Clinical trials: Preoperative
Breast Cancer
Preoperative Breast Irradiation
The PROBI is a phase I/II trial assessing the feasibility of preoperative whole breast irradiation in female patients with low to intermediate risk breast cancer, who undergo breast conserving therapy, including a boost dose of…
- Trial name
- PROBI (NCT02941835)
- Testing
- pre-operative irradiation
- Where
- Netherlands
- Volunteers
- 4 people
- Sponsor
- The Netherlands Cancer Institute
Periampullary Cancers With Obstructive Jaundice, Pancreas Head Cancer
Comparison Between Internal and External Preoperative Biliary Drainage in Periampullary Cancers
Preoperative biliary drainage methods include percutaneous transhepatic biliary drainage (PTBD), endoscopic nasobiliary drainage (ENBD), and endoscopic retrograde biliary drainage (ERBD).
- Conditions
- Periampullary Cancers With Obstructive Jaundice, Pancreas Head Cancer, Bile Duct Cancer, Ampulla of Vater Cancer
- Trial name
- NCT01134276
- Testing
- biliary drainage
- Where
- South Korea
- Volunteers
- 211 people
- Sponsor
- Seoul National University Hospital
Old Age
Effect of Preoperative Oral Carbohydrates on the Insulin Resistance of Elderly Patients
Postoperative cognitive dysfunction (POCD) is more common in older patients, and increased insulin resistance is an important factor for POCD.
- Trial name
- NCT04206189
- Testing
- carbohydrate group - carbohydrate (400ml)
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Yonsei University
Rectal Neoplasms, Rectal Cancer
Organ-preserving Management in Patients With Complete or Near-complete Tumour Response After Preoperative Radio(Chemo)Therapy for Rectal Cancer
Watch-and-wait strategy in rectal cancer is gaining momentum. There is a large variability in reporting the proportion of patients achieving clinical complete response (cCR) after routinely delivered preoperative…
- Trial name
- NCT04095468
- Testing
- Preoperative Radio(Chemo)Therapy
- Where
- 7 sites in Poland
- Volunteers
- 215 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Lymphedema Arm, Breast Cancer Lymphedema
Preoperative Indocyanine Green Lymphography and High-Frequency Ultrasound as Predictors of Lymphaticovenous Anastomosis Outcome in Post-Mastectomy Upper Limb Lymphedema
This study aims to evaluate the predictive value of preoperative indocyanine green (ICG) lymphography and high-frequency ultrasound in determining the outcomes of lymphaticovenous anastomosis (LVA) in patients with…
- Trial name
- NCT07614815
- Testing
- lymphatic-venous anastamosis
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Arthroplasty, Knee Replacement
The Effectiveness of Combined Care for Knee Replacement Patients
The goal of this clinical trial is to compare the effectiveness of combined care guidance and general care guidance on pain scores, anxiety levels and joint mobility in patients undergoing total artificial knee replacement.
- Trial name
- NCT06393075
- Testing
- combined care guidance, general care guidance
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Post Abdominal Surgery, Gastrointestinal Motility Disorder
Association Between Preoperative Mediterranean Diet Adherence and Postoperative Bowel Motility
Postoperative bowel motility is an important indicator of recovery after abdominal surgery and may be influenced by preoperative nutritional status.
- Conditions
- Post Abdominal Surgery, Gastrointestinal Motility Disorder, Postoperative Ileus
- Trial name
- NCT07808281
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Bahçeşehir University
Esophageal Cancer
Gefitinib, Cisplatin, Irinotecan, and Radiation Therapy Before Surgery in Treating Patients With Esophageal Cancer or Gastroesophageal Junction Cancer That Can Be Removed By Surgery
RATIONALE: Gefitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as cisplatin and irinotecan, work in different ways to stop the growth of tumor…
- Trial name
- NCT00290719
- Testing
- cisplatin, gefitinib, irinotecan hydrochloride
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of California, San Francisco
Surgery, Aging
Preparing Older Adults for Major Surgery With Preoperative Comprehensive Geriatric Assessments
The researchers will conduct observations, interviews, and focus groups with clinicians, staff and patients of the Perioperative Optimization of Senior Health (POSH) clinic, which conducts preoperative comprehensive geriatric…
- Conditions
- Surgery, Aging, Health Care Utilization, Frailty
- Trial name
- NCT06184919
- Testing
- Process Mapping: Observations, Process Mapping: Interviews, Process Mapping: Focus Group
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Wisconsin, Madison
Carcinoma, Squamous Cell, Oral Cancer
Carboplatin, Nab-Paclitaxel, Durvalumab Before Surgery and Adjuvant Therapy in Head and Neck Squamous Cell Carcinoma
Participants in this study have a type of cancer called squamous cell carcinoma of the head and neck (SCCHN). Their SCCHN has spread around the area where the cancer first started. This is called locally-advanced SCCHN.
- Conditions
- Carcinoma, Squamous Cell, Oral Cancer, Oropharynx Cancer, Larynx Cancer
- Trial name
- NCT03174275
- Testing
- Durvalumab, Carboplatin, Nab-paclitaxel
- Where
- 2 sites in United States
- Volunteers
- 39 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Anxiety, Anxiety Disorder (Panic Disorder or GAD)
Preoperative Pregabalin vs Gabapentin in Elderly Undergoing Surgry,Controlled Trial
Several studies have evaluated the efficacy of pregabalin in reducing preoperative anxiety, with inconsistent results. Similarly, inconclusive results have been reported regarding gabapentin and its effects in reducing…
- Trial name
- NCT07000201
- Testing
- One hour prior to admission to the operating room, patients will receive the study medication (as premedication) by mouth with a sip of water;
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Cairo University
Severe Mitral Regurgitation, Preserved Ventricular Ejection Fraction
Use of Pre-operative Global Longitudinal Strain to Predict Post-operative Left Ventricular Dysfunction in Mitral Regurgitation Surgery
Primary mitral regurgitation (MR) is the second most frequent valve disease requiring surgery and it is important to identify patients whose outcome could be improved with surgery by considering the risks and benefits.
- Trial name
- DysPO IM (NCT03968601)
- Testing
- Mitral regurgitation surgery such as mitral valve replacement or repair
- Where
- France
- Volunteers
- 79 people
- Sponsor
- University Hospital, Clermont-Ferrand
Fractures, Bone, Fracture Malunion, Bone
Image Fusion System for 3D Preoperative Planning in the Osteosynthesis and Osteotomy
Utility of image fusion system for the fracture and fracture malunion management will be evaluated.
- Trial name
- NCT03764501
- Testing
- Image fusion system
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Tokyo Medical University
Breast Cancer
SIGNAL During a COVID-19 Pandemic
The standard treatment for early stage, estrogen-receptor positive breast cancer is lumpectomy and sentinel lymph node biopsy followed by 16-25 treatments of adjuvant whole-breast radiation therapy plus or minus hormone therapy.
- Trial name
- NCT05037019
- Testing
- Radiation therapy
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Tracheal Intubation Morbidity
Preoperative Fibroscopy as a Predictor of the Difficulty of Laryngoscopy and Intubation
The aim of this study is the evaluation of preoperative transnasal fiberoscopy, as a possible predictor of difficult laryngoscopy and intubation during elective general anesthesia in an adult population.
- Trial name
- TubeDiff (NCT02671877)
- Testing
- Transnasal fiberoscopy
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS San Raffaele
Distal Humerus Fracture
Development of Three Dimensional Preoperative Planning System for the Osteosynthesis of Distal Humerus Fractures
To reproduce anatomical reduction and appropriate implant placement/choices during osteosynthesis for elbow fractures, a 3D preoperative planning system was developed.
- Trial name
- NCT04349319
- Testing
- Digital preoperative planning
- Where
- Japan
- Volunteers
- 60 people
- Sponsor
- Tokyo Medical University
Pheochromocytoma, Paraganglioma
Correlation Between Preoperative Images of PPGL and Intraoperative Hemodynamics
This is a retrospective observational cohort study involving patients with suspected PPGLs who underwent 131I-MIBG scanning and surgical treatment between January 2020 and April 2023.
- Trial name
- NCT06669481
- Testing
- Semiquantitative 131I-MIBG Scintigraphy Assessment
- Where
- China
- Volunteers
- 159 people
- Sponsor
- Peking Union Medical College Hospital
Colon Cancer
Preoperative i.v. Iron Substitution in Patients With Colon Cancer
About 70% of colon cancer patients are anemic. Preoperative anemia in patients with colorectal cancer is associated with both impaired disease-free survival and overall survival.
- Trial name
- PREFECO (NCT04653181)
- Testing
- Ferric carboxymaltose
- Where
- Finland
- Volunteers
- 514 people
- Sponsor
- Helsinki University Central Hospital
Pancreatic Cancer
Preoperative Intratumor Dendritic Cells Injection Immunotherapy for Patients With Pancreatic Cancer
The purpose of this study is to confirm safety and immunological responses of Preoperative intratumor dendritic cells injection immunotherapy using immature dendritic cells with S pyogenes Preparation (OK-432) for patients with…
- Trial name
- NCT00795977
- Testing
- dendritic cells, OK-432
- Where
- Japan
- Volunteers
- 20 people
- Sponsor
- Fukushima Medical University
Perioperative Care, Bariatric Surgery
Do Text Message Reminders Increase Preoperative Exercise in Obesity Surgery Candidates?
Preoperative exercise has been shown to improve physiological and functional capacity in patients undergoing abdominal surgery to prepare them for the stress of surgery.
- Conditions
- Perioperative Care, Bariatric Surgery, Obesity
- Trial name
- NCT01607177
- Testing
- Daily text message reminders
- Where
- New Zealand
- Volunteers
- 102 people
- Sponsor
- University of Auckland, New Zealand
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