Clinical trials: Premature Ovarian Failure
Primary Ovarian Insufficiency
Human Umbilical Cord Mesenchymal Stem Cells (HUC-MSCs) Transplantation in Women With Primary Ovarian Insufficiency (POI)
There is a high incidence of women suffering from Primary Ovarian Insufficiency (POI). One of the most common treatments for POI is hormone replacement therapy (HRT), but HRT doesn't work well, and it has been shown to increase…
- Trial name
- NCT03033277
- Testing
- HUC-MSCs transplantation
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Chinese Academy of Sciences
Perimenopausal Disorder, Menopause
Inovium Ovarian Rejuvenation Trials
The Inovium Ovarian Rejuvenation Treatment is a PRP-based autologous treatment used in combination with a stimulated IVF sequence and Pre-Implantation Genetic Screening to treat infertility in women experiencing menopause…
- Conditions
- Perimenopausal Disorder, Menopause, Menopause, Premature, Menopause Related Conditions
- Trial name
- NCT03178695
- Testing
- Autologous PRP injection into human ovarian tissue
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ascendance Biomedical
Hematopoietic Stem Cell Transplantation, Premature Ovarian Failure
A Multicenter Open-label Clinical Study on the Prevention of Premature Ovarian Failure After HSCT
HSCT is an effective method to cure hematologic malignancies. However, the reproductive system is prone to be damaged during radiotherapy and chemotherapy before transplantation, leading to ovarian failure, followed by…
- Trial name
- NCT05667428
- Testing
- leuprorelin, normal saline
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Premature Ovarian Insufficiency
Effect and Mechanism of Jiajian Guishen Optimized Formula on Premature Ovarian Insufficiency: Insights Into m6A Modification and Oxidative Stress
The goal of this clinical study is to evaluate the effectiveness of JiaJian GuiShen Optimized Formula (JJGS) and explore its mechanisms involving m6A modification and oxidative stress in women with premature ovarian insufficiency…
- Trial name
- JJGS ; POI (NCT07843030)
- Testing
- JJGS
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Shi Yun
Activation of Primordial Follicles
Ovarian Needle Puncture for Follicle Activation in IVF Patients With Diminished Ovarian Reserve
Premature ovarian insufficiency (POI), is cessation of ovarian function characterized by hypergonadotropic amenorrhea and hypoestrogenic syndrome before 40 years of age.
- Trial name
- NCT04608695
- Testing
- Ovarian puncture
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Hacettepe University
Primary Ovarian Insufficiency, Azoospermia
Identifying Genome Variants in Non-Obstructive Azoospermia (NOA) or Primary Ovarian Insufficiency (POI)
Background: Infertility affects 1 in 6 people. Often, the causes of infertility are unknown. Treatments are successful in only about 50% of cases.
- Conditions
- Primary Ovarian Insufficiency, Azoospermia, Oligospermia
- Trial name
- NCT07357701
- Where
- 2 sites in United States
- Volunteers
- 500 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Bone Loss, Bone Loss, Age-related
Strength Training for Osteoporosis Prevention During Early Menopause
The goal of this clinical pilot trial is to learn about the feasibility of a high-intensity resistance training intervention in peri- and early menopausal females.
- Conditions
- Bone Loss, Bone Loss, Age-related, Osteoporosis, Musculoskeletal Diseases
- Trial name
- STOP-EM (NCT05961371)
- Testing
- Resistance Training
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Primary Ovarian Insufficiency, Poor Ovarian Response
Single Center, Prospective Controlled Pilot Study of the OvaPrime Procedure
This is a single center, prospective, controlled pilot safety research study. The primary objective of this research study is to assess the safety with the use of the OvaPrime procedure in women who are diagnosed with either…
- Trial name
- NCT03021915
- Testing
- OvaPrime Treatment
- Where
- Canada
- Volunteers
- 81 people
- Sponsor
- OvaScience, Inc.
Premature Ovarian Failure
Autologous Bone Marrow-Derived Stem Cell Transplantation in Patients With Premature Ovarian Failure (POF)
This is an open label, single arm, single center investigation to assess the safety and efficacy of purified adult autologous bone marrow derived specific populations of stem cells and mesenchymal stem cells injected into the…
- Trial name
- NCT03069209
- Testing
- Stem Cells
- Where
- Jordan
- Volunteers
- 50 people
- Sponsor
- Stem Cells Arabia
Primary Ovarian Insufficiency, Infertility
Parental Project and Premature Ovarian Insufficiency
One of the main repercussions of POI is infertility. When the diagnosis of POI is announced, the question of fertility is addressed and the patient is often directed towards egg donation or adoption when she has a parental…
- Trial name
- ParentIOP (NCT05310617)
- Testing
- Survey
- Where
- France
- Volunteers
- 324 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Turner Syndrome, Primary Ovarian Insufficiency
Sexuality and Sexual Quality of Life in Adult Patients With Turner Syndrome (TS) Compared With Patients With Primary Ovarian Insufficiency Different From TS
Turner syndrome (TS) is a rare disease affecting 1/2500 female. It is defined by a complete or partial loss of an X chromosome associated with clinical signs.
- Trial name
- SEXATURN (NCT05223621)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Menstrual Disorder, Premature Ovarian Failure
The Effect of HPV Vaccine on Menstrual Cycle in Women of Reproductive Age
Cervical cancer is one of the most common cancer in women, making it the fourth largest cause of female cancer mortality worldwide.
- Trial name
- NCT05838157
- Testing
- prophylactic HPV vaccine(bivalent HPV、quadrivalent HPV、9-valent HPV)
- Where
- 2 sites in China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Ovarian Failure, Ovarian Insufficiency
Ovarian Tissue Allo-transplantation
Premature ovarian failure, also known as primary ovarian insufficiency (POI), or premature menopause, affects 1-2% of women under 40.
- Conditions
- Ovarian Failure, Ovarian Insufficiency, Menopause Ovarian Failure, Menopause, Premature
- Trial name
- NCT06673004
- Testing
- Ovarian tissue allo-transplantation
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Effects of Chemotherapy
The Longitudinal Ovarian Reserve Study
Postmenarchal female cancer patients scheduled to undergo cancer therapy may enroll in this study to assess changes in existing and novel surrogate measures of fertility potential before, during and after chemotherapy.
- Trial name
- NCT02395341
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Diminished Ovarian Reserve, Premature Ovarian Insufficiency
Effect of NMN (Nicotinamide Mononucleotide) on Diminished Ovarian Reserve (Including Premature Ovarian Insufficiency)
The purpose of the study is to understand the effect of nicotinamide mononucleotide (NMN) on patients with diminished ovarian reserve (including premature ovarian insufficiency).
- Trial name
- NCT05485610
- Testing
- NMN intervention
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
Premature Ovarian Failure
Effects of an Estrogen Replacement Therapy Skin Patch on Ovulation in Women With Premature Ovarian Failure
This study will determine whether giving estrogen replacement therapy through an estradiol patch can improve ovulation rates in women with spontaneous premature ovarian failure.
- Trial name
- NCT00370019
- Testing
- Estradiol/Medroxyprogesterone acetate
- Where
- United States
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Premature Ovarian Insufficiency
Finerenone for Premature Ovarian Insufficiency (POI)
This study is testing whether finerenone, a medicine currently used to protect the kidneys and heart, can help women with premature ovarian insufficiency (POI) grow ovarian follicles and produce eggs that can be collected for in…
- Trial name
- NCT07815509
- Testing
- Finerenone
- Where
- China
- Volunteers
- 46 people
- Sponsor
- The University of Hong Kong-Shenzhen Hospital
Premature Ovarian Failure
Effects of ADSC Therapy in Women With POF
The purpose of this study is to determine whether Adipose Derived Stem Cells are effective in the treatment of Premature Ovarian Failure (POF).
- Trial name
- NCT01853501
- Testing
- Autologous fat grafting
- Where
- China
- Volunteers
- 4 people
- Sponsor
- Nanjing University
Poor Ovarian Response
A RCT Study on Autologous Cell Injection Into the Ovaries of Patients With POR
Poor ovarian response (POR) is a pathological state where the ovaries do not respond well to the stimulation of gonadotropins. It is mainly characterized by a small number of developing follicles, a high cancellation rate of the…
- Trial name
- NCT07282288
- Testing
- PRP injection, SVF injection
- Volunteers
- 198 people
- Sponsor
- Peking University Third Hospital
Infertility, Female, Premature Ovarian Failure
Second Step Protocol in Poor Ovarian Responder (POR)
Reduced ovarian reserve and the consequent poor ovarian response are very recurent in infertile patients, indeed a percentage of 10%-24% of couples addressed to infertility program may be classified as Poor Ovarian Responder…
- Conditions
- Infertility, Female, Premature Ovarian Failure, Fertility Disorders
- Trial name
- POR (NCT03480412)
- Testing
- Follicular Phase, Luteal Phase
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Università degli Studi 'G. d'Annunzio' Chieti e Pescara