Clinical trials: Premenopausal
Healthy
Effect of Multiple BI 1356 Doses of on the Multiple-dose Pharmacokinetics of a Combination of Ethinylestradiol and Levonorgestrel in Healthy Female Premenopausal Subjects
The objective was to investigate the effect of multiple oral doses of 5 mg BI 1356 on the steady-state pharmacokinetics of ethinylestradiol (EE) and levonorgestrel (LNG), the components of Microgynon®
- Trial name
- NCT02175394
- Testing
- Microgynon®, BI 1356
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Osteoporotic Fracture
Preventing the Risk of Osteoporotic Fracture in Premenopausal Women by a Spa Residential Physical Activity Program
Osteoporosis is an increasing public health problem. Involution of bone mass in women is due to a reduction in sensitivity of the bone to the mechanical stress due to the slow-down of the bone turnover after 35 years old.
- Trial name
- ThermOs (NCT03570008)
- Testing
- 9 days spa residential program, 3 sessions of 10 minutes per day of physical exercise
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Gastrointestinal Stromal Tumor
Long Term Effects of Tyrosine Kinase Inhibitor Therapy on Ovarian Reserve and Fertility in Patients With Chronic Myeloid Leukemia or Gastrointestinal Stromal Tumor
This pilot research trial studies the long term effects of tyrosine kinase inhibitor therapy on ovarian reserve and fertility in patients with chronic myeloid leukemia or gastrointestinal stromal tumor.
- Conditions
- Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Gastrointestinal Stromal Tumor, Premenopausal
- Trial name
- NCT02734823
- Testing
- Cytology Specimen Collection Procedure, Laboratory Biomarker Analysis, Questionnaire Administration
- Where
- United States
- Sponsor
- University of Southern California
Coronary Heart Disease
Relationship Between the Menstrual Cycle and Heart Disease in Women
Women who have regular menstrual cycles have a lower risk of heart disease than men of the same age or women who no longer have menstrual cycles.
- Trial name
- NCT01546454
- Testing
- Ethinyl Estradiol-Levonorgestrel combination, leuprolide acetate, Estradiol
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Healthy
Oral Contraceptive DDI Study
A Two-way Study to Evaluate the Potential Pharmacokinetic Interactions Between Sotagliflozin (LX4211) and an Oral Contraceptive Containing Norgestimate and Ethinyl Estradiol, in Healthy Premenopausal Women.
- Trial name
- NCT02494609
- Testing
- sotagliflozin, oral contraceptive, oral contraceptive + sotagliflozin
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Lexicon Pharmaceuticals
Breast Cancer
A Pilot Observational Study to Assess Changes in Biochemical Parameters of Ovarian Reserve With Chemotherapy
Premenopausal women who are diagnosed with breast cancer are frequently treated with chemotherapy. Chemotherapy can affect the ovaries, and the effects can range from temporary loss of menstrual periods to permanent menopause.
- Trial name
- NCT00644683
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Lynn Henry
Breast Cancer
Safety of OFS Combined With AI Endocrine Therapy in Chinese Premenopausal Breast Cancer Patients
To compare safety of adjuvant OFS combined with anastrozole versus OFS combined with exemestane in Chinese premenopausal hormonal receptor(HR) positive breast cancer patients.
- Trial name
- SEAT (NCT02440230)
- Testing
- OFS + Anastrozole, OFS + Exemestane
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Premenopausal Women, Overweight and Obese Women
A Pilot Study to Characterize the Bioavailability and Plasma Profile of Potato Polyphenols in Humans
Primary objective is to determine the bioavailability of and characterize the kinetic profile of target polyphenol metabolites of potatoes over 6 hour postprandial period.
- Trial name
- PPT (NCT02167607)
- Testing
- Active Comparator
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Uterine Fibroids
Evaluating the Safety and Efficacy of Proellex® (CDB-4124) in Premenopausal Women With Symptomatic Uterine Fibroids
Premenopausal women with symptomatic uterine fibroids will be randomized to either Proellex 25mg or 50mg or placebo for one treatment cycle (four months).
- Trial name
- NCT00735553
- Testing
- Proellex
- Where
- 15 sites in United States
- Volunteers
- 77 people
- Sponsor
- Repros Therapeutics Inc.
Healthy Adult Females
Postprandial Triglyceride Concentrations Across Menstrual Cycle Phases
The goal of this clinical trial is to investigate the effect of menstrual cycle phases on postprandial triglyceride concentrations in healthy young female adults.
- Trial name
- NCT07459465
- Testing
- Early Follicular Phase, Mid-Luteal Phase
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Healthy
Bioequivalence Trial of Liquid Versus Freeze-Dried Pergoveris® in Pituitary Suppressed Healthy Premenopausal Female Subjects
Some women cannot have children because they cannot produce enough follicle stimulating hormone (FSH) and luteinising hormone (LH).
- Trial name
- NCT02317809
- Testing
- Liquid pergoveris, Freeze-dried pergoveris
- Where
- Germany
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Merck KGaA, Darmstadt, Germany
Folliculogenesis
An Open-label Study of the Effects of Elagolix in Adult Premenopausal Females
This is an open-label Phase 1 study in healthy premenopausal females evaluating the effects of different dosing regimens of elagolix on ovarian activity, ovulation, and ovarian reserve and to assess the effect of elagolix on…
- Trial name
- NCT01403038
- Testing
- Elagolix
- Where
- 22 sites in United States, Puerto Rico
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- AbbVie (prior sponsor, Abbott)
Menopause, Cardiovascular
Comparing the Effects of Multicomponent Exercise on Cardiovascular Health and Lipid Profiles in Premenopausal and Postmenopausal Women
Background: The present study aimed to examine the effects of a 26-week multicomponent exercise program on lipid and lipoprotein profiles, blood pressure, and anthropometric parameters in healthy but sedentary premenopausal and…
- Trial name
- NCT06802484
- Testing
- Experimental: Pre-Menopausic, Experimental: Post- Menopausic
- Where
- Portugal
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Évora
Estrogen Receptor-positive Breast Cancer, HER2-negative Breast Cancer
Goserelin and Letrozole or Anastrozole in Premenopausal Patients With Stage II-III Estrogen Receptor-Positive Breast Cancer
This phase II trial studies the impact of a presurgical endocrine therapy, consisting of goserelin with letrozole or anastrozole on the treatment of premenopausal patients with stage II-III estrogen receptor-positive (ER+) and…
- Conditions
- Estrogen Receptor-positive Breast Cancer, HER2-negative Breast Cancer, Stage II Breast Cancer, Stage IIIA Breast Cancer
- Trial name
- NCT01368263
- Testing
- goserelin acetate, letrozole, anastrozole
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Washington University School of Medicine
Breast Cancer
Leuplin SR 11.25 mg Injection Kit Specified Drug-use Survey: "QOL Survey in Premenopausal Breast Cancer Patients"
The purpose of this survey is to examine the effect on quality of life (QOL) improvement and convenience of switching to leuprorelin acetate 3 months depot 11.25 milligram (mg) injection kit (Leuplin SR 11.25 mg injection kit)…
- Trial name
- NCT02134977
- Testing
- Leuprorelin Acetate
- Volunteers
- 2,816 people
- Sponsor
- Takeda
Bone Health, Osteoporosis
Effects of Yoga on Bone Metabolism in Premenopausal Women
This study examined the effects of 8 months of Yoga training on bone density and bone turnover markers in premenopausal women, ages 35-50 years.
- Trial name
- NCT02163668
- Testing
- Yoga Group
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Breast Cancer
Safety of Toremifene and Tamoxifen Therapy in Premenopausal Patients With Operable Breast Cancer
To compare the safety of toremifene and tamoxifen therapy in premenopausal patients with operable breast cancer by monitoring gynecological abnormality,blood lipid level,hepatic abnormality,estrogen level and perimenopausal…
- Trial name
- TTOS (NCT02344940)
- Testing
- Toremifene, Tamoxifen
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Urinary Incontinence, Menopause
The Effect of Kegel Exercise and Ba Duan Jin Applications on Premenopausal Women With Urinary Incontinence
This study aimed to determine the effects of Kegel exercise and Ba Duan Jin applications applied to premenopausal women with urinary incontinence on quality of life and psychological well-being.
- Conditions
- Urinary Incontinence, Menopause, Wolman Disease, Quality of Life
- Trial name
- NCT06287658
- Testing
- Training on Kegel exercise and Ba Duan Jin applications online, training on Kegel exercises and Ba Duan Jin applications after the research is completed
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Breast Cancer, Breast Cancer and Pregnancy
The Immune System's Response to Young Women's Breast Cancer
This study plans to learn more about the immune system's response to breast cancer in young women.
- Trial name
- NCT01503190
- Where
- 5 sites in United States
- Volunteers
- 800 people
- Sponsor
- University of Colorado, Denver
Hypoactive Sexual Desire Disorder
2. Study to Evaluate the Efficacy/Safety of Bremelanotide in Premenopausal Women With Hypoactive Sexual Desire Disorder
A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group Trial with an optional Open-label Extension to evaluate the efficacy of bremelanotide (BMT), administered subcutaneously (SC) on an as needed basis for the…
- Trial name
- HSDD (NCT02338960)
- Testing
- Bremelanotide
- Where
- 91 sites in United States, Canada
- Volunteers
- 714 people
- Sponsor
- Palatin Technologies, Inc