Clinical trials: Preterm Labor, Premature Birth
Premature Birth
Population PK/PD of Off Label Drugs in Premature Neonates
This study will provide information on the pharmacokinetics, safety and effectiveness of off--label drugs used in critically ill premature infants: doxapram, fentanyl, midazolam, paracetamol, phenobarbital, sildenafil…
- Trial name
- DINO (NCT02421068)
- Where
- 4 sites in Netherlands
- Volunteers
- 246 people
- Sponsor
- Sinno H.P. Simons
Lactation
Growth Hormones and Cells in Human Milk Depending on Gestational Age
Human breast milk contains growth factors including neurotrophins and cells with neuroprotective potential. Concerning growth factors milk of preterms differs significantly from term milk.
- Trial name
- BMProfile (NCT02662517)
- Where
- Germany
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University Hospital of Cologne
Preterm Birth, Artificial Intelligence (AI) in Diagnosis
The Impact of Image Acquisition in Cervical Ultrasound on AI-Based Prediction of Preterm Birth in Clinical Practice
This study prospectively evaluates whether the performance of an already-developed artificial intelligence (AI) model for predicting spontaneous preterm birth changes when cervical ultrasound images are obtained using different…
- Trial name
- NCT07598097
- Testing
- Cervical ultrasound image acquisition
- Where
- Denmark
- Volunteers
- 2,000 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Infant, Premature, Diseases, Bronchopulmonary Dysplasia
Growth of Airways and Lung Tissues in Premature and Healthy Infants
The purpose of this study is to evaluate the growth of the lung and how easily gas can be taken up by the lung in healthy infants born at full term without any breathing problems and infants born prematurely.
- Conditions
- Infant, Premature, Diseases, Bronchopulmonary Dysplasia, Asthma
- Trial name
- NCT00419588
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- Indiana University
Neurodevelopmental Abnormality
Two Year Developmental Follow-up for PREMOD2 Trial (Premature Infants Receiving Milking or Delayed Cord Clamping)
An extension of the PREMOD2 trial, the PREMOD2 Follow-Up trial will evaluate the neurodevelopmental outcomes at 22-26 months corrected age of preterm children who received UCM or DCC.
- Trial name
- PREMOD2FU (NCT03476980)
- Testing
- Randomized to Umbilical Cord Milking at birth, Randomized to Delayed Cord Clamping at birth
- Where
- 18 sites in United States, Canada and 2 more
- Volunteers
- 1,200 people
- Sponsor
- Sharp HealthCare
Preterm, Preterm Infant Development
Nutritional Maturity in Preterm Newborns (Premature Infant Oral Motor Intervention, PIOMI)
Premature Infant Oral Motor Intervention (PIOMI) has been found to improve short-term clinical outcomes in preterm infants and contribute to their feeding skills.
- Trial name
- PIOMI (NCT07894380)
- Testing
- The PIOMI initiative in maternal interaction, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Premature Birth
Therapeutic Effects of Maternal Melatonin Administration on Brain Injury and White Matter Disease
Neurocognitive sequelae observed in preterm represent a major health problem for which there is no preventive treatment approved to date.
- Trial name
- PREMELIP (NCT02395783)
- Testing
- Melatonin 10 µg, Melatonin 20 µg
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bottle Feeding, Premature
A Comparison Study of Feeding Prematures in the Side-lying Position on the Right and Left Side - a Pilot Study.
Methods and techniques to improve the quality and safety of oral feeding in preterm infants are still a significant challenge in modern neonatology.
- Trial name
- NCT04987983
- Testing
- Experimental SLP-R, Experimental SLP-L
- Where
- Poland
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Polish Mother Memorial Hospital Research Institute
Obstetric Labor, Labor Onset
The Prognostic Value of Cervical Elastography for Identifying Patients at Risk for Preterm Delivery
The hypothesis tested is that the physical changes associated with cervical ripening result in a detectable decrease in rigidity.
- Conditions
- Obstetric Labor, Labor Onset, Obstetric Labor, Premature
- Trial name
- ElastoMAP (NCT02021539)
- Testing
- Cervical ultrasound +elastography 1, Vaginal fibronectin measurement, Tocolytic treatment for 2 hours
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Preterm Pregnancy, Labor Induction
Preterm Induction of Labor Timing of Amniotomy: A Randomized Controlled Trial
Artificial rupture of membranes (amniotomy) is a commonly used technique to safely induce and augment labor. It has been shown to reduce the duration of spontaneous and induced labor in term patients (≥37 weeks' gestation).
- Trial name
- PITA (NCT03504670)
- Testing
- Early Amniotomy, Late Amniotomy
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- University of Alabama at Birmingham
Hypoglycemia, Infant, Small for Gestational Age
Dextrose Gel Does Not Prevent Neonatal Hypoglycemia
This was a quasi-experimental pilot study comparing blood glucose values 30 minutes after feeding alone or feeding + dextrose gel in newborns at risk for transient neonatal hypoglycemia.
- Conditions
- Hypoglycemia, Infant, Small for Gestational Age, Premature Birth of Newborn, Fetal Macrosomia
- Trial name
- NCT02523222
- Testing
- 40% Dextrose gel
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Baylor College of Medicine
Respiratory Distress Syndrome in Premature Infant, RDS of Prematurity
Pragmatic Evaluation of Respiratory Distress Syndrome Treatment in Africa
The goal of this pragmatic clinical trial is to learn if the drug surfactant given by a less invasive technique works to treat respiratory distress in preterm infants in low- and middle-income African countries where invasive…
- Conditions
- Respiratory Distress Syndrome in Premature Infant, RDS of Prematurity, Surfactant Deficiency Syndrome Neonatal, Premature Birth
- Trial name
- NCT06554522
- Testing
- Surfactant
- Where
- 8 sites in Central African Republic, Ghana and 2 more
- Volunteers
- 1,512 people
- Sponsor
- Indiana University
Necrotizing Enterocolitis, Digestive System Abnormalities
Brain Manganese Deposition in High Risk Neonates
Excessive exposure to manganese (Mn) results in Mn deposition in the brain causing adverse neurological effects. Sick infants requiring parenteral nutrition (PN) may be at increased risk of Mn neurotoxicity because neonatal PN…
- Conditions
- Necrotizing Enterocolitis, Digestive System Abnormalities, Cholestasis
- Trial name
- NCT00392977
- Testing
- remove Mn from PN if evidence of increased brain Mn on MRI
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Vanderbilt University
Premature, Coronary Artery Disease
Premature Coronary Artery Disease and Familial Dyslipidemia in Patients Presenting With Acute Coronary Syndrome
This study aimed to explore the relationship between familial hypercholesterolemia and premature coronary artery disease, particularly in the context of acute coronary syndrome, by reviewing current evidence and highlighting the…
- Conditions
- Premature, Coronary Artery Disease, Familial Dyslipidemia, Acute Coronary Syndrome
- Trial name
- NCT07267312
- Testing
- Cardiovascular risk assessment
- Where
- Egypt
- Volunteers
- 2,000 people
- Sponsor
- Cairo University
Preterm Birth
Placental Inflammation in Prenatal Care
Objective of study is to explore expression of stress-related genes and inflammation in placentas and umbilical cord blood for women participating in group prenatal care compared with women receiving individual prenatal care.
- Trial name
- PINC (NCT02476656)
- Volunteers
- 40 people
- Sponsor
- Prisma Health-Upstate
Facilitated Tucking, Non Nutritive Sucking
Efficacy of Facilitated Tucking During Pain Procedure in Preterm Infants
Preterm infants undergo very frequent painful procedures during neonatal care particularly during the first few days. The support for the pain of the preterm is a priority for nurses and neonatologists.
- Conditions
- Facilitated Tucking, Non Nutritive Sucking, Preterm, Pain Relief
- Trial name
- BABYDOUL (NCT02096822)
- Testing
- Facilitated tucking + non-nutritive sucking, non-nutritive sucking
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Preterm Labour
Monocyte Chemotactic Protein-1 (MCP-1) Expressing Monocytes to Predict Preterm Delivery: PhenoMAP Study
The threat of preterm labour (PTL) is the first cause of hospitalization in the course of pregnancy. Its diagnostic is based on clinical examination with a positive predictive value of about 40 %.
- Trial name
- PHENOMAP (NCT01340222)
- Testing
- biological samples
- Where
- France
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Preterm Birth
Protein and Ultrasound Indicators of Preterm Birth
Women are being asked to participate in a research study that is looking for new methods to understand and predict premature birth (birth before 37 weeks of pregnancy-full term pregnancy is 40 weeks).
- Trial name
- NCT01412931
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Premature Newborn
Reproducibility of a New Practical Newborn Behavioral Observation Scale
Neonatal intensive care is necessary for the survival of preterm baby. Several studies show the deleterious effect on the immature brain due to stimulations caused by the environment and hospital care.
- Trial name
- NCT02844205
- Testing
- quotation of the newborn behavioral observation scale
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Montpellier
Premature Infant
Efficacy Study of an Audio Device Outside Incubator Allowing Broadcasting Maternal Voice on Stability in Preterm Infants
The study aims to evaluate the impact on the preterm infants' short-term physiological, neurodevelopmental states by employing maternal voice intervention in NICU routine care.
- Trial name
- NCT05543005
- Testing
- maternal voice intervention
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chia-Jung Lin
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