Clinical trials: Premature Birth of Newborn
Premature Infants
The Effect of Using Clinical Guidelines on Kangaroo Care on Newborn and Maternal Outcomes
The aim of this study was to determine the effect of the use of clinical guidelines in kangaroo care (KB) practice on neonatal and maternal outcomes in premature infants.
- Trial name
- NCT05807191
- Testing
- Kangaroo care based on kangaroo care guide
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Premature Birth
Placental and Cord Blood Markers Associated With Premature Birth and Disorders of Premature Birth in Newborn Infants
The purpose of this study is to determine if changes in specific gene products in the placenta or cord/infant blood affect a baby's birth weight, increase the risk of premature birth, or increase the risk of developing diseases…
- Trial name
- NCT01439048
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Bronchopulmonary Dysplasia, Vitamin D Overdose
25OH Vitamin D Overdoses and Risk of Bronchopulmonary Dysplasia or Death
Several studies have demonstrated that vitamin D deficiency at birth is a risk factor of bronchopulmonary dysplasia. However, in an animal model of bronchopulmonary dysplasia vitamin D overdose has also been associated with an…
- Trial name
- 25OHVDORBPDD (NCT05944055)
- Testing
- Is 25 OH vitamin D overdose a risk factor of bronchopulmonary dysplasia or death ?
- Where
- France
- Volunteers
- 173 people
- Sponsor
- Hospices Civils de Lyon
Retinopathy of Prematurity, Pain Management
Pain Management During Screening for Retinopathy of Prematurity
Abstract Background: Screening examinations for retinopathy of prematurity (ROP) is critical to reduce ROP-related vision loss, however, the procedure is painful and uncomfortable, and topical anesthetics do not completely…
- Trial name
- NCT04767178
- Testing
- Ibuprofen (Sanofi, Istanbul, Turkey), Paracetamol (GlaxoSmithKline, Istanbul, Turkey)
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Istanbul Medeniyet University
Bronchopulmonary Dysplasia
Phase 1 Intravenous Citrulline for the Prevention of Bronchopulmonary Dysplasia in Preterm Infants
Premature infants are at risk for developing bronchopulmonary dysplasia (BPD). L-citrulline may decrease that risk, but we do not know the safety or dose of this drug for use in premature babies.
- Trial name
- NCT00742534
- Testing
- Intravenous L-Citrulline
- Where
- United States
- Sponsor
- Vanderbilt University
Prematurity
Preterm Neonates Brain Ultrasound With CEUS and Elastography
The aim of the study is to investigate levels of brain perfusion and elasticity in preterm neonates when they reach the estimated due date and to compare the data with magnetic resonance imaging at term.
- Trial name
- NCT05694611
- Testing
- Brain contrast enhanced ultrasound, brain ultrasound elastography, Sulfur Hexafluoride
- Where
- Finland
- Sponsor
- Turku University Hospital
Pregnancy Preterm, Neonatal Hypoglycemia
Continuous Glucose Monitoring of Late Preterm Birth After Corticosteroids
Women undergoing late preterm birth are at high risk of delivering a newborn with neonatal hypoglycemia. The investigators plan to monitor interstitial glucose levels prior to delivery in these women in order to develop a better…
- Conditions
- Pregnancy Preterm, Neonatal Hypoglycemia, Prematurity
- Trial name
- NCT03738293
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pediatrix
Respiratory Distress Syndrome, Bronchopulmonary Dysplasia
Study of the Pathobiology of Bronchopulmonary Dysplasia in Newborns
OBJECTIVES: I. Create a clinical sample bank of neonates with lung disease to test hypotheses regarding the pathogenesis of bronchopulmonary dysplasia (BPD). II.
- Trial name
- NCT00006058
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Center for Research Resources (NCRR)
Respiratory Distress Syndrome in Premature Infant, Patent Ductus Arteriosus After Premature Birth
Combined Lung Ultrasounds and Transthoracic Electrical Bioimpedance in Preterm Infants With Respiratory Distress.
Respiratory distress syndrome (RDS) is among the most common complications of preterm birth, and typically becomes manifested soon after birth.
- Conditions
- Respiratory Distress Syndrome in Premature Infant, Patent Ductus Arteriosus After Premature Birth, Perinatal Morbidity
- Trial name
- NCT04359134
- Where
- 2 sites in Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bronchopulmonary Dysplasia
Prediction for Bronchopulmonary Dysplasia
In this Multi-center study performed from January 2018, we reviewed data on infants whose gestational ages were below 36 weeks. we collected data containing maternal diseases and neonatal clinical features.
- Trial name
- NCT05181319
- Testing
- occurrence of bronchopulmonary dysplasia
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Kai Mu
Preterm Birth
Multiperfusion Neonatal System
Infusion and parenteral nutrition play an important role in the management of neonatal intensive care patients. Administration of drugs and parenteral nutrition solutions to the patient is performed via different systems…
- Trial name
- EDELWEISS (NCT05058534)
- Testing
- Multiline Neo®
- Where
- France
- Volunteers
- 640 people
- Sponsor
- Hospices Civils de Lyon
Apnea of Prematurity, Premature Newborn
Effect of Feedings on Caffeine in Premature Infants
Almost all infants born <29 weeks gestational age develop apnea of prematurity and are treated with caffeine. Type of diet and disease states may be significant contributors of variability in caffeine metabolism and…
- Conditions
- Apnea of Prematurity, Premature Newborn, Caffeine
- Trial name
- NCT02293824
- Testing
- Caffeine
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Duke University
Periventricular Leukomalacia
Telerehabilitation of Working Memory in Children With Periventricular Leukomalacia and Bilateral Cerebral Palsy
Periventricular Leukomalacia (PVL) is a white matter lesion surrounding the lateral ventricles of the brain occurring in the prenatal period, associated with a disorder of movement and posture, known as bilateral cerebral palsy.
- Trial name
- NCT02342990
- Testing
- Cluster B CogMed: an home-based and computer-based solution to improve working memory deficit, Cluster A No training. Delay start of CogMed
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS Fondazione Stella Maris
Vitamin A Deficiency
Newborn Vitamin A (VA) Supplementation Pilot Project, Pakistan
Vitamin A is an essential micronutrient for the normal functioning of the visual system, growth and development, immunity and reproduction. Its deficiency causes anemia, growth retardation and xerophthalmia.
- Trial name
- VA (NCT00674089)
- Testing
- Vitamin A
- Where
- Pakistan
- Volunteers
- 7,400 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Transient Tachypnea of Newborn and Fetal Acidosis
Impact Of Maternal Spinal Anesthesia-Induced Hypotension At Scheduled Cesarean Delivery On Risk Development Of Transient Tachypnea Of Newborn And Fetal Acidosis
We will evaluate the association between transient tachypnea of newborns and fetal acidosis development to the degree and duration of maternal hypotension and anesthesia to delivery time during spinal anesthesia at scheduled…
- Trial name
- NCT06383624
- Where
- Egypt
- Volunteers
- 115 people
- Sponsor
- Benha University
Premature Infant, Patent Ductus Arteriosus
Non-Invasive Detection of Tissue Oxygen Deprivation in Premature Infants With Patent Ductus Arteriosus.
The proposed research evaluates tissue oxygenation (StO2) as measured by resonance raman spectroscopy (RRS) in premature infants with and without patent ductus arteriosus (PDA).
- Conditions
- Premature Infant, Patent Ductus Arteriosus, Hemodynamic Instability
- Trial name
- NCT03277768
- Testing
- Resonance Raman Spectroscopy (RRS)
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- University of Florida
Sepsis Newborn
The Effects of Two Different Intravenous Lipid Emulsions on the Outcomes of Preterm Infants With Sepsis
Introduction and objectives: Lipid emulsions play an important role in parenteral nutrition in preterm infants. We aim to evaluate the effect of two different intravenous lipid emulsions on the outcomes of neonatal sepsis in…
- Trial name
- NCT03275090
- Testing
- Smoflipid ®
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Mansoura University Children Hospital
Patent Ductus Arteriosus
Closure of Patent Ductus Arteriosus With Indomethacin or Ibuprofen in Extreme Low Birth Weight Infants
Pharmacological closure of ductus arteriosus with prostaglandin (PG) inhibitors has been used for years. Previous studies indicated that ibuprofen has similar effect on ductal closure as indomethacin but has less adverse effects…
- Trial name
- NCT01758913
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Taipei Medical University Hospital
Preterm Premature Rupture of Membrane, Pregnancy, High Risk
Improvement of PPROM Management With Prophylactic Antimicrobial Therapy (iPROMPT)
To conduct an unblinded pragmatic randomized controlled trial (pRCT) "Improvement of PPROM Management with Prophylactic Antimicrobial Therapy (iPROMPT)" of a seven-day course of ceftriaxone, clarithromycin, and metronidazole…
- Conditions
- Preterm Premature Rupture of Membrane, Pregnancy, High Risk, Preterm Birth
- Trial name
- NCT06396078
- Testing
- Ceftriaxone 1000 MG, Clarithromycin 500mg, Metronidazole 500 mg
- Where
- 2 sites in United States
- Volunteers
- 56 people
- Sponsor
- Ohio State University
Lung Function, BPD - Bronchopulmonary Dysplasia
Early-life MRI Biomarkers of Longer-term Respiratory Morbidity in Infants Born Extremely Preterm (EMBLEM)
Bronchopulmonary dysplasia (BPD) is a common, major complication of premature birth, associated with developmental and health consequences that continue into adulthood.
- Trial name
- EMBLEM (NCT06065215)
- Testing
- Magnetic Resonance Imaging (MRI), Echocardiogram, Lung ultrasound
- Where
- 4 sites in Canada
- Volunteers
- 319 people
- Sponsor
- Children's Hospital of Eastern Ontario
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