Clinical trials: Premature Ovarian Failure，
Perimenopause, Perimenopause-Related Depression
Intra Ovarian Muse Cell Injection for Perimenopause Symptom Relief and Ovarian Function Restoration (MUSE-OVARY)
This observational study examines the safety and effects of injecting Muse cells (a type of naturally occurring stem like cells found in adult tissues such as fat or bone marrow) directly into the ovaries of women aged 28 to 70…
- Conditions
- Perimenopause, Perimenopause-Related Depression, Premature Ovarian Insufficiency, Premature Ovarian Failure (POF)
- Trial name
- MUSE-OVARY (NCT07511660)
- Where
- Mexico
- Volunteers
- 12 people
- Sponsor
- Healing Hope International
Premature Ovarian Insufficiency
4-step ASCOT in POI Women to Promote Follicular Rescue
To promote follicular development in POI women, G-CSF mobilized activated platelet rich plasma will be directly injected into the ovarian medulla.
- Trial name
- NCT04475744
- Testing
- G-CSF treatment for Bone marrow derived stem cell Mobilization, Platelet Rich Plasma ovarian injection
- Where
- 2 sites in Spain
- Volunteers
- 42 people
- Sponsor
- Fundación IVI
Premature Ovarian Failure
X-Chromosome Inactivation Status and Premature Ovarian Failure
Women who are affected with premature ovarian failure will exhibit skewed X-chromosome inactivation patterns compared to women with normal menstrual function (as defined by being pregnant), indicating a possible X-chromosome…
- Trial name
- NCT00295087
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Premature Ovarian Insufficiency
Clinical Study on the Safety and Efficacy of Human Amniotic Mesenchymal Stem Cells in the Treatment of Premature Ovarian Insufficiency
There is a high incidence of women suffering from Primary Ovarian Insufficiency (POI). So far, there was no treatment sufficient enough to cure POI.
- Trial name
- NCT07115082
- Testing
- Climen 21 Tablets, hA-MSCs
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Yan Hongli
Autoimmune Disease, Infertility
Steroid Therapy in Autoimmune Premature Ovarian Failure
No therapy for infertile patients with premature ovarian failure has been proven effective. Some anecdotal reports have suggested that high dose, long term prednisone (steroid) therapy may be useful in treating autoimmune ovarian…
- Conditions
- Autoimmune Disease, Infertility, Premature Ovarian Failure
- Trial name
- NCT00001306
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Infertility, Premature Ovarian Failure
Modified Natural Cycle Offers a Chance of Pregnancy in Patients With Poor Response and High Basal FSH
The purpose of this study is to evaluate the effectiveness of a modified natural cycle in patients with previous poor response to infertility drugs and high basal FSH, prior to proceeding to oocyte donation or abandoning…
- Trial name
- NCT00417157
- Testing
- recombinant FSH (Puregon, Organon, The Netherlands), GnRH antag: Ganirelix (Orgalutran, Organon, The Netherlands), hCG (Pregnyl, Organon, The Netherlands)
- Where
- Greece
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Eugonia
Menstrual Disorder, Premature Ovarian Failure
The Effect of HPV Vaccine on Menstrual Cycle in Women of Reproductive Age
Cervical cancer is one of the most common cancer in women, making it the fourth largest cause of female cancer mortality worldwide.
- Trial name
- NCT05838157
- Testing
- prophylactic HPV vaccine(bivalent HPV、quadrivalent HPV、9-valent HPV)
- Where
- 2 sites in China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Primary Ovarian Insufficiency, Genetic Predisposition to Disease
Genetic Etiology in Premature Ovarian Insufficiency
Premature Ovarian Insufficiency (POI), first described by Albright in 1942, is defined as an increase in Follicle Stimulating Hormone (FSH), an insufficiency of the ovarian function leading to an early menopause (<40 years of…
- Trial name
- POI (NCT01973075)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- BEGUM AYDOGAN
Healthy, Osteoporosis
Hormone Replacement in Young Women With Premature Ovarian Failure
The human ovary produces male sex hormones (androgen) and female sex hormones (estrogen). Currently, androgen is not included in hormone replacement therapy for women with premature ovarian failure.
- Conditions
- Healthy, Osteoporosis, Premature Ovarian Failure
- Trial name
- NCT00001951
- Testing
- TMTDS
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
in Vitro Activation, Dormant Follicle
In Vitro Activation of Dormant Follicles for Patients With Primary Ovarian Insufficiency
In this study, the investigators used the newly developed technique i.e. in vitro activation of dormant follicles (IVA) to promote ovarian follicle growth much more efficiently than natural, in vivo process for women with Primary…
- Conditions
- in Vitro Activation, Dormant Follicle, Primary Ovarian Insufficiency, Ovarian Resistance Syndrome
- Trial name
- IVADFPOI (NCT02322060)
- Testing
- Ovariotomy, Activate dormant follicles, Ovary tissue transplantation
- Where
- China
- Volunteers
- 35 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Primary Ovarian Insufficiency, Menopause, Premature
Oral Contraceptives as Infertility Treatments for Premature Ovarian Failure
Premature ovarian insufficiency (POI) is a life-changing condition that affects women in their reproductive age. There is a lack of reports which focus on how to improve the reproductive outcome of these women who wish to…
- Trial name
- NCT02757469
- Testing
- Drospirenone and ethinyl estradiol combination (Yasmin)
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Navy General Hospital, Beijing
Ovarian Failure, Premature Ovarian Failure
Ovarian Fragmentation Study (Crespo Medical Team)
This is a study designed to validate Kawamura´s theory and investigation of activation of primordial follicles through ovarian cortex fragmentation.
- Conditions
- Ovarian Failure, Premature Ovarian Failure, IVF
- Trial name
- NCT04306185
- Testing
- OVARIAN FRAGMENTATION
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Equipo Juana Crespo
Ovarian Failure, Infertility, Female
Ovarian Rejuvenation for Premature Ovarian Insufficiency and Poor Ovarian Response
The objective of this study is to perform a prospective randomized controlled trial seeking to characterize the effects of intra-ovarian injection of platelet rich plasma (PRP) on biomarkers of ovarian reserve as well as IVF…
- Trial name
- NCT04163640
- Testing
- intra-ovarian platelet rich plasma injection
- Where
- 2 sites in United States, Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Diminished Ovarian Reserve, Premature Ovarian Insufficiency
Effect of NMN (Nicotinamide Mononucleotide) on Diminished Ovarian Reserve (Including Premature Ovarian Insufficiency)
The purpose of the study is to understand the effect of nicotinamide mononucleotide (NMN) on patients with diminished ovarian reserve (including premature ovarian insufficiency).
- Trial name
- NCT05485610
- Testing
- NMN intervention
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
Osteoporosis
Effects of Phytoestrogen-rich Diets on Bone Turnover in Postmenopausal Women
Osteoporosis is a major health problem. It was hypothesized that isoflavone-containing products may be a potential alternative to HRT for preventing bone loss during the menopausal transition.
- Trial name
- NCT00301353
- Testing
- Isoflavones-enriched foods
- Where
- 3 sites in France, Italy and 1 more
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- TNO
Infertility, Female, Premature Ovarian Failure
Is There A Role For Mechanical Stimulation In Ovarian Follicular Activation?
Premature ovarian failure (POI) is a loss of normal function before age 40, leading to infertility and hypoestrogenism. About 1% of women younger than 40 years old and 0.1% before 30 are affected.
- Conditions
- Infertility, Female, Premature Ovarian Failure, IVF
- Trial name
- NCT04390308
- Testing
- Ovarian puncture, Hormonal blood Test, Transvaginal ultrasound
- Where
- United Arab Emirates
- Volunteers
- 70 people
- Sponsor
- ART Fertility Clinics LLC
Dysfunction; Endocrine, Effects of Chemotherapy
Blood Spot Self-administered Test and Assay
The current study will compare hormone levels of AMH, FSH and inhibin B in blood specimens collected by venipuncture and fingerstick in a sample of pre-menopausal women ages 18-45 years with normal menstrual cycles.
- Conditions
- Dysfunction; Endocrine, Effects of Chemotherapy, Premature Ovarian Failure
- Trial name
- NCT03840824
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Anti-Müllerian Hormone, Polycystic Ovarian Syndrome
Clinical Application of Serum Anti-Müllerian Hormone (AMH) Measurements
This study aims to assess the association of Anti-Müllerian hormone (AMH) with polycystic ovarian syndrome, premature ovarian insufficiency and fertility. The main objectives include the following: 1.
- Conditions
- Anti-Müllerian Hormone, Polycystic Ovarian Syndrome, Premature Ovarian Insufficiency, Fertility Issues
- Trial name
- NCT05858307
- Where
- Hong Kong
- Volunteers
- 300 people
- Sponsor
- Chinese University of Hong Kong
Activation of Primordial Follicles
In Vitro Follicle Activation in Patient With Premature Ovarian Failure Under 36 Years Old
This is a clinical trial that the investigators aim to validate In-vitro Activation (IVA) treatment protocol, which was previously defined by Kazuhiro Kawamura (MD) and Aaron Hsueh (PhD), in Turkish patient with Premature Ovarian…
- Trial name
- NCT04131244
- Testing
- In vitro activation of primordial follicles by PTEN inhibitor and AKT stimulator
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people
- Sponsor
- Hacettepe University
Poor Ovarian Response
A RCT Study on Autologous Cell Injection Into the Ovaries of Patients With POR
Poor ovarian response (POR) is a pathological state where the ovaries do not respond well to the stimulation of gonadotropins. It is mainly characterized by a small number of developing follicles, a high cancellation rate of the…
- Trial name
- NCT07282288
- Testing
- PRP injection, SVF injection
- Volunteers
- 198 people
- Sponsor
- Peking University Third Hospital