Clinical trials: Premature Neonates
Tracheomalacia, Bronchopulmonary Dysplasia (BPD)
Enhancing Lung Health in Kids With Structural Lung Damage and Malformations: Azithromycin (AZI) for Airway Infection Prevention
Children with lung and airway malformations or early structural lung damage face significant challenges, often leading to recurrent respiratory infections, hospitalizations, and decreased quality of life.
- Conditions
- Tracheomalacia, Bronchopulmonary Dysplasia (BPD), Vascular Ring, Cystic Lung Disease
- Trial name
- TRALULALA-AZI (NCT06409299)
- Testing
- Azithromycin 40 MG/ML
- Volunteers
- 150 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Retinopathy of Prematurity
Evaluation of the Frequency, Risk Factors, and Outcomes of ROP in Infants With a BW >1500 Grs or GA ≥33 Wks in Turkey.
The study includes preterm infants who are being screened for ROP between August 1,2023 and August 1, 2024 in 94 neonatal intensive care units (NICUs) in Turkey.
- Trial name
- TR-ROP-2 (NCT06265363)
- Where
- Turkey (Türkiye)
- Volunteers
- 1,000 people
- Sponsor
- Baskent University Ankara Hospital
Very Low Birth Weight Baby
Serum Folic Acid Levels in Preterm Infants
Therefore preterm infants must need folic acid replacement than term babies.
- Trial name
- FALIPI (NCT01360528)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Mehmet Yekta
Bronchopulmonary Dysplasia (BPD)
Continued Pressure for Alveolar Protection (CPAP Trial)
The objective of the CPAP Trial is to test whether extending CPAP until 34 weeks' PMA or for at least 2 additional weeks compared to weaning to a nasal canula will decrease the likelihood of bronchopulmonary dysplasia or death at…
- Trial name
- CPAP (NCT07417111)
- Testing
- CPAP, Nasal Cannula
- Where
- 15 sites in United States
- Volunteers
- 860 people
- Sponsor
- NICHD Neonatal Research Network
Gastroesophageal Reflux
Intravenous (IV) Pantoprazole for Gastroesophageal Reflux Disease (GERD) in Neonates and Infants
The purpose of this study is to determine how the body uses and eliminates pantoprazole, a drug used to treat GERD. This is a pharmacokinetic (PK) study.
- Trial name
- NCT00744419
- Testing
- pantoprazole
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Louisville
Pain
Effectiveness of Intranasal Versus Intravenous Fentanyl in Preterm and Term Newborns for Pain Prevention
Neonatal intensive care unit patients undergoes many painful procedures during their hospitalization. Effective pain control in such procedures as intubation, catheterization, central line insertion, chest tube insertion, etc.
- Trial name
- NCT02125201
- Testing
- Fentanyl
- Where
- Israel
- Volunteers
- 21 people
- Sponsor
- HaEmek Medical Center, Israel
Apnea of Prematurity
Stochastic Resonance Mattress (Physiological Interventions) and Biomarkers for Enhancing Neonatal Health
The purpose of this study is to explore physiological interventions and biomarkers for Apnea of Prematurity in newborn infants.
- Trial name
- NCT01643057
- Testing
- Stochastic Resonance Mattress
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Wyss Institute at Harvard University
Premature Newborn, Necrotizing Enterocolitis
Defining Normal Citrulline Levels as a Diagnostic Tool for Screening of Gastrointestinal Disease in Premature Infants
Since the first description of citrulline as a potential marker for intestinal function in 1998, its use has been investigated in a variety of disease processes including Short Bowel Syndrome, Celiac disease, chemotherapy and…
- Trial name
- NCT01062828
- Testing
- Citrulline samples
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Miami
Retinopathy of Prematurity
Long Term Outcome of Intravitreal Ranibizumab for ROP
premature infants who had a history of intravitreal injection of (Ranibizumab) not less than one year were examined for refractive state and biometry
- Trial name
- NCT04537065
- Testing
- cycloplegic refraction
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Ameera Gamal Abdelhameed
Ophthalmological Disorder
Multi-Center Study to Determine the Role of Fatty Acids in Serum in Preventing Retinopathy of Prematurity (MDM)
The study is a Randomized Intervention, Multi-Center Study to Determine the Role of Fatty Acids in Serum and Breast Milk in preventing Retinopathy of Prematurity Subjects who meet all inclusion and none of the exclusion criteria…
- Trial name
- MDM (NCT03201588)
- Testing
- Formulaid
- Where
- 3 sites in Sweden
- Volunteers
- 210 people
- Sponsor
- Göteborg University
Preterm Birth, Apnea of Newborn
The Use of Wireless Sensors in Neonatal Intensive Care
The study will be conducted in a convenience sample of 75 infants admitted to the NICU at the Montreal Children's Hospital, divided into 3 phases: (a) Phase 1a - monitoring for 8h per day for 4 consecutive days, (b) Phase 1b …
- Trial name
- NCT04956354
- Testing
- ANNE™ Monitoring System (2 sensors) - version B, ANNE™ Monitoring System (2 sensors) - version C
- Where
- Canada
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Neonatal Respiratory Distress, Preterm Birth
Study of the Feasibility of Early Lung Ultrasound in Neonatal Respiratory Distress in Premature Newborns Born Between 32 Weeks of Amenorrhea and 36 Weeks Plus 6 Days of Amenorrhea, Hospitalized in the Neonatal Pediatrics and Intensive Care Units of the Dijon University Hospital
Monocentric study carried out in the Neonatal and Intensive Care Units of the Dijon University Hospital. The objective is to evaluate the feasibility of performing a pulmonary ultrasound within 6 hours after admission in…
- Trial name
- REchoPP (NCT05737095)
- Testing
- Pulmonary ultrasound
- Where
- France
- Volunteers
- 69 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Prematurity, Mechanical Ventilation
The Effect of Breast Milk Odor and Swaddling on Physiological Parameters and Stress Levels in Premature Infants Receiving Ventilator Support
It will be done to shorten the hospital stay of the newborn and increase the quality of care by proving the positive effect of the safe wrapping method and the smell of breast milk on the physiological parameters and stress level…
- Trial name
- NCT07681934
- Testing
- Breast Milk Smell, Arson, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- KTO Karatay University
Premature Birth
Assessment of the Impact of the Return Home of Premature Newborns Less Than 2 Kilos Morbidity/Mortality
The aim of this study is to evaluate the impact of discharge from hospital with a weight of less than 2 kilos. To do this, the investigator will look at the short-term and long-term outcome of newborns weighing less than 2 kilos…
- Trial name
- Petit-Poids (NCT06224764)
- Testing
- Mother and Father questionnaires
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hôpital NOVO
Preterm Birth, Low; Birthweight, Extremely (999 Grams or Less)
Effect of Support for Low-Income Mothers of Preterm Infants
Preterm birth is a leading cause of childhood mortality and developmental disabilities. Socioeconomic disparities in the incidence of preterm birth and morbidities, mortality, and quality of care for preterm infants persist.
- Trial name
- NCT06362798
- Testing
- Financial Transfers
- Where
- 5 sites in United States
- Volunteers
- 420 people
- Sponsor
- University of Massachusetts, Worcester
Bronchopulmonary Dysplasia
Mesenchymal Stem Cell Therapy for Bronchopulmonary Dysplasia in Preterm Babies
Bronchopulmonary Dysplasia (BPD) is the most frequent disease related to a premature birth, 15-50% of very low birth newborns (<1500 gr.) will develop BPD.
- Trial name
- NCT02443961
- Testing
- Mesenchymal Stem Cell (MSC) therapy
- Where
- 4 sites in Spain
- Volunteers
- 10 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Duchenne Muscular Dystrophy, Becker Muscular Dystrophy
Study of Ataluren (PTC124) in Nonambulatory Participants With Nonsense-Mutation-Mediated Duchenne/Becker Muscular Dystrophy (nmDMD/BMD)
Duchenne/Becker muscular dystrophy (DMD/BMD) is a genetic disorder that develops in boys. It is caused by a mutation in the gene for dystrophin, a protein that is important for maintaining normal muscle structure and function.
- Trial name
- NCT01009294
- Testing
- Ataluren, Chronic Corticosteroid Therapy
- Where
- 6 sites in United States, United Kingdom
- Volunteers
- 6 people
- Sponsor
- PTC Therapeutics
Neonatal Infection, Invasive Fungal Infections
Micafungin Versus Amphotercine B in Treatment of Invasive Fungal Infection
The incidence of fungal infection has increased dramatically over the past few decades.This is due to increase in survival rates of preterm neonates, advances in medical technology and drug therapy, broad spectrum antibiotics and…
- Trial name
- NCT06413056
- Testing
- Micafungin, Amphotericin B
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Ain Shams University
Transient Tachypnea of the Newborn
Fluid Management in Transient Tachypnea of the Newborn
Transient tachypnea of the newborn (TTN) is a diagnosis given to infants born between 34 and 42 weeks gestation who develop difficulty breathing during the first days of life when no specific cause of the breathing difficulty can…
- Trial name
- NCT01225029
- Testing
- Amount of total fluids
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Preterm, Bonding
Effectiveness of Bonding-Based Education Intervention
The study aimed to determine the impact of the Father-Preterm Newborn Bonding Programme (B-PreBAP) on fathers' parenting behaviours, stress levels, and support needs.
- Trial name
- NCT06186453
- Testing
- Father-Preterm Newborn Bonding Program
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
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