Clinical trials: Prenatal Diagnosis
Intrauterine Growth Restriction (IUGR), Fetal Growth Restriction (FGR)
Sildenafil Therapy In Dismal Prognosis Early-Onset Intrauterine Growth Restriction
Early-onset placental intrauterine growth restriction (EO IUGR) is associated with a high risk of perinatal morbidity and mortality.
- Trial name
- STRIDERCan (NCT02442492)
- Testing
- Sildenafil
- Where
- 5 sites in Canada
- Volunteers
- 21 people
- Sponsor
- University of British Columbia
High Risk Pregnancy
Investigation of the Impact of Noninvasive Prenatal Testing for Fetal Aneuploidy on Utilization of Prenatal Diagnostic Procedures and Pregnant Women's Views
This is a prospective, single-institution observational study to be conducted at 4 clinics within the Southern California Permanente Medical Group.
- Trial name
- NCT01708746
- Where
- 4 sites in United States
- Volunteers
- 205 people
- Sponsor
- Verinata Health, Inc.
Prenatal Anxiety, Generalized Anxiety
Willkommen Mutterglück: Online CBT for Pregnant and Postpartum Women With Depression and Anxiety
This intervention study aims to evaluate the effectivity of web-based cognitive therapy in reducing depression and anxiety in pregnant and postpartum women.
- Conditions
- Prenatal Anxiety, Generalized Anxiety, Postpartum Depression, Major Depressive Disorder
- Trial name
- NCT04183946
- Testing
- Online Cognitive Behavioural Therapy
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- University of Zurich
Fetuses With at Least 2 Malformations, and no Diagnosis After Fetopathological and Radiological Examinations
Contribution of High-throughput Exome Sequencing in the Diagnosis of the Cause Fetal Polymalformation Syndromes
This research concerns the contribution of a new examination, high-throughput exome sequencing, in the diagnosis of the cause of polymalformative fetal syndromes.
- Trial name
- FOETEX (NCT02512354)
- Testing
- Sample of a fragment of fetal tissue, Parent's blood samples
- Where
- 10 sites in France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Fetal Alcohol Syndrome, Attention Deficit Hyperactivity Disorder (ADHD)
Open-Label Study of the Long Term Tolerability and Safety of Atomoxetine in Children With FASD and ADD/ADHD
Determine if atomoxetine is safe and well tolerated by children with fetal alcohol syndrome.
- Trial name
- B4Z-US-050 (NCT00418262)
- Testing
- Atomoxetine
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Oklahoma
HIV Infections, Pregnancy
A Study of Nevirapine to Prevent HIV Transmission From Mothers to Their Babies
The purpose of this study is to see if giving the anti-HIV drug nevirapine (NVP) to HIV-positive pregnant women and their babies can help reduce the chance that a mother will give HIV to her baby during delivery.
- Trial name
- NCT00000942
- Testing
- Nevirapine
- Where
- 5 sites in France, Italy and 2 more
- Volunteers
- 1,244 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Gestational Diabetes, Diabetes, Gestational
Gestational Diabetes: a Cohort Study
Gestational diabetes (GDM) is the most common hormonal complication during pregnancy. Its occurrence implies an increased risk of maternal and fetal complications and, therefore, its diagnosis and treatment are extremely…
- Conditions
- Gestational Diabetes, Diabetes, Gestational, Diabetes Mellitus in Pregnancy, Diabetes Mellitus, Type 2
- Trial name
- NCT03307486
- Where
- Brazil
- Volunteers
- 1,400 people
- Sponsor
- University of Sao Paulo General Hospital
Pregnancy Related, Autoimmune Diseases
Fetal-Hope Study: Home Monitoring of Fetal Heart Rate in SSA+ Pregnant Women
Serological positivity for anti Ro-SSA antibodies is frequently found in pathologies such as Sjogren's Syndrome and SLE. Worldwide, approximately 0.5-1% of women of reproductive age are positive for Ro-SSA antibodies, and in 1-2%…
- Conditions
- Pregnancy Related, Autoimmune Diseases, Neonatal Lupus, SLE
- Trial name
- FH (NCT05958446)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- ASST Fatebenefratelli Sacco
Pregnancy, Birth Weight
Prenatal Multi-micronutrient Supplementation and Pregnancy Outcome
Prenatal maternal micronutrient supplementation has been suggested as a means to reduce the proportion of low birth weight babies in low-income countries.
- Trial name
- NCT00168688
- Testing
- multi micronutrient supplement, MN1, MN2
- Where
- Guinea-Bissau
- Volunteers
- 2,100 people, healthy volunteers welcome
- Sponsor
- Bandim Health Project
Recurrent Pregnancy Loss, Fetal Demise
Pharmacokinetics of Low Molecular Weight and Unfractionated Heparin in Pregnancy
To determine, through pharmacokinetic parameters, the ideal dosing protocol for dalteparin (a low molecular weight heparin) and unfractionated heparin for women desiring pregnancy who have evidence of an acquired (specifically…
- Conditions
- Recurrent Pregnancy Loss, Fetal Demise, Abortion, Habitual, Antiphospholipid Antibodies
- Trial name
- NCT00721591
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Chicago
Fetal Growth Retardation, Preeclampsia
Management of Early-onset Fetal Growth Restriction: Angiogenic Factors Versus Feto-placental Doppler
This is a multicentre, open-label, randomized controlled trial. A total of 340 singleton pregnancies with an EFW ≤10th percentile between 26+0 and 31+6 weeks will be recruited and randomly allocated to either the control or the…
- Conditions
- Fetal Growth Retardation, Preeclampsia, Placenta Diseases
- Trial name
- earlyGRAFD (NCT05284474)
- Testing
- soluble fms-like tyrosine kinase to placental growth factor ratio (sFlt-1/PlGF)
- Where
- 27 sites in Spain
- Volunteers
- 340 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Fetal Growth Restriction
Prediction of Growth Restricted Fetuses Using Femur Length to Mid-thigh Circumference Ratio: A Case-control Study
One of the most challenging areas currently facing obstetricians is the detection and management of pregnancies in which the growth of the fetus is poor.
- Trial name
- IUGR (NCT01981824)
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Corpus Callosum Agenesis
BECOME CHILDREN OF HOLDERS Corpus Callosum Agenesis Screened IN PERIOD Antenatal
The corpus callosum agenesis is an interesting malformation between 0.05% and 1.5% of the general population. This malformation is mostly diagnosed prenatally by ultrasound, usually at 22 weeks of gestation, and the use of…
- Trial name
- NCT02826824
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Strasbourg, France
Macrosomia, Fetal, Large for Gestational Age
Fetal Clavicular Measurement to Predict Fetal Macrosomia
Macrosomia is associated with increased risks for both the mother and the baby, including complications during delivery, injuries, and even death. The accurate diagnosis of macrosomia is often difficult before birth.
- Conditions
- Macrosomia, Fetal, Large for Gestational Age, Shoulder Dystocia
- Trial name
- NCT06283277
- Testing
- Obstetric Ultrasound
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Assiut University
Blood Pressure, Hypertension
Community-based Implementation of Adapted STAC
This study is being done to adapt the Staying Healthy After Childbirth (STAC) intervention for implementation among Black Women and Birthing Persons (WBP).
- Conditions
- Blood Pressure, Hypertension, Pregnancy Related, Health Equity
- Trial name
- NCT06689930
- Testing
- PDSA Cycles
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Brain Malformation
Comparison of Abnormal Cortical Development in Brain Malformations on Postmortem Imaging With Autopsy
Examination of the fetal brain at autopsy is technically challenging because of marked fragility of the brain tissue. Studies have found postmortem fetal MR to be particularly useful in examining gross structural abnormalities in…
- Trial name
- NCT00686530
- Testing
- MR Imaging, Autopsy
- Where
- 2 sites in Canada
- Sponsor
- The Hospital for Sick Children
Placental Malaria Infection, HIV Infections
Intermittent Preventive Treatment of Malaria in HIV-Seropositive Pregnant Women in Zambia
Prevention of malaria in pregnancy is critical given the high incidence of malaria in Zambia and its serious impact on both maternal and infant survival.
- Conditions
- Placental Malaria Infection, HIV Infections, Stillbirth, Prematurity
- Trial name
- NCT00270530
- Testing
- Sulfadoxine-pyrimethamine (Fansidar)
- Where
- Zambia
- Volunteers
- 454 people
- Sponsor
- Center for International Health and Development
Perinatal Death, Third Trimester Modified Biophysical Profile Scan
Third Trimester Modified Biophysical Profile Scan for Predicting Fetal Outcome.
Study topic: Predicting fetal outcome using third trimester modified biophysical profile (BPP) scan compared with standard of care; a randomized clinical trial at St. Francis Hospital, Nsambya.
- Trial name
- NCT03729089
- Testing
- Modified Biophysical Profile scan
- Where
- Uganda
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Dr Andrew Odur
Substance Use Disorders, Pregnancy Related
The Oklahoma Parent-Child Assistance Program
The Parent-Child Assistance Program (PCAP) helps mothers who have used alcohol, opioids, or other drugs during pregnancy and their children through the work of highly trained, closely supervised case managers.
- Conditions
- Substance Use Disorders, Pregnancy Related, Alcohol Use Disorder (AUD), Alcohol Use Complicating Pregnancy, First Trimester
- Trial name
- NCT05534568
- Testing
- Parent-Child Assistance Program
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Oklahoma
Congenital Disorders
Prevalence and Clinical Spectrum of the 22q11 Deletion
The purpose of this project is to conduct population based surveillance for prenatally diagnosed congenital defects amount residents of the five counties to: improve the comprehensiveness of the Metropolitan Atlanta Congenital…
- Trial name
- NCT00267397
- Where
- United States
- Sponsor
- Children's Healthcare of Atlanta
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