Clinical trials: Premature Birth of Newborn
Preterm, Ventilator Lung; Newborn
Evaluation of Nasal Non Invasive Ventilation in Management of Neonates With Respiratory Distress Using Lung Ultrasound
This study aims to evaluate the effect of non-invasive ventilation (nIPPV) , (nCPAP), and nasal high flow cannula (NHFC) as a primary mode of ventilation in preterm neonates <37 gestational week with moderate to severe RD using…
- Trial name
- NCT06550219
- Testing
- Nasal humidified heated high flow cannula (NHHHC), Nasal intermittent positive pressure ventilation (NIPPV), Nasal continuous positive airway pressure NCPAP
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Polycystic Ovary Syndrome, Preterm Birth
Metabolic and Endocrine Status in Women With Prior Preterm Birth
The prevalence of preterm birth is rising in most western countries. The causes of preterm birth is not fully understood and seem to be multifactorial.
- Conditions
- Polycystic Ovary Syndrome, Preterm Birth, Diabetes Mellitus
- Trial name
- NCT01355536
- Where
- Norway
- Volunteers
- 262 people
- Sponsor
- Namsos Hospital
Premature Birth
Assessment of the Impact of the Return Home of Premature Newborns Less Than 2 Kilos Morbidity/Mortality
The aim of this study is to evaluate the impact of discharge from hospital with a weight of less than 2 kilos. To do this, the investigator will look at the short-term and long-term outcome of newborns weighing less than 2 kilos…
- Trial name
- Petit-Poids (NCT06224764)
- Testing
- Mother and Father questionnaires
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hôpital NOVO
Bronchopulmonary Dysplasia
MRI of Lung Structure and Function in Preterm Children
The MRI tools developed by the investigators are well positioned for assessing regional changes in lung structure and function in preterm children with bronchopulmonary dysplasia (BPD), in which airway limitation similar to…
- Trial name
- NCT03475264
- Testing
- Lung MRI
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Infant, Newborn, Respiratory Insufficiency
Inhaled PGE1 in Neonatal Hypoxemic Respiratory Failure
This pilot study was a randomized, placebo-controlled, clinical trial to test the safety of using the intravenous form of Prostaglandin E1 (PGE1) in an inhaled form for treatment of hypoxemic respiratory failure in term newborns.
- Conditions
- Infant, Newborn, Respiratory Insufficiency, Pulmonary Hypertension, Respiratory Distress Syndrome, Newborn
- Trial name
- IPGE1 (NCT00598429)
- Testing
- Inhaled Prostaglandin E1
- Where
- 11 sites in United States
- Sponsor
- NICHD Neonatal Research Network
Respiratory Distress Syndrome, Newborn, Endotracheal Intubation
An Educational Intervention to Improve the Success of Intubation in Newborns Using a Video Laryngoscope by Reducing the Time the Procedure Takes.
This research focuses on one of the most common problems in newborn medicine: breathing difficulties. Breathing problems are the most common reason for admission to our neonatal unit at the National Maternity Hospital.
- Conditions
- Respiratory Distress Syndrome, Newborn, Endotracheal Intubation, Neonatal Intubation Performance, Prematurity
- Trial name
- NINJA (NCT06898801)
- Testing
- Just-in-time video training
- Where
- Ireland
- Volunteers
- 140 people
- Sponsor
- University College Dublin
Retinopathy of Prematurity
Ultrasound to Detect Evidence for Retinal Detachment in Retinopathy of Prematurity
Premature infants stand a risk of danger to the layer of the eye that creates sight that, if untreated, can cause severe vision problems, leading to blindness in some cases.
- Trial name
- NCT00279669
- Testing
- Ultrasound examination
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Weill Medical College of Cornell University
Infant Premature
Evaluation of a Peer Counseling Breastfeeding Support Program for Mother-preterm Infant Dyads
Breastfeeding has a fundamental impact on the short-, medium- and long-term health of children and has an important impact on women's health.
- Trial name
- ALAIS (NCT03156946)
- Testing
- breastfeeding mother-to-mother support, Control
- Where
- 8 sites in Belgium, France and 1 more
- Volunteers
- 1,774 people
- Sponsor
- Hospices Civils de Lyon
Respiratory Distress Syndrome, Newborn
Antepartum Betamethasone Treatment for Prevention of Respiratory Distress in Infants Born by Elective Cesarean Section
This is a randomized, multicenter, double blind, placebo controlled trial of betamethasone versus a placebo given prior to the mothers at term and near term gestation (>34 and <40 weeks of gestation) who are scheduled to undergo…
- Trial name
- NCT00139256
- Testing
- Betamethasone
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Emory University
Retinopathy of Prematurity
Mother Milk as a Eye Drop & Premature Retinopathy
The aim of this study is to investigate the effect of using breast milk as eye drops on ROP (Retinopathy of prematurity) disease observed in less then 32 weeks gestational age preterm babies.
- Trial name
- NCT04883931
- Testing
- Normal Saline, Breast milk
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people
- Sponsor
- Baskent University
Necrotizing Enterocolitis, Intraventricular Hemorrhage
PUFAs in Preterm Infants
The research endeavors to examine the critical composition of Polyunsaturated Fatty Acids (PUFAs) in premature infants across different gestational stages and under varying disease conditions, and delineate the metabolic…
- Conditions
- Necrotizing Enterocolitis, Intraventricular Hemorrhage, BPD - Bronchopulmonary Dysplasia, Sepsis
- Trial name
- PIPI (NCT06045130)
- Volunteers
- 600 people
- Sponsor
- The First Hospital of Jilin University
Respiratory Distress Syndrome, Newborn
Randomized Controlled Trial of Surfactant Administration by Laryngeal Mask Airway (LMA)
In this protocol we will conduct a randomized controlled trial where babies with respiratory distress syndrome (RDS) who have not yet reached criteria for intubation, will be randomized to receive surfactant by LMA or to continue…
- Trial name
- NCT00599651
- Testing
- Surfactant administered via Laryngeal Mask Airway (LMA), standard of care (nasal CPAP and supplemental oxygen)
- Where
- United States
- Volunteers
- 380 people
- Sponsor
- University of Virginia
Gastric Tube Placement
Correct Gastric Tube Placement in Very Low Birth Weight Neonates
Gastric tube (GT) placement is a recurrent procedure in VLBW infants due to feeding impairment correlated with low birth weight.
- Trial name
- NCT04127773
- Testing
- oro gastric tube
- Where
- Italy
- Volunteers
- 220 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Small for Gestational Age, Infant, Very Low Birth Weight
Effect of Low Dose Aspirin on Birthweight in Twins: The GAP Trial.
Low-dose aspirin started in the first-trimester has been associated with a decrease of preeclampsia, fetal growth restriction and preterm birth in high-risk pregnancies.
- Conditions
- Small for Gestational Age, Infant, Very Low Birth Weight, Fetal Growth Retardation, Preeclampsia
- Trial name
- GAP (NCT02280031)
- Testing
- Acetylsalicylic Acid
- Where
- 2 sites in Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Bronchopulmonary Dysplasia
OCTA Evaluation of Retinal Vascularization in Preterm Infants With or Without Bronchopulmonary Dysplasia
Retinal vascularization in humans develops between the 16th and 36th weeks of amenorrhea, in a centrifugal pattern starting from the optic disc.
- Trial name
- OCTA_BRO (NCT07586683)
- Testing
- OCT Angiography
- Where
- France
- Volunteers
- 56 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Analgesia
Analgesic Efficacy of Oral Glucose in Preterm Neonates During Suctioning
Nasopharyngeal suctioning is a painful procedure that often becomes necessary in the care of preterm infants under CPAP therapy several times a day.
- Trial name
- Glucose FG (NCT00761059)
- Testing
- Glucose 20%, Aqua
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Cologne
Antioxidant Role of the Lutein in Preterm Newborn
Early Administration of the Lutein/Zeaxanthin in Premature Newborns
Premature birth is the most common cause of mortality, morbidity and disability. Premature infants have a higher risk of developing damage in the eyes (retinopathy of prematurity ROP), in the central nervous system…
- Trial name
- NCT03340103
- Testing
- LUTEIN ofta 0,5 gocce
- Where
- 4 sites in Italy
- Sponsor
- Sooft Italia
Respiratory Distress Neonatal, Noninvasive Ventilation
Comparison of the Silverman-Andersen Score and the Downes Score
This study aimed to compare the Silverman-Andersen score and the Downes score in predicting noninvasive ventilation (NIPPV) failure in preterm and term infants who received NIPPV support due to postnatal respiratory distress, as…
- Conditions
- Respiratory Distress Neonatal, Noninvasive Ventilation, Intubation, Scoring Systems
- Trial name
- CSASDS (NCT07183956)
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 220 people
- Sponsor
- Muğla Sıtkı Koçman University
Hyaline Membrane Disease (HMD)
Impact of Antenatal Corticosteroid Therapy on Postnatal Surfactant Use in Preterm Infants
No study has shown that two doses of corticosteroids are more effective than a single dose in lung maturation and prevention of hyaline membrane disease (HMD) The aim of this study is to assess the impact of the number of doses…
- Trial name
- CORISURF (NCT05455879)
- Testing
- Impact of antenatal corticosteroid therapy on surfactants use postnatal
- Where
- France
- Volunteers
- 145 people
- Sponsor
- Hôpital NOVO
Neonatal Sepsis
Role of Montelukast in Modulation of Response to Sepsis in Preterm Infants
The investigators will conduct this study to explore the role of Montelukast in treatment of neonatal sepsis and whether it has an effect on inflammatory markers, the duration of antibiotic use, or on the patients´ outcome.
- Trial name
- NCT04474327
- Testing
- Montelukast Sodium
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Mansoura University Children Hospital
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