Clinical trials: Preterm Intraventricular Hemorrhage
Intraventricular Hemorrhage
The Risk of Intraventricular Hemorrhage With Flat Midline Versus Right-Tilted Flat Lateral Head Positions
Intraventricular hemorrhage (IVH) in preterm infants is one of many devastating consequences of prematurity that have both acute and long-term sequelae.
- Trial name
- NCT01584375
- Testing
- Flat midline head position, Right flat lateral head position
- Where
- 3 sites in Saudi Arabia
- Volunteers
- 71 people
- Sponsor
- King Abdul Aziz General Hospital
Premature Birth, Respiratory Distress Syndrome in Premature Infant
Physiologically Based Cord Clamping To Improve Neonatal Outcomes In Moderate And Late Preterm Newborns
Before birth, the baby's lungs are filled with fluid and babies do not use the lungs to breathe, as the oxygen comes from the placenta. As delivery approaches, the lungs begin to absorb the fluid.
- Conditions
- Premature Birth, Respiratory Distress Syndrome in Premature Infant, Sepsis, Intraventricular Hemorrhage of Prematurity
- Trial name
- PhyCordPrem (NCT06280872)
- Testing
- Physiological Based Cord Clamping, Differed Cord Clamping
- Where
- 2 sites in Belgium
- Volunteers
- 180 people
- Sponsor
- Queen Fabiola Children's University Hospital
Infant, Premature, Erythropoietin
High-Dose Erythropoietin in Extremely Premature Infants to Prevent/Attenuate Brain Injury: A Phase II Study
The highest risk for perinatal brain injury occurs among extremely premature infants who weigh less than 1250 grams at birth. Such perinatal brain injury is currently irreversible, associated with neurodevelopmental disability…
- Conditions
- Infant, Premature, Erythropoietin, Brain Injury, Intraventricular Hemorrhage
- Trial name
- NCT00589953
- Testing
- Erythropoietin
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Atlantic Health System
Bronchopulmonary Dysplasia, Intraventricular Hemorrhage
The Efect of Azithromicyn on Bronchopulmonary Displasia in Extremely Preterm and Very Preterm Infant
This study was to see the effectiveness of azithromycin in preventing the incidence of bronchopulmonary dysphasia in extremely preterm and very premature infants.
- Conditions
- Bronchopulmonary Dysplasia, Intraventricular Hemorrhage, Necrotizing Enterocolitis
- Trial name
- NCT05311228
- Testing
- Azithromycin Powder
- Where
- Indonesia
- Volunteers
- 120 people
- Sponsor
- Universitas Indonesia
Intraventricular Haemorrhage Neonatal
Prophylactic Acetaminophen for Prevention Intraventricular Hemorrhage in Premature Infants
The purpose of this study is to determine whether acetaminophen is effective in prevention or reducing the severity of IVH in premature infants.
- Trial name
- NCT03024814
- Testing
- Acetaminophen, Dextrose 5
- Where
- Saudi Arabia
- Volunteers
- 300 people
- Sponsor
- King Saud Medical City
PreTerm Birth, Intraventricular Hemorrhage
Deferred Cord Clamping Compared to Umbilical Cord Milking in Preterm Infants
For preterm infants, deferred cord clamping has been shown to improve both short term and long-term neonatal outcomes without an established harm for both the mother and her infant.The interference with resuscitative measures for…
- Trial name
- NCT02996799
- Testing
- Umbilical cord milking
- Where
- Saudi Arabia
- Volunteers
- 180 people
- Sponsor
- King Abdulaziz University
Intraventricular Hemorrhage of Prematurity, Nursing Caries
Effectiveness of Nursing Care Bundle for the Prevention of Intraventricular Hemorrhage in Preterm Infants
Existing measures to prevent intraventricular hemorrhage in preterm infants include preventing premature delivery, pre-natal administration of corticosteroid, active treatment of chorioamnionitis, and improvement of postnatal…
- Trial name
- NCT05844709
- Testing
- IVH care Bundle
- Where
- Taiwan
- Volunteers
- 178 people
- Sponsor
- National Taiwan University Hospital
Necrotizing Enterocolitis, Intraventricular Hemorrhage
PUFAs in Preterm Infants
The research endeavors to examine the critical composition of Polyunsaturated Fatty Acids (PUFAs) in premature infants across different gestational stages and under varying disease conditions, and delineate the metabolic…
- Conditions
- Necrotizing Enterocolitis, Intraventricular Hemorrhage, BPD - Bronchopulmonary Dysplasia, Sepsis
- Trial name
- PIPI (NCT06045130)
- Volunteers
- 600 people
- Sponsor
- The First Hospital of Jilin University
Intraventricular Hemorrhage
Intranasal Human Milk for Intraventricular Hemorrhage
Intraventricular hemorrhage (IVH) is a leading cause of brain injury in infants born before term. Severe IVH, which occurs nearly exclusively in very preterm infants (born before 32 weeks gestation) who are already at risk of…
- Trial name
- NCT04225286
- Testing
- Human breast milk
- Where
- 2 sites in Canada
- Volunteers
- 37 people
- Sponsor
- The Hospital for Sick Children
Retinopathy of Prematurity (ROP), Intraventricular Hemorrhage
Safety and Efficacy Outcomes Following Previously Administered Short-Term Treatment With SHP607 in Extremely Premature Infants
The purpose of this study is to evaluate long-term safety and efficacy outcomes following previously administered short-term exposure to SHP607, as compared to a standard neonatal care group.
- Conditions
- Retinopathy of Prematurity (ROP), Intraventricular Hemorrhage, Bronchopulmonary Dysplasia, Chronic Lung Disease of Prematurity
- Trial name
- NCT04506619
- Testing
- No Intervention
- Where
- 8 sites in United States, Italy and 1 more
- Volunteers
- 26 people
- Sponsor
- Oak Hill Bio Ltd
Neonatal Thrombocytopenia, Intraventricular Hemorrhage
PRedicting OutcomeS in Preterm nEonates With thromboCyTopenia
Preterm neonates often receive platelet transfusions when their platelet count is low to prevent bleeding. However, it is currently unclear which infants benefit from such transfusions.
- Conditions
- Neonatal Thrombocytopenia, Intraventricular Hemorrhage, Platelet Transfusion
- Trial name
- PROSPECT (NCT06043050)
- Testing
- Platelets
- Where
- 12 sites in Germany, Netherlands and 1 more
- Volunteers
- 1,042 people
- Sponsor
- Leiden University Medical Center
Intraventricular Haemorrhage Neonatal, Death; Neonatal
Premature Infants Receiving Milking or Delayed Cord Clamping: PREMOD2
This study is being done to find out whether umbilical cord milking (UCM) is at least as good as or better than delayed cord clamping (DCC) to reduce bleeding in the brain or prevent death in premature newborns.
- Trial name
- PREMOD2 (NCT03019367)
- Testing
- Umbilical cord milking UCM, Delayed cord clamping DCC
- Where
- 18 sites in United States, Canada and 2 more
- Volunteers
- 1,201 people
- Sponsor
- Sharp HealthCare
Premature Birth, Neonatal Hypoglycemia
Higher-Dose Dexamethasone Improves Breathing and Shortens NICU Stay in Preterm Babies
The goal of this observational study was to compare two doses of dexamethasone given to pregnant women at risk of preterm birth. Dexamethasone is a medicine used before birth to help a baby's lungs mature.
- Conditions
- Premature Birth, Neonatal Hypoglycemia, Maternal Infection During Pregnancy, Neurodevelopmental Disorder of Foetus
- Trial name
- NCT07765329
- Testing
- Dexamethasone 12 mg Every 12 Hours, Dexamethasone 6 mg Every 12 Hours
- Where
- Indonesia
- Volunteers
- 200 people
- Sponsor
- Stella Maris Women and Children Hospital
Hypoxic-Ischemic Encephalopathy, Periventricular Leukomalacia
Evaluation of Long-term Neurodevelopment in Neonatal Encephalopathy by Infant Treadmill
There is no international application of infant running stimulation system to evaluate the brain injury in children with various stages of nerve and motor development in a large sample of studies.
- Conditions
- Hypoxic-Ischemic Encephalopathy, Periventricular Leukomalacia, Intraventricular Hemorrhage, Bilirubin Encephalopathy
- Trial name
- NCT03527498
- Testing
- Baby treadmill, Physical rehabilitation training
- Where
- China
- Sponsor
- Children's Hospital of Fudan University
Delayed Umbilical Cord Clamping Benefits, Postpartum Haemorrhage
Timing of Umbilical Cord Occlusion in Premature Babies( <33 w). Delayed vs Early.
Early cord clamping after delivery has been common practice for many decades as part of the active management of the third stage of labour.
- Conditions
- Delayed Umbilical Cord Clamping Benefits, Postpartum Haemorrhage, Intraventricular Haemorrhage
- Trial name
- CODE-P (NCT02187874)
- Testing
- delayed umbilical cord occlusion, early umbilical cord occlusion, Oxytocin
- Where
- Spain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Intraventricular Hemorrhage, Periventricular Leukomalacia
Effects of Delayed Cord Clamp and/or Indomethacin on Preterm Infant Brain Injury
Intraventricular hemorrhage (IVH) and periventricular leukomalacia (PVL) are brain lesions that commonly occur in preterm infants and are well-recognized major contributors to long-term brain injury and related disabilities later…
- Conditions
- Intraventricular Hemorrhage, Periventricular Leukomalacia, Brain Injury, Renal Injury
- Trial name
- NCT02221219
- Testing
- Indomethacin, delay in umbilical cord clamp at birth, immediate cord clamp at birth
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- Hong Huang
Intraventricular Hemorrhage
Research a New Predictive Marker of Intraventricular Hemorrhage in Very Preterm Infants
The most frequent complications in premature infants are neurological complications: intracranial hemorrhages and white matter lesions. In Epipage 2 study the incidence of severe intraventricular hemorrhages remains stable.
- Trial name
- HEMO PREMA (NCT02400853)
- Testing
- Standard cranial echography, Cord blood analysis
- Where
- France
- Volunteers
- 175 people
- Sponsor
- University Hospital, Rouen
Prematurity; Extreme, Cerebral Circulatory Failure
Sonographic QUantification of Venous Circulation In the Preterm Brain
The aim of the study is to develop an accessible, reproducible ultrasound tool for objective clinical measurement of brain circulation in preterm infants in order to identify infants being at risk for preterm brain injury at an…
- Conditions
- Prematurity; Extreme, Cerebral Circulatory Failure, Intraventricular Hemorrhage, Periventricular Leukomalacia
- Trial name
- SQUIB (NCT04535375)
- Testing
- Doppler Ultrasound of venous cerebral circulation
- Where
- Belgium
- Volunteers
- 47 people
- Sponsor
- Universitair Ziekenhuis Brussel
Intraventricular Hemorrhage, Sepsis
Placental Transfusion Project for Preterm Infants
The American College of Obstetrics and Gynecology, American Academy of Pediatrics and the World Health Organization have recently published recommendations related to placental transfusions in preterm infants.
- Conditions
- Intraventricular Hemorrhage, Sepsis, Necrotizing Enterocolitis
- Trial name
- NCT02400697
- Testing
- <30 wks gestation or 1500 grams
- Where
- United States
- Volunteers
- 2,856 people
- Sponsor
- Indiana University
Neonatal Cerebral Leukomalacia, Intracranial Nontraumatic Haemorrhage of Fetus and Newborn
The Role of Cerebral NIRS in Preventing Brain Injury of Very Low Birth Weight Preterm Infants
This study determines the effectiveness of cerebral Near Infrared Spectroscopy (NIRS) as a monitoring device combined with a SafeboosC treatment guideline in order to prevent brain injury in very low birth weight preterm…
- Conditions
- Neonatal Cerebral Leukomalacia, Intracranial Nontraumatic Haemorrhage of Fetus and Newborn, Neonatal Mortality
- Trial name
- NCT06729398
- Testing
- NIRS, SafeboosC
- Where
- Indonesia
- Volunteers
- 129 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital