Clinical trials: Prescriptions
Bronchiolitis
Evaluation of the Impact of EHR-Alerts on Clinical Decision Support Pathway Use in Bronchiolitis, and the Impact of Pathway Use on the Prescription of High Flow Nasal Cannula and Other Elements of High Value Care.
The goal of this experimental study is to learn whether different types of Electronic Health Record (EHR) alerts that direct clinicians to reference clinical guidelines embedded in the increase the use of these guidelines and the…
- Trial name
- NCT06932341
- Testing
- Non-interruptive, Interruptive
- Where
- 3 sites in United States
- Volunteers
- 2,965 people
- Sponsor
- Johns Hopkins University
Insomnia, Insomnia Disorder
A SMART Approach to Evaluating the Benefits of Common Prescription and OTC Medications for Insomnia
The purpose of this study is to assess the relative effectiveness, safety, and durability of the most commonly used prescription (zolpidem, trazodone) and over-the-counter (OTC) (melatonin, diphenhydramine) medications for…
- Conditions
- Insomnia, Insomnia Disorder, Chronic Insomnia, Chronic Insomnia Disorder
- Trial name
- NCT07542756
- Testing
- Sleep Hygiene Education, Melatonin IR, 3 mg, Melatonin IR, 5 mg
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- University of Pennsylvania
Metabolic Syndrome X
A Study on the Intervention of Metabolic Syndrome Patients With Exercise Prescription Based on Ventilatory Threshold Using Cardiopulmonary Exercise Test
Analyze the clinical intervention effects and differences of progressive precision exercise prescriptions formulated by two methods for determining exercise intensity on metabolic syndrome (MS).
- Trial name
- NCT06379204
- Testing
- the maximum physiological value standardized group, the ventilatory threshold individualized group
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Taiyuan Central Hospital of Shanxi Medical University
Respiratory Insufficiency, Overdose of Opiate
ARM-ED: Advanced Respiratory Monitoring Events in Drug Toxicity
There is a drug-related death crisis in Scotland. The majority of these deaths have involved the misuse of opiates (e.g. heroin) and benzodiazepines (e.g. valium) which cause an individual to stop breathing.
- Conditions
- Respiratory Insufficiency, Overdose of Opiate, Sedative Overdose, Sedative Toxicity
- Trial name
- ARM-ED (NCT05358132)
- Testing
- Pneumowave Device placement and data capture
- Where
- United Kingdom
- Volunteers
- 78 people
- Sponsor
- NHS Greater Glasgow and Clyde
Opioid Overdose, Opiate Overdose
Nalmefene vs Naloxone for the Treatment of Recurrent Respiratory Depression After Opioid Overdose
The goal of this clinical trial is to compare naloxone to nalmefene for the treatment of opioid overdose in adults. The main questions it aims to answer are: Does nalmefene lower the number of doses of medicine participants need…
- Trial name
- NCT06408714
- Testing
- Nalmefene Injection, Naloxone Injection
- Where
- United States
- Sponsor
- University of New Mexico
Sepsis
A Prospective Cluster-Randomized, Controlled Crossover Trial to Validate an Electronic "Resistance Calculator"
Primary objective: Our aim is to validate the "Shamir Resistance Calculator" in a prospective crossover trial, in order to shorten the time to initiation of appropriate antimicrobials among hospitalized septic patients.
- Trial name
- NCT05304221
- Where
- 2 sites in Israel
- Volunteers
- 1,500 people
- Sponsor
- Dror MarChaim, MD
Experts in Physical Activity Prescription and Risk Health Screening
Expert Validation of an Autonomous Personalized Physical Activity Algorithm
This study aims to validate a personalized physical activity algorithm for risk screening and individualized exercise prescription using a modified online Delphi process.
- Trial name
- APPA e-Delphi (NCT07475221)
- Where
- Portugal
- Volunteers
- 9 people
- Sponsor
- Polytechnic Institute of Porto
Opioid Abuse, Opioid Dependence
Effects of Ibudilast on Oxycodone Self-administration in Opioid Abusers
Opioid drugs increase glial cell activation which may be related to the abuse liability of opioid drugs. Data supporting this hypothesis have demonstrated that glial cell attenuators decrease the positive rewarding aspect of…
- Trial name
- NCT01740414
- Testing
- MN-166 (50 mg) First
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- New York State Psychiatric Institute
Overdose, Opioid-related Disorders
Phone Interview to Prevent Recurring Opioid Overdoses
There has been a dramatic rise in opioid overdose (OOD) deaths in recent years. Attempts to ameliorate the problem have largely focused on increasing the accessibility of naloxone, an opioid antagonist that is effective in OOD…
- Conditions
- Overdose, Opioid-related Disorders, Drug Addiction, Drug Abuse
- Trial name
- TTIP-PRO (NCT02282306)
- Testing
- TTIP-PRO
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Cincinnati
Esophagus Cancer
Clinical Trial of Qizhu Yuling Prescription in the Prevention and Treatment of Esophagus Cancer
The purpose of this study is to evaluate the efficacy and safety of Qizhu Yuling prescription for postoperative esophagus cancer.
- Trial name
- NCT05626309
- Testing
- Qizhu Yuling Prescription
- Where
- 3 sites in China
- Volunteers
- 310 people
- Sponsor
- Jie Li
Anxiety Disorders
Benzodiazepine Taper With Cognitive Behavioral Therapy in Patients Using Prescription Opioids
Taking prescription opioids for pain together with benzodiazepines for the treatment of anxiety disorders is not recommended by the U.S.
- Trial name
- NCT05573906
- Testing
- Cognitive behavioral therapy for anxiety plus benzodiazepine taper, Health education control plus benzodiazepine taper
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- University of California, Los Angeles
Pain, Abuse, Drug
Effects of Cannabis on Prescription Drug Abuse Liability and Analgesia
The purpose of this research is to assess the impact of cannabis on the analgesic and abuse-liability effects of a sub-threshold dose of a commonly used analgesic.
- Trial name
- NCT03679949
- Testing
- Oxycodone, Cannabis (THC:CBD = ~ 1:0), Cannabis (THC:CBD = ~ 0:1)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Hypertension, Metabolic Syndrome
Jiangzhuo Qinggan Prescription and Irbesartan in the Treatment of Essential Hypertension(Hepatogastric Damp-heat)Clinical Study
Jangzhuo Qinggan prescription and irbesartan in the treatment of essential hypertension(Hepatogastric Damp-heat), randomized, parallel-controlled, multi-center clinical study.
- Trial name
- JZQG (NCT01082835)
- Where
- 5 sites in China
- Volunteers
- 240 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Opioid Prescribing, Prescription Drug Misuse
E-mails to Nudge Safer and Better-Informed Prescribing of Risky Drugs
This study will test e-mails to encourage engagement with the Minnesota prescription monitoring program (PMP/PDMP) and will evaluate the effect of these e-mails on PMP/PDMP use and controlled substance prescribing.
- Trial name
- NCT06443385
- Testing
- PDMP Legal Mandate E-mail, PDMP Clinical Benefit E-mail
- Where
- United States
- Volunteers
- 7,872 people, healthy volunteers welcome
- Sponsor
- Columbia University
Cardiac Surgery With Cardiopulmonary Bypass
Beta Blocker Use in Cardiac Surgery and Association With Postoperative Course
The objective of this study is to describe in a cohort of cardiac surgery patients the use of beta-blockers before surgery and their maintenance or withdraw according to international recommendations in order to compare patients…
- Trial name
- BLOCK (NCT04769752)
- Testing
- collection of the allocated treatment, collection of medical complications
- Where
- France
- Volunteers
- 1,789 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Long QT Syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia Type 1
Evaluation of Exercise Testing and Physical Activity in Children and Adolescents Living With Inherited Arrhythmias
The goal of this observational study is to evaluate exercise testing and daily physical activity in children and adolescents who are diagnosed with an inherited arrhythmia.
- Conditions
- Long QT Syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia Type 1, Catecholaminergic Polymorphic Ventricular Tachycardia Type 2
- Trial name
- ACTIVELY (NCT06661278)
- Testing
- Exercise tolerance test, Physical activity & heart rate monitoring
- Where
- 2 sites in United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Chronic Disease, Sedentary Lifestyle
Evidence-Based Lifestyle Prescription Program: Pilot Study
The HealtheSteps™ (HeS) Program is an evidence-based, community-focused, lifestyle prescription (Rx) program, supported by in-person coaching and innovative health technologies.
- Conditions
- Chronic Disease, Sedentary Lifestyle, Overweight
- Trial name
- HeSP (NCT02413385)
- Testing
- HealtheSteps Program
- Where
- Canada
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Obesity, Childhood
Brighter Bites & University of Texas Physicians Produce Rx Extension: Evaluating the Effectiveness of a Prospective Clinical Nutrition Study With Produce Prescriptions
The purpose of this study is to clinically evaluate the effectiveness of an at-home delivery produce prescription in improving weight status and obesity-related health outcomes and to examine the impacts of the program on child…
- Trial name
- NCT06390397
- Testing
- Produce prescription program, Standard of care
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- The University of Texas Health Science Center, Houston
Erectile Dysfunction
Actual Use Trial of Tadalafil 5 mg
The purpose of this actual use trial (AUT) is to evaluate if participants can appropriately select and use the study product [Cialis over the counter (OTC)] using the labeling and the mandatory health survey assessment (HSA) for…
- Trial name
- NCT06805513
- Testing
- Tadalafil 5 mg tablets with a digital tool.
- Where
- United States
- Volunteers
- 2,212 people, healthy volunteers welcome
- Sponsor
- Sanofi
Postoperative Pain, Ambulatory Surgery
Comparison Between Pre-operative Prescription Delivered During Anesthesia Consultation or Post-operative Prescription
This study evaluates the comparison of the incidence of postoperative home pain after ambulatory surgery with general anesthesia between a group with pre-surgical prescription delivered during anesthesia preoperative clinic and a…
- Conditions
- Postoperative Pain, Ambulatory Surgery, Anesthesia, Postoperative Complication
- Trial name
- AMBUPRESS (NCT03205189)
- Testing
- Comparison between pre-operative prescription and post-operative prescription
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
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