Clinical trials: Preterm Labor, Premature Birth
Hypothermia
Clinical Performance of the Embrace Isothermal Mattress
The purpose of this pilot study is to evaluate the performance of a new warming technology (Embrace Isothermal Mattress) during the thermal weaning of premature infants from incubators to open cribs.
- Trial name
- KBW (NCT01425086)
- Testing
- Embrace, PCM, warming blanket
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Stanford University
Breast Milk Fortifier Supplements, Premature
The Effect of Time to Start Breast Milk Fortifiers on Neonatal Outcomes in Very Low Birth Weight Premature Infants.
In the study, very low birth weight babies born in our hospital will be randomized in the closed envelope method, and breast milk fortifier will be started when 50 ml/kg/day breastfeeding volume is reached in one group, and…
- Trial name
- NCT05251441
- Testing
- Breast Milk Fortifier supplements
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Ankara City Hospital Bilkent
Sepsis, Prematurity
An Open Label Study to Describe the Pharmacokinetics of Cefazolin in Preterm Neonates
This is a phase I open label multi-dose study to investigative the pharmacokinetics and safety of cefazolin in infants <121 days of age and < 28 weeks gestation with suspected sepsis.
- Trial name
- NCT00850122
- Testing
- cefazolin
- Where
- Brazil
- Volunteers
- 9 people
- Sponsor
- Phillip Brian Smith
Patent Ductus Arteriosus After Premature Birth
Indomethacin PK-PD in Extremely Preterm Neonates
This is a phase II open-label study evaluating the pharmacokinetics and pharmacodynamics of targeted early use of indomethacin for PDA treatment in preterm neonates <27 weeks' gestational age.
- Trial name
- INDO (NCT04025177)
- Testing
- Indomethacin Injection
- Where
- 2 sites in Canada
- Sponsor
- University of Manitoba
Infant, Newborn, Infant, Low Birth Weight
Multi-dose Pharmacokinetics and Dose Ranging of Inositol in Premature Infants (INS-2)
This pilot study is a randomized, placebo-controlled, clinical trial to measure changes in blood and urine levels of inositol in premature infants at high risk for retinopathy of prematurity (ROP) following repeated doses of…
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- INS-2 (NCT01030575)
- Testing
- Inositol lower volume, Inositol mid-level volume, Inositol high volume
- Where
- 17 sites in United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Premature Birth
Effects of Baby Massage on Parenting Stress and Attachment in Premature
This study is an experimental randomized controlled clinical trial. To explore the effect of infant massage on parental pressure and parent-child attachment of premature infants.
- Trial name
- NCT04255797
- Testing
- baby massage
- Where
- Taiwan
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Chung Shan Medical University
PreTerm Birth
Supporting Mothers of Preterm Infants
Preterm birth is the leading contributor to mortality among children younger than 5 years. One effective and inexpensive intervention is providing skin-to-skin care (STSC) whereby the mother of a preterm baby provides…
- Trial name
- NCT03013660
- Testing
- Limited Financial Support
- Where
- 2 sites in United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Premature Newborn
Influence of the Use of Hearing Protection in the Salivary Cortisol Level and in the Sleep of Premature Infants
The aim of this study was to investigate the influence of the use of headphones in salivary cortisol levels in newborns (NB) during periods of nap aimed at noise reduction, brightness and handling NB, measure the concentrations…
- Trial name
- NCT02781168
- Testing
- use of earmuffs
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Preterm Birth, Pregnancy, High Risk
Inpatient vs Outpatient Management of Short Cervix
The presence of short cervix during pregnancy is a risk factor for preterm birth though in many cases women will eventually deliver at term or near term.
- Trial name
- NCT03979196
- Testing
- Inpatient Management, Outpatient Management
- Where
- 2 sites in Canada
- Volunteers
- 5 people
- Sponsor
- Sunnybrook Health Sciences Centre
Preterm Birth, Gestational Diabetes Mellitus (GDM)
Evaluation of Maternal and Neonatal Outcomes in Women Are Conceived Through Assisted Reproductive Technology Compared to Other Fertility Treatments and Naturally Conceived Women: It is a Retrospective Cohort Study Conducted Over a 5-year Period at a Fertility Center in a Lebanese Hospital
Background: The number of couples experiencing difficulties conceiving and seeking treatment for infertility has increased dramatically over time.
- Conditions
- Preterm Birth, Gestational Diabetes Mellitus (GDM), Gestational Hypertension
- Trial name
- non (NCT06836843)
- Testing
- Since this is an observational study rather than an interventional study, the exposure type refers to all potential factors influencing pregnancy both before and during pregnancy
- Where
- Lebanon
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Lebanese University
Infant, Extremely Premature, Length of Stay
Trial of Patterned Oral Somatosensory Entrainment for Shortening Time to Oral Feeding
The primary hypothesis is that the preterm infants (26 0/7 to 30 6/7 weeks gestational age) who undergo the NTrainer System® training will transition to full oral feeds faster than the control group (i.e.
- Conditions
- Infant, Extremely Premature, Length of Stay, Feeding
- Trial name
- NCT01158391
- Testing
- NTrainer® Intervention, Control Intervention
- Where
- 5 sites in United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- KC BioMediX, Inc
Premature Infants, Respiratory Distress Syndrome
Cytokine Change in Bronchoalveolar Lavage Fluid After Early Budesonide-Surfactant Treatment in Premature Infants
Pulmonary inflammation plays an important role in the development of chronic lung disease (CLD) in preterm infants. This inflammation occurs very early in postnatal life.
- Conditions
- Premature Infants, Respiratory Distress Syndrome, Chronic Lung Disease, Bronchoalveolar Lavage Fluid
- Trial name
- NCT00146497
- Testing
- Budesonide-Surfactant
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- China Medical University Hospital
Term and Preterm Neonates (24-41 Weeks Gestational Age), Hematopoietic Stem Cell Transplant Recipient Children
Ontogeny of MAIT Cells in Neonates and Hematopoietic Stem Cell Transplant Recipients
The objective of this study is 1/ to determine the rate and kinetics of MAIT cell expansion and maturation in neonates in relation with gestational age, and in HSCT recipient children in relation with the source of donor stem…
- Trial name
- NEOMAIT (NCT02403089)
- Testing
- Tubes fund recovery blood count, the rest of the blood test and stool sample
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Nasogastric Tube, Orogastric Tube
Effects of Intermittent Feeding Methods With Nasogastric and Orogastric Tubes in Preterm Infants
The study is a randomized controlled, prospective, double-blind trial planned to compare the effects of intermittent feeding methods using nasogastric and orogastric tubes on the growth, nutrition, and physiological parameters of…
- Trial name
- NCT06765720
- Testing
- Intermittent feeding method with nasogastric tube, Intermittent feeding method with orogastric tube
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- İstanbul Yeni Yüzyıl Üniversitesi
Preterm Delivery
Comparison of Fetal Fibronectin (fFN) Specimen Collection Methodologies: With Speculum Versus Without Speculum
Observational study to determine whether the proposed method of fFN specimen collection without a speculum is substantially equivalent to the approved method with a speculum examination when obtained at the gestational age of ≥…
- Trial name
- SpecOp (NCT00883324)
- Where
- 5 sites in United States
- Volunteers
- 329 people
- Sponsor
- Hologic, Inc.
Cerebral Oxygenation, Premature
Evaluation of Cerebral Oxygenation Results in Premature Infant
The general purpose of this project is; Evaluation of cerebral oxygenation results in premature infants. These results will be evaluated in two different applications.
- Conditions
- Cerebral Oxygenation, Premature, Kangaroo Care, Facilitated Tucking
- Trial name
- NCT04725435
- Testing
- Kangaroo care, Facilitated Tucking Position
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Resuscitation
Co2 Monitoring at Preterm Delivery-Observational Study
CO2 data, serving as a proxy marker for tidal volume, might enable titration of tidal volume/pressure thereby providing optimal ventilation during neonatal resuscitation.
- Trial name
- COSTA (NCT04699708)
- Testing
- Carbon dioxide monitoring
- Where
- 2 sites in United Kingdom
- Volunteers
- 150 people
- Sponsor
- South Tees Hospitals NHS Foundation Trust
Premature Birth
Follow-Up of VLBW Infants With Chronic Lung Disease: Respiratory Health and Neurodevelopment
Although previous studies showed that preterm infants resolving from neonatal respiratory disease are more likely to exhibit respiratory illness, developmental disorders, impaired growth and cognitive limitations compared with…
- Trial name
- NCT00358891
- Where
- Taiwan
- Volunteers
- 98 people
- Sponsor
- National Taiwan University Hospital
Pulmonary Arterial Hypertension (PAH), Premature Infants
PNEUMOSTEM® for Improving Respiratory Outcomes in Very Premature Infants Diagnosed With Early Pulmonary Arterial Hypertension
The goal of this clinical trial is to evaluate the safety and potential efficacy of PNEUMOSTEM® for improving respiratory outcomes in very premature infants diagnosed with Early Pulmonary Arterial Hypertension.
- Trial name
- REVIVE-PH (NCT07368088)
- Testing
- PNEUMOSTEM®
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- Samsung Medical Center
Threatened Preterm Labor
Nifedipine Treatment in Preterm Labor
This is a study for pregnant women who have been diagnosed with Threatened Preterm Labor. The principal aim of this study is to compare the efficacy and safety of Nifedipine treatment versus Atosiban treatment over these…
- Trial name
- NCT01314859
- Testing
- Nifedipine, Atosiban
- Sponsor
- Hospital Clinico Universitario de Santiago
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