Clinical trials: Preterm Premature Rupture of Membranes (PPROM)
Preterm Premature Rupture of the Membranes
Antibiotics Study in Preterm Premature Rupture of the Membranes
The purpose of this study is to compare the efficacy on maternal infection, chorioamnionitis and neonatal morbidity and mortality, and to review the evidence and provide recommendations on the use of antibiotics in PPROM.
- Trial name
- PPROM (NCT01401179)
- Testing
- cefazolin, erythromycin, clarithromycin
- Where
- South Korea
- Volunteers
- 101 people
- Sponsor
- Samsung Medical Center
Preterm Premature Rupture of Membrane
Vaginal Cleansing With Chlorhexidine Gluconate in Women With Preterm Pre-labor Rupture of Membranes
Randomized controlled trial studying the use of vaginal cleansing with chlorhexidine gluconate for pregnant women with PPROM (preterm pre labor rupture of membranes). The primary outcome will be pregnancy latency.
- Trial name
- NCT04516226
- Testing
- Vaginal cleansing with chlorhexidine gluconate solution
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Albany Medical College
Preterm Premature Rupture of Membranes
PPROM Erythromycin Versus Azithromycin
Preterm Premature Rupture of Membranes (PPROM) is treated with an antibiotic, erythromycin or azithromycin, to prolong pregnancy.
- Trial name
- PEACE (NCT01431248)
- Volunteers
- 7 people
- Sponsor
- University of Oklahoma
PPROM, Preterm
Preterm Rupture of Membranes Optimising Antibiotics Trial
The goal of this clinical trial is to learn which antibiotic regimen works best to prevent infection in pregnant women whose waters break early (preterm, pre-labour rupture of membranes, or PPROM) and assess the health outcomes…
- Trial name
- PROMOAT (NCT06906757)
- Testing
- Erythromycin 250mg and Amoxicillin 500mg
- Volunteers
- 3,900 people
- Sponsor
- University of Melbourne
Rupture of Membranes; Delayed Delivery (Following Spontaneous Rupture), Rupture of Membranes; Premature
Latency Antibiotics in Previable PPROM, 18 0/7- 22 6/7 WGA
This study is a non-blinded, prospective, randomized controlled trial designed to compare the effect of outpatient oral antibiotics (i.e., amoxicillin and azithromycin) on the length of time (days) that pregnancy continues after…
- Conditions
- Rupture of Membranes; Delayed Delivery (Following Spontaneous Rupture), Rupture of Membranes; Premature, Rupture of Membranes; Premature, Affecting Fetus, Preterm Birth
- Trial name
- NCT04047849
- Testing
- Antibiotics, oral Azithromycin and oral Amoxicillin
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Woman's
Preterm Premature Rupture of Membrane
Tocolysis in the Management of Preterm Premature Rupture of Membranes Before 34 Weeks of Gestation
The purpose of this study is to assess whether short-term (48 hr) tocolysis reduces perinatal morti-morbidity in cases of PPROM at 22 to 33 completed weeks' gestation.
- Trial name
- TOCOPROM (NCT03976063)
- Testing
- Nifedipine
- Where
- France
- Volunteers
- 857 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pregnancy Complications
Progesterone for the Management of Preterm, Premature Rupture of the Membranes: A Randomized Controlled Trial.
Preterm birth is the leading cause of neonatal death and a significant cause of life long disability and health problems. It has been shown that the drug 17-hydroxyprogesterone caproate can help reduce the risk of preterm…
- Trial name
- NCT01050647
- Testing
- 17-Hydroxyprogesterone Caproate, Caster Oil injections
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Stanford University
Preterm Premature Rupture of Membranes
Melatonin, Soluble Urokinase-type Plasminogen Activator Receptor, and Orosomucoid 2 Levels in PPROM
Introduction: To evaluate the maternal blood serum melatonin, soluble urokinase-type plasminogen activator receptor, and orosomucoid 2 levels in pregnant women complicated by preterm premature rupture of membranes (PPROM) and to…
- Trial name
- melatonin&PROM (NCT04588220)
- Testing
- Obstetric ultrasound and fetal-maternal assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Cengiz Gokcek Women's and Children's Hospital
Preterm Rupture of Membranes
Identification of Microbial DNA in Maternal Plasma After PPROM
This study evaluates the use of metagenomic next generation sequencing in identifying microbial DNA in plasma samples of patients with preterm premature rupture of membranes.
- Trial name
- NCT04318470
- Testing
- mNGS
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Preterm Premature Rupture of Membranes (PPROM)
TAILORED Therapeutic Regime in Patients With Preterm Premature Rupture Of Membranes to Prolong Pregnancy, Improve Maternal and Neonatal Outcomes, and Reduce Antibiotic Burden
The goal of this clinical trial is to learn whether tailoring antibiotic and steroid treatment based on a lab result (interleukin-6, or IL-6) from amniotic fluid can help safely prolong pregnancy in people with preterm premature…
- Trial name
- TAILORED-PROM (NCT07107477)
- Testing
- Tailored antibiotic and steroid therapy based on the IL-6 value in amniotic fluid obtained by amniocentesis in patients with premature rupture of membranes, Antenatal steroids administration, Neuroprotection
- Where
- 3 sites in Czechia
- Volunteers
- 138 people
- Sponsor
- The Central and Eastern European Gynecologic Oncology Group
Preterm Premature Rupture of Membranes, Fetal Inflammatory Response Syndrome
Multimodal Monitoring of Fetal Risk of Inflammation in Preterm Premature Rupture of Membranes
The purpose of this study is to examine whether the value of vaginal fluid cytokine levels as well as computerized fetal ECG analysis are suitable clinical parameters to detect an imminent intra-amniotic inflammation with a high…
- Conditions
- Preterm Premature Rupture of Membranes, Fetal Inflammatory Response Syndrome, Early Onset Neonatal Sepsis, Infection of Amniotic Cavity
- Trial name
- MuMFI-PPROM (NCT02702297)
- Testing
- single arm
- Where
- 4 sites in Germany
- Volunteers
- 57 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Labor, Premature, Preterm Premature Rupture of the Membranes
N-acetylcysteine in Intra-amniotic Infection/Inflammation
The aim of the study is to determine if N-acetylcysteine (a potent free radical scavenger) prevents the occurrence of adverse neonatal outcomes in preterm deliveries complicated by infection associated with preterm labor or…
- Conditions
- Labor, Premature, Preterm Premature Rupture of the Membranes, Infection, Inflammation
- Trial name
- NCT00397735
- Testing
- amniocentesis
- Where
- 2 sites in United States
- Volunteers
- 68 people
- Sponsor
- Ohio State University
Premature Rupture of Membrane, Amniotic Fluid Leakage
The Impact of Amniotic Fluid Index (AFI) on Maternal and Perinatal Outcomes in Pregnant Women With Preterm Premature Rupture of Membranes
Pregnant women who admitted with the complaint of amniotic fluid leakage between the gestational ages of 23+0 and 33+0 and who finally were diagnosed as PPROM were included in the study.
- Conditions
- Premature Rupture of Membrane, Amniotic Fluid Leakage, Maternal Complication of Pregnancy, Fetal Complications
- Trial name
- AFI in PPROM (NCT04100252)
- Testing
- AFI via transabdominal ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Istanbul Medeniyet University
Preterm Premature Rupture of Membranes
Matrix Metalloproteinase 14, Neopterin, and Orosomucoid 1 Levels in PPROM
Introduction: To evaluate the maternal blood serum matrix metalloproteinase 14, neopterin, and orosomucoid 1 levels in pregnant women complicated by preterm premature rupture of membranes (PPROM) and to compare the results with…
- Trial name
- MMP-14&PPROM (NCT04532021)
- Testing
- matrix metalloproteinase 14, neopterin, and orosomucoid 1 measurements
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Cengiz Gokcek Women's and Children's Hospital
Preterm Parturation, Preterm Premature Rupture of Membranes (PPROM)
Preterm Parturation Study
In this study (study group) non-invasively measured fetal parameters in pregnant patients with preterm premature rupture of membranes (PPROM) or preterm parturation (cervical dilation before 37+0 weeks of gestation) will be…
- Trial name
- PrePart (NCT07869160)
- Testing
- Fetal ultrasound, blood draw, vaginal swab
- Where
- Austria
- Volunteers
- 300 people
- Sponsor
- Medical University of Graz
PPROM
Pomegranate to Reduce Maternal and Fetal Oxidative Stress and to Improve Outcome in Pregnancies Complicated With Preterm Premature Rupture of Membranes
Preterm premature rupture of membrane is associated with increased oxidative stress and inflammatory process, enhancing the activity or the availability of antioxidants may modulate the inflammatory response associated with…
- Trial name
- NCT02069587
- Testing
- pomegranate
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Hillel Yaffe Medical Center
Preterm Birth, Preterm Premature Rupture of Membrane
Cerclage After Full Dilatation Caesarean Section
CRAFT-OBS: Observational Study; To evaluate subsequent pregnancy risk of preterm birth in women with a history of previous caesarean in established labour.
- Conditions
- Preterm Birth, Preterm Premature Rupture of Membrane, Preterm Spontaneous Labor With Preterm Delivery
- Trial name
- CRAFT (NCT04110704)
- Testing
- Insertion of transvaginal cerclage
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Preterm Premature Rupture of Membranes (PPROM), Prophylaxis
Effects of Different Antibiotic Regimens in Preterm Premature Rupture of Membranes
To investigate the effects of different antibiotic regimens used in preterm premature rupture of membranes (PPROM) on maternal and fetal outcomes after 34 weeks of gestation.
- Conditions
- Preterm Premature Rupture of Membranes (PPROM), Prophylaxis, Perinatal Outcomes
- Trial name
- NCT07148622
- Testing
- Antibiotic regimen 1: sulbactam + ampicillin + azithromycin, Antibiotic regimen 2: ceftriaxone + clarithromycin + amoxicillin
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Yuzuncu Yil University
Vaginal Infections, Bacterial Vaginosis
Va-Sense - Bacterial Vaginosis Once A Week Screening And Treatment To Reduce Infective Complications, Abortion And Preterm Delivery In Pregnant Women With Previous Preterm Delivery
The purpose of this study is to determine whether screening of pregnant women with history of previous preterm delivery, once a week, for bacterial vaginosis using VA-SENSE, and treatment of positive women will reduce the risk of…
- Conditions
- Vaginal Infections, Bacterial Vaginosis, Late Miscarriage, Preterm Birth
- Trial name
- NCT01152528
- Testing
- VA-SENSE
- Where
- Israel
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- Common Sense
Preterm PROM (Pregnancy)
Oxytocin/Foley vs. Oxytocin for Induction in Patients With PPROM
Data on the optimal mode of labor induction after preterm prelabor rupture of membranes (PPROM) is lacking. Studies have shown no difference between oxytocin and misoprostol use for labor induction in this cohort (1).
- Trial name
- NCT07119398
- Testing
- Oxytocin plus Foley Catheter, Oxytocin
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Eastern Virginia Medical School