Clinical trials: Preterm Preeclampsia
Hypertension in Pregnancy
Docosahexaenoic Acid Supplementation of Women With Hypertension in Pregnancy to Improve Endothelial Health
The Investigator would like to see if taking a DHA supplement at a dose recommended for heart health will improve brachial artery dilation (relaxation) and help blood pressure.
- Trial name
- DHA-2 (NCT02137408)
- Testing
- Docosahexaenoic acid 200 mg, Docosahexaenoic acid 1000 mg
- Where
- United States
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Pregnancy Complications, Endothelial Dysfunction
Oxidative Stress and Endothelial Function in Pregnancy Complications
Pregnancy complications like pre-eclampsia (PE), pregnancy induced hypertension (PIH), intra-uterine growth restriction (IUGR) and preterm labor (PTL), (i.e.
- Trial name
- ENDOPREG (NCT02603913)
- Where
- Belgium
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Threatened Abortion, Pre-Eclampsia
Progesterone for First Trimester Vaginal Bleeding
The purpose of this study is to investigate whether treatment with progesterone for patients with first trimester vaginal bleeding will alter the rates of obstetrical complications and adverse pregnancy outcomes.
- Conditions
- Threatened Abortion, Pre-Eclampsia, Abruptio Placentae, Fetal Growth Retardation
- Trial name
- NCT01501890
- Testing
- dihydroxyprogesterone caproate
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Preeclampsia
Proof-of-Concept Trial on Selective Removal of sFlt-1 in Pregnant Women With Preeclampsia Via Apheresis
This clinical investigation is a medical device trial to examine the safety and efficacy of TheraSorb sFlt-1 adsorber treatment of pregnant patients with preeclampsia.
- Trial name
- SAVE (NCT02923206)
- Testing
- TheraSorb sFlt-1 adsorber
- Where
- 4 sites in Germany, United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Miltenyi Biomedicine GmbH
Preeclampsia, Severe Preeclampsia
Pre-Eclampsia And Growth Restriction: a Longitudinal Study
Preeclampsia may have several causes leading to different characteristics of the pathology. Differentiation between the "type of preeclampsia" would help to treat patients more accurately.
- Conditions
- Preeclampsia, Severe Preeclampsia, Fetal Growth Restriction, Preterm Birth
- Trial name
- PEARL (NCT02379832)
- Where
- Canada
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Cardiovascular Diseases, Diabetes
Fit After Baby: Increasing Postpartum Weight Loss in Women at Increased Risk for Cardiometabolic Disease
This study plans to learn more about how to increase postpartum weight loss and how to decrease risk factors for postpartum women at increased risk for diabetes and heart disease.
- Conditions
- Cardiovascular Diseases, Diabetes, Gestational Diabetes, Preeclampsia
- Trial name
- FAB (NCT03215173)
- Testing
- Fit After Baby, Text4Baby Control Group
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Heart Failure With Preserved Ejection Fraction (HFPEF)
Association of Heterogeneous Circulating Biomarkers and Anamnestic Factors of Pregnancy Adverse Course and Outcomes With the Prognosis of Heart Failure With Preserved Ejection Fraction
The primary purpose of this study is to evaluate possible association of some heterogeneous circulating biomarkers and anamnestic factors of pregnancy adverse course and outcomes with the prognosis of heart failure with preserved…
- Trial name
- CARPO-HF (NCT06803849)
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Hypertensive Disorder of Pregnancy, Premature Preterm Rupture of Membranes
HOME: Home Monitoring of High-risk Pregnancies
High-risk pregnancies often require long-term hospitalization or outpatient maternal and/or fetal monitoring, placing a burden on patients, hospital resources and society.
- Conditions
- Hypertensive Disorder of Pregnancy, Premature Preterm Rupture of Membranes, Preeclampsia, High Risk Pregnancy
- Trial name
- NCT05763069
- Testing
- Home surveillance of pregnancies at risk
- Where
- Norway
- Volunteers
- 250 people
- Sponsor
- Oslo University Hospital
Preterm Birth Complication, Preterm Birth
Personalized Care for Prenatal Stress Reduction & Prevention of Preterm Birth (PTB) Disparities
The goal of this clinical trial is to learn if a personalized prenatal support program [(Personalized Toolkit Building a Comprehensive Approach to Resource optimization and Empowerment in Pregnancy \& Beyond, (PTBCARE+)] works to…
- Conditions
- Preterm Birth Complication, Preterm Birth, Preterm Birth Recurrence, Preeclampsia
- Trial name
- PTBCARE+ (NCT06915428)
- Testing
- Care coordination, Electronic massage, support gift #1
- Where
- United States
- Volunteers
- 1,228 people
- Sponsor
- University of North Carolina, Chapel Hill
Polycystic Ovary Syndrome
Metformin in Pregnant PCOS Women
To investigate the effect of metformin on pregnancy complications and pregnancy outcome in the II. and III. trimester of pregnancy in women with polycystic ovary syndrome.
- Trial name
- PregMet (NCT00159536)
- Testing
- Metformin
- Where
- 10 sites in Norway
- Volunteers
- 257 people
- Sponsor
- Norwegian University of Science and Technology
Preeclampsia, Labor, Premature
Use of Nitrous Oxide Donor for Labor Induction in Women With PreEclampsia
A randomized controlled trial (RCT) of nitric-oxide donor (NOD) isosorbide mononitrate (IMN) versus placebo as an adjuvant to misoprostol/ intra-cervical Foley bulb for induction of labor to decrease rate of cesarean deliveries…
- Trial name
- NOPE (NCT03171480)
- Testing
- Monoket Pill
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Ohio State University
Pre-Eclampsia
L-Arginine and Antioxidant Vitamins During Pregnancy to Reduce Preeclampsia
This study is intended to assess the efficacy of L-arginine supplementation with antioxidant vitamins delivered in a medical food in reducing the incidence of preeclampsia in a high-risk population.
- Trial name
- L-Arg (NCT00469846)
- Testing
- L-arginine supplementation in a medical food, Vitamin C and E supplementation in a medical food
- Where
- 2 sites in United States, Mexico
- Volunteers
- 585 people
- Sponsor
- Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes
Preeclampsia
Pharmacokinetics, Safety and Efficacy Study of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia
The purpose of the study is to assess the efficacy, safety and pharmacokinetics (PK) of recombinant human antithrombin (ATryn) in addition to expectant management for the treatment of preterm preeclampsia (PPE).
- Trial name
- PRESERVE-1 (NCT02059135)
- Testing
- Recombinant human antithrombin (ATryn), Normal Saline 0.9%
- Where
- 23 sites in United States
- Volunteers
- 120 people
- Sponsor
- rEVO Biologics
Hypertensive Disorder of Pregnancy, Preeclampsia
Blood Pressure Goal in Preterm Preeclampsia
The purpose of this study is to compare latency (prolongation of pregnancy from diagnosis till delivery) in patients with hypertensive disorders of pregnancy (HDP) with severe features < 34 weeks gestational age (GA), undergoing…
- Trial name
- NCT07894705
- Testing
- Treating BP acutely with intravenous or rapid acting oral medications
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Ohio State University
Preterm Birth, PPROM
Antenatal Breastmilk Expression in Pregnant Women at High Risk of Preterm Birth
In this randomized controlled study, the investigators aim to examine if antenatal breastmilk expression (aBME) from week 28 in high-risk pregnancies is a safe and effective method to ensure early access to mother's own milk.
- Conditions
- Preterm Birth, PPROM, Preeclampsia, Previous Preterm Birth
- Trial name
- EXPRESSMOM2 (NCT07191366)
- Testing
- Handstimulation of breast
- Volunteers
- 250 people
- Sponsor
- Odense University Hospital
Preeclampsia, Preterm Birth
Prediction of Preeclampsia and Other Pregnancy Complications Following Combined Iterative Screening
Preterm birth (PTB), preeclampsia (PE), fetal growth restriction (FGR) and intra-uterine fetal death (IUFD) constitutes the main causes of perinatal morbidity and mortality and are called "Great Obstetrical Syndromes".
- Conditions
- Preeclampsia, Preterm Birth, Fetal Growth Restriction, Intra Uterine Fetal Death
- Trial name
- PREDICTION2 (NCT03067298)
- Where
- Canada
- Volunteers
- 805 people, healthy volunteers welcome
- Sponsor
- Emmanuel Bujold
Preterm Birth, Preeclampsia
Selected Immunological Indicators and Microbiota in Patients With Premature Birth and Preeclampsia
The goal is to demonstrate the relationship of the circulating pool of T-regulatory lymphocytes in the mother's peripheral blood with populations in the placentas and to compare with controls, what is the difference in the…
- Trial name
- PRIME (NCT06281262)
- Testing
- Peripheral blood collection, Swab sample collection
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- General University Hospital, Prague
Preeclampsia, Preterm Birth
The Effect of Prematurity and Hypertensive Disorders of Pregnancy on Offspring Cardiovascular Health
The purpose of this study is to investigate whether exposure to hypertensive disorders of pregnancy and/or a preterm birth results in alterations in the cardiovascular system during infancy.
- Trial name
- EPOCH (NCT01888770)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- University of Oxford
Pre-Eclampsia, Premature Birth
PREPARE, Prematurity Reduction by Pre-eclampsia Care
Investigators will test a novel system of integrated care, to promote the use of the WORLD HEALTH ORGANIZATION Guidelines for the management of pre-eclampsia and initiate the use of a structured risk assessment strategy to reduce…
- Trial name
- PREPARE (NCT03073317)
- Testing
- FullPIERS and sFlit/PLGF (Soluble fms-Like Tyrosine Kinase-1-to-Placental Growth Factor Ratio)
- Where
- 8 sites in Brazil
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Instituto Fernandes Figueira
Preeclampsia, Preterm Birth
Biobank on Prematurity, Preeclampsia and Other Pregnancy Complications
The Biobank includes data and biological specimens of women from three original studies: 1) First-trimester Prediction of Preeclampsia (PREDICTION Study, NCT02189148), 2) Pre-Eclampsia And growth Retardation, an evaluative…
- Conditions
- Preeclampsia, Preterm Birth, Pregnancy Complications, Fetal Anomalies
- Trial name
- NCT02744365
- Testing
- Observational
- Where
- Canada
- Volunteers
- 7,845 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval