Clinical trials: Preterm Labor, Premature Birth
Premature, Parent-Child Relations
Effect of Parental Enteral Nutrition on Quality Of Parent-Child Interactions
Studies underline both the importance of the link and contact that occurs in the earliest days of life and the need to involve parents early with their premature child.
- Trial name
- PREMIAM (NCT05313464)
- Testing
- parent-pushed enteral feeding, syringe-push enteral feeding
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Fetal Membranes, Premature Rupture, Premature Birth
The Use of Cranberries in Women With Preterm Premature Rupture of Membranes
Cranberries have been proved to reduce the rate of urinary tract infections in a population of women with recurrent urinary tract infections in previous studies.
- Trial name
- NCT00247104
- Testing
- Cranberries - Vaccinium macrocarpon
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Prematurity, Respiratory Disease
Caffeine as an Adjuvant Therapy for Late Preterm Infants With Respiratory Distress
Use of caffeine citrate in late-preterm infants with respiratory distress is questionable. Oliphant and colleagues found in a recently published study that caffeine therapy use in late-preterm infants at a loading dose of 20 and…
- Conditions
- Prematurity, Respiratory Disease, Ventilator Lung; Newborn
- Trial name
- CAT/LPT (NCT06026163)
- Testing
- Caffeine citrate
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 134 people
- Sponsor
- Ministry of Health, Saudi Arabia
Premature Birth, Extremely Low Birth Weight
DCS Study in Extremely Premature Newborns
The researchers are attempting to improve the cerebral monitoring of extremely low gestational age (ELGA) infants, such that in the future, real-time monitoring will be possible, to aid clinicians in management of these infants.
- Conditions
- Premature Birth, Extremely Low Birth Weight, Infant, Small for Gestational Age, Intracerebral Hemorrhage
- Trial name
- NCT04367181
- Testing
- Diffuse Correlation Spectroscopy (DCS), Amplitude Integrated Electroencephalography (aEEG)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Maria Angela Franceschini
Acute Respiratory Deficiency, Prematurity
Comparison of RAM Cannula Nasal Continuous Positive Airway Pressure Versus Infant Flow Nasal Continuous Positive Airway Pressure (NCPAP)
This study is designed to compare the effectiveness and ease of use of two commonly used NCPAP interfaces: the RAM NC and the Infant Flow prongs and nasal mask.
- Conditions
- Acute Respiratory Deficiency, Prematurity, Assisted Ventilation
- Trial name
- NCT02032511
- Volunteers
- 19 people
- Sponsor
- University of Michigan
Infant, Newborn, Infant, Low Birth Weight
The Effects of Erythropoietin (EPO) on the Transfusion Requirements of Very Low Birth Weight Infants
This study tested the safety and efficacy of transfusing erythropoietin (Epo) and iron in infants of <1,250g birth weight. For infants 401-1,000g birth weight, we tested whether early erythropoietin (Epo) and iron therapy would…
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- EPO (NCT01203514)
- Testing
- Erythropoietin
- Where
- 9 sites in United States
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Behavior, Child
Effect of Kangaroo Mother Care Versus Hammock Positioning
Aim This study aimed to investigate the effect of kangaroo mother care (KMC)versus hammock positioning (HP) on physiological indices and behavioral organization among preterm neonates.
- Trial name
- Kangaroo (NCT05165004)
- Testing
- Kangaroo Mother Care, Hammock Positioning, Routine Care of NICU
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Preterm Birth
Brief Delay in Cord Clamping and Neurobehaviour in Preterms
RESEARCH HYPOTHESIS Brief delay(>30 sec to <60 sec ) in cord clamping as compared to early cord clamping (< 20 sec) leads to a better short term neurobehavioural outcome in preterm (34-36 wks) neonates when assessed by…
- Trial name
- NCT01753843
- Testing
- early cord clamping, Brief Delay in cord clamping
- Where
- India
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Lady Hardinge Medical College
Resuscitation
Pilot Study to Assess Safety and Feasibility of Resuscitation of Preterm Infants With Controlled Volume of Air/Oxygen
QUESTION: Is controlled tidal volume delivery during the resuscitation of preterm infants < 28 weeks' gestation safe and feasible? BACKGROUND AND RATIONALE: Current resuscitation of preterm neonates follows the Neonatal…
- Trial name
- NCT00157989
- Testing
- Controlled tidal volume resuscitation
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Mount Sinai Hospital, Canada
Pregnancy, High Risk, Preterm Birth
Prevention of Preterm Birth by Screening of the Consistency Index and Length of the Uterine Cervix in Women With a Single Pregnancy
Preterm birth (PTB) is the major cause of perinatal morbidity and mortality. Worldwide, about 15 million babies are born too soon every year, causing 1.1 million deaths, as well as short- and long-term disability in countless…
- Conditions
- Pregnancy, High Risk, Preterm Birth, Cervix; Pregnancy, Obstetric Labor, Premature
- Trial name
- PreBirthCerv (NCT04444206)
- Testing
- Transvaginal ultrasound cervical length screening
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- University of Campania Luigi Vanvitelli
ROP, Jaundice, Neonatal
Hyperbilirubinemia and Retinopathy of Prematurity in Preterm Infants: a Retrospective Study.
The goal of this retrospective observational study is to [learn about the correlation between hyperbilirubinemia and retinopathy of prematurity in preterm infants.
- Conditions
- ROP, Jaundice, Neonatal, Premature, Very Low Birth Weight Infant
- Trial name
- biliROP (NCT05806684)
- Testing
- ROP
- Where
- Italy
- Volunteers
- 1,586 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Prematurity, Stress Reaction
Pilot Study of Nursing Touch and Biobehavioral Stress
Randomized cross-over clinical trial to determine the effect of a nurse-administered comforting touch intervention on the biobehavioral stress responses of preterm infants hospitalized in the neonatal intensive care unit.
- Trial name
- P-NAT-BIO (NCT05030233)
- Testing
- Nurse-Administered Touch Intervention
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Ohio State University
Trophic Feeding, Very Low Birth Weight Baby
Effect of Oral Colostrum Applications Every 2 Hours and 4 Hours In Order to Achieve Trophic Feeding in Preterm Infants
The goal of this clinical trial is aims to evaluate the effects of applying colostrum orally every 4 and 2 hours in order to achieve trophic feeding in preterm infants.
- Conditions
- Trophic Feeding, Very Low Birth Weight Baby, Preterm
- Trial name
- NCT06379178
- Testing
- Oral colostrum application 2 hours, Oral colostrum application 4 hours
- Where
- Indonesia
- Volunteers
- 47 people
- Sponsor
- Gadjah Mada University
Necrotizing Enterocolitis, Premature
Fecal Calprotectin in Breastfed vs Formula-Fed Preterm Infants and NEC
This prospective observational study aims to evaluate fecal calprotectin levels as an early indicator of necrotizing enterocolitis in preterm infants and to compare levels between breastfed and formula-fed preterm infants at…
- Conditions
- Necrotizing Enterocolitis, Premature, Breast Feeding
- Trial name
- NCT07810543
- Volunteers
- 112 people
- Sponsor
- Assiut University
Neonatal Respiratory Distress Related Conditions, Neonatal Respiratory Failure
Automated Versus Manual Control Of Oxygen For Preterm Infants On Continuous Positive Airway Pressure In Nigeria
One in ten babies are born preterm (<37 weeks gestation) globally. Complications of prematurity are the leading cause of death in children under 5 years, with the highest mortality rate in Sub-Saharan Africa (SSA).
- Conditions
- Neonatal Respiratory Distress Related Conditions, Neonatal Respiratory Failure, Prematurity, Oxygen Toxicity
- Trial name
- NCT05508308
- Testing
- OxyMate, Manual oxygen control
- Where
- 2 sites in Nigeria
- Volunteers
- 49 people
- Sponsor
- Murdoch Childrens Research Institute
Preterm Birth, Cervical Incompetence
Preventing Preterm Birth With a Negative Pressure Cervical Cup: a Feasibility Study
The goal of this Phase I clinical trial is to generate proof-of-concept data to demonstrate that a cervical cup in combination with vacuum application will create negative pressure on uterine cervical tissue, thereby creating…
- Conditions
- Preterm Birth, Cervical Incompetence, Cervical Insufficiency, Short Cervix
- Trial name
- NCT05512052
- Testing
- Hannah Cervical Cup (2 mm Delta), Hannah Cervical Cup (4 mm Delta), Hannah Cervical Cup (6 mm Delta)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Galena Innovations, LLC
Bronchopulmonary Dysplasia
Cellular Therapy for Extreme Preterm Infants at Risk of Developing Bronchopulmonary Dysplasia
Bronchopulmonary dysplasia (BPD) is a common and chronic lung disease that occurs in preterm infants following ventilator and oxygen therapy and is associated with long-term health consequences.
- Trial name
- NCT04255147
- Testing
- Allogeneic Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells
- Where
- 2 sites in Canada
- Volunteers
- 9 people
- Sponsor
- Ottawa Hospital Research Institute
Premature Birth, Counseling
Counseling for Prematurity Using a Multimedia Education Tool
This study evaluates the effectiveness of prenatal counseling when verbal counseling is supplemented with a multi-media mobile application versus a written gestational age handout.
- Conditions
- Premature Birth, Counseling, Decision Making, Prenatal Care
- Trial name
- NCT03225885
- Testing
- Multimedia Information, Printed Handout
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Medical College of Wisconsin
Preterm Birth, Pain, Procedural
Maternal Speech Decreases Pain Scores and Increases Oxytocin Levels in Preterm Infants During Painful Procedures
Preterm infants undergo early separation from parents and are exposed to frequent painful clinical procedures, with resultant short- and long-term effects on their neurodevelopment.
- Trial name
- NCT04762004
- Testing
- Maternal speech, Maternal singing, Standard care
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Geneva, Switzerland
Prematurity
Pilot Study of Electronic Uterine Contraction Inhibitor
The objective is to test a novel paradigm for the inhibition of human preterm uterine contractions. The study hypothesis is that human preterm contractions can be safely inhibited with a weak electrical current provided by an…
- Trial name
- PSEUCI (NCT00994058)
- Testing
- Electrical Inhibition (EI) Uterine Pacemaker
- Where
- United States
- Sponsor
- Winthrop University Hospital
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