Clinical trials: Preterm Labor, Premature Birth
Preterm, Respiratory Distress Syndrome in Premature Infant
The Hemodynamic Impact of High-frequency Oscillatory Ventilation and Periodic Sighs in Preterm Infants
To evaluate the effectiveness of early lung recruitment using high-frequency oscillatory ventilation (HFOV) alone versus HFOV with superimposed sigh breaths in moderate-to-late preterm infants requiring invasive respiratory…
- Conditions
- Preterm, Respiratory Distress Syndrome in Premature Infant, Recruitment, Mechanical Ventilation
- Trial name
- NCT07896824
- Testing
- Superimposed sigh breaths, High frequency ventilation
- Volunteers
- 100 people
- Sponsor
- Alexandria University
Neonatal Infection, Invasive Fungal Infections
Micafungin Versus Amphotercine B in Treatment of Invasive Fungal Infection
The incidence of fungal infection has increased dramatically over the past few decades.This is due to increase in survival rates of preterm neonates, advances in medical technology and drug therapy, broad spectrum antibiotics and…
- Trial name
- NCT06413056
- Testing
- Micafungin, Amphotericin B
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Ain Shams University
Placenta Previa
Vaginal Pessary Versus Expectant Management for Placenta Previa
The purpose of this study is to perform a large multi-center randomized trial comparing the role of vaginal pessary versus expectant management in women with placenta previa between 22w0d and 32w0d of gestation in prolonging…
- Trial name
- NCT01996345
- Testing
- Cervical Pessary Placement
- Where
- 10 sites in United States
- Volunteers
- 17 people
- Sponsor
- Pediatrix
Premature Birth
Single-center Retrospective Study : Developmental Trajectories of Children Born Prematurely Before 32 Weeks Assessed With the Revised Brunet Lézine Scale at 1, 2 and 3 Years
This study will assess professionals in the CHI Créteil neonatal department and the Val de Marne perinatal network to gain a better understanding of the developmental trajectories of children hospitalized at the CHI Créteil, with…
- Trial name
- NCT06731686
- Testing
- Retrospective study
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Transient Tachypnea of the Newborn
Fluid Management in Transient Tachypnea of the Newborn
Transient tachypnea of the newborn (TTN) is a diagnosis given to infants born between 34 and 42 weeks gestation who develop difficulty breathing during the first days of life when no specific cause of the breathing difficulty can…
- Trial name
- NCT01225029
- Testing
- Amount of total fluids
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Preterm, Bonding
Effectiveness of Bonding-Based Education Intervention
The study aimed to determine the impact of the Father-Preterm Newborn Bonding Programme (B-PreBAP) on fathers' parenting behaviours, stress levels, and support needs.
- Trial name
- NCT06186453
- Testing
- Father-Preterm Newborn Bonding Program
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Infant, Newborn, Infant, Small for Gestational Age
Vitamin E for Extremely Preterm Infants
The purpose of this pilot trial is to test the safety and efficacy of administering one dose of vitamin E, via a tube into the stomach, to extremely preterm infants (less than 27 weeks gestation and less than 1000 grams birth…
- Conditions
- Infant, Newborn, Infant, Small for Gestational Age, Infant, Very Low Birth Weight, Infant, Premature
- Trial name
- NCT01193270
- Testing
- Vitamin E
- Where
- 16 sites in United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Preterm Birth, Sensory Processing Disorder
Sensory Processing Associated With Motor Skills
In the study, sensory processing skills of 1-year-old preterm and term children will be evaluated. The relationship between sensory processing skills and gross and fine motor development will be investigated.
- Conditions
- Preterm Birth, Sensory Processing Disorder, Motor Delay
- Trial name
- NCT06216379
- Testing
- Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people
- Sponsor
- Gazi University
Preterm
Automated Versus Manual Oxygen Control in Preterm Babies on Respiratory Support
Babies admitted in the NICU (neonatal intensive care unit) frequently need supplemental oxygen to keep their oxygen saturation (SpO2) in target range (TR).
- Trial name
- NCT06622161
- Testing
- automated oxygen vs manual oxygen
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Aga Khan University Hospital, Pakistan
Attention-deficit, Prematurity
Early Childhood Attention Battery in Preterm Children
The aims of this project are: 1. To explore, using the ECAB, if and in which measure the attentional abilities of young preterm children are different from term peers, whom reference data are already published27. 2.
- Trial name
- NCT05843266
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Intraventricular Hemorrhage, Premature Birth
Intranasal Fresh Mother's Own Milk to Prevent Intraventricular Hemorrhage in Extremely Preterm Infants
Babies born very prematurely are at risk of intraventricular hemorrhage (IVH), which is bleeding in or around the fluid-filled spaces of the brain. Most IVH occurs during the first week after birth.
- Trial name
- iF-MOM-IVH (NCT07812922)
- Testing
- Intranasal Fresh Mother's Own Milk (iF-MOM)
- Volunteers
- 67 people
- Sponsor
- University of Manitoba
Feeding Intolerance in Preterm, Intestinal Permeability in Preterm
Influence of Bovine Lactoferrin on Feeding Intolerance and Intestinal Permeability in Preterm Neonates
Preterm infants are at increased risk of developing feeding intolerance due to functional immaturity of their gastrointestinal tract and may lead to discontinuation of enterak feeding.
- Trial name
- NCT04738058
- Testing
- Bovine Lactoferrin Supplement
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University Children Hospital
Asthma, Diabetes Mellitus
Coordinated HEalthcare for Complex Kids
The University of Illinois Health and Health Sciences System (UI Health) developed an integrated care management quality improvement model designed to provide comprehensive care coordination for Medicaid insured minority children…
- Conditions
- Asthma, Diabetes Mellitus, Sickle Cell Disease, Premature Birth
- Trial name
- CHECK (NCT04057521)
- Testing
- Care Coordination
- Volunteers
- 6,259 people
- Sponsor
- University of Illinois Chicago
Bronchopulmonary Dysplasia
Comparison of Classification Standards of Bronchopulmonary Dysplasia (BPD) in Premature Infants
Bronchopulmonary dysplasia of premature infants is a common respiratory disease in premature infants. Long-term complications such as recurrent respiratory infection and abnormal lung function may occur in the survivors, and may…
- Trial name
- NCT04184648
- Testing
- no interventions
- Where
- China
- Volunteers
- 322 people
- Sponsor
- Wang Jianhui
Preterm Birth
PremCry Study : Study of Ontogeny of Crying in Preterm Infants.
Crying is a survival mechanism for babies and their almost exclusive means of expression until the age of 4 months. Babies 'cry is mostly related to pain, a feeling of hunger, discomfort or separation following the departure of a…
- Trial name
- PremCry (NCT04522414)
- Testing
- cries longitudinally registered
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Preterm
Efficacy of a Video-based, Parent-centered Home Developmental Intervention for Infants at High Risk for Developmental Delay: a Multicenter Randomized Controlled Trial
The purpose of this study is to determine whether the Motor Composite Score on the Bayley-III (administered at 6 months of corrected age) shows significant improvement in an intervention group-receiving usual care combined with a…
- Trial name
- NCT07882199
- Testing
- Family-centered developmental training intervention
- Volunteers
- 170 people
- Sponsor
- Seoul National University Hospital
Infant, Premature
Respiratory Dynamics During Birth Stabilization in Preterm Infants Less Than 32+6/7 Weeks Gestation
Approximately 50% of preterm infants less than 32 weeks require respiratory assistance at the time of transition at birth. For that stabilization during resuscitation is successful, it is essential for proper ventilation.
- Trial name
- NCT02748720
- Testing
- RFM (device) Visible
- Where
- Spain
- Volunteers
- 126 people
- Sponsor
- Manuel Sanchez Luna
Preterm Birth
Trial of the Use of Antenatal Corticosteroids in Developing Countries
Multi-country two-arm, parallel cluster randomized controlled trial to reduce neonatal mortality through increasing the rate of antenatal corticosteroid administration to eligible women.
- Trial name
- ACT (NCT01084096)
- Testing
- Increasing use of Antenatal Corticosteroids (ACS)
- Where
- 7 sites in Argentina, Guatemala and 4 more
- Volunteers
- 103,117 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Obstetric Labor, Premature
Randomized Controlled Trial of Vaginal Progesterone in Women With Threatened Preterm Labor
Prematurity remains the most important single factor in perinatal morbidity and mortality. Unfortunately, the rate of premature delivery is increasing in Canada and is especially high in Alberta with 7.5% of pregnancies ending…
- Trial name
- PROTO (NCT01286246)
- Testing
- Vaginal progesterone
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- University of Calgary
Heart Rate Variability, Preterm Infant
Skin to Skin and Heart Rate Variability
The objective of this study is to monitor heart rate variability in preterm infants receiving respiratory support, including conventional mechanical ventilation, during skin-to-skin care.
- Trial name
- NCT05018910
- Testing
- Skin to Skin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of New Mexico
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