Clinical trials: Prescription Opioid Abuse
Opioid Abuse, Prescription Drug Abuse (Not Dependent)
Validation of a Community Pharmacy-Based Prescription Drug Monitoring Program Risk Screening Tool
The goal of the study is to validate a Prescription Drug Monitoring Program-based opioid risk metric to discriminate between low, moderate, and high-risk opioid use disorder.
- Trial name
- PHARMSCREEN (NCT03936985)
- Where
- 2 sites in United States
- Volunteers
- 1,464 people, healthy volunteers welcome
- Sponsor
- University of Utah
Drug Overdose, Opioid-Related Disorders
A Tailored, Peer-delivered Intervention to Reduce Recurring Opioid Overdoses
This project will further develop and test the Tailored Telephone Intervention delivered by Peers to Prevent Recurring Opioid Overdoses (TTIP-PRO), a promising, low-cost, intervention to facilitate entry into medication assisted…
- Conditions
- Drug Overdose, Opioid-Related Disorders, Drug Addiction, Drug Abuse
- Trial name
- TTIP-PRO (NCT02922959)
- Testing
- Peer Intervention, naloxone nasal spray kit, Personally-tailored opioid overdose prevention education (information packet)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Cincinnati
Opioid Abuse, Opioid Dependence
Effects of Ibudilast on Oxycodone Self-administration in Opioid Abusers
Opioid drugs increase glial cell activation which may be related to the abuse liability of opioid drugs. Data supporting this hypothesis have demonstrated that glial cell attenuators decrease the positive rewarding aspect of…
- Trial name
- NCT01740414
- Testing
- MN-166 (50 mg) First
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- New York State Psychiatric Institute
Opioid-Related Disorders, Substance-Related Disorders
Prescription Opioid Effects in Abusers Versus Non-Abusers
The purpose of this study is to examine the abuse liability of oxycodone in individuals with, and without, a history of prescription opioid abuse.
- Trial name
- NCT00158184
- Testing
- oxycodone 15 mg, oxycodone 30 mg
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Opioid Use, Pain
Evaluation of Medical Cannabis and Prescription Opioid Taper Support for Reduction of Pain and Opioid Dose in Patients With Chronic Non-Cancer Pain
This study will use a randomized controlled design to test whether medical marijuana use by adults on high-dose chronic opioid therapy (COT) for chronic non-cancer pain is associated with reduced opioid dose and improved pain…
- Conditions
- Opioid Use, Pain, Marijuana Use
- Trial name
- NCT04827992
- Testing
- Cannabis, Prescription Opioid Taper Support (POTS)
- Where
- 3 sites in United States
- Volunteers
- 87 people
- Sponsor
- Massachusetts General Hospital
Opioid Safety, Prescription Opioid Misuse
A Patient-Centered Intervention to Improve Opioid Safety
This is a randomized controlled trial of a multifaceted intervention designed to improve the safety of opioid prescribing. The specific aims of this study are to: (a) evaluate whether a multifaceted intervention (Improving the…
- Conditions
- Opioid Safety, Prescription Opioid Misuse, Chronic Pain
- Trial name
- ISOP (NCT02791399)
- Testing
- ISOP Intervention with the Nurse Care Manager
- Where
- United States
- Volunteers
- 286 people
- Sponsor
- VA Office of Research and Development
Chronic Disease, Pain
Conversion to Embeda With Rescue Trial
The purpose of the research study is to find out if opioid dependent chronic pain patients who are judged by their physician to be eligible to change their current opioid medicine and to participate in this study can be…
- Trial name
- ConvERT (NCT01179191)
- Testing
- morphine sulfate and naltrexone hydrochloride (EMBEDA)
- Where
- 166 sites in United States
- Volunteers
- 684 people
- Sponsor
- Pfizer
Opioid Dependence
Prescription Opioid Abuse Among Pain Patients: Predictors of Relapse
In this study, we will assess opioid self-administration in a laboratory setting in persons with pain who have a history of opioid abuse.
- Trial name
- PAIN (NCT01967641)
- Testing
- buprenorphine/naloxone combination
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- New York State Psychiatric Institute