Clinical trials: Preterm Labor, Premature Birth
Preterm Birth, Complication of Prematurity
Single Dose Antenatal Corticosteroids (SNACS) for Women at Risk of Preterm Birth
Antenatal corticosteroids (ACS) reduce the risks of neonatal death and morbidities, such as respiratory distress syndrome, in preterm infants.
- Conditions
- Preterm Birth, Complication of Prematurity, Obstetric Labor, Premature, Obstetric Labor Complications
- Trial name
- SNACS Pilot (NCT04494529)
- Testing
- 24 mg betamethasone
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Preterm Infants
Single-Session Physiotherapy Versus Massage in Premature Infants
This study investigates the effects of a single-session physiotherapy intervention compared to massage in premature infants hospitalized in the neonatal intensive care unit.
- Trial name
- SPIM-Preterm (NCT07207161)
- Testing
- Infant Massage, Physiotherapy (Moyer-Mileur Protocol)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Necmettin Erbakan University
Prematurity, Neonatal Encephalopathy
Evaluating the NeoTree in Malawi and Zimbabwe
Neonatal mortality remains unacceptably high. Globally, the majority of mothers now deliver in health facilities in low resource settings where quality of newborn care is poor.
- Conditions
- Prematurity, Neonatal Encephalopathy, Neonatal Sepsis, Neonatal Death
- Trial name
- NCT05127070
- Testing
- Neotree
- Where
- 5 sites in Malawi, Zimbabwe
- Volunteers
- 19,000 people
- Sponsor
- University College, London
Preterm Birth
Maternal and Fetal/Neonatal Pharmacokinetics and - Dynamics of Corticosteroids During Pregnancy
Improving pregnancy outcome is essential in improving health of both parents and their offspring during the life course. Preterm birth (PTB) occurs in 10-15% of all pregnancies, is the leading cause of perinatal mortality and…
- Trial name
- MaDyCo (NCT06264973)
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Erasmus Medical Center
Pain
Randomised Trial of Eutectic Mixture of Local Anaesthetics Cream and Oral Sucrose Solution for Venepuncture
This randomized bicentric trial will investigate the efficacy of topical EMLA cream with oral sucrose solution compared to oral sucrose solution alone before venepuncture in preterm infants.
- Trial name
- VIEP (NCT00470080)
- Testing
- venepuncture
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Preterm Birth
Does Fetal Fibronectin and Ultrasound Cervical Length Help in the Evaluation of Women With Suspected Preterm Labor?
The objective of this study is to investigate the effect of the use of both sonographic cervical length (CL) and fetal fibronectin (FFN) on the length of outpatient triage and preterm labor interventions in symptomatic women with…
- Trial name
- NCT00371046
- Testing
- Transvaginal ultrasound cervical length, Cervicovaginal fetal fibronectin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Thomas Jefferson University
Premature Delivery
Interest of Placental Alpha-microglobulin-1 Detection Test to Assess Risk of Premature Delivery in Reunion Island
Prematurity is the leading cause of mortality and perinatal morbidity. Despite the many preventive measures and use of tocolytic therapy, the incidence of premature births has not decreased in recent decades.
- Trial name
- PARTOSURE-OI (NCT02904070)
- Testing
- Vaginal swabbing
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Hypoglycemia, Infant, Small for Gestational Age
Dextrose Gel Does Not Prevent Neonatal Hypoglycemia
This was a quasi-experimental pilot study comparing blood glucose values 30 minutes after feeding alone or feeding + dextrose gel in newborns at risk for transient neonatal hypoglycemia.
- Conditions
- Hypoglycemia, Infant, Small for Gestational Age, Premature Birth of Newborn, Fetal Macrosomia
- Trial name
- NCT02523222
- Testing
- 40% Dextrose gel
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Baylor College of Medicine
Prematurity
Preterm Neonates Brain Ultrasound With CEUS and Elastography
The aim of the study is to investigate levels of brain perfusion and elasticity in preterm neonates when they reach the estimated due date and to compare the data with magnetic resonance imaging at term.
- Trial name
- NCT05694611
- Testing
- Brain contrast enhanced ultrasound, brain ultrasound elastography, Sulfur Hexafluoride
- Where
- Finland
- Sponsor
- Turku University Hospital
Motor Skills Disorders, Premature Birth
Premie DCD Imaging Intervention Study
This study will leverage a current longitudinal study of brain development in preterm children. In the Miller/Grunau Trajectories study, preterm children are returning for follow-up at 8-9 years.
- Trial name
- NCT04483401
- Testing
- Cognitive Orientation to Occupational Performance (CO-OP)
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of British Columbia
Parenteral Nutrition, Necrotizing Enterocolitis
Neurodevelopment and Neuroimaging in Parenterally-fed Infants and Young Children
Manganese (Mn) is an essential metal required for normal growth and development. However, exposure to high Mn levels can be toxic to the brain.
- Conditions
- Parenteral Nutrition, Necrotizing Enterocolitis, Digestive System Abnormalities, Cholestasis
- Trial name
- NCT00392730
- Testing
- Remove Mn from PN if evidence of increased brain Mn on MRI
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Twin Pregnancy, Preeclampsia
Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies
Twin pregnancies are associated with increased risk of perinatal adverse outcomes , including preeclampsia , fetal growth restriction , preterm premature rupture of membranes and preterm birth.
- Conditions
- Twin Pregnancy, Preeclampsia, Preterm Birth, Fetal Growth Restriction
- Trial name
- NCT04051567
- Testing
- Aspirin 100mg
- Where
- China
- Volunteers
- 425 people, healthy volunteers welcome
- Sponsor
- Ministry of Science and Technology of the People´s Republic of China
Infant, Premature
The Effects of Family Centered Intervention Program on Preterm Infants
Infant born preterm have an increased risk of adverse long-term developmental outcomes.The risk associated with preterm birth increase as gestational age decreases, and vulnerability remains in moderate and early preterm (<34…
- Trial name
- NCT03146351
- Testing
- Family based early intervention program (NDT-Bobath based)
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Gazi University
Preterm Birth
Cervical Cerclage for Preventing Spontaneous Preterm Birth in Singleton Pregnancies Without Prior Spontaneous Preterm Birth and With Short Transvaginal Ultrasound Cervical Length
Spontaneous preterm birth (SPTB) remains the number one cause of perinatal mortality in many countries, including the United States.
- Trial name
- NCT02746900
- Testing
- Cervical cerclage
- Where
- Italy
- Volunteers
- 587 people
- Sponsor
- Federico II University
Premature Birth
Delayed Umbilical Cord Clamping in Infants Less Than 32 Weeks
The overall objective of the present study is to examine the effects of delayed umbilical cord clamping in preterm infants on neonatal outcomes using a prospective randomized controlled trial comparing immediate cord clamping…
- Trial name
- DUC (NCT00562536)
- Testing
- Umbilical cord clamping
- Where
- Canada
- Volunteers
- 296 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
PreTerm Birth
Physical Examination-Indicated Pessary
Cervical insufficiency, previously referred to as cervical incompetence, has classically been defined as painless dilation of the cervix in the absence of contractions or bleeding in the second trimester resulting in recurrent…
- Trial name
- NCT02967445
- Testing
- Arabin Pessary, Cervical cerclage
- Where
- Italy
- Sponsor
- Federico II University
Infant, Premature
Prematurity-Related Ventilatory Control: Role in Respiratory Outcomes
The objective of this common multicenter protocol is to test the hypothesis that algorithmic tools using clinical Neonatal Intensive Care Unit (NICU) cardiorespiratory monitoring data can detect ventilatory control instability…
- Trial name
- Pre-Vent (NCT03174301)
- Where
- United States
- Volunteers
- 739 people
- Sponsor
- University of Virginia
Apnoea, Prematurity
Automated Apnoea Detection in Preterms on Non-invasive Ventilation
The aim of this study is to monitor the frequency of apnoeas (pauses in breathing) on various methods of non-invasive respiratory support that are detected by an automated machine-learning (ML) model based on diaphragmatic…
- Trial name
- NCT07794007
- Testing
- Diaphragmatic electromyography
- Volunteers
- 30 people
- Sponsor
- King's College Hospital NHS Trust
Newborn Respiratory Distress, Preterm Infant
Short Term Effects of Synchronized vs. Non-synchronized NIPPV in Preterm Infants.
Comparing the cardio-respiratory adaptation and differences to non invasive ventilation techniques, nasal intermittent positive pressure ventilation (NIPPV) non synchronized vs synchronized (SNIPPV) in preterm newborns…
- Trial name
- SyncNIV (NCT03289936)
- Testing
- NIPPV, SNIPPV
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Turin, Italy
PROM (Pregnancy), Induced; Birth
Effects of Acupuncture in Spontaneous Rapture of Membranes: Applicability and Effectiveness
The aim of the study is to investigate the effects of acupuncture in women presenting with spontaneous rapture of membranes (PROM) at term and negative swab for Streptococcus Agalactie to promote a spontaneous onset of labour and…
- Conditions
- PROM (Pregnancy), Induced; Birth, Acupuncture, Labour
- Trial name
- NCT06623175
- Testing
- Acupuncture needles
- Where
- Italy
- Volunteers
- 131 people
- Sponsor
- Prof. Fabio Facchinetti
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