Clinical trials: Prescribing, open to volunteers
Deprescribing, Statin Prescribing
Testing the Impact of Pre-visit Priming for Medications
We will use EHR data to identify eligible patients at BWH primary care clinics. Patients will be eligible if they have an upcoming primary care provider (PCP) appointment at an included BWH clinic, are ≥65 years, and are eligible…
- Trial name
- NCT07281131
- Testing
- Pre-visit prompts
- Where
- United States
- Volunteers
- 1,700 people
- Sponsor
- Brigham and Women's Hospital
Medication Abuse, Harm Reduction
Evaluation of Clinical Decision Support in Opioid Tapering
The 2022 Center for Disease Control and Prevention (CDC) clinical practice guideline for prescribing opioids for pain recommends that when tapering a patient's opioid dose, doses should be decreased at a slow rate to reduce the…
- Conditions
- Medication Abuse, Harm Reduction, Opioid Use Disorder, Opioid Prescribing
- Trial name
- NCT06527079
- Testing
- Observational study without a prospective intervention
- Volunteers
- 200,000 people
- Sponsor
- University of Colorado, Denver
Inappropriate Prescribing, Reflux Disease
Deprescribing Inappropriate Proton Pump Inhibitors
The DROPIT Trial is an interventional, open-labelled, cluster-randomized controlled trial conducted in the Swiss primary care setting.
- Conditions
- Inappropriate Prescribing, Reflux Disease, Proton Pump Inhibitors
- Trial name
- DROPIT (NCT06129474)
- Testing
- Proton Pump Inhibitor deprescribing tool
- Where
- 2 sites in Switzerland
- Volunteers
- 400 people
- Sponsor
- University of Bern
Inappropriate Prescribing, Implementation Science
Reduction of Low-value Prescribing Through Audit and Feedback
The objective is to estimate the effect attributable to a primary care pharmacist-led audit and feedback (AF) strategy compared to the currently used AF strategy as a management tool to evaluate healthcare performance focusing on…
- Conditions
- Inappropriate Prescribing, Implementation Science, Behavioral Sciences
- Trial name
- AFFAP (NCT07336550)
- Testing
- Usual AF, Facilitated AF
- Where
- Spain
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Basque Health Service
Opioid Prescribing
Reducing Post-Operative Opioid Prescribing in Southeastern North Carolina
The goal of this stepped-wedge cluster randomized trial is to evaluate whether an opioid stewardship intervention improves post-operative opioid prescribing practices.
- Trial name
- NCT07566182
- Testing
- Usual Care, Opioid Stewardship Intervention
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of North Carolina, Chapel Hill
Prescribing Patterns, Physician, Physician's Practice Patterns
Optimizing Proton Pump Inhibitors (PPI) Prescribing With EHR-Based Decision Support
The proposed study is a quality improvement initiative designed to rigorously evaluate new variations of UCLA Health's proton pump inhibitor (PPI) order panels, building on internal quality improvement efforts to optimize…
- Conditions
- Prescribing Patterns, Physician, Physician's Practice Patterns, Drug Utilization Review
- Trial name
- NCT06998966
- Testing
- Algorithmic Defaulting (Indication-Based Default), Active Physician Choice
- Where
- United States
- Volunteers
- 372 people
- Sponsor
- University of California, Los Angeles
VAP - Ventilator Associated Pneumonia, Antibiotic
EARLY Antibiotics aDAptation in Severe Pneumonia(The EARLY ADAPT Study)
The objective of the study is to determine whether rapid multiplex PCR testing of respiratory samples can reduce exposure to broad-spectrum antibiotics in intensive care unit patients with suspected or confirmed…
- Conditions
- VAP - Ventilator Associated Pneumonia, Antibiotic, Antibiotic Stewardship, Antibiotic Prescribing for Acute Respiratory-tract Infections
- Trial name
- EARLY ADAPT (NCT07267624)
- Testing
- PCR multiplex BioFire Pneumonia plus
- Where
- 5 sites in Switzerland
- Volunteers
- 170 people
- Sponsor
- University Hospital, Geneva
Quality Improvement, Feedback
British Columbia Prescriber Feedback Program - Antimicrobial Resistance
The goal of this study is to evaluate an educational intervention that aims to reduce the number of unnecessary antibiotics prescribed by family physicians and nurse practitioners in British Columbia, Canada.
- Conditions
- Quality Improvement, Feedback, Prescribing, Antibiotics
- Trial name
- NCT07431190
- Testing
- Prescribing portrait audit and feedback
- Where
- Canada
- Volunteers
- 7,626 people
- Sponsor
- University of British Columbia
Antimicrobial Prescribing Practices, Antimicrobial Resistance (AMR)
Development and Implementation of Mobile Antibiograms to Optimize Empirical Antibiotic Prescriptions Among Prescribers in Tertiary Hospitals in Tanzania
Antimicrobial resistance (AMR) is a critical issue, especially in Africa, with resistance to common antibiotics reaching 100% in some areas.
- Trial name
- AMR; AMU; DDD (NCT07393308)
- Testing
- Mobile antibiogram application, standard of care
- Where
- 2 sites in Tanzania
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Muhimbili University of Health and Allied Sciences
Opioid Use, Opioid Prescribing, Dispensing, and Patient Use
Opioid Package Prototype (OPP)
The overall objective of this clinical trial is to identify the impact of selected package features, known as the Opioid Package Prototype (OPP), on the safe and effective use of opioids.
- Trial name
- NCT04598074
- Testing
- Opioid Package Prototype (OPP), Usual Care (standard amber vial)
- Where
- United States
- Volunteers
- 352 people
- Sponsor
- UConn Health
Youth Mental Health and Wellbeing, Feasibility and Acceptability of the Social Prescribing Program
Social Prescribing for Advancing Resilience in Kids: A Pilot Study of Social Prescribing
The goal of this clinical trial is to learn if the Social Prescription (SP) intervention helps improve mental health and wellbeing in youth.
- Trial name
- SPARK (NCT07022561)
- Testing
- Social Prescribing
- Where
- Canada
- Volunteers
- 170 people
- Sponsor
- University of Ottawa
Antibiotic Prescribing is the Study Focus (no Condition)
Shared Decision-making and Antimicrobial Stewardship in Secondary Care
To identify opportunities for antibiotic prescribing shared decision making between patients and prescribers in secondary care.
- Trial name
- SHARE (NCT06605820)
- Testing
- None - Interview Only
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Royal Cornwall Hospitals Trust
Nursing Home Residents, Older People
Improved Prescribing for Older Nursing Home Patients
Research aim: To investigate the effect of training health care professionals in medication assessments on the medication use of nursing home residents with a limited life expectancy (< 1.5-2 years).
- Conditions
- Nursing Home Residents, Older People, Prescribing, Advance Care Planning
- Trial name
- IMPETUS (NCT06731361)
- Testing
- Systematic multidisciplinary medication review + ACP (SMMR+)
- Where
- 7 sites in Netherlands
- Volunteers
- 450 people
- Sponsor
- Amsterdam UMC, location VUmc