Clinical trials: Prescription Drug Misuse
Vitamin D Deficiency, Osteopenia
Monitored vs Standard Supplementation of Vitamin D in Preterm Infants
The purpose of this study is to determine wheather the monitored vitamin D (vit D) therapy is safer and more effective than standard therapy in pretrem infants.
- Conditions
- Vitamin D Deficiency, Osteopenia, Nephrolithiasis, Drug Overdose
- Trial name
- MOSVID (NCT03087149)
- Testing
- monitored vit D supplementation, standard vit D supplementation
- Where
- Poland
- Volunteers
- 109 people
- Sponsor
- Princess Anna Mazowiecka Hospital, Warsaw, Poland
Drug Overdose
Bioavailability of a New Formulation of Nasal Naloxone for Prehospital Use
Overdose with potential deadly outcome is a serious problem among opioid abusers, not least in Norway. The annual death toll from overdose is about 250, twice the annual death toll from traffic accidents.
- Trial name
- NCT02158117
- Testing
- nasal naloxone
- Where
- Norway
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Overdose
A Universal Primary Care Based Intervention to Reduce Youth Overdose Risk Aim 3
Between 2015 and 2019, overdose deaths translated to 1.25 million years of life lost among adolescents and young adults (youth) aged 12 to 24 years, and the percent change in fatal overdose rates among adolescents ages 14 to 18…
- Trial name
- NCT07797933
- Testing
- Brief youth overdose prevention education, Usual Standard of Care
- Where
- United States
- Volunteers
- 648 people
- Sponsor
- Boston Medical Center
Mental Health Disorders, Substance Use Disorders
Supporting Treatment Access and Recovery Through Linkage and Support
This 3-year Hybrid Type 1 study will randomize 208 people with co-occurring substance use and mental health disorders (COD) referred from the Worcester Hub.
- Trial name
- STAR-LS (NCT05713695)
- Testing
- Full MISSION, Linkage Only Delivered by a Peer Specialist
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- University of Massachusetts, Worcester
Substance Use Disorder (SUD)
Trauma-informed Intervention to Reduce Substance Use and to Support Community Transition
The overall aim of this study is to reduce overdose risk for criminal legal system (CLS) involved women during community re-entry through the adaptation and testing of an innovative, trauma-informed, relational intervention…
- Trial name
- TRUST (NCT06651528)
- Testing
- TAU + TRUST, TAU + TRUST + Re-entry Recovery Support, Treatment as Usual (TAU)
- Where
- 4 sites in United States
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Michele Staton
Substance Abuse, Risk Reduction
First Years Away From Home: Letting Go and Staying Connected
Alcohol abuse is the leading cause of death and serious injury among college students, and students also experience significant harms from other types of substance misuse and risk behaviors.
- Conditions
- Substance Abuse, Risk Reduction, RIsky Sexual Behavior
- Trial name
- FYAH:LGSC (NCT03227809)
- Testing
- Handbook condition, Handbook plus condition
- Where
- United States
- Volunteers
- 910 people, healthy volunteers welcome
- Sponsor
- Washington State University
Overdose
An Evaluation of a Social Network Intervention for Primary and Secondary Prevention of Opioid Overdoses
The purpose of this study is to pilot and implement a peer mentor intervention focused on overdose prevention and care. The intervention consists of 3 sessions.
- Trial name
- NCT04212364
- Testing
- Peer Education, Narcan Nasal Product
- Where
- United States
- Volunteers
- 614 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Opioid-Related Disorders
The OPT-IN Project
Prescription opioid overdose represents a public health crisis. A number of efforts have been implemented to address opioid prescribing and opioid risk mitigation strategies for prescribers, but relatively few efforts have sought…
- Trial name
- NCT03526380
- Testing
- Behavioral: the OPT-IN Intervention
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- University of Michigan
Opiate Overdose, Fentanyl Overdose
Evaluation of a Novel Intervention to Prevent Polysubstance Overdoses Involving Illicit Stimulants
The purpose of the study is to investigate the feasibility, acceptability, and associated benefits and harms of integrating FTS education and distribution into select courts in rural and urban communities in Ohio.
- Conditions
- Opiate Overdose, Fentanyl Overdose, Harm Reduction
- Trial name
- NCT05493475
- Testing
- Fentanyl Test Strips
- Where
- United States
- Volunteers
- 653 people
- Sponsor
- Nationwide Children's Hospital
Opioid Overdose
Opioid Rapid Response System: Naloxone Training in Communities
The pervasive impact of the opioid epidemic has touched all layers of society for the past two decades, resulting in over 115 deaths daily and imposing annual costs of $78.5 billion.
- Trial name
- NCT06238128
- Testing
- Opioid Rapid Resonse System (ORRS) training, Non-active opioid overdose response training
- Where
- United States
- Volunteers
- 773 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Pain, Postoperative, Opioid Overdose
Ultrasound-guided PENG Block in Total Hip Replacement
This randomized controlled study will be carried out on 60 adult patients undergoing primary total hip replacement in Tanta University Hospitals.
- Trial name
- NCT04984109
- Testing
- Real PENG block
- Where
- Egypt
- Volunteers
- 71 people
- Sponsor
- Tanta University
Prescription Drug Abuse
Using m-Health Tools to Reduce the Misuse of Opioid Pain Relievers
The aim of this study is to pilot test a web-based, patient-centered educational program that encourages the patient to have an informed discussion about pain medication options with their emergency department (ED) provider.
- Trial name
- NCT03012087
- Testing
- MyHealthyChoices, Health Risk Assessment
- Where
- 2 sites in United States
- Volunteers
- 123 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Drug Overdose, Substance Abuse
EEG Monitoring in the Emergency Department
This study seeks to investigate whether drug effects in suspected overdose patients could be identified using the electroencephalogram (EEG).
- Conditions
- Drug Overdose, Substance Abuse, Alcohol Abuse
- Trial name
- NCT04070521
- Testing
- Observational EEG Monitoring
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Vitiligo, Depressive Episode
Mental Health Associations With Vitiligo
This cohort study is a large population-based study in the UK to determine the risks of comorbid mental health conditions (including depression, anxiety and other potential psychological complications of vitiligo) in adults with…
- Conditions
- Vitiligo, Depressive Episode, Recurrent Depressive Disorder, Anxiety Disorders
- Trial name
- NCT04953338
- Testing
- Exposure of mental health condtion of interest
- Where
- United Kingdom
- Volunteers
- 36,104 people, healthy volunteers welcome
- Sponsor
- Momentum Data
Opioid Use, Opioid-Related Disorders
Surviving Opioid Overdose With Naloxone Education and Resuscitation Trial (SOONER)
Among people at risk of opioid overdose and receiving care in an academic emergency department, family practice, opioid substitution clinic or general inpatient units, does brief opioid overdose resuscitation training and…
- Conditions
- Opioid Use, Opioid-Related Disorders, Opioid Withdrawal, Opioid Overdose
- Trial name
- SOONER (NCT04740099)
- Testing
- SOONER Video & Kit, Standard of Care
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Opioid Use Disorder, Opioid Use
Overdose Recovery and Care Access (ORCA) Qualitative Stakeholder Interviews and County-level Data
The study is a quasi-experimental investigation of a sub-acute stabilization center (SASC) for people who have had or are at risk for having an opioid overdose and have an encounter with Seattle Fire Department emergency medical…
- Trial name
- NCT06768814
- Testing
- Sub-acute stabilization
- Where
- United States
- Volunteers
- 40,000 people
- Sponsor
- University of Washington
Drug Overdose, Opioid-Related Disorders
Development of an Algorithm That Predicts Hypoventilation Due to an Opioid Overdose
RTM Vital Signs, LLC is developing a miniature wearable tracheal sound sensor that communicates with a cell phone containing a machine-learning diagnostic algorithm designed to detect and predict the onset of mild, moderate, and…
- Trial name
- NCT03845699
- Testing
- Diagnostic algorithms that detects/predicts hypoventilation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- RTM Vital Signs, LLC
Suicide, Firearm Injury
Emergency Room Firearm and Medication Safety Intervention
Seventeen United States Veterans die by suicide each day. Nearly three-fourths of those Veterans die from firearm injury or poisoning, and many seek care in VA Emergency Departments (ED) prior to suicide attempts.
- Conditions
- Suicide, Firearm Injury, Overdose
- Trial name
- NCT04797221
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- VA Office of Research and Development
Stimulant Overdose
Stimulant Overdose in the Medicaid Population: Who is at Risk, and When Are They at Risk
This project addresses Objective 2 of RFA-CE-21-002: to assess risk and protective factors for illicit stimulant use, use disorder, or overdose that can contribute to the development or adaptation of intervention strategies.
- Trial name
- NCT05976984
- Testing
- Aim 1 (case-cohort study), Aim 2 (case-crossover study), Aim 3 (cohort study)
- Where
- United States
- Volunteers
- 634,939 people
- Sponsor
- University of Pennsylvania
Bronchopulmonary Dysplasia, Vitamin D Overdose
25OH Vitamin D Overdoses and Risk of Bronchopulmonary Dysplasia or Death
Several studies have demonstrated that vitamin D deficiency at birth is a risk factor of bronchopulmonary dysplasia. However, in an animal model of bronchopulmonary dysplasia vitamin D overdose has also been associated with an…
- Trial name
- 25OHVDORBPDD (NCT05944055)
- Testing
- Is 25 OH vitamin D overdose a risk factor of bronchopulmonary dysplasia or death ?
- Where
- France
- Volunteers
- 173 people
- Sponsor
- Hospices Civils de Lyon