Clinical trials: Premature Retinopathy
Premature Retinopathy, Pain, Eye
Multisensory Stimulation in Infants for Eye Examination
This study aimed to evaluate the effects of multisensory stimulation on pain and physiological parameters resulting from ROP examination in preterm newborns. It was planned as a randomized controlled trial.
- Trial name
- NCT05830409
- Testing
- Multisensorial Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Akdeniz University
Retinopathy of Prematurity
Bevacizumab Treatment For Type 1 ROP
Type 1 retinopathy of prematurity in zone I represents the most severe type of ROP and has the worst prognosis. It is unknown whether low-dose bevacizumab will be successful in these severe cases.
- Trial name
- ROP4 (NCT04634578)
- Testing
- Bevacizumab
- Where
- 26 sites in United States, Canada
- Volunteers
- 77 people
- Sponsor
- Jaeb Center for Health Research
Premature Birth, Mortality
Trial to Evaluate a Specified Type of Apgar (TEST-APGAR) Follow Up Study
A specified version of the Apgar-Score, that can be used in newborns under resuscitation, was developed and its value to predict chronic damage in preterm infants will be tested.
- Conditions
- Premature Birth, Mortality, Apgar Score
- Trial name
- NCT01186627
- Where
- Germany
- Volunteers
- 1,500 people
- Sponsor
- Technische Universität Dresden
Retinopathy of Prematurity
Ultrasound to Detect Evidence for Retinal Detachment in Retinopathy of Prematurity
Premature infants stand a risk of danger to the layer of the eye that creates sight that, if untreated, can cause severe vision problems, leading to blindness in some cases.
- Trial name
- NCT00279669
- Testing
- Ultrasound examination
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Weill Medical College of Cornell University
Retinopathy of Prematurity
Mother Milk as a Eye Drop & Premature Retinopathy
The aim of this study is to investigate the effect of using breast milk as eye drops on ROP (Retinopathy of prematurity) disease observed in less then 32 weeks gestational age preterm babies.
- Trial name
- NCT04883931
- Testing
- Normal Saline, Breast milk
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people
- Sponsor
- Baskent University
Retinopathy of Prematurity
Registry for Severe ROP and Treatment on Visual Outcomes
The purpose of this study is to determine what factors influence the visual outcomes of infants with severe retinopathy of prematurity (ROP) and to monitor the outcomes.
- Trial name
- NCT01559571
- Where
- 2 sites in United States
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- Pediatrix
Infant, Newborn, Infant, Low Birth Weight
Supplemental Therapeutic Oxygen for Prethreshold Retinopathy of Prematurity
The purpose of this trial was to determine the efficacy and safety of supplemental therapeutic oxygen for infants with prethreshold retinopathy of prematurity (ROP) to reduce the probability of progression to threshold ROP and…
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- STOP-ROP (NCT01203436)
- Testing
- Supplemental Oxygen Management, Conventional Oxygen Management
- Where
- 9 sites in United States
- Volunteers
- 649 people
- Sponsor
- NICHD Neonatal Research Network
Retinopathy of Prematurity
Stress Induced by Screening for Retinopathy of Prematurity - Should Speculum and Indentation Rather be Avoided
The purpose is to assess the hypothesis that indirect ophthalmoscopy for retinopathy of prematurity eye examination (ROPEE) screening without the use of a lid speculum and scleral indentation (speculum-free, SpF) is less…
- Trial name
- stressROP (NCT04408807)
- Testing
- Speculum-free (SpF) fundoscopy, Speculum (Sp) fundoscopy
- Where
- Greece
- Volunteers
- 37 people
- Sponsor
- Aristotle University Of Thessaloniki
Retinopathy of Prematurity
Sucrose Analgesia for the Reduction of Pain During Retinopathy of Prematurity Screening
Retinopathy of Prematurity (ROP) screening is one of many potentially painful diagnostic and therapeutic procedures performed routinely on preterm infants in the Neonatal Intensive Care Unit.
- Trial name
- NCT00921544
- Testing
- Sucrose, Sterile water
- Where
- Ireland
- Volunteers
- 40 people
- Sponsor
- Coombe Women and Infants University Hospital
Retinopathy of Prematurity Both Eyes
Ranibizumab Vs Bevacizumab for Type 1 Retinopathy of Prematurity
Retinopathy of prematurity (ROP) with inadequate growth and development of retinal blood vessels in premature infants is one of the foremost reasons for childhood blindness.
- Trial name
- NCT05033106
- Testing
- Bevacizumab, Ranibizumab
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Zagazig University
Retinopathy of Prematurity
umBilical Or Adult Donor Red Blood Cells in Extremely Low Gestational Age Neonates and Retinopathy of Prematurity (BORN)
Extremely low gestational age neonates (ELGAN, i.e., born before 28 gestation weeks) are among the most heavily transfused pediatric patients.
- Trial name
- BORN (NCT05100212)
- Testing
- cord blood-RBC concentrates, adult donor RBC concentrates
- Where
- 10 sites in Italy
- Volunteers
- 146 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Retinopathy of Prematurity
Efficacy of Mydriatic Drops in Premature Infants
Because of the neonatologists reported that some infants had suffered from vomiting, bradycardia, hypotonia, and aspiration risk about 30-60 minutes after the fundus examination in the intensive care unit.
- Trial name
- NCT03448640
- Testing
- Drug used in the examination of premature infants.
- Volunteers
- 60 people
- Sponsor
- Bulent Ecevit University
Preterm
Bovine Colostrum in Prevention of Sepsis and Retinopathy of Prematurity
The aim of this study is to evaluate efficacy of bovine colostrum administration as a prophylaxis to decrease the incidence and the occurrence of retinopathy of prematurity in preterm neonates of gestational age less than 32…
- Trial name
- NCT05438680
- Testing
- The bovine colostrum ( trade name : baby steps sachets, 300mg )
- Where
- 2 sites in Egypt
- Volunteers
- 200 people
- Sponsor
- Alexandria University
Retinopathy of Prematurity
Phase 1 Trial of Bevacizumab Treatment for Severe Retinopathy of Prematurity
The purpose of this study is to find a dose of intravitreal bevacizumab that is lower than currently used for severe retinopathy of prematurity (ROP), is effective in this study, and can be tested in future larger studies.
- Trial name
- ROP1 (NCT02390531)
- Testing
- Bevacizumab
- Where
- 11 sites in United States
- Volunteers
- 120 people
- Sponsor
- Jaeb Center for Health Research
Early-Onset Sepses, Neonatal, Periventricular Haemorrhage Neonatal
Zinc Supplementation on Very Low Birth Weight Infant
Premature birth is a major cause of neonatal death in addition to neonatal asphyxia and infections. Early in life, premature babies must get aggressive nutrition so that there is no extrauterine growth restriction (EUGR) in the…
- Conditions
- Early-Onset Sepses, Neonatal, Periventricular Haemorrhage Neonatal, Bronchopulmonary Dysplasia, Retinopathy of Prematurity
- Trial name
- NCT04050488
- Testing
- Zinc Sulfate
- Volunteers
- 364 people, healthy volunteers welcome
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Retinopathy of Prematurity
Prospective Evaluation of iCam-OCT
This is a prospective, non-significant-risk clinical study sponsored by Siloam Vision, Inc. to evaluate whether ophthalmologists can assess retinopathy of prematurity (ROP) using images from the iCam-OCT device as effectively as…
- Trial name
- NCT07839923
- Testing
- imaged with i-Cam OCT
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Siloam Vision
Pain, Breast Milk Odour
Breast Milk Odour and Mother's Voice on Pain and Comfort
This study will be conducted to examine the effect of breast milk smell and mother's voice on pain and comfort in retinopathy examination in premature infants.
- Conditions
- Pain, Breast Milk Odour, Comfort
- Trial name
- NCT06609252
- Testing
- Breast milk odour, Mother voice
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Tarsus University
Pain During ROP Exam
ROP Screening: Comparison of Pain Using Two Eyelid Retractors
Retinopathy of prematurity (ROP) is a major cause of blindness in the world. Initial ocular examinations of infants at risk for ROP are generally conducted between 4-6 weeks postnatally.
- Trial name
- NCT02152046
- Testing
- ROP exam with spring loaded retractor, ROP exam with screw retractor
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Wake Forest University Health Sciences
Premature, Retinopathy of Prematurity
Comfort Level in Premature Infants Undergoing Retinopathy of Prematurity Screening
Retinopathy of prematurity (ROP) screening is a routine yet painful procedure for premature infants, often necessitating pharmacological mydriasis.
- Conditions
- Premature, Retinopathy of Prematurity, Pain
- Trial name
- NCT07016984
- Testing
- standard phototherapy eye patches
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Istanbul Nisantasi University
Retinopathy of Prematurity
Lucentis to Treat Retinopathy of Prematurity (ROP) 3 Plus Disease
Retinopathy of prematurity (ROP) is a neovascular retinal disorder of premature born children, characterized by the development of retinal neovascularisation, macular dragging and eventually retinal detachment.
- Trial name
- NCT02164604
- Testing
- intravitreal injection of 0.03ml ranibizumab
- Where
- Switzerland
- Volunteers
- 6 people
- Sponsor
- Kantonsspital Aarau