Clinical trials: Prescriptions
Iatrogenic Effect
OPTIM-EHPAD Optimization of Drug Prescription for Each Resident Entering in Nursing Home (EHPAD).
Elderly people are at high risk of multiple medication which increases drug interactions and side effects. This problem is accentuated in EHPAD due to the multiplication of prescribers (the referring physician, the hospital…
- Trial name
- OPTIM-EHPAD (NCT05179642)
- Testing
- OPTIM-EHPAD tool
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Hospices Civils de Lyon
Smoking Cessation
A Multi-National Study To Assess How Effective And Safe The Smoking Cessation Medicine Varenicline Is In Smokers Who Have Already Tried Varenicline In The Past As A Prescription Medicine From Their Usual Healthcare Provider
The main purpose of this study is to compare the effectiveness and safety of the re-treatment of smokers with varenicline with placebo for smoking cessation during the last 4 weeks of a 12 week course of treatment.
- Trial name
- NCT01244061
- Testing
- Varenicline
- Where
- 37 sites in United States, Australia and 6 more
- Volunteers
- 498 people
- Sponsor
- Pfizer
Antibiotic Prescriptions, In-Patient Treatment
Impact of a Simple Automated Best Practice Alert (BPA) on Quantity and Quality of In-hospital Antibiotic Use in a Tertiary and Three Secondary Hospitals
The goal of the stepped-wedge cluster-randomized trial is to assess the impact of an antimicrobial stewardship intervention: a simple, automated Best Practice Alert (BPA) that reminds prescribers to reevaluate antibiotic therapy…
- Trial name
- TARGET (NCT07115966)
- Testing
- Computerized decision support by best practice alert (BPA)
- Where
- Switzerland
- Volunteers
- 58 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Opioid Misuse, Opioid-Related Disorders
Healthy Opioid Prescription Engagement
This study is a randomized controlled trial across 14 community pharmacies to test the efficacy of the Brief Intervention-Medication Therapy Management intervention (BI-MTM).
- Conditions
- Opioid Misuse, Opioid-Related Disorders, Pharmacist-Patient Relations
- Trial name
- HOPE (NCT05141266)
- Testing
- Patient Navigation, Standard Medication Counseling (SMC)
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Jerry Cochran
Hospices, Poly Pharmacy
Standardized Patient-Centered Medication Review in Home Hospice
This is a pilot cluster randomized trial that tests the effect of a novel intervention that trains hospice staff to 1. regularly review, simplify, and align patients' prescribed medications with their goals of care as their…
- Conditions
- Hospices, Poly Pharmacy, Deprescriptions, Caregivers
- Trial name
- SPECTORx (NCT03972163)
- Testing
- NIA Medication Management - Active Comparator, STOPPFrail (Screening Tool of Older Persons Prescriptions), "Discontinuing Medication Appropriately" and "Understanding the Art of Communication about Deprescribing"
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Massachusetts, Worcester
Overdose
Overdose Prevention Centers and Behavioral Health
The aims of this study are: (Aim 1) Identify sources of heterogeneous impacts of opioid prevention center (OPC) use on non-fatal and fatal overdose risk among individuals with histories of polysubstance use (PSU); (Aim 2)…
- Trial name
- NCT06236087
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- NYU Langone Health
Medication Adherence
Managing Insulin With a Voice AI
This study randomizes participants to have their basal insulin titrated either through standard of care or by receiving prompts through interactions with an AI-enabled smart speaker device.
- Trial name
- MIVA (NCT05081011)
- Testing
- Voice Assistant Device
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Stanford University
Medication Dosing Error
Working With Doctors and Pharmacists to Help Parents Give Children's Liquid Medicines Safely
The study objective is to assess the impact of an automated electronic health record (EHR)-based intervention that leverages e-prescriptions to support pharmacist adherence to recommended dispensing practices, with the goal of…
- Trial name
- NCT05146388
- Testing
- EHR-Based Approach
- Where
- 3 sites in United States
- Volunteers
- 500 people
- Sponsor
- NYU Langone Health
Acute Disease
Effectiveness and Safety of the Nursing Prescription in Acute Health Problems of Low Complexity
Objective: To compare the efficacy/effectiveness of pharmacological nurse prescription with medical prescription in patients attended in a primary care center for minor acute health problems.
- Trial name
- NCT03892850
- Testing
- Nurse prescription, Medical prescription
- Volunteers
- 374 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Head and Neck Cancer
Individualized Response-adaptive Radiation Dose Prescription in HNC Based on MRI
This Phase 1 dose-finding study investigates the maximal tolerated dose for a subsequent phase 2 trial testing MR-guided individualized response-adaptive dose prescription in HNC.
- Trial name
- MRL-02 (NCT05160714)
- Testing
- Real-time ADC-guided response adaptive Boost in HNC
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- University Hospital Tuebingen
Non-infectious Uveitis
Ozurdex® in Patients With Non-infectious Uveitis Affecting the Posterior Segment of the Eye
This observational study will evaluate the safety, efficacy, characteristics of patients, characteristics of physicians and quality of life in patients who are prescribed OZURDEX® as treatment for non-infectious uveitis of the…
- Trial name
- Louvre 2 (NCT02951975)
- Testing
- dexamethasone intravitreal implant
- Where
- 21 sites in France
- Volunteers
- 246 people
- Sponsor
- Allergan
Community-acquired Acute Lower Respiratory Infection
Advanced Diagnostics for Enhanced QUality of Antibiotic Prescription in Respiratory Tract Infections in Emergency Rooms
This study is a randomized controlled trial where participants are randomly assigned in a 1:1 ratio to either a rapid test group or a control group. Standard care is provided in the control group.
- Trial name
- ADEQUATE (NCT04781530)
- Testing
- BioFire FilmArray Respiratory Panel 2.1 plus (RP2.1plus)
- Where
- 6 sites in Germany, Greece and 3 more
- Volunteers
- 522 people
- Sponsor
- PENTA Foundation
Pain, Postoperative
Evaluation of the Analgesia Nociception Index and Videopupillometry to Predict a Child's Post-tonsillectomy Morphine Prescription
Some surgeries, such as tonsillectomies, are particularly painful postoperatively because they are not very accessible to a complementary technique of loco-regional anesthesia and require the use of opioids in the postoperative…
- Trial name
- ENIGME (NCT03698565)
- Testing
- Nerve stimulation of the ulnar nerve
- Where
- France
- Volunteers
- 93 people
- Sponsor
- University Hospital, Limoges
Social Support, Screen Time
The Green Prescription Program for Increasing Physical Activity in Adolescents
This study evaluated the effectiveness of the Green Prescription, a school-based behavioral intervention that incorporated health education, designed to increase physical activity among adolescents aged 15-17 years who were…
- Conditions
- Social Support, Screen Time, Physical Inactivity, Sedentary Lifestyle
- Trial name
- NCT07770997
- Testing
- Green Prescription (Teacher-Led), Green Prescription (Interdisciplinary)
- Where
- Poland
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Breast Cancer
Rx for Better Breast Health
This randomized controlled trial will test the impact of a patient-navigated, anti-inflammatory, culinary-based intervention (reinforced by motivational interviewing [MI] and tailored newsletters) on obese (body mass index [BMI]…
- Trial name
- NCT02279303
- Testing
- Dietary Intervention, Dietary Control
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Prescribing, Off-Label
CMO Letter to Reduce Unnecessary Antibiotic Prescribing March 2018
This trial aims to reduce unnecessary prescription of antibiotics by general practitioners (GPs) in England. Unnecessary prescriptions are defined as those that do not improve patient health outcomes.
- Trial name
- NCT03582072
- Testing
- letter from the CMO
- Where
- United Kingdom
- Volunteers
- 4,796 people
- Sponsor
- Public Health England
Medical Cannabis
Medical Marijuana and Open Road Driving Task
Medical marijuana use among adults 50 and older has more than doubled in the past decade with exponential increases projected in this demographic by 2050, and prescription opioids are one of the most common treatments for pain…
- Trial name
- ROADACE (NCT06995937)
- Where
- 2 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Florida State University
Cardiovascular-kidney-metabolic Syndrome, Diabete Type 2
SWitching to Appropriate Prescription in Cardiovascular-Kidney-Metabolic Syndrome
SWAP-CKM (SWitching to Appropriate Prescription in Cardiovascular-Kidney-Metabolic Syndrome) is a pragmatic, cluster-randomized clinical trial designed to evaluate whether electronic health record (EHR)-based alerts can improve…
- Conditions
- Cardiovascular-kidney-metabolic Syndrome, Diabete Type 2, Chronic Kidney Disease, Heart Failure
- Trial name
- SWAP-CKM (NCT07910968)
- Testing
- Real-Time EHR Prompts and Audit-and-Feedback Reports
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Kaiser Permanente
AOD Prescription
Impact of Renal Function Availability to Community Pharmacist for Dispensing Direct Oral Anticoagulant in Ambulatory Patients on Bleeding Occurrence
The use of direct oral anticoagulants (AODs) in the prevention and treatment of thromboembolic diseases is increasing, with a favorable benefit/risk balance and improved quality of life for patients.
- Trial name
- Hemorrag-IR (NCT06739603)
- Testing
- pharmaceutical analysis
- Volunteers
- 1,920 people
- Sponsor
- Université de Reims Champagne-Ardenne
Primary Gout, Hyperuricemia
Study on the Bioavailability of Three Different Prescription Processes of SHR4640 Tablets in Healthy Volunteers
The primary objective of the study is to evaluate the relative bioavailability of three different prescription processes of SHR4640 tablets in healthy volunteers.
- Trial name
- NCT04586803
- Testing
- SHR4640
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
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