibromatosis, Fibromatosis Hyalinica Multiplex Juvenilis
- Trial name
- BioHFS (NCT03196115)
- Where
- 3 sites in Germany, India and 1 more
- Sponsor
- CENTOGENE GmbH Rostock
Bronchopulmonary Dysplasia
Study to Justify Steroid Use in Preterm Neonates to Prevent Bronchopulmonary Dysplasia
Most preterm babies require supplemental oxygen for a variable period of time, up to several weeks or months after birth. The aim of oxygen therapy is to achieve adequate oxygen supply to the tissues without causing oxygen…
- Trial name
- NCT03035214
- Testing
- Dexamethasone (Steroids)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Maadi Military Hospital
Infant, Premature
Preliminary Study to the Conception of a Non-invasive Neonatal Monitoring System With Development of a Database
Each year, 300 000 new borns are hospitalised in neonatology units in Europe. This period is very sensitive as newborns are exposed to a high risk of morbidity and mortality, with severe impact on neuro-developmental prognostic.
- Trial name
- Digi-NewB (NCT02863978)
- Testing
- Multimodal signal acquisitions
- Where
- 6 sites in France
- Volunteers
- 746 people
- Sponsor
- Rennes University Hospital
BPD - Bronchopulmonary Dysplasia, NEC - Necrotizing Enterocolitis
Targeted vs Standard Fortification of Breast Milk
BACKGROUND: Human milk (HM) is recommended for all very low birth infants (VLBW)). Breast-milk is highly variable in nutrient content, failing to meet the nutritional demands of VLBW.
- Conditions
- BPD - Bronchopulmonary Dysplasia, NEC - Necrotizing Enterocolitis, Weight Gain, VLBW - Very Low Birth Weight Infant
- Trial name
- NCT03775785
- Testing
- Tailored enteral nutrition
- Where
- 2 sites in Poland
- Volunteers
- 200 people
- Sponsor
- Princess Anna Mazowiecka Hospital, Warsaw, Poland
Premature Birth, Extremely Premature Infants
Prenatal Counseling in Extreme Prematurity: Professionals' View
This study is part of the PreCo study, evaluating Dutch care in (imminent) extreme preterm birth including current and preferred counseling, barriers and facilitators for preferred counseling from both obstetricians and…
- Trial name
- PreCo-profs (NCT02782650)
- Testing
- survey and interview
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Retinopathy of Prematurity, Dexmedetomidine
Intranasal Dexmedetomidine for Pain Management During Screening for Retinopathy of Prematurity
Background: Preterm infants undergo serial eye examinations during their hospital stay to monitor for the development of a specific disease termed "retinopathy of prematurity".
- Trial name
- NCT06067958
- Testing
- Dexmedetomidine, Saline
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Assaf-Harofeh Medical Center
Infant, Premature, Diseases
Serum Vascular Endothelial Growth Factor in Infants With Intravitreal Ranibizumab
To determine the serum concentrations of ranibizumab and vascular endothelial growth factor (VEGF) in infants with retinopathy of prematurity (ROP) who received intravitreal ranibizumab
- Trial name
- NCT03115255
- Testing
- intravitreal ranibizumab
- Where
- China
- Volunteers
- 17 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Neonatal Sepsis
Intravenous Immunoglobulin in Prevention of Preterm Neonatal Sepsis
Majority of healthcare authorities believe that due to the methodological weakness and small number of patients in conducted therapeutic trials, the evidences are insufficient to support the efficacy of intravenous immunoglobulin…
- Trial name
- NCT02954926
- Testing
- IVIG
- Where
- Iran
- Volunteers
- 92 people
- Sponsor
- Hormozgan University of Medical Sciences
Bronchopulmonary Dysplasia, Pulmonary Hypertension Due to Lung Diseases and Hypoxia
Ventilator Pressure and Optimization of Compliance and Hemodynamics
In preterm infants < 34 weeks' gestation at birth receiving respiratory support with invasive positive pressure ventilation, the positive end-expiratory pressure (PEEP) of best compliance will increase the cardiac output and…
- Conditions
- Bronchopulmonary Dysplasia, Pulmonary Hypertension Due to Lung Diseases and Hypoxia, Extreme Prematurity, Ventilator Lung; Newborn
- Trial name
- VPOCH (NCT06512935)
- Testing
- Increase in the PEEP followed by decrease in the PEEP, Decrease in the PEEP followed by increase in the PEEP
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Alabama at Birmingham
Nosocomial Infections, Sepsis
Safety and Efficacy of Veronate® Versus Placebo in Preventing Nosocomial Staphylococcal Sepsis in Premature Infants
The purpose of this study is to show whether Veronate, a donor-selected staphylococcal human immune globulin intravenous (IGIV), can prevent an infection in the blood caused by staphylococcal bacteria in premature babies weighing…
- Conditions
- Nosocomial Infections, Sepsis, Staphylococcal Infections, Candidemia
- Trial name
- NCT00113191
- Testing
- Veronate
- Where
- 93 sites in United States, Canada
- Volunteers
- 2,000 people
- Sponsor
- Bristol-Myers Squibb
Infant Development, Hypoglycemia Neonatal
Continuous Glucose Monitoring and Cerebral Oxygenation in Preterm Infants
Neonatal hypoglicaemia is associated with impaired neurodevelopment outcomes in preterm infants. Thus, hypoglicemic events should be diagnosed and treated promptly.
- Conditions
- Infant Development, Hypoglycemia Neonatal, Neurodevelopmental Abnormality
- Trial name
- Glucolight (NCT04347590)
- Testing
- Unblinded - CGM (Medtronic Guardian), Blinded - CGM (Medtronic Guardian)
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University Hospital Padova