Clinical trials: Preterm Labor, Premature Birth
COVID-19 Pandemic, Preterm
Socioeconomic Inequalities Exacerbated by Mitigation Measures to COVID-19 and Differences in Prematurity Prevalence
Objective: to assess the perinatal results in Uruguay during the semester of successful control of the COVID 19 pandemic to evaluate the impact of the crises in the public and private sub sectors of the Health System.
- Conditions
- COVID-19 Pandemic, Preterm, Low Birth-weight
- Trial name
- NCT05087160
- Testing
- mitigation measures against COVID 19
- Where
- Uruguay
- Volunteers
- 37,323 people
- Sponsor
- Universidad de la Republica
Preterm Birth, Low Birthweight Neonate
Xylitol and the Prevention of Periodontal Disease and Preterm Birth Trial
The ground-breaking Prevention of Prematurity and Xylitol (PPaX) cluster randomized controlled clinical trial was conducted in Lilongwe, Malawi and enrolled approximately 10,069 pregnant individuals seeking to evaluate the impact…
- Conditions
- Preterm Birth, Low Birthweight Neonate, Periodontitis, Gingivitis
- Trial name
- XaPPP (NCT07424846)
- Testing
- Xylitol Chewing gum, Sorbitol chewing gum
- Where
- Malawi
- Volunteers
- 6,000 people
- Sponsor
- University of Washington
Respiratory Distress Syndrome, Newborn
High Flow Nasal Cannula Versus Nasal Continuous Positive Airway Pressure for Respiratory Support of Preterm Neonates
This work is designed to: 1. Evaluate the efficacy of HHHFNC in comparison with nCPAP in preterm neonates. 2. Investigate hemodynamic changes associated with HHHFNC in comparison to nCPAP in preterm neonates during periods of…
- Trial name
- NCT04238273
- Testing
- Functional Echocardiography
- Where
- Egypt
- Volunteers
- 123 people
- Sponsor
- Ain Shams University
Infant, Premature
The Impact of Implementing NIDCAP on Preterm Infants in the NICU
The purpose of this study is to evaluate the impact of the NIDCAP program of individualized patient consultation on the neurobehavioral organization of transported preterm infants in the NICU.
- Trial name
- NCT00179933
- Testing
- Newborn Individualized Assessment Program
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Infant, Premature, Brain Injuries
Structural Brain Abnormalities in Children Born Prematurely: New Detection Methods and Clinical-Pathological Correlates
The purpose of the study is to detect structural brain changes using MRI and to correlate these findings with neurodevelopmental assessments in two-year old children previously enrolled in the NIH sponsored trial of inhaled…
- Trial name
- NCT00153855
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Pre-Term
I-InTERACT Preterm
Open pilot of a brief online parenting-skills intervention for young children ages 3-8 who were born very preterm (< 32 weeks gestational age).
- Trial name
- NCT05282628
- Testing
- Building Better Brains and Behavior program (B4 Preterm)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Premature Infant, Extremely Low Birth Weight
Time to Accurate Heart Rate on Neonatal Outcomes
The goal of this trial is to compare the time to first heart rate displayed for iRes Warmer with ResusView and using iRes Warmer without ResusView when used in the resuscitation (e.g.
- Conditions
- Premature Infant, Extremely Low Birth Weight, Extreme Prematurity
- Trial name
- GE-EKG (NCT04587934)
- Testing
- iRes Warmer with ResusView, iRes Warmer without ResusView
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Sharp HealthCare
Breast Milk Expression
Early Initiation of Milk Expression in Mothers of Very Low Birth Weight Infants
Compelling evidence exists that breast milk helps protect very premature infants from prematurity-specific morbidities. Unfortunately, mothers of premature infants often exhibit delayed lactogenesis stage II (when the milk "comes…
- Trial name
- NCT01892085
- Testing
- Early initiation, Intermediate expression, Late initiation
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Florida
Premature Birth, NICU
NICU2HOME+: Supporting Illinois Families
The purpose of this project is to provide a stepwise, methodical approach to developing and testing the ability of Neonatal Intensive Care Unit 2 Home (NICU2HOME+) to support diverse Illinois families of premature infants during…
- Conditions
- Premature Birth, NICU, Premature, Infant
- Trial name
- NCT04480255
- Testing
- Group 1: Standard of Care, Group 2: NICU2HOME+ app
- Where
- 3 sites in United States
- Volunteers
- 413 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Adverse Pregnancy Outcomes, Cardiovascular Diseases
A Study to Lower Blood Pressure One Year After Childbirth in Women Who Had Preeclampsia
GESTA-SCORE is a prospective, randomized clinical trial designed to evaluate whether an early, personalized cardiovascular prevention strategy can achieve a clinically meaningful 6 mmHg reduction in systolic blood pressure at one…
- Trial name
- GESTA-SCORE (NCT06798649)
- Testing
- The intervention in the GESTA-SCORE study involves providing detailed feedback from vascular imaging to women who have experienced adverse pregnancy outcomes (APOs).
- Volunteers
- 150 people
- Sponsor
- Maternal-Infantil Vall d´Hebron Hospital
Bronchopulmonary Dysplasia
The Role of Volatile Organic Compounds (VOCs), Airway Mucins and the Microbiome in the Early Prediction of Bronchopulmonary Dysplasia (BPD)
Bronchopulmonary dysplasia (BPD), the most common respiratory complication of extremely preterm birth, significantly impacts healthcare with high morbidity and mortality rates.
- Trial name
- INFANCY (NCT06342752)
- Testing
- Breath test, Throat swabs, Placental samples
- Where
- Belgium
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Intracranial Hemorrhages, Prematurity
Neurophysiology and Anatomy of Severe Intraventricular Hemorrhage (IVH)
Currently, when premature infants develop severe intraventricular hemorrhage (IVH), a type of intracerebral bleed, there are no proven therapeutic interventions to prevent the devastating consequences of this event.
- Trial name
- NCT00817310
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University
Premature Birth, Premature Labor
Treatment of Preterm Labor With 17 Alpha-hydroxyprogesterone Caproate
The goal of our research will be to determine the effectiveness of 17 alpha-hydroxyprogesterone caproate (17P) in the treatment of preterm delivery.
- Trial name
- NCT00120640
- Testing
- 17 hydroxyprogesterone caproate intramuscular injections
- Sponsor
- Yale University
Respiratory Tract Infection
Impact of Respiratory Pathogens in Infants
This clinical study will investigate the relationships between sequential respiratory viral infections, patterns of intestinal and respiratory bacterial colonization, and adaptive cellular immune phenotypes which are associated…
- Trial name
- NCT01789268
- Testing
- Respiratory Inductive Plethysmography
- Where
- United States
- Volunteers
- 267 people
- Sponsor
- University of Rochester
Bronchopulmonary Dysplasia, Premature
THE EFFECT OF NEBULIZED AZITHROMYCIN AS THERAPY FOR BRONCHOPULMONARY DYSPLASIA
The aim of the study is to determine the effectiveness of nebulized azithromycin therapy in prevention of BPD in very low birth weight preterm infants when compared with placebo.
- Conditions
- Bronchopulmonary Dysplasia, Premature, Ventilation, Mechanical
- Trial name
- NCT06584474
- Testing
- Azithromycin neubilization, Lung ultrasound
- Where
- 2 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Alexandria University
Preterm Birth, Postpartum Women
Effect of Banana Blossom on Breast Milk Volume in Mothers of Preterm Newborns
The purpose of this study is to assess the effect of banana blossom in increasing breast milk volume
- Trial name
- NCT05465460
- Testing
- Banana Blossom
- Where
- Thailand
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Hypoxic Ischemic Encephalopathy of Newborn, Premature Birth
Metformin Treatment in Infants After Perinatal Brain Injury
A phase I study to test the feasibility and safety of treatment with metformin in infants affected by hypoxic ischemic encephalopathy (HIE) or prematurity-related brain injury
- Trial name
- NCT05590676
- Testing
- Metformin Hydrochloride
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- The Hospital for Sick Children
Parent-Child Relations
Assessment of the Mental State of Parents of Premature Children and Impact on Neurodevelopment of the Child
The objective of the study is to assess the psychic profile of parents of children born prematurely
- Trial name
- PoPPY (NCT04827225)
- Testing
- questionnaires
- Where
- 2 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Angers
Response to Hyperoxia
Neonatal Cerebral Oxygenation After Exposure to Oxygen Evaluated With the INVOS Oximeter
Due to the increased risk of brain damage, continuous monitoring of the cerebral oxygenation is interesting. The investigators will evaluate the capability of the INVOS Oximeter to detect induced changes in the cerebral regional…
- Trial name
- NCT01690650
- Testing
- Oxygen
- Where
- Denmark
- Volunteers
- 33 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Premature Birth of Newborn, Intestinal Malabsorption
Study to Assess the Efficacy and Safety of NTRA-2112 on Intestinal Malabsorption in Preterm Infants
The study will evaluate the effect of NTRA-2112 on intestinal malabsorption in preterm infants.
- Trial name
- NCT02510560
- Testing
- NTRA-2112
- Where
- 50 sites in United States, Belgium and 8 more
- Volunteers
- 300 people
- Sponsor
- Elgan Pharma Ltd.
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