Clinical trials: Premature Birth of Newborn
Retinopathy of Prematurity (ROP)
Comparing Alternative Ranibizumab Dosages for Safety and Efficacy in Retinopathy of Prematurity
This study is designed as an exploratory study to assess safety and efficacy of two different doses of the anti-VEGF agent ranibizumab (0.12 mg vs. 0.20 mg) in the treatment of infants with retinopathy of prematurity.
- Trial name
- CARE-ROP (NCT02134457)
- Testing
- ranibizumab
- Where
- 9 sites in Germany
- Volunteers
- 19 people
- Sponsor
- University Hospital Freiburg
Placental Insufficiency, Preterm Infant
Impact of Umbilical Cord Milking in Preterm Neonates With Placental Insufficiency
To investigate the effect of umbilical cord milking (UCM) on peripheral hematologic parameters including hematopoietic progenitor cells in premature infants ≤ 34 weeks gestational age with placental insufficiency.
- Trial name
- NCT03731611
- Testing
- Umbilical Cord Milking
- Where
- 2 sites in Egypt
- Volunteers
- 90 people
- Sponsor
- Mansoura University Children Hospital
Retinopathy of Prematurity
A Dosing Study of Intravitreal Bevacizumab for Retinopathy of Prematurity
The aim of our study was to determine whether a low dose of 0.3125mg intravitreal bevacizumab is effective in treatment of type 1 ROP as the standard 0.625 mg dose., regarding : Serum Systemic VEGF levels. Retinal Vascularization.
- Trial name
- NCT05712642
- Testing
- Intravitreal Bevacizumab
- Where
- Egypt
- Volunteers
- 19 people
- Sponsor
- Cairo University
Premature Birth
Initial Nutritional Strategy and Stature-level Growth During the Neonatal Period of Children Born Moderately Premature
The growth and nutrition of premature infants during the neonatal period is a concern of neonatology services; it impacts the child's health in the short and long term.
- Trial name
- EPIPAGE2 (NCT03662503)
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Retinopathy of Prematurity
Omega-3 Long Chain Polyunsaturated Fatty Acid (LCPUFA) Supplementation in Very Low Birth Weight Infants for The Prevention Retinopathy of Prematurity
Retinopathy of prematurity (ROP) is a blinding disease affecting infants born prematurely. These infants do not have enough essential fatty acids to structurally support the retina, the nerve tissue in the eye which allows us to…
- Trial name
- NCT02486042
- Testing
- Omegaven, Standard lipids (primarily omega-6 fatty acids)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of California, San Diego
Low Birth Weight, Premature Birth
Comparison of Outcomes of Early Kangaroo Mother Care and Standard Method Care in Healthy Low Birth Weight Preterm Neonates at a Tertiary Care Hospital
The goal of this clinical trial is to learn whether early initiation of kangaroo mother care (KMC) can improve clinical outcomes in healthy low birth weight preterm neonates (gestational age 30-37 weeks, birth weight <2000 g).
- Conditions
- Low Birth Weight, Premature Birth, Preterm Infant
- Trial name
- NCT07259486
- Testing
- Kangaroo Mother Care, Standard Medical Care (SMC)
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- University of Health Sciences Lahore
Other Preterm Infants, Transitory Neonatal Electrolyte Disturbance
Clinical Tolerance of Numeta 13%
Numeta G13% is a triple chamber bag including amino acids plus electrolytes, glucose and lipids, dedicated for parenteral nutrition in preterm newborn infants when oral/enteral nutrition is not possible, insufficient or contra…
- Conditions
- Other Preterm Infants, Transitory Neonatal Electrolyte Disturbance, Disorder of Mineral Metabolism, Failure to Thrive
- Trial name
- BAXTERULG2 (NCT01772927)
- Testing
- Parenteral Nutrition
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- University of Liege
Ventilator Lung; Newborn
Influence of Respiratory Rate Settings on CO2 Levels During Nasal Intermittent Positive Pressure Ventilation (NIPPV).
Infants will be monitored by TcCO2 during three consecutive time periods of one hour each on a high and low rate of NIPPV, when in a stable condition.
- Trial name
- NCT04836689
- Testing
- nasal intermittent positive pressure ventilation (NIPPV).
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Rambam Health Care Campus
Premature Infant, Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse)
Preventing Vulnerable Child Syndrome in the NICU With Cognitive Behavioral Therapy (PreVNT Trial)
This study is being done to see if outcomes for both a premature infant's parents and the infant born prematurely who have spent time in the neonatal intensive care unit (NICU) can be improved through parent cognitive behavioral…
- Conditions
- Premature Infant, Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse), Development, Child, Parent-Child Relations
- Trial name
- PreVNT (NCT03906435)
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Gastroesophageal Reflux Disease, Bronchopulmonary Dysplasia
The Role of Anti-Reflux Surgery for Gastroesophageal Reflux Disease in Premature Infants With Bronchopulmonary Dysplasia
The purpose of this study is to evaluate the efficacy of fundoplication in premature infants with GERD and BPD.
- Trial name
- GERD-BPD (NCT00926276)
- Testing
- Fundoplication
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- The University of Texas Health Science Center, Houston
Respiratory Distress Syndrome, Newborn, Premature Birth
SURFAXIN® Treatment for Prevention of Bronchopulmonary Dysplasia (BPD) in Very Low Birth Weight (VLBW) Infants.
SURFAXIN® (lucinactant) treatment will be examined in very low birth weight infants to prevent development of chronic lung disease, commonly known as bronchopulmonary dysplasia (BPD), in premature infants who have required…
- Conditions
- Respiratory Distress Syndrome, Newborn, Premature Birth, Bronchopulmonary Dysplasia
- Trial name
- NCT00215540
- Testing
- Lucinactant 175 mg/kg, Lucinactant 90 mg/kg
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Windtree Therapeutics
Premature Birth, Brain Injuries
S100B as a Marker of Brain Injury of Preterm Infants
The improvement of treatment of preterm neonates improved their survival, however there is still significant portion of preterm infants (specifically very preterm infants) that suffers from brain insults and as a result…
- Conditions
- Premature Birth, Brain Injuries, Leukomalacia Periventricular, Developmental Disabilities
- Trial name
- PTS100B (NCT02082535)
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Respiratory Distress Syndrome, Bronchopulmonary Dysplasia
Intratracheal Budesonide/Surfactant Prevents BPD
A double-blind study includes: 1) birth Wt 500-1499 gm, 2) respiratory distress shortly after birth and requires resuscitation 3) failure to NCPAP within 4 hrs after birth, defined as: a) FIO2 ≥ 0.30, pressure > 5cmH2O b) severe…
- Trial name
- NCT03275415
- Testing
- budesonide, Saline
- Where
- Taiwan
- Volunteers
- 310 people
- Sponsor
- Taipei Medical University
Tracheal Intubation
Flow Sensor and Colourimetric Capnometer in Verifying Tracheal Tube Positioning in Term and Preterm Infants
This is a multicentre clinical trial with medical device. As currently recommended by international neonatal resuscitation guidelines, the most reliable method to verify the correct positioning of the endotracheal tube, in…
- Trial name
- FlowNET (NCT05162313)
- Testing
- confirmation of endotracheal tube positioning
- Where
- Italy
- Volunteers
- 105 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
High Risk Pregnancy, Incompetent Cervix
Amniotic Fluid Sludge in Cerclage Patients as an Indicator for Increased Risk of Preterm Delivery and Neonatal Outcome.
Amniotic Fluid "Sludge" Does Not Increase Risk of Preterm Delivery in Cerclage Patients.
- Conditions
- High Risk Pregnancy, Incompetent Cervix, Cerclage, Amniotic Fluid Sludge
- Trial name
- NCT00722085
- Where
- United States
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Center For Maternal Fetal Medicine
Preterm Infant, Respiratory Insufficiency Syndrome of Newborn
Non-invasive Respiratory Support in Preterm Infants
Lungs of babies born early are not fully developed and they often need a machine to help them breathe. The traditional approach to provide this support is with a breathing tube passed into the windpipe.
- Conditions
- Preterm Infant, Respiratory Insufficiency Syndrome of Newborn, Bronchopulmonary Dysplasia
- Trial name
- NOVEL (NCT03512158)
- Testing
- Non-invasive respiratory support mode
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- McMaster Children's Hospital
Premature Newborns, Cranial Asymmetry
Effects of Tummy Time Associated With Therapeutic Positioning in Premature Newborns With Cranial Asymmetry
Deformational plagiocephaly is an alteration in the shape of a baby's head caused by pressure exerted on the skull. This condition can begin during gestation and worsen after birth, especially when the baby spends a lot of time…
- Trial name
- plagiocephaly (NCT07758426)
- Testing
- Tummy Time Protocol
- Where
- Brazil
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Infant, Premature Development
The Impact of Implementing NIDCAP on the Developmental Sensitivity of Nurses Caring for Preterm Infants
The purpose of this study is to determine whether implementing the Newborn Individualized Developmental Care and Assessment Program increases NICU nurses' sensitivity in meeting the developmental care needs of preterm infants.
- Trial name
- NCT00179985
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Premature Baby 26 to 32 Weeks, Preterm Birth
Effectiveness of Positioning in Preterm Neonates
Introduction: When babies are born prematurely, they are deprived of their usual space limits (uterus walls). This along with the action of gravity to which they are exposed after birth, makes the neonates have a low muscle tone…
- Trial name
- NCT04251260
- Testing
- Positioning in flexion
- Where
- Greece
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Patras
Neonatal Intensive Care, Preterm
The Effect of Simulated Intrauterine Sound Applied to Preterms
Preterm infants lack intrauterine sounds suitable for their development as they are born early. In addition, they are exposed to many unfamiliar sounds for weeks or months in the neonatal intensive care unit (NICU) where their…
- Trial name
- NCT05806320
- Testing
- Intrauterine Sound Listening Group 1, Intrauterine Sound Listening Group 2
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.