Clinical trials: Premature Rupture of Membrane
Rupture of Membranes; Premature
Urea and Creatinine Level in Vaginal Fluid as a Predicator for Length of Latency Period in Prelabour Membranes Rupture
This study aims to investigate the relation between the concentration of urea and creatinine in vaginal fluid and length of latency period in women with PROM between 32 and 35 weeks gestation.
- Trial name
- NCT03213535
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Covid19, Pregnancy Complications
Spanish Registry of Pregnant Women With COVID-19
Study title Spanish Registry of Pregnant Women with COVID-19 Protocol number and version Number 55/20. Version V8. Sponsors This registry is a project promoted by Dr.
- Conditions
- Covid19, Pregnancy Complications, Premature Rupture of Membrane, Abruptio Placentae
- Trial name
- OBS COVID (NCT04558996)
- Where
- Spain
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Puerta de Hierro University Hospital
Preterm Premature Rupture of Membrane, Pregnancy, High Risk
Improvement of PPROM Management With Prophylactic Antimicrobial Therapy (iPROMPT)
To conduct an unblinded pragmatic randomized controlled trial (pRCT) "Improvement of PPROM Management with Prophylactic Antimicrobial Therapy (iPROMPT)" of a seven-day course of ceftriaxone, clarithromycin, and metronidazole…
- Conditions
- Preterm Premature Rupture of Membrane, Pregnancy, High Risk, Preterm Birth
- Trial name
- NCT06396078
- Testing
- Ceftriaxone 1000 MG, Clarithromycin 500mg, Metronidazole 500 mg
- Where
- 2 sites in United States
- Volunteers
- 56 people
- Sponsor
- Ohio State University
Chorioamnionitis, Cerebral Palsy
Early Identification of Brain Insult in Chorioamnionitis
Premature breaking of the amniotic fluids during pregnancy caries high risk for infection of the amniotic fluid. One of the results of chorioamnionitis is brain injury of the fetus.
- Trial name
- NCT01778725
- Where
- Israel
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Pregnancy, Preterm Labor
Biomarkers in Obstetrical Complications
Objective: To study the natural history of normal pregnancy and the most frequent pregnancy complications responsible for the excessive rate of perinatal morbidity and mortality, in order to develop models to predict the…
- Conditions
- Pregnancy, Preterm Labor, Maternal Fetal Factors, Preterm Birth
- Trial name
- NCT03480139
- Where
- United States
- Volunteers
- 746 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Chorioamnionitis
Intrapartum Study of Sterile and Clean Gloves
The purpose of this study is to determine whether the use of sterile or clean gloves during labor exams affects the rate of chorioamnionitis. Chorioamnionitis is an infection of the membranes around the baby.
- Trial name
- NCT01852188
- Testing
- Type of glove used for intrapartum vaginal exams
- Where
- United States
- Volunteers
- 507 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Premature Rupture of Membranes, Enterobacteriaceae
Prevalence of Carriage of Extended-Spectrum Beta-Lactamase (ESBL)-Producing Enterobacteria in Preterm Premature Rupture of Membranes : A French Multicenter Cohort Study
This study looks at how common certain antibiotic-resistant bacteria (called extended-spectrum beta-lactamase-producing Enterobacteriaceae, or E-BLSE) are in pregnant women who experience premature breaking of their water before…
- Conditions
- Premature Rupture of Membranes, Enterobacteriaceae, Beta-Lactams, Drug Resistance, Bacterial
- Trial name
- NCT07200999
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Centre Hospitalier de Saint-Denis
Labor Long, Nulliparity
HIDRATA Study: Efficacy of a Hydration Protocol in Nulliparous Women During Labor
Aim. To evaluate the efficacy of optimizing hydration during labor in nulliparous women with respect to reducing the duration of dilation and the second stage of labor, lowering the incidence of Cesarean sections and fever, and…
- Conditions
- Labor Long, Nulliparity, Premature Rupture of Membrane, Pregnancy, Prolonged
- Trial name
- HYDRATA (NCT03607929)
- Testing
- optimal, variability
- Where
- Spain
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Puerta de Hierro University Hospital
Rupture of Membranes; Delayed Delivery (Following Spontaneous Rupture), Rupture of Membranes; Premature
Latency Antibiotics in Previable PPROM, 18 0/7- 22 6/7 WGA
This study is a non-blinded, prospective, randomized controlled trial designed to compare the effect of outpatient oral antibiotics (i.e., amoxicillin and azithromycin) on the length of time (days) that pregnancy continues after…
- Conditions
- Rupture of Membranes; Delayed Delivery (Following Spontaneous Rupture), Rupture of Membranes; Premature, Rupture of Membranes; Premature, Affecting Fetus, Preterm Birth
- Trial name
- NCT04047849
- Testing
- Antibiotics, oral Azithromycin and oral Amoxicillin
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Woman's
Preterm Premature Rupture of Membranes (PPROM), Premature Rupture of Membranes (PROM)
Effects of Emotional Freedom Technique and Music Therapy in High-Risk Pregnancy
Pregnancy is a physiological process; however, it is also a dynamic period during which obstetric and medical complications that may threaten maternal and fetal health can occur.
- Conditions
- Preterm Premature Rupture of Membranes (PPROM), Premature Rupture of Membranes (PROM), High-Risk Pregnancy
- Trial name
- NCT07559071
- Testing
- Emotional Freedom Technique (EFT), Music Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 177 people
- Sponsor
- Selcuk University
Induction of Labor Affected Fetus / Newborn, Rupture of Membranes Prior to Onset of Labor
Nitric Oxide Donor Isosorbide Mono Nitrate for Induction of Labor With Pre-labor Rupture of Membranes
The study aims to evaluate and assess the effectiveness and safety of vaginal administration of isosorbide mono nitrate (IMN) to induce cervical ripening and shorten the interval time between induction and delivery in women…
- Trial name
- NCT03665779
- Testing
- isosorbide mononitrate
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- ahmed nagy shaker ramadan
Pathology of Pregnancy
Maternal Plasmatic Regulatory T Cells and Th17 as Possible Diagnosis Markers of Acute Chorioamnionitis
The purpose of this study is to evaluate if regulator T cells (Treg) and Th17 level modifications in maternal blood and placenta could be correlated to a chorioamnionitis, in women hospitalized for PPROM.
- Trial name
- ICAR (NCT01610258)
- Testing
- Blood and placenta samples
- Where
- 2 sites in France
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Operation Wound; Infection, Endometritis
Use of Antiseptic Solution for Vaginal Wash Before Cesarean Section
To evaluate the rate of infections after cesarean sections in patients with premature rupture of membranes after vaginal wash either with an antiseptic solution (clorhexidine solution) vs. saline solution (placebo).
- Trial name
- NCT03442218
- Testing
- Clorhexidine, Saline solution
- Where
- Panama
- Volunteers
- 203 people
- Sponsor
- Saint Thomas Hospital, Panama
Premature Rupture of Fetal Membranes
Evaluation of CRB in PROM Patients
The CRB study is designed to study the safety and effectiveness of the Cook Cervical Ripening Balloon (CRB) for the induction of labor in term and near-term patients with premature rupture of membranes (PROM).
- Trial name
- NCT01736852
- Testing
- CRB, Pitocin
- Where
- 4 sites in United States
- Volunteers
- 129 people
- Sponsor
- Cook Group Incorporated
PROM, Preterm (Pregnancy)
Novel Use of Central Venous Pressure (CVP) Set With McDonald Cerclage Technique for Amnioinfusion in Preterm Premature Rupture of Membranes Improves Amniotic Fluid Index and Neonatal Outcomes
This prospective, two-arm, non-randomized comparative interventional study evaluated the effectiveness of amnioinfusion using a central venous pressure (CVP) set compared with conventional transabdominal amnioinfusion in pregnant…
- Trial name
- CAM-PPROM (NCT07774832)
- Testing
- CVP-Set Amnioinfusion With McDonald Cerclage, Conventional transabdominal amnioinfusion
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Herlambang Herlambang
Premature Rupture of Membranes
FOLCROM Trial: Foley Catheter in Rupture of Membranes
Multicenter randomized clinical trial comparing oxytocin versus oxytocin and foley catheter for induction in women who present with premature rupture of membranes who are not in labor.
- Trial name
- FOLCROM (NCT01973036)
- Testing
- Foley Catheter, Oxytocin
- Where
- 5 sites in United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic
Pregnancy Related, Remote Monitoring
Feasibility of Remote eCTG Monitoring Home@Hospital in Complicated Pregnancies
The objective of this single center, interventional cohort study is to evaluate the feasibility of remote electrophysiological cardiotocography (eCTG) monitoring in complicated pregnancies in a home@hospital setting.
- Conditions
- Pregnancy Related, Remote Monitoring, Feasibility
- Trial name
- HASTA (NCT06859177)
- Testing
- Remote eCTG
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Maxima Medical Center
PROM, Preterm (Pregnancy)
Outcome of Conservative Management in Cases of Pre Mature Rupture of Membranes (PROM) Between 20 and 28 Weeks of Pregnancy in Sohag City Hospitals
Prospective observational study
- Trial name
- NCT06271863
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Pregnancy Related, Fever
Assessment of Labour Progress by Intrapartum Ultrasound
Assessment of labor progress via digital exams is considered the standard of care in most delivery rooms. However, this method can be stressful, painful and imprecise and multiple exams increase the risk for chorioamnionitis.
- Conditions
- Pregnancy Related, Fever, Chorioamnionitis, Labor Complication
- Trial name
- NCT04651309
- Testing
- Transperineal Ultrasound
- Where
- Israel
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Kaplan Medical Center
PPROM, Early-Onset Neonatal Sepsis
Predicting EONS in PPROM Patients
An EONS occurred in nearly 14-22 % of the preterm infant of pregnant women with PPROM. To this day no risk prediction is established.
- Trial name
- PEONS (NCT03819192)
- Testing
- microbiome analysis, Conventional cultures, CAAP48 measurement
- Where
- 2 sites in Germany
- Volunteers
- 150 people
- Sponsor
- Jena University Hospital