Clinical trials: Prenatal Diagnosis
Obesity
BMI-based Vitamins in Obese Pregnant Women
The purpose of this study is to devise and pilot a BMI-based prenatal vitamin for obese pregnant women. Currently, all pregnant women, regardless of body mass index, take the same prenatal vitamin.
- Trial name
- NCT02802566
- Testing
- BMI-based prenatal vitamin, Standard prenatal vitamin
- Where
- 2 sites in United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Immunization; Infection, Pregnancy Related
Increasing Influenza and Tdap Vaccination of Pregnant Women
Pregnant women who get influenza are more likely than non-pregnant women to have serious complications, including hospitalizations, death, preterm labor and premature birth.
- Trial name
- NCT04444518
- Testing
- VAX-MOM Intervention, Standard of Care
- Where
- United States
- Volunteers
- 12,760 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Congenital Diaphragmatic Hernia
North American Fetal Therapy Network Prospective Registry for Long-term Outcome Following Fetoscopic Endoluminal Tracheal Occlusion in Severe Left and Right Congenital Diaphragmatic Hernia
The purpose of this research is to determine if babies who undergo a Fetoscopic Endoluminal Tracheal Occlusion (FETO) procedure survive more often and have less long-term complications than babies who have similarly severe…
- Trial name
- NCT07564297
- Testing
- Fetoscopic Endoluminal Tracheal Occlusion, Standard of Care
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
Chikungunya Virus Infection
Consequences of a Maternal-fetal Chikungunya Virus Infection
Chikungunya is an infectious disease caused by an alphavirus transmitted by the Aedes mosquitoes which has known a worldwide expansion since its re-emergence in 2004.
- Trial name
- CHIK13+ (NCT04909411)
- Testing
- OPHTHALMOLOGICAL ASSESSMENT, NEUROPSYCHOLOGICAL ASSESSMENT
- Where
- Reunion
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Premature Infants
Impact of Antenatal Exposure to Pesticides on Neurophysiological Functions (Sleep, Respiration) of Preterm Neonates
During pregnancy, the foetus is therefore chronically exposed to a large number of substances. A number of studies have started to emphasize the effects of this antenatal exposure on the newborn infant's morphological parameters…
- Trial name
- PHYSIOMECO (NCT02785926)
- Where
- France
- Volunteers
- 53 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Breast Cancer
Circulating Fetal Cells and Breast Cancer
After pregnancy, fetal cells remain in a woman's body for years. These cells may be involved in different physiological situations (e.g. wound healing) and diseases (e.g.
- Trial name
- MoSaiC2 (NCT04903990)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Prematurity, Mechanical Ventilation
Circadian Feeding and Reciprocal Scent Intervention in NICU
Objective: This study evaluated the effects of circadian-aligned feeding and reciprocal scent intervention on premature infants receiving mechanical ventilation and on postpartum depression levels in their mothers.
- Trial name
- NCT07622459
- Testing
- Reciprocal Scent Intervention, Circadian-Aligned Feeding, Standard Care (in control arm)
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Inonu University
Fetal Alcohol Spectrum Disorders
Contraception and Alcohol Risk Reduction Internet Intervention Randomized Trial
The goal of the proposed research is to develop and pilot test a novel Internet intervention to reduce the risk of Alcohol-exposed pregnancy (AEP).
- Trial name
- CARRII (NCT02128880)
- Testing
- CARRII, CARRII Education
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Empowerment, Cervical Cancer, Endometrial Cancer, Follow-up, Nurse-led, PROM
An Individualised and Patient-centred Follow-up Program for Women With Gynaecological Cancer
This randomized controlled trial is testing the hypothesis that an individually focused and need-based nurse led follow-up program supported by electronic Patient Reported Outcome Measures for women with gynecological cancer will…
- Trial name
- NEMO (NCT03838861)
- Testing
- NEMO: NEw MOdel of follow-up
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- University of Southern Denmark
Endometrial Cancer
Immunotolerance in Endometrial Cancer and at the Maternal-fetal Interface: Immunological Profiling of the Tumor Microenvironment in Risk Stratification of Recurrence
This pilot/exploratory study will be configured as a non-retro-prospective study interventional on endometrial tissue samples taken from surgically treated patients at the Regina Elena National Cancer Institute, IRE - IFO and…
- Trial name
- NCT06250010
- Testing
- tissue samples (healthy and tumor taken from the same patient) and tissue samples (decidualized endometrium and trophoblast taken from it patient)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Regina Elena Cancer Institute
Fetal Movement Disorder
Interest of the Kleihauer in Patients With Decreased Active Fetal Movements
Fetomaternal hemorrhage is the passage of fetal red blood cells through the placental barrier into the maternal blood. This phenomenon frequently occurs in the third trimester for small quantities of blood < 0.5 ml and is without…
- Trial name
- MAF (NCT04948021)
- Where
- France
- Volunteers
- 1,683 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Premature Rupture of Membranes, Enterobacteriaceae
Prevalence of Carriage of Extended-Spectrum Beta-Lactamase (ESBL)-Producing Enterobacteria in Preterm Premature Rupture of Membranes : A French Multicenter Cohort Study
This study looks at how common certain antibiotic-resistant bacteria (called extended-spectrum beta-lactamase-producing Enterobacteriaceae, or E-BLSE) are in pregnant women who experience premature breaking of their water before…
- Conditions
- Premature Rupture of Membranes, Enterobacteriaceae, Beta-Lactams, Drug Resistance, Bacterial
- Trial name
- NCT07200999
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Centre Hospitalier de Saint-Denis
Fetal Anomaly
Prevalence of Fetal Congenital Anomalies Among Pregnant Women Attending University Hospital
Congenital anomalies occur in 2-3% of births. They account for 20-30% of perinatal deaths. The aim is to assess the prevalence of fetal malformations in pregnant women attending University hospital
- Trial name
- NCT04174235
- Testing
- Ultrasound scan
- Where
- Egypt
- Volunteers
- 20,225 people
- Sponsor
- Beni-Suef University
IUD, Analgesia
TENS Unit for Analgesia During IUD Insertion
Subjects will be screened over the phone or in Tufts GYN clinic for participation in the study. If eligible and interested in participating, written informed consent (and assent if applicable) will be obtained.
- Conditions
- IUD, Analgesia, Patient Preference, Pain, Acute
- Trial name
- NCT06240260
- Testing
- TENS (transcutaneous electrical nerve stimulation) unit, Standard care
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Hemolytic Disease of the Newborn
Application of Quantitative Hemorrhage Detection in Fetomaternal Hemorrhage Syndrome for the Diagnosis of Hemolytic Disease of the Newborn
This study adopted a single-center, prospective, observational study design. A consecutive cohort of pregnant and postpartum women who met the inclusion criteria was recruited from Shanghai First People's Hospital between January…
- Trial name
- NCT07371520
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Down Syndrome, Fetal Aneuploidy
Specimen Collection From Pregnant Women at Increased Risk for Fetal Aneuploidy
The specimen collection is designed for the purpose of the development of a noninvasive prenatal test for T21.
- Trial name
- NCT01429389
- Where
- 14 sites in United States, Canada
- Volunteers
- 2,000 people
- Sponsor
- Sequenom, Inc.
Pregnancy, HELLP Syndrome
Pancreatic Stone Protein (PSP) in Pregnant Women
This prospective, single centred cohort study evaluates the physiological course of the potentially novel biomarker PSP in pregnant women as well as its predictive role in the development of inflammatory complications during…
- Conditions
- Pregnancy, HELLP Syndrome, Preterm Premature Rupture of Fetal Membranes, Preeclampsia
- Trial name
- NCT02247297
- Testing
- Blood collection
- Where
- Switzerland
- Volunteers
- 486 people
- Sponsor
- Nicole Ochsenbein
Parents
New Programme for Antenatal Preparation for Early Parenthood
Becoming a parent is a challenging stage in life, which provokes feelings of both excitement and insecurity; parents strive to develop confidence in their parenting role.
- Trial name
- NCT03679520
- Testing
- New programme, Regular programme
- Where
- 7 sites in Sweden
- Volunteers
- 71 people
- Sponsor
- Region Skane
Infertility, Aneuploidy
Single Embryo TrAnsfeR of Euploid Embryo
The purpose of the current study is to evaluate the effect of preimplantation genetic screening (PGS) by next generation sequencing (NGS) compared to standard morphological assessment of embryos on pregnancy rates through a…
- Trial name
- STAR (NCT02268786)
- Testing
- Preimplantation Genetic Screening by NGS
- Where
- 38 sites in United States, Australia and 2 more
- Volunteers
- 661 people
- Sponsor
- Illumina, Inc.
Cardiovascular Diseases, Heart Diseases
Fetal Growth Restriction & Maternal Cardiovascular Risk
To determine whether or not women with a history of having a baby with intrauterine growth retardation (IUGR) was more likely to have risk factors for cardiovascular disease versus women with a pregnancy not complicated by IUGR.
- Trial name
- NCT00241683
- Volunteers
- 704 people
- Sponsor
- The University of Texas Health Science Center, Houston
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