Clinical trials: Prenatal Diagnosis
Severe Congenital Diaphragmatic Hernia
Percutaneous Endoscopic Tracheal Plug/Unplug for CDH (Congenital Diaphragmatic Hernia)
Congenital diaphragmatic hernia is an anatomically simple birth defect in which contents of the fetal abdomen migrate into the chest due to incomplete formation of the diaphragm.
- Trial name
- NCT00768703
- Testing
- Percutaneous endoscopic fetal tracheal occlusion/unocclusion
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
First Pregnancy
The Effect of Prenatal Haptonomy on Anxiety, Distress and Psychological Well-being
Introduction:Anksiyete experienced during prenatal can increase Distress, cause negative perinatal outcomes, and adversely affect the psychological well-being.
- Trial name
- NCT05494840
- Testing
- Haptonomy
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Hilal Özbek
Twin; Pregnancy, Affecting Fetus or Newborn, Fetal Growth Retardation
Selective Fetal Growth Restriction in Monochorionic Twins - an International Investigation
Optimal diagnostic management and underlying pathophysiological mechanisms of selective fetal growth restriction (sFGR) in monochorionic diamniotic (MCDA) twin pregnancies have not been fully clarified.
- Conditions
- Twin; Pregnancy, Affecting Fetus or Newborn, Fetal Growth Retardation, Twin Monochorionic Diamniotic Placenta, Twin Diseases
- Trial name
- CONTRAST (NCT05952583)
- Testing
- Ultrasound
- Where
- 6 sites in United States, Belgium and 4 more
- Volunteers
- 274 people
- Sponsor
- Leiden University Medical Center
HIV Infections, Pregnancy Complications, Infectious
Prenatal and Postnatal Studies of Interventions for Prevention of Mother-To-Child Transmission
The purpose of this study is to collect and study clinical and laboratory information about a pregnant or new mother and her medical care that will increase our knowledge of the best care for HIV-infected pregnant women and their…
- Trial name
- NCT00028145
- Testing
- Adherence assessment
- Where
- 77 sites in United States, Puerto Rico
- Volunteers
- 3,090 people
- Sponsor
- International Maternal Pediatric Adolescent AIDS Clinical Trials Group
Deglutition Disorder, High Risk Pregnancy
Study of Fetal Swallowing
This study will establish a database of fetal movements associated with feeding. It will use information obtained from standard fetal ultrasound procedures to identify and measure the growth of the baby's face, lips, tongue, jaw…
- Trial name
- NCT00004566
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Hypoglycemia, Infant, Small for Gestational Age
Dextrose Gel Does Not Prevent Neonatal Hypoglycemia
This was a quasi-experimental pilot study comparing blood glucose values 30 minutes after feeding alone or feeding + dextrose gel in newborns at risk for transient neonatal hypoglycemia.
- Conditions
- Hypoglycemia, Infant, Small for Gestational Age, Premature Birth of Newborn, Fetal Macrosomia
- Trial name
- NCT02523222
- Testing
- 40% Dextrose gel
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Baylor College of Medicine
Respiratory Failure, Infant
Inhaled Nitric Oxide by Oxygen Hood in Neonates
Inhaled nitric oxide (iNO) improves oxygenation in term infants with respiratory failure. However, iNO has been primarily used in infants receiving mechanical ventilation.
- Conditions
- Respiratory Failure, Infant, Persistent Fetal Circulation
- Trial name
- NCT00732537
- Testing
- inhaled Nitric Oxide, Oxygen (>90% by hood) - standard therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Alabama at Birmingham
Fetal Anomaly of Central Nervous System
Diagnosis Of Neurological Fetal Anomalies
This is a descriptive cross-sectional study 300 patients coming for antenatal care at sohag governorate undergo mid anatomical scan.
- Trial name
- NCT05058001
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Sohag University
Preterm Birth
Placental Inflammation in Prenatal Care
Objective of study is to explore expression of stress-related genes and inflammation in placentas and umbilical cord blood for women participating in group prenatal care compared with women receiving individual prenatal care.
- Trial name
- PINC (NCT02476656)
- Volunteers
- 40 people
- Sponsor
- Prisma Health-Upstate
Umbilical Cord Coiling Index and Fetal Cardiac Functions
The Relationship Between Umbilical Cord Coiling Index and Fetal Cardiac Functions.
The maximum efficiency of umbilical cord blood flow depends on a specific number of coils. With modern ultrasound techniques, investigators can now detect cord abnormalities even before birth.
- Trial name
- NCT06915051
- Testing
- Determining the relationship between the coiling number and fetal echocardiography findings.
- Where
- Turkey (Türkiye)
- Volunteers
- 202 people
- Sponsor
- Sanliurfa Education and Research Hospital
Malaria, Severe Malaria
Examination of Protective Factors Against Severe Malaria
This study, sponsored by the National Institutes of Health and the University of Bamako in Mali, Africa, will examine factors that may protect against progression of malaria from mild to severe disease.
- Trial name
- NCT00342043
- Where
- Mali
- Volunteers
- 4,850 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Intrauterine Growth Retardation, Prematurity
Severe Intrauterine Growth Retardation: Developmental Newborn Intensive Care Unit (NICU) Care
The purpose of the study is to learn more about the development of small for gestational age (SGA) preterm infants and whether focusing on the infant's behavior has a positive effect on outcome.
- Trial name
- NCT00914108
- Testing
- Newborn Individualized Developmental Care
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Boston Children's Hospital
Infant, Newborn, Hypertension, Pulmonary
Inhaled Nitric Oxide Study for Respiratory Failure in Newborns
Respiratory failure in term newborns is associated with increased rates of death and long-term neurodevelopmental problems. This large international multicenter trial randomized newborns who had failed to respond to intensive…
- Conditions
- Infant, Newborn, Hypertension, Pulmonary, Persistent Fetal Circulation Syndrome, Pneumonia, Aspiration
- Trial name
- NINOS (NCT00005776)
- Testing
- Inhaled nitric oxide
- Where
- 20 sites in United States, Canada
- Volunteers
- 235 people
- Sponsor
- NICHD Neonatal Research Network
EOS, Pregnancy Related
Breech Pelvimetry by EOS® Technique With Change of Maternal Position and Delivery Route
When a patient presents with a fetus in PS after 36+0SA, after acceptance of participation in the study, pelvimetry with evaluation of the height of the fetal presentation by EOS® system in the upright and sitting position will…
- Conditions
- EOS, Pregnancy Related, Fetus Fetus, Breech Fetal Presentation
- Trial name
- PelviEOS (NCT05224908)
- Testing
- EOS
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Pregnancy, Mental Health
Life vs. Digital Music Interventions Performed by Professionals Throughout Pregnancy to Increase Mental Health for Mothers and Their Offspring
This prospective study was preceded by an extensive feasibility study between 2021-2024. Thereby, pregnant women were exposed to live music and a variety of creative workshops such as vibration, modelling, creative writing…
- Conditions
- Pregnancy, Mental Health, Maternal and Child Health Outcomes
- Trial name
- MusicMums (NCT07003048)
- Testing
- Singing, dancing in small groups and active listening to live music at the Berlin Philharmony building
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Clara Angela Foundation
Placenta Accreta
Detection of Urinary Bladder Wall Involvement in Abnormally Invasive Placenta (AIP) by 3D Ultrasonography
In the last three decades , the raise in cesarean delivery rates has led to a massive increase in the incidence of the abnormally invasive placenta .Complete separation of the abnormally invasive placenta is very difficult and…
- Trial name
- NCT05813743
- Testing
- 3 dimensional ultrasound
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Cairo University
Genetic Diseases
Prenatal Cytogenetic Diagnosis by Array-Based Copy Number Analysis
The main objective of the multi-centered collaborative study is to evaluate the accuracy, efficacy and clinical advantages of prenatal diagnosis using microarray analysis as compared with conventional karyotyping.
- Trial name
- Microarray (NCT01279733)
- Testing
- Microarray analysis
- Where
- United States
- Volunteers
- 4,450 people, healthy volunteers welcome
- Sponsor
- Columbia University
Fetal Macrosomia, Obesity Complicating Childbirth
Investigating the Relationship Between Triglycerides and Fetal Overgrowth in Gestational Diabetes
This is a prospective, observational study which examines the association between maternal triglycerides in the antepartum period and fetal overgrowth in pregnancies complicated by gestational diabetes.
- Conditions
- Fetal Macrosomia, Obesity Complicating Childbirth, Gestational Diabetes
- Trial name
- NCT06067685
- Testing
- Observation
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Antenatal Care Model, Gestatiaonl Diabetes Mellitus
Effects Of Core Canister Training in Pregnant Women With History of Gestational Diabetes Mellitus
This randomized control trial aims to determine the effects of structured Core Canister Training on muscular thickness, lumbopelvic stability and pelvic floor function in pregnant women diagnosed with GDM
- Trial name
- NCT07889791
- Testing
- core canister training, traditional antenatal exercises
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Lahore
Beta Thalassemia Intermedia
Trial of HQK-1001 in Beta Thalassemia Intermedia in Lebanon
Beta thalassemia intermedia syndromes are genetic anemias caused by mutations which reduce production of beta globin, a major component of adult hemoglobin A, the protein which delivers oxygen throughout the body.
- Trial name
- LB-04-THAL (NCT01642758)
- Testing
- Sodium 2,2 dimethylbutyrate
- Where
- Lebanon
- Volunteers
- 10 people
- Sponsor
- Boston University
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