Clinical trials: Premature Birth of Newborn
Prematurity
PIOMI Effects on Preterm Infant Outcomes
Objective: This study aimed to investigate the effects of Premature Infant Oral Motor Intervention (PIOMI) on body weight gain, breastfeeding behavior, and length of hospital stay in preterm infants hospitalized in the neonatal…
- Trial name
- NCT07366190
- Testing
- Premature Infant Oral Motor Intervention (PIOMI), nursing care
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Premature Birth
Prediction Tool for Premature Labour and Neonatal Outcome
A register and prediction model will be developed to predict the outcome of preterm labour and birth.
- Trial name
- PRETURN (NCT03405116)
- Where
- Belgium
- Volunteers
- 2,037 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Retinopathy of Prematurity, Neurodevelopmental Abnormality
Analysis of Ocular and Neurodevelopmental Function for Retinopathy of Prematurity
The goal of this research project is to identify the long-term outcome of neurodevelopment in patients with retinopathy of prematurity(ROP) and the treatment of anti-vascular endothelial growth factor (VEGF) such as intravitreal…
- Trial name
- NCT05186155
- Testing
- Severe ROP
- Where
- Taiwan
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Respiratory Distress Syndrome in Premature Infant, Bronchopulmonary Dysplasia
Safety, Pk and Anti-inflammatory Effects of CC10 Protein in Premature Infants With Respiratory Distress Syndrome (RDS)
Bronchopulmonary Dysplasia (BPD) is a multi-factorial disease process that is the end result of an immature, surfactant deficient lung that has been exposed to hyperoxia, mechanical ventilation and infection.
- Trial name
- NCT01473264
- Testing
- recombinant human CC10 (rhCC10)
- Where
- 4 sites in United States
- Volunteers
- 22 people
- Sponsor
- Clarassance, Inc.
Postpartum Depression, Preterm Infant
The Impact of a Newborn Behavioral Intervention on the Mental Health of Mothers With Late Pre-Term Infants
Preterm birth is a serious public health issue, affecting 10% of all births in the US alone. Three quarters of these infants are born between 34 0/7 and 36 6⁄7 weeks' gestation or late-preterm (LP).
- Conditions
- Postpartum Depression, Preterm Infant, Infant Development
- Trial name
- BabyAMOR (NCT03836430)
- Testing
- Newborn Behavioral Observation-Family Wellness (NBO-FW)
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- Brigham and Women's Hospital
Retinopathy of Prematurity
European Disease Registry on Retinopathy of Prematurity (ROP)
The EU-ROP registry is a European wide multicenter non-interventional observational registry study intended to run open-ended in as many countries as possible including infants treated for retinopathy of prematurity irrespective…
- Trial name
- EU-ROP (NCT04939571)
- Testing
- Registry of preterm born infants with treatment-requiring ROP
- Where
- 59 sites in Austria, Bulgaria and 10 more
- Volunteers
- 3,000 people
- Sponsor
- University Medicine Greifswald
Bronchopulmonary Dysplasia
Lung Ultrasound Score for Early Prediction of Bronchopulmonary Dysplasia in Preterm Newborns
Bronchopulmonary dysplasia (BPD) is one of the most common and severe complications of extreme prematurity, affecting approximately 40% of infants born before 28 weeks of gestation.
- Trial name
- LUS_BPD (NCT07633184)
- Testing
- Lung ultrasound at 7 (±1) days of life, Lung ultrasound at 14 (±2) days of life
- Where
- 4 sites in Italy
- Volunteers
- 40 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Cystic Fibrosis
PTC124 for Cystic Fibrosis
In some patients with cystic fibrosis (CF), the disease is caused by a nonsense mutation (premature stop codon) in the gene that makes the cystic fibrosis transmembrane regulator (CFTR) protein.
- Trial name
- NCT00234663
- Testing
- PTC124
- Where
- 5 sites in United States
- Volunteers
- 24 people
- Sponsor
- PTC Therapeutics
Hypoxic-Ischemic Encephalopathy, Birth Asphyxia
Umbilical Cord Milking in Neonates Who Are Depressed at Birth-Developmental Follow Up (MIDAB-FU)
An extension of the MIDAB trial, the MIDAB-Follow-up trial will evaluate the neurodevelopmental outcomes at 22-26 months age of term/late preterm infants who were depressed at birth and received umbilical cord milking (UCM) or…
- Trial name
- MIDAB-FU (NCT03681314)
- Testing
- Umbilical Cord Milking
- Where
- 3 sites in India
- Sponsor
- Nemours Children's Clinic
Retinopathy of Prematurity
Use of Pan-vascular Endothelial Growth Factor Receptor (Pan-VEGF) Blockade for the Treatment of Retinopathy of Prematurity (ROP) (Compassionate Use BLOCK-ROP)
The purpose of this study is to provide access to intravitreal injection of Avastin in high-risk infants who do not otherwise qualify for study NCT00702819, an investigational multi-site study examining Avastin use for…
- Trial name
- NCT00870636
- Testing
- Bevacizumab (Avastin)
- Where
- United States
- Sponsor
- Children's Hospital Los Angeles
Retinopathy of Prematurity (ROP)
Intravitreal Ranibizumab for Aggressive Posterior Retinopathy of Prematurity: A Prospective Interventional Case Series
Aggressive posterior retinopathy of prematurity (AP-ROP) is a severe form of retinopathy of prematurity that can progress rapidly and lead to retinal detachment and permanent vision loss if not treated promptly.
- Trial name
- NCT07721298
- Testing
- Intravitreal Ranibizumab injection
- Where
- Egypt
- Volunteers
- 39 people
- Sponsor
- Ain Shams University
Respiratory Distress Syndrome, Newborn
Amniotic Fluid Optical Density Determination as a Test for Assessment of Fetal Lung Maturity.
To determine the relationship between the result of amniotic fluid optical density between 26 and 36 6/7 weeks of pregnancy and the risk of developing neonatal respiratory distress syndrome.
- Trial name
- NCT02332304
- Testing
- Preterm fetus
- Where
- Panama
- Volunteers
- 200 people
- Sponsor
- Saint Thomas Hospital, Panama
Respiratory Distress Syndrome, Newborn, Neonatal Respiratory Distress
Chest Ultrasound as Diagnostic and Prognostic Tool in Neonatal RDS
This cross-sectional study aims to evaluate the diagnostic accuracy of chest ultrasound in neonatal respiratory distress syndrome and to assess its potential prognostic value compared with chest X-ray.
- Trial name
- NCT07857304
- Volunteers
- 82 people
- Sponsor
- Assiut University
Neonatal Sepsis
Distribution of Haptoglobin Phenotype in Septic and Non Septic Pre-term Neonates (PTSH)
The Haptoglobin (Hp) gene locus at chromosome 16q22 is polymorphic with two alleles denoted 1 and 2 .The gene product exists in three phenotypes: 1-1, 2-1, and 2-2.
- Trial name
- NCT00800449
- Where
- Israel
- Volunteers
- 133 people
- Sponsor
- Irina Kessel
Bronchopulmonary Dysplasia
Safety of Sildenafil in Premature Infants
Describe the safety of sildenafil in premature infants at risk of bronchopulmonary dysplasia and determine preliminary effectiveness and pharmacokinetics (PK) of sildenafil.
- Trial name
- SIL02 (NCT03142568)
- Testing
- Sildenafil
- Where
- 15 sites in United States, Canada
- Volunteers
- 109 people
- Sponsor
- University of North Carolina, Chapel Hill
Preterm Premature Rupture of Membranes, Fetal Inflammatory Response Syndrome
Multimodal Monitoring of Fetal Risk of Inflammation in Preterm Premature Rupture of Membranes
The purpose of this study is to examine whether the value of vaginal fluid cytokine levels as well as computerized fetal ECG analysis are suitable clinical parameters to detect an imminent intra-amniotic inflammation with a high…
- Conditions
- Preterm Premature Rupture of Membranes, Fetal Inflammatory Response Syndrome, Early Onset Neonatal Sepsis, Infection of Amniotic Cavity
- Trial name
- MuMFI-PPROM (NCT02702297)
- Testing
- single arm
- Where
- 4 sites in Germany
- Volunteers
- 57 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Infant, Low Birth Weight, Infant, Premature, Diseases
Farm Work & Preterm Low Birthweight Among Hispanic Women
The most persistent and intractable cause of infant and child mortality and morbidity in the US remains preterm and low birthweight deliveries.
- Trial name
- NCT00015613
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Vitamin A Deficiency
Newborn Vitamin A (VA) Supplementation Pilot Project, Pakistan
Vitamin A is an essential micronutrient for the normal functioning of the visual system, growth and development, immunity and reproduction. Its deficiency causes anemia, growth retardation and xerophthalmia.
- Trial name
- VA (NCT00674089)
- Testing
- Vitamin A
- Where
- Pakistan
- Volunteers
- 7,400 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Tracheomalacia, Bronchopulmonary Dysplasia (BPD)
Enhancing Lung Health in Kids With Structural Lung Damage and Malformations: Azithromycin (AZI) for Airway Infection Prevention
Children with lung and airway malformations or early structural lung damage face significant challenges, often leading to recurrent respiratory infections, hospitalizations, and decreased quality of life.
- Conditions
- Tracheomalacia, Bronchopulmonary Dysplasia (BPD), Vascular Ring, Cystic Lung Disease
- Trial name
- TRALULALA-AZI (NCT06409299)
- Testing
- Azithromycin 40 MG/ML
- Volunteers
- 150 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Respiratory Distress Syndrome, Infant, Premature
Feasibility of Use of the PATH bCPAP and Oxygen Blenders Device With Neonates in Uganda
In this mixed methods study, the investigators assessed feasibility of use of the PATH bCPAP kit on neonatal patients as well as the usability and acceptability of the device by healthcare workers.The study took place in a rural…
- Trial name
- NCT05462509
- Testing
- bCPAP with blenders
- Where
- Uganda
- Volunteers
- 14 people
- Sponsor
- PATH
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