Clinical trials: Preoperative Risk Assessment
Thoracic Cancer, Complication,Postoperative
Variability and Post-op AEs: Does Preoperative CardioPulmonary Variability Assessment Identify Risk of Postoperative Adverse Events Following Thoracic Surgery
Major thoracic surgery is high risk as it carries a significant risk of postoperative Adverse Events (AEs), where patients experience complications and do not recover as expected.
- Trial name
- CPVA (NCT07016022)
- Testing
- CardioPulmonary Variability Assessment
- Where
- Canada
- Volunteers
- 130 people
- Sponsor
- Ottawa Hospital Research Institute
Pulmonary Aspiration During Anaesthetic Induction, Gastric Emptying Time
Gastric Emptying With Metoclopramide in GLP-1 Agonist Patients Undergoing Elective Surgery
This is a multicentre, investigator-blinded, randomised controlled trial evaluating whether the use of oral metoclopramide before surgery can reduce the amount of residual gastric content in patients who are taking glucagon-like…
- Conditions
- Pulmonary Aspiration During Anaesthetic Induction, Gastric Emptying Time, Preoperative Risk Assessment, Obesity (Disorder)
- Trial name
- GEM-GLP1RA (NCT07100691)
- Testing
- Metoclopramide
- Where
- 2 sites in Ireland
- Volunteers
- 80 people
- Sponsor
- Mater Misericordiae University Hospital
Abdominal Neoplasm, Surgery
Remote Patient Monitoring for Preoperative Risk Assessment
Preoperative risk assessment (an evaluation of overall health before surgery) is important to determine the overall risk of mortality and complications for patients undergoing major abdominal surgery to allow the appropriate…
- Conditions
- Abdominal Neoplasm, Surgery, Surgery-Complications, Risk Assessment
- Trial name
- REMOTES (NCT06042023)
- Testing
- Lifesignals Wearable Sensor
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University of Leeds
Risk
Remembering Risk Using Visual Risk Display of MINS to Obtain Informed Consent to Undergo Elective Surgery
Disclosure of anticipated risks to individuals considering undergoing an elective operative procedure is an important aspect of informed consent process.
- Trial name
- NCT05098535
- Testing
- Visual Aid, Scripted Risk Discussion
- Where
- Canada
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Queen's University
Cervical Adenocarcinoma, Cervical Adenosquamous Cell Carcinoma
Fludeoxyglucose (FDG) F 18 PET Scan, CT Scan, and Ferumoxtran-10 MRI Scan Before Chemotherapy and Radiation Therapy in Finding Lymph Node Metastasis in Patients With Locally Advanced Cervical Cancer or High-Risk Endometrial Cancer
This phase I/II trial is studying how well fludeoxyglucose F 18 PET scan, CT scan, and ferumoxtran-10 MRI scan finds lymph node metastasis before undergoing chemotherapy and radiation therapy in patients with locally advanced…
- Conditions
- Cervical Adenocarcinoma, Cervical Adenosquamous Cell Carcinoma, Cervical Small Cell Carcinoma, Cervical Squamous Cell Carcinoma
- Trial name
- NCT00416455
- Testing
- fludeoxyglucose F 18, positron emission tomography, computed tomography
- Where
- 33 sites in United States, Canada and 2 more
- Volunteers
- 384 people
- Sponsor
- National Cancer Institute (NCI)
Perioperative Risk Assessment
Frailty Assessment Reveals Cognitive Differences in ASA Classification: Anesthesiologists vs Large Language Models
The American Society of Anesthesiologists (ASA) Physical Status Classification System is widely used to assess perioperative risk, but it does not explicitly include frailty as a standardized variable.
- Trial name
- ASA-AI (NCT07399938)
- Testing
- Observational Assessment Only
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Diastolic Dysfunction, Heart Failure
Assessment of Diastolic Function in High Risk Patients Undergoing Major Vascular Surgery
Patients scheduled for Thoracic Endovascular Aortic Repair (TEVAR) surgery will have transthoracic echocardiography evaluation of left ventricle diastolic function during the perioperative period.
- Conditions
- Diastolic Dysfunction, Heart Failure, Aneurysm Aortic
- Trial name
- NCT03534440
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Medical University of Warsaw
Acute Kidney Injury After Adult Cardiac Surgery, Gastrointestinal Microbiome
Development and Validation of a Risk Prediction Model for Cardiac Surgery-associated Acute Kidney Injury Based on the Gut-Kidney Axis, Incorporating Gut Microbiota and Their Metabolites
This is a single-center prospective observational cohort study enrolling adult patients scheduled for cardiac surgery. Multi-timepoint clinical indicators, stool samples for gut microbiota and metabolomics profiling and artery…
- Conditions
- Acute Kidney Injury After Adult Cardiac Surgery, Gastrointestinal Microbiome, Metabolome, Risk Assessment
- Trial name
- NCT07738796
- Where
- China
- Volunteers
- 182 people
- Sponsor
- Peking Union Medical College Hospital
Anesthesia, Preoperative Risk Prediction
Large Language Models Versus Anesthesiologists for ASA Physical Status Classification
The American Society of Anesthesiologists Physical Status (ASA-PS) classification is a cornerstone of preoperative risk assessment, yet interrater variability among clinicians is well documented.
- Conditions
- Anesthesia, Preoperative Risk Prediction, Preoperative Risk Assessment
- Trial name
- ASA-LLM (NCT07696221)
- Volunteers
- 350 people
- Sponsor
- Marmara University Pendik Training and Research Hospital
Colorectal Cancer, Postoperative Complications
Optimizing Physical Function Before Cancer Surgery in Older People at Risk
This randomized controlled trial is a multicentre study designed to explore the effects of preoperative exercise on physical fitness, postoperative complications, recovery, and health-related quality of life in older individuals…
- Trial name
- CanOptiPhys (NCT04878185)
- Testing
- Exercise
- Where
- 4 sites in Sweden
- Volunteers
- 53 people
- Sponsor
- Karolinska Institutet
Cardiac Surgery, Cardiopulmonary Bypass
Safety and Efficacy of Preoperative Antithrombin Supplementation in Patients Undergoing High-Risk Cardiopulmonary Bypass
This is a prospective, multicenter, randomized, double-blind, placebo-controlled study. The purpose of this study is to determine the safety and effectiveness of human-derived antithrombin III (AT-III [Human]) supplementation…
- Trial name
- NCT02037555
- Testing
- AT-III (Human)
- Where
- 41 sites in United States
- Volunteers
- 425 people
- Sponsor
- Grifols Therapeutics LLC
Prostate Cancer
Abiraterone Acetate Plus LHRH Agonist and Abiraterone Acetate Plus LHRH Agonist and Enzalutamide
The goal of this clinical research study is to learn if adding the combination of abiraterone acetate and prednisone with or without enzalutamide to hormonal therapy can help to control prostate cancer when given before surgery.
- Trial name
- NCT01946165
- Testing
- Abiraterone Acetate, Prednisone, Enzalutamide
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- M.D. Anderson Cancer Center
Patients Undergoing Elective Surgery With Anesthesia
Telemedical Risk Assessment and Preoperative Evaluation (TAPE)
The purpose of this study is to assess the feasibility, patient satisfaction and time saving of a telemedical risk assessment and preoperative evaluation for anesthesia.
- Trial name
- NCT04518514
- Testing
- TAPE-Software
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- RWTH Aachen University
Perioperative Cardiovascular Risk, Postoperative Complications (Cardiopulmonary)
AI-ECG for Preoperative Cardiovascular Risk Stratification Before General Surgery
This randomized controlled trial evaluates whether an artificial intelligence-enhanced electrocardiography (AI-ECG)-based strategy for preoperative cardiovascular risk stratification is noninferior to usual care in patients…
- Conditions
- Perioperative Cardiovascular Risk, Postoperative Complications (Cardiopulmonary), Preoperative Care
- Trial name
- NCT07774689
- Testing
- AI-ECG-based preoperative risk stratification (ECG Buddy)
- Where
- South Korea
- Volunteers
- 3,200 people
- Sponsor
- Seoul National University Bundang Hospital
Hepatic Cancer, Hepatocellular Carcinoma
Preoperative 3D Magnetic Resonance Elastography for Predicting Surgical Risk in Patients Undergoing Hepatectomy
How to accurately and safely evaluate regional liver function before hepatectomy remains an important unsolved problem in the surgical management of hepatocellular carcinoma (HCC).
- Conditions
- Hepatic Cancer, Hepatocellular Carcinoma, Intrahepatic Cholangiocellular Carcinoma, Metastatic Hepatocellular Carcinoma
- Trial name
- NCT07704203
- Testing
- Three-Dimensional Magnetic Resonance Elastography
- Volunteers
- 150 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Preoperative Risk Assessment, ASA Physical Status Classification
AI-Based ASA Classification in Preoperative Patients
This prospective observational study aims to evaluate the performance of multiple artificial intelligence-based large language models in assigning American Society of Anesthesiologists Physical Status (ASA-PS) classifications in…
- Trial name
- AI-Based ASA C (NCT07407998)
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Bursa City Hospital
Pulmonary Hypertension (Diagnosis), Pre-operative Assessment
GUARD-PH: Guided Use of AI-ECG for Risk Detection of PH in Surgery (GUARD-PH Trial)
This study is a prospective, open-label, randomized controlled trial designed to evaluate a new artificial intelligence (AI) tool for heart monitoring.
- Conditions
- Pulmonary Hypertension (Diagnosis), Pre-operative Assessment, Postoperative Complications (Cardiopulmonary), Treatment Outcomes
- Trial name
- GUARD-PH (NCT07344207)
- Testing
- Artificial Intelligence-Enabled Electrocardiography System
- Where
- Taiwan
- Volunteers
- 1,380 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Liver Cancer
A Clinical Study to Evaluate the Clinical Outcomes of Hepatectomy With Nutritional Risk After Preoperative Nutritional Support
Objective:to Study the clinical outcomes of hepatectomy with Nutritional risk After Preoperative Nutritional Support. Study design: 1.Prospective，randomized, controlled clinical study;2.Patients: The subjects were from Peking…
- Trial name
- NCT01292330
- Testing
- nutritional support before operation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Pediatric Surgical Patients
Evaluation of Preoperative Risk Factors in Children
This study aimed to evaluate preoperative risk factors in pediatric patients and to determine their effectiveness in predicting intensive care unit admission within 72 hours.
- Trial name
- NCT05852899
- Where
- Turkey (Türkiye)
- Volunteers
- 326 people
- Sponsor
- Istanbul University - Cerrahpasa
Spine Degeneration, Lumbar Degenerative Disease
Pre-operative Risk Assessment Combined With Targeted Intervention in the Chinese Elderly With Spine Surgery II
This multicenter, parallel-group, assessor-blinded randomized controlled trial will enroll 248 adults aged ≥75 years with degenerative lumbar spinal diseases scheduled for elective lumbar fusion surgery, and they will be…
- Conditions
- Spine Degeneration, Lumbar Degenerative Disease, Frail Elderly, Enhanced Recovery After Surgery (ERAS) Protocol
- Trial name
- PRACTICE-2 (NCT07396077)
- Testing
- Multimodal physiological reserve optimizing prehabilitation program, Usual Care
- Where
- 4 sites in China
- Volunteers
- 248 people
- Sponsor
- Xuanwu Hospital, Beijing