Clinical trials: Preoperative
Hemorrhoids, Hemorrhoid Pain
Preoperative Micronized Flavonoid Fraction (MFF) Use in Multimodal Anesthesia in Anorectal Surgery
Aim: To assess the efficiency of the micro-flavonoid fraction (MMF) administration prior to anorectal surgery with spinal anesthesia on postoperative pain severity reduction.
- Conditions
- Hemorrhoids, Hemorrhoid Pain, Hemorrhoidal Bleeding
- Trial name
- NCT05772351
- Testing
- micronized flavonoid fraction
- Where
- Russia
- Volunteers
- 182 people
- Sponsor
- Center of Endourology "Endocenter"
Uterine Fibroids, Hysteroscopic Myomectomy
Preoperative Administration of EGCG, Vitamin D and DCI Prior Hysteroscopic Myomectomy
The administration of Epigallocatechin gallate (EGCG), Vitamin D and D-Chiro-Inositol (DCI) are effective in reducing the volume of fibroids and improving the symptoms of uterine fibroids.
- Conditions
- Uterine Fibroids, Hysteroscopic Myomectomy, Treatment Compliance, Patient Compliance
- Trial name
- PREHYSMYOM (NCT06768086)
- Testing
- Hysteroscopic myomectomy
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centro di Ricerca Clinica Salentino
Ovarian Cancer, Ovarian Tumor
AI Analysis of CT Scans to Classify Ovarian Tumours as Benign, Borderline or Malignant Before Surgery
The goal of this observational study is to learn if a computer program can tell what type of ovarian tumour a person has from a CT scan taken before surgery. The program uses artificial intelligence (AI).
- Conditions
- Ovarian Cancer, Ovarian Tumor, Borderline Ovarian Tumor
- Trial name
- OvaClass (NCT07883551)
- Where
- 7 sites in Belgium, Netherlands
- Volunteers
- 1,300 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Lung Hydatid Cyst
The Importance of Inflammatory Markers Calculated From Preoperative and Postoperative Peripheral Blood Results in the Diagnosis and Treatment of Patients Operated for Hydatid Cyst of the Lung (Lung Echinococcus Granulosus)
This study aims to investigate the role of these laboratory findings in the differential diagnosis and management of pulmonary hydatid cyst (PHC) by examining the number of euzonophils, neutrophils, lymphocytes, platelets and…
- Trial name
- Echinococcusis (NCT06281522)
- Testing
- Operated patients with hydatid cyst of the lung
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Abdullah Adiyaman
Heart Diseases, Atrial Fibrillation
Clinical Value of Remote Ischemic Preconditioning
Objectives: Despite utilization of available means for cardioprotection during cardiac surgery, myocardial injury still occurs. Further improvement of cardioprotection is therefore necessary.
- Trial name
- NCT01740102
- Testing
- RIPC
- Where
- Norway
- Volunteers
- 92 people
- Sponsor
- Norwegian University of Science and Technology
Nasal Polyps
The Effect of Preoperative Oral Prednisone on the Operative Field During Nasal Polypectomy.
This study aims to determine if a short course of oral prednisone helps to improve the operative field and ease of surgery by minimizing bleeding during nasal polypectomy surgery.
- Trial name
- NCT00440219
- Testing
- Oral Prednisone
- Where
- 2 sites in Canada
- Volunteers
- 34 people
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Preoperative Risk Assessment
Comparison of Artificial Intelligence and Anesthesiologist in Preoperative Risk Assessment
Preoperative evaluation is essential for identifying patient-related risks before elective surgery and for planning safe anesthesia management.
- Trial name
- AI-PREOP (NCT07364942)
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- Gülgün Elif Aksoy
Glioblastoma, Gliosarcoma
Sapanisertib Before and After Surgery in Treating Patients With Recurrent Glioblastoma
This partially randomized pilot phase I trial studies how much sapanisertib reaches the brain tumor and how well it works when given before and after surgery in treating patients with glioblastoma that has grown or come back and…
- Trial name
- NCT02133183
- Testing
- Laboratory Biomarker Analysis, Pharmacological Study, Sapanisertib
- Where
- 10 sites in United States
- Volunteers
- 40 people
- Sponsor
- National Cancer Institute (NCI)
Music Therapy, Anxiety
Therapy on Perioperative Anxiety and Pain in Patients
This study aims to explore the effects of preoperative education combined with intraoperative music therapy on perioperative anxiety and pain in patients undergoing elective cesarean section.
- Conditions
- Music Therapy, Anxiety, Health Education
- Trial name
- NCT06970431
- Testing
- eoperative Education + Intraoperative Music Therapy Arm, Preoperative Education Alone Arm
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Maternal and Child Health Hospital of Hubei Province
Thoracic Surgery, Prehabilitation
Preoperative Inspiratory Muscle Training Effects on the Perioperative Inflammatory Reaction in Cardiac Surgery.
This study evaluates the impact of preoperative high-intensity inspiratory muscle training (IMThi) before cardiac surgery on perioperative inflammatory response.
- Conditions
- Thoracic Surgery, Prehabilitation, Respiratory Therapy
- Trial name
- EMI HiPo (NCT03158402)
- Testing
- Prehabilitation with inspiratory muscle training
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Angers
Breast Cancer
A Study of Multiparametric MRI and pHLIP® ICG in Breast Cancer Imaging During Surgery
The purpose of this study is to find out whether pre-operative mpMRI using additional MRI sequences may improve surgical outcomes by providing more accurate information about the extent and acidity of the tumor than standard MRI…
- Trial name
- NCT05130801
- Testing
- pHLIP® ICG NIRF imaging
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Postoperative Recovery
Preoperative Oral Carbohydrate Loading in Gynecologic Surgery
The advantage of carbohydrate loading in minimally invasive surgeries are not well established. We designed this study to evaluate whether preoperative oral carbohydrate improve postoperative recovery after laparoscopic…
- Trial name
- NCT03955419
- Testing
- NO-NPO (Daesang WelLife Co., Ltd., Korea)
- Where
- South Korea
- Volunteers
- 88 people
- Sponsor
- Eunah Cho, MD
Locally Advanced Rectal Cancer (LARC)
A Pospective, Single-arm, Multicenter Clinical Trial Evaluating Preoperative Neoadjuvant mFOLFOX6 Chemotherapy in Combination With PD1 Monoclonal Antibody in MSS/pMMR Locally Advanced Rectal Cancer
Preoperative neoadjuvant chemoradiotherapy can induce tumor regression and reduce the risk of postoperative recurrence, serving as the standard treatment for locally advanced rectal cancer.
- Trial name
- FIRM (NCT06688786)
- Testing
- neoadjuvant mFOLFOX6 chemotherapy combined with PD-1 inhibitor therapy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Post Operative Nausea and Vomiting
Effects of Preoperative Carbohydrate Rich Drinks on Immediate Postoperative Outcome in Total Knee Arthroplasty
The aim of this study is to investigate the effect of preoperative carbohydrate rich drinks on postoperative nausea and vomiting in total knee arthroplasty. This is a prospective, double blinded, randomized controlled trial.
- Trial name
- PONV (NCT03380754)
- Testing
- Nutricia preOp
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Breast Cancer
Intensified IAA With PBPC Support in Breast Tumors With Evidence of a HRD
This phase II/III trial will investigate the ability of chemotherapy with 'Intensified Aklylating Agents (IAA) to achieve a high pathological complete response (pCR) rate when employed in the preoperative chemotherapy of breast…
- Trial name
- NCT00448266
- Testing
- Intensified Cyclophophamide, Carboplatin and Thiotepa, dose dense adriamycine and cyclophosphamide
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- The Netherlands Cancer Institute
Sleep Apnea, Obstructive
Comparison of Preoperative Screening Score for Obstructive Sleep Apnea (OSA)
Comparison of preoperative screening score for OSA. In a preoperative population, comparison of the STOP-BANG, DES-OSA, P-SAP and OSA50 score.
- Trial name
- NCT02051829
- Testing
- Comparison of the four screening score
- Where
- Belgium
- Volunteers
- 1,584 people, healthy volunteers welcome
- Sponsor
- Astes
Preoperative Anxiety
Lavender Oil on Preoperative Anxiety and Sedation Requirement in General Anaesthesia
Assessment of how Lavender oil reduces preoperative anxiety and subsequently influences requirement of induction agents for general anesthesia.
- Trial name
- NCT03460145
- Testing
- Lavender Oil on Nasal Strip (Lx), Strip without Lavender Oil (Px), Propofol 1 % Injectable Suspension
- Where
- Malaysia
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Blood Platelet Disorders, Cardiac Surgery
Observational Study of Platelet Dysfunction Assessed by Thromboelastography in Cardiovascular Surgery (DISPLATEG)
Perioperative bleeding requiring blood transfusion is common during cardiovascular surgery, especially in procedures requiring cardiopulmonary bypass. Adenosine diphosphate (ADP) plays a fundamental role in platelet function.
- Conditions
- Blood Platelet Disorders, Cardiac Surgery, Postoperative Bleeding
- Trial name
- DISPLATEG (NCT06961175)
- Where
- Spain
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
Post-operative Delirium
Neuroimaging Risk of Postoperative Delirium
Postoperative delirium (POD) is a frequent disorder of consciousness, arousal and attention in elderly patients following surgery. The glymphatic system is a newly discovered waste cleaning system of the brain.
- Trial name
- NCT06236854
- Testing
- Delirium assessment (observational, not interventional)
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Technical University of Munich
Midline Catheter, Orthopedic Surgery
VADIOR: Advantages of Pre-operative Positioning of Peripherally Inserted Vascular Accesses in DIVA Patients Undergoing Orthopedic Surgery
Our goal is to demonstrate how a standardized approach that involves the pre-operative implantation of the venous access devices in the DIVA patients (EA-DIVA score> or =8), scheduled for orthopedic surgery, impacts both the…
- Trial name
- VADIOR (NCT06904651)
- Testing
- pre-operative positioning of peripherally inserted vascular accesses devices such as midline or minimidline
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Istituto Ortopedico Rizzoli
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