Clinical trials: Prenatal Diagnosis
Hypertension in Pregnancy
Prenatal Mindfulness & Hypertension Study
Hypertensive disorders of pregnancy are one of the greatest causes of death to mothers and babies. These disorders affect 1 out of every 10 pregnancies, the rate is increasing in the United States, and rate of recurrence is as…
- Trial name
- HTN (NCT03679117)
- Testing
- Mindfulness Training
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Lifespan
Substance Use Disorders, Prenatal Care
Routine Pregnancy Screening for Women on Opioid Substitution Therapy
Women who take opioid substitution therapy have higher rates of unintended pregnancy, more pregnancies, and a higher risk of pregnancy complications than the general population.
- Conditions
- Substance Use Disorders, Prenatal Care, Pregnancy Outcome
- Trial name
- PREG-O (NCT03489174)
- Testing
- Monthly Pregnancy Screening, Usual Care
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- McMaster University
Malaria, Sexually Transmitted Diseases
Gestational Sulfadoxine-pyrimethamine and Azithromycin Treatment to Prevent Preterm Birth
The purpose of this study is to examine whether treatment of pregnant Malawian women with repeated doses of sulfadoxine-pyrimethamine and azithromycin antibiotics will prevent preterm deliveries and result in other health…
- Conditions
- Malaria, Sexually Transmitted Diseases, Preterm Birth, Pregnancy
- Trial name
- NCT00131235
- Testing
- Sulfadoxine-pyrimethamine treatment twice during pregnancy, Sulfadoxine-pyrimethamine at 4-week intervals, Sulfadoxine-pyrimethamine every 4 weeks + azithromycin twice
- Where
- Malawi
- Volunteers
- 1,320 people, healthy volunteers welcome
- Sponsor
- Tampere University
Persistent Fetal Vasculature, Congenital Cataract
Congenital Cataract With Persistent Fetal Vasculature
To observe the clinical characteristics and surgical treatment of 24 cases of congenital cataract complicated with Persistent Fetal Vasculature (PFV) in 28 cases of congenital cataract in our hospital.
- Trial name
- NCT03341624
- Testing
- cataract surgery cataract extraction and intraocular implantation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Yune Zhao
Anxiety, Attachment Disorder
The Effect of Lullaby Intervention on Anxiety and Attachment in Pregnancy
The aim of present study was to investigate the effect of lullaby intervention on anxiety and prenatal attachment in women with high-risk pregnancy.
- Conditions
- Anxiety, Attachment Disorder, Pregnancy Related
- Trial name
- NCT04064320
- Testing
- Lullaby intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Smoking, Cigarette, Maternal Exposure
Effects of Maternal Smoking on Fetal Liver Circulation
According to the hypothesis of this study presented, the effects of smoking on the fetus can be determined by the liver circulation and hepatic metabolism.
- Conditions
- Smoking, Cigarette, Maternal Exposure, Ultrasound, Fetal; Circulation
- Trial name
- NCT04721782
- Testing
- smoking
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Myelomeningocele
Prenatal and Postnatal Ultrasonographic Evaluation of Myelomeningocele to Predict Post-Surgical Outcomes
Myelomeningocele (MMC), also known as open spina bifida, is a serious congenital condition in which the cord and meninges protrude through the spinal column's defective bony encasement due to a defective closure of the posterior…
- Trial name
- NCT07048691
- Testing
- G.E HEALTHCARE ultrasound machine with high-resolution convex probe
- Where
- Pakistan
- Volunteers
- 20 people
- Sponsor
- Superior University
Gestational Diabetes
Fetal Cardiac Function Parameters and HbA1c As Screening for Gestational Diabetes Mellitus
This is a prospective cohort study to assess the predictive value of fetal cardiac parameters, the change in fetal cardiac parameters (CFP), HbA1c, and/or the change in HbA1c (ΔHbA1c) for gestational diabetes.
- Trial name
- NCT05019508
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Beta-Thalassemia
Testing SIROLIMUS in Beta-thalassemia Transfusion Dependent Patients (THALA-RAP)
In β-thalassaemia and Sickle Cell Disease (SCD), a significant production of fetal haemoglobin (HbF) may reduce the severity of clinical course and reactivation of γ-globin gene expression in adulthood.
- Trial name
- THALA-RAP (NCT04247750)
- Testing
- Sirolimus 0.5 mg
- Where
- 4 sites in Italy
- Volunteers
- 45 people
- Sponsor
- Università degli Studi di Ferrara
Tuberculosis (TB), Tuberculosis Infection, Latent
Burden of Tuberculosis Among Pregnant and Postpartum Women in Guinea-Bissau
This study aims to address critical diagnostic and data gaps in tuberculosis (TB) care among pregnant and postpartum women in Guinea-Bissau, a high-burden, resource-limited setting.
- Conditions
- Tuberculosis (TB), Tuberculosis Infection, Latent, Pregnancy, Tuberculosis Diagnosis
- Trial name
- TIPP (NCT07419568)
- Testing
- Enhanced protocol
- Where
- Guinea-Bissau
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
FASD
Hyperbaric Oxygen Therapy Compared to Cognitive Training in FASD
Fetal Alcohol Spectrum Disorder (FASD) describes a wide range of adverse physical, behavioral and cognitive effects resulting from prenatal alcohol exposure (PAE) during embryonic and fetal development.
- Trial name
- NCT04664790
- Testing
- Hyperbaric Oxygen, Cognitive training
- Where
- Israel
- Sponsor
- Assaf-Harofeh Medical Center
Stillbirth, Neonatal Respiratory Depression
Newborn Heart Rate as a Catalyst for Improved Survival
Heart rate (HR) is not routinely assessed during newborn resuscitations in low- and lower-middle income countries (LMICs). Many non-breathing newborns classified as fresh stillbirths have a heartbeat and are live born.
- Conditions
- Stillbirth, Neonatal Respiratory Depression, Neonatal Bradycardia, Neonatal Resuscitation
- Trial name
- NCT03799861
- Testing
- Epoch 2: HBB with NeoBeat, Epoch 3: HR-guided HBB
- Where
- 3 sites in Democratic Republic of the Congo
- Volunteers
- 24,034 people, healthy volunteers welcome
- Sponsor
- American Academy of Pediatrics
Congenital Heart Disease in Pregnancy
Prenatal Screening for Congenital Heart Diseases in the Antwerp Region
No systematic research has been done in the last 15 years on the accuracy of prenatal ultrasound of congenital heart diseases in Belgium. Nor are there any population-based studies available on this subject for Belgium.
- Trial name
- SEC (NCT04382222)
- Testing
- prenatal ultrasound
- Where
- Belgium
- Volunteers
- 2,500 people
- Sponsor
- Universiteit Antwerpen
Fetal Growth Restriction
A Randomized Air Filter Intervention Study of Air Pollution and Fetal Growth in a Highly Polluted Community
The purpose of this study is to use an air filter intervention to evaluate the relationship between particulate matter air pollution exposure during pregnancy and fetal growth.
- Trial name
- NCT01741051
- Testing
- HEPA Filter
- Where
- Mongolia
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Simon Fraser University
Prenatal Anxiety
Interactive Ultrasound Examination
Relationship between mother and child starts to develop during pregnancy and continues after birth. Drug abuse, depression, very young or old age, weak social network, mothers´ own negative experiences from childhood's…
- Trial name
- 4D ultrasound (NCT03424642)
- Testing
- Interactive 4D-ultrasound examination
- Where
- Finland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Hydrops Fetalis, Fetal Growth Retardation
Amniotic Fluid Tandem Mass Spectrometry for Pregnancies Complicated by NIH and Severe Symmetrical IUGR
The objective of this pilot study is to prospectively evaluate amniotic fluid of pregnancies complicated by non-immune hydrops and severe symmetrical intrauterine growth restriction by tandem mass spectrometry for inborn errors…
- Trial name
- TandemMS (NCT00143039)
- Testing
- Tandem MS test for inborn errors of metabolism
- Where
- 11 sites in United States
- Volunteers
- 48 people
- Sponsor
- Obstetrix Medical Group
Large for Gestational Age Baby, Macrosomia, Fetal
A First Trimester Prediction Model for Large for Gestational Age Infants: a Preliminary Study
Large for gestational age infants (LGA) have increased risks of adverse short-term perinatal outcomes. This study aims to develop a multivariable prediction model for the risk of giving birth to a LGA baby, by using biochemical…
- Trial name
- PreMoLGA (NCT04838431)
- Testing
- Blood sample and ultrasound at first trimester
- Where
- Italy
- Volunteers
- 503 people, healthy volunteers welcome
- Sponsor
- University of Modena and Reggio Emilia
Pre-Eclampsia, Pregnancy Induced Hypertension
Clinical Antenatal Randomised Study to CharactErise Key Roles of TetrahydroFOLate in HyperTensive Pregnancies
Study background High blood pressure during pregnancy is a worldwide health problem that can be dangerous to mothers and commonly causes premature birth and small babies.
- Conditions
- Pre-Eclampsia, Pregnancy Induced Hypertension, Pregnancy Related
- Trial name
- CAREFOL-HT (NCT05434195)
- Testing
- Arcofolin® 5-Methyltetrahydrofolate
- Where
- 2 sites in United Kingdom
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Birth Weight, Macrosomia, Fetal
Association Between Labor Induction and Birth Weight in Cases of Fetal Macrosomia: The MACROMODA Cohort Study
The rising prevalence fof fetal macrosomia represents a significant challenge in obstetrics, affecting both maternal and neonatal outcomes. Such challenges include complications like perineal tears and postpartum hemorrhage.
- Trial name
- MACROMODA (NCT06198881)
- Where
- 3 sites in France
- Volunteers
- 4,500 people
- Sponsor
- Hospices Civils de Lyon
Congenital Heart Disease
Interpretation of Fetal Echocardiography by Artificial Intelligence
The study to be performed aims to design and develope an automated Intelligent Decision Support System for fetal echocardiography that can significantly assist the obstetric physician in the improvement of detection of fetal…
- Trial name
- LIFE (NCT05090306)
- Testing
- Routine ultrasound examination
- Where
- Romania
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy Craiova
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