Clinical trials: Premature Infant Disease
Non-invasive Ventilatory Support, Infant Respiratory Distress Syndrome
Observational Study in Preterm Neonates Who Are Sufficiently Stable on Non-Invasive Ventilatory Support
The purpose of this observational study is to collect data on vital signs, oxygen requirements and other data related to ventilator care in preterm neonates under standard of care treatment.
- Trial name
- NCT01861795
- Testing
- Preterm Neonates
- Where
- 3 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Takeda
Premature Birth
Use of a Tummy Time Intervention and Parent Education in Infants Born Preterm
The purpose of this research study is to see if tummy time and parent education helps motor development among infants born preterm. Participants will be recruited from Ann and Robert H.
- Trial name
- NCT03759119
- Testing
- Tummy time and parent education, Parent education only
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Indianapolis
Retinopathy of Prematurity (ROP)
VEGF In Systemic Circulation Of ROP-infants
The purpose of this study is to measure systemic levels of vascular endothelial growth factor (VEGF) and other proteins (e.g. IGF-1) in the systemic circulation of infants with retinopathy of prematurity (ROP) following ocular…
- Trial name
- NCT01470430
- Where
- Germany
- Sponsor
- University Hospital Freiburg
Bronchopulmonary Dysplasia (BPD)
Lung Ultrasound for Prediction of Bronchopulmonary Dysplasia
Extreme preterm infants (GA ≤ 28+6 weeks) are at high risk for bronchopulmonary dysplasia (BPD) that has been associated with significant long-term impairment.
- Trial name
- NCT04756297
- Where
- 2 sites in Canada
- Volunteers
- 152 people
- Sponsor
- Adel Mohamed
Necrotizing Enterocolitis
Enteral Administration of Docosahexaenoic Acid to Prevent Necrotizing Enterocolitis in Preterm Neonates
The purpose of this study is to determine whether docosahexaenoic acid is effective in the prevention or reducing severity of necrotizing enterocolitis (NEC) in preterm neonates < 1500 g at birth who are starting enteral feeding.
- Trial name
- NCT01745510
- Testing
- Docosahexaenoic acid (DHA)
- Where
- Mexico
- Volunteers
- 225 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Infant, Premature
The Comparison of Gentle Human Touch's Effect by Mother and Nurse on Pain Level During Heel Blood Sampling in Preterm Infants
This study is an experimental randomized controlled study conducted to compare the effect of gentle human touch applied by mother and nurse on pain level during heel blood sampling in preterm infant.
- Trial name
- NCT05857423
- Testing
- Gentle Human Touch
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
RDS of Prematurity, Prematurity
Fast Assessment of Surfactant Deficiency to Speed up Treatment
The aim is to validate a FTIR spectroscopy test for measuring lung maturity/Respiratory Distress Syndrome (RDS) in terms of safety, usability, and efficacy.
- Trial name
- FAST (NCT03235882)
- Testing
- LS-ratio
- Where
- Denmark
- Volunteers
- 72 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Infant Development, Neonatal Intensive Care Unit
Individual Structured Therapy in Early Premature Infants at the Neonatal Intensive Care Unit
In this study, investigators aimed to apply an individual structured therapy protocol within the framework of neurodevelopmental therapy principles in early premature infants hospitalized in the neonatal intensive care unit and…
- Conditions
- Infant Development, Neonatal Intensive Care Unit, INDIVIDUALIZED THERAPY
- Trial name
- NCT06648213
- Testing
- Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Development
Neurodevelopmental Outcomes of Preterm Infants Treated for Pain Management With Repeated Doses of Sucrose 24%
The purpose of this study is to determine the effect of sucrose 24% for pain prevention on preterm infants. Our hypothesis is that repeated doses of sucrose 24%, given prior to painful procedure,do not impair neurodevelopmental…
- Trial name
- NCT01742520
- Testing
- multiple doses of sucrose, Formula or breast milk
- Where
- Israel
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Retinopathy of Prematurity
Vascular Endothelial Growth Factor in Stage V ROP
Vascular Endothelial Growth Factor (VEGF) is a dimeric glycoprotein, naturally expressed in epithelial and tumor cells (1). Normal Retinal vascularization has two phases: In the first fase, cells of mesenquimatous origin form the…
- Trial name
- NCT00500396
- Testing
- Open-Sky Vitrectomy
- Where
- Mexico
- Volunteers
- 15 people
- Sponsor
- Asociación para Evitar la Ceguera en México
Respiratory Distress Syndrome, Newborn
Feasibility of Mid-frequency Ventilation in Newborns With RDS: Randomized Crossover Pilot Trial
Respiratory distress syndrome (RDS) is the most common respiratory disorder in preterm infants. Despite improved survival of extremely premature infants with RDS, complications related to mechanical ventilation still occur.
- Trial name
- NCT01242462
- Testing
- Conventional Pressure Controlled SIMV, Mid-frequency Ventilation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Alabama at Birmingham
Premature Infants
Kangaroo Care an EffectonTransitionTime From Gavage Feeding
Objectives: Kangaroo care is a safe and effective alternative method to conventional neonatal care for newborn babies. The aim of this study was to evaluate the effect of kangaroo care on the transition time to full oral feeding…
- Trial name
- KangarooCare (NCT05492747)
- Testing
- Kangaroo Care an Effect
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Firat University
Bronchopulmonary Dysplasia
Neurally Adjusted Ventilatory Assist vs Proportional Assist Ventilation
This study aims to assess whether neurally adjusted ventilatory assist or proportional assist ventilation is more effective in infants born prematurely with evolving or established bronchopulmonary dysplasia
- Trial name
- NCT02967549
- Testing
- NAVA, PAV
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- King's College London
Preterm Infants, Metabolic Bone Disease
Calciuric Effect and Cyclic Parenteral Nutrition in Preterm Infants
The aim of our work is to study the effect of total parenteral nutrition (TPN) cycling in preterm infants on hypercalcuria (excessive calcium excretion in urine).
- Trial name
- NCT00711763
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Feeding, Bottle, Infant, Premature, Diseases
Biobehavioral Efficacy of the Semi-Elevated Side-Lying Position
The objective of the proposed research is to conduct a within-subject cross-over trial that will compare the efficacy of the two bottle-feeding positions on physiologic and behavioral responses of preterm infants prior to…
- Conditions
- Feeding, Bottle, Infant, Premature, Diseases, Behavior, Infant
- Trial name
- NCT04942106
- Testing
- Arm 1 - Side-lying position followed by Supine position, Arm 2 - Supine position followed by Side-lying position
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Boston College
Preterm Less Than 32wks With IVH, WMI/PVL, Late Preterm or Term (37-42wks) With Neonatal Encephalopathy Treated With Hypothermia for HIE
Cerebral/ Cortical Visual Impairment: Screening, Identification and Outcome Prediction in Neonates
Cerebral/Cortical Visual Impairment (CVI) is the leading cause of childhood visual impairment in the United States and other industrialized countries.
- Trial name
- CVI (NCT07275021)
- Testing
- Prospective Clinical and Neurodevelopmental Data Collection
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brigham and Women's Hospital
Necrotizing Enterocolitis
Administration of Arginine Supplementation in Preterm Infants
Calprotectin is a cytosolic component of neutrophils .Fecal calprotectin(FC) is a useful marker for exacerbation of inflammatory bowel disease in children .FC may be a useful marker for necrotizing enterocolitis (NEC).
- Trial name
- NCT01336998
- Testing
- arginine
- Where
- Greece
- Volunteers
- 80 people
- Sponsor
- Alexandra Hospital, Athens, Greece
Feeding Intolerance, Preterm Infants
Protocol for Feeding Intolerance in Preterm Infants
Background: Feeding intolerance is a common problem in preterm infants, which is associated with increased risk of infections, prolonged hospitalization, and increased economic costs.
- Trial name
- NCT05347706
- Testing
- formula
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Children's Hospital of Chongqing Medical University
Prematurity, Low Birth Weight
Paternal Involvement in Nursing Guidance and Breastfeeding Self-Efficacy in Mothers of High-Risk Newborns
This study aims to evaluate whether a structured nursing guidance program that increases fathers' participation in the care of hospitalized high-risk newborns improves maternal outcomes compared with routine nursing care.
- Conditions
- Prematurity, Low Birth Weight, Respiratory Distress Syndrome, Newborn, Neonatal Hyperbilirubinemia
- Trial name
- NCT07834008
- Testing
- step-by-step parent education, active father participation in breastfeeding support
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Newborn; Vitality, Nursing Caries
Effect of Intranasal Breast Milk Administration in Preterm Infants
The aim of the study was to investigate the effect of intranasal breast milk administration on cerebral oxygenation level, vital signs and time to full oral feeding in preterm infants.
- Conditions
- Newborn; Vitality, Nursing Caries, Breast Feeding
- Trial name
- NCT06706115
- Testing
- Intranasal human breast milk
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Selcuk University