Clinical trials: Prenatal Diagnosis
Pregnancy, Premature Birth
Use of the Perinatal Database and Biologic Tissue Bank at The Perinatology Research Branch (PRB)
The purpose of this application is to request permission to use a bank of biological specimens and clinical information collected by the investigators prior to their joining the intramural program.
- Conditions
- Pregnancy, Premature Birth, Prenatal Care, Preterm Delivery
- Trial name
- NCT00340249
- Where
- United States
- Volunteers
- 20,964 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Pregnancy, High-Risk
The Effect of Showing Fetal Images to High-Risk Pregnant Women on Stress and Sleep
The study will be conducted to determine the effect of showing fetal images to high-risk pregnant women on pregnancy stress and sleep quality.
- Trial name
- NCT07260838
- Testing
- Showing fetal images
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Melike Nur SÖNMEZ
Pregnancy, Down Syndrome
Comparison of Aneuploidy Risk Evaluations
This is a prospective, multi-center observational study designed to compare the test results of the Verinata Health Prenatal Aneuploidy Test to results of conventional prenatal screening for fetal chromosome abnormalities in…
- Conditions
- Pregnancy, Down Syndrome, Edwards Syndrome, Patau Syndrome
- Trial name
- CARE (NCT01663350)
- Where
- 26 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Verinata Health, Inc.
Pregnancy Related
Effects of Snakehead Fish on IUGR and LBW Among Second and Third Trimester Women
This study uses a Randomized Controlled Trial (RCT) design, conducted on pregnant women in Yogyakarta Province, Indonesia. This study aims to observe the effects of snakehead fish prepared-meal intervention on fetal growth…
- Trial name
- NCT07005609
- Testing
- Snakehead fish meal
- Where
- Indonesia
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Gadjah Mada University
Postpartum Depression, Pregnancy Related
Clinical Pilates and Prenatal Education on Perinatal Depressive Symptoms
This study evaluated whether a combined program of supervised Clinical Pilates Exercise and structured Prenatal Education, added to routine antenatal care, reduces perinatal depressive symptoms compared with routine antenatal…
- Conditions
- Postpartum Depression, Pregnancy Related, Low Back Pain, Labor Pain
- Trial name
- CPE-PE (NCT07647809)
- Testing
- Clinical Pilates Exercise, Prenatal Education
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Pregnancy, Postpartum
HIIT vs MICT During Pregnancy and Health and Birth Outcomes in Mothers and Children
Regular exercise during pregnancy and postpartum leads to health benefits for mother and child. Inactivity during pregnancy and after delivery is now treated as risky behavior.
- Conditions
- Pregnancy, Postpartum, Childbirth, Health Status
- Trial name
- HIIT MAMA (NCT05009433)
- Testing
- High intensity interval training program for pregnant women, Moderate intensity continuous training program for pregnant women, Standard obstetric care with extended education on healthy lifestyle
- Where
- Poland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Overweight and Obesity, Pregnancy Related
Healthy Habits in Pregnancy and Beyond
More than 50% of pregnant women are considered to have a BMI that is classified as overweight or obese when they present for antenatal care.
- Trial name
- HHIPBe (NCT04336878)
- Testing
- Healthy Habits in Pregnancy and Beyond
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Fetal Diagnose, Fetal Cardiac Disorder
Modified Myocardial Performance Index and Epicardial Thickness in Cases With Idiopathic Polyhydramnios
In cases diagnosed as idiopathic polyhydramnios and healthy pregnancy between 24-40 weeks (total number of cases (100-120)), prospective fetal echocardiography will be performed to evaluate MPI and EFT.
- Trial name
- NCT05737043
- Testing
- prenatal diagnose
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Excessive Weight Gain in Pregnancy With Baby Delivered
The Blossom Project: "Be-Well" Behavioral Wellness Study in Pregnancy
Multiple studies have demonstrated a very low prevalence of women meeting physical activity and weight gain recommendations during pregnancy.
- Trial name
- Be-Well (NCT02168647)
- Testing
- Behavioral Lifestyle counseling, Control
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Iowa State University
Fetal Growth Restriction (FGR)
Observational Study on Fetal Growth Restriction Complicated by Early Flowmetric Alterations
The goal of this observational study is to to understand whether the presence of flowmetric alterations in association with early growth retardation (i.e., before 22 weeks gestational age) is associated with worse neonatal and…
- Trial name
- ARDEF (NCT06717555)
- Where
- Italy
- Volunteers
- 63 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
X-Linked Hypohidrotic Ectodermal Dysplasia (XLHED)
Intraamniotic Administrations of ER004 to Male Subjects With X-linked Hypohidrotic Ectodermal Dysplasia
This is an open-label, prospective, genotype-match controlled for primary estimand, non randomized, multicenter, international Phase 2 clinical trial designed to investigate the efficacy and safety of ER004 administered…
- Trial name
- EDELIFE (NCT04980638)
- Testing
- ER004
- Where
- 8 sites in United States, France and 4 more
- Volunteers
- 20 people
- Sponsor
- EspeRare Foundation
Fetal Alcohol Spectrum Disorders
A Study of Parent and Child Emotions in Fetal Alcohol Spectrum Disorder (FASD)
The purpose of this study is to learn about the emotion regulation skills of children with fetal alcohol spectrum disorders (FASD) and different strategies that may improve these skills.
- Trial name
- NCT03524664
- Testing
- Tuning In to kids intervention
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- University of Rochester
Fetal Growth Retardation
OPtimal TIming of COrticosteroids in Early-onset Fetal Growth REstriction: the OPTICORE Study
The aim of this observational study is to optimize the timing of antenatal corticosteroids administered to patients with pregnancies complicated by early-onset fetal growth restriction in order to reduce neonatal morbidity and…
- Trial name
- OPTICORE (NCT05606497)
- Testing
- Corticosteroid
- Where
- Netherlands
- Volunteers
- 1,800 people
- Sponsor
- UMC Utrecht
Maternal Syphilis During Pregnancy - Baby Not Yet Delivered, Congenital Syphilis
Point-Of-Care Testing for Congenital Syphilis in Mothers and Newborns
A dramatic rise in syphilis has been recently reported in the US between 2000-2017, which was followed also by a dramatic rise in congenital syphilis (CS).
- Trial name
- NCT03814096
- Testing
- Syphilis Health Check POC-test (Diagnostics Direct LLC, NJ)
- Where
- 2 sites in United States
- Sponsor
- Stanford University
Chorioamnionitis, Early Onset Neonatal Sepsis
Chorioamnionitis: Observation of at Risk Infants vs Standard Care
This study evaluates the non-inferiority of a protocol of limited evaluation (complete blood count, blood culture) and clinical observation by standardized physical examination versus the algorithm suggested in the CDC's 2010…
- Conditions
- Chorioamnionitis, Early Onset Neonatal Sepsis, Sepsis of the Newborn
- Trial name
- CHORIS-RCT (NCT02886910)
- Testing
- Clinical observation, Standard management
- Where
- Italy
- Sponsor
- IRCCS Burlo Garofolo
Congenital Diaphragmatic Hernia
Fetal Endotracheal Occlusion (FETO) in Severe and Extremely Severe Congenital Diaphragmatic Hernia
Congenital diaphragmatic hernia (CDH) occurs when the diaphragm fails to fully fuse and leaves a portal through which abdominal structures can migrate into the thorax.
- Trial name
- FETO (NCT00881660)
- Testing
- Goldballoon Detachable Balloon and delivery microcatheter
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Michael A Belfort
Thermally Neutral Condition With Light-intensity Work, Thermally Neutral Condition With Moderate-intensity Work
Evaluating Pathophysiological Mechanisms of Acute and Chronic Heat Stress on Maternal and Fetal Health
This study examined the effects of environmental heat and physical work on maternal thermoregulation and fetal physiology in late pregnancy.
- Conditions
- Thermally Neutral Condition With Light-intensity Work, Thermally Neutral Condition With Moderate-intensity Work, Warm Condition With Light-intensity Work, Warm Condition With Moderate-intensity Work
- Trial name
- GaHPS (NCT07326176)
- Testing
- Heat and Physical Work Exposure Protocol
- Where
- Greece
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Embryo/Fetus Death, Blastocyst Disintegration
Assessment of Implantation Potential of Embryos by Time-lapse Technology
1. Culture conditions of developing embryos are highly controlled in the Embryoscope and are monitored by Time-lapse videography to produce 3D images at different stages.This cannot be done under conventional culture conditions.
- Conditions
- Embryo/Fetus Death, Blastocyst Disintegration, Aneuploidy, Complication of Implant
- Trial name
- Embryoscope (NCT01760278)
- Testing
- recombinant Follicle Stimulating Hormone (rFSH)
- Where
- India
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Bloom IVF and Fertility Centre
Fetal Growth Retardation
Day to Day Variation in Fetal Heart Rate Variability
This study evaluates the day-to-day variation in fetal heart rate variability based on non-invasive fetal-ECG (NI-FECG). Furthermore, the effect of fetal movements on fetal heart rate variability will be assessed.
- Trial name
- (FHRV) (NCT04289350)
- Testing
- fetal heart rate variability
- Where
- Denmark
- Volunteers
- 44 people
- Sponsor
- University of Aarhus
Hyperglycemia
Impact of Antenatal Betamethasone on Plasma Glucose Levels
It is known that administration of steroids increases blood sugar levels. Administration of betamethasone is common practice during pregnancy to women at risk for preterm delivery.
- Trial name
- NCT00585676
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of California, Irvine
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