Clinical trials: Preterm Premature Rupture of Membranes (PPROM)
Rupture of Fetal Membranes
Clinical Evaluation of the AmniSure ROM Test
To show that having less qualified personnel (non-Laboratory trained professionals) perform the test yields the same result as if a Laboratory trained professional performed the test.
- Trial name
- NCT01847820
- Testing
- AmniSure ROM test
- Where
- 4 sites in United States
- Volunteers
- 383 people
- Sponsor
- QIAGEN Gaithersburg, Inc
Preterm Birth, Low Birth Weight
Perinatal Conditions Influencing Morbidity, Mortality, and Medical Care in Newborns
This study focuses on understanding the conditions that affect newborn health and survival from pregnancy to the first weeks of life at the Isidro Ayora Hospital.
- Conditions
- Preterm Birth, Low Birth Weight, Intrauterine Growth Restriction (IUGR), Perinatal Asphyxia
- Trial name
- UCE (NCT06653374)
- Testing
- Infant, Premature
- Where
- Ecuador
- Volunteers
- 26,000 people
- Sponsor
- HOSPITAL GINECO OBSTETRICO ISIDRO AYORA
Preterm Premature Rupture of Membranes (PPROM)
Treatment of ppROM With Erythromycin vs. Azithromycin Trial
Preterm premature rupture of membranes (PPROM) complicates 4% of pregnancies annually. This pregnancy complication is a major contributor to preterm births and results in neonatal morbidity and mortality.
- Trial name
- TREAT (NCT03060473)
- Testing
- Azithromycin, Erythromycin, Ampicillin
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Preterm Premature Rupture of Membranes
The Relation Between Serum Ascorbic Acid Concentration and Preterm Premature Rupture of Membranes
To study the association between maternal serum vitamin C concentration in women with preterm premature rupture of membranes (PPROM) and women without PPROM.
- Trial name
- NCT02635451
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Pregnancy, HELLP Syndrome
Pancreatic Stone Protein (PSP) in Pregnant Women
This prospective, single centred cohort study evaluates the physiological course of the potentially novel biomarker PSP in pregnant women as well as its predictive role in the development of inflammatory complications during…
- Conditions
- Pregnancy, HELLP Syndrome, Preterm Premature Rupture of Fetal Membranes, Preeclampsia
- Trial name
- NCT02247297
- Testing
- Blood collection
- Where
- Switzerland
- Volunteers
- 486 people
- Sponsor
- Nicole Ochsenbein
Fetal Membranes, Premature Rupture, Preterm Premature Rupture of the Membranes
PPROM Registry (Preterm Premature Rupture of Membranes)
Preterm Premature Rupture of Membranes (PPROM) before 37 weeks of pregnancy is responsible for 40% of preterm births in the United States.
- Conditions
- Fetal Membranes, Premature Rupture, Preterm Premature Rupture of the Membranes, Oligohydramnios, Premature Birth
- Trial name
- NCT02997345
- Testing
- There is no intervention associated with this study.
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- American Alliance for pProm Support
Premature Rupture of Membrane
Fetal and Maternal Outcome in Preterm Premature Rupture of Membranes (PPROM)
The aim of this study is to compare fetal and maternal outcome in cases of PPROM before 34 weeks versus after 34 weeks.
- Trial name
- NCT03491826
- Testing
- rupture of membrane
- Where
- Egypt
- Volunteers
- 1,011 people
- Sponsor
- sarah mohamed hassan
Preterm Premature Rupture of Fetal Membranes
Core-temperature Monitoring in Patients With PPROM
The most common reason for preterm prelabor rupture of membrane (PPROM) is an ascendance of infection. Moreover PPROM is one of the main risk factors for chorioamnionitis.
- Trial name
- NCT02125708
- Testing
- OvulaRing®
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Preterm Labor, Preterm Birth
MIRACLE of LIFE Study
The goal of this observational study is to develop and validate cell-free RNA-based biomarkers for predicting a variety of adverse pregnancy outcomes in a pregnant person population. The main question it aims to answer are: 1.
- Conditions
- Preterm Labor, Preterm Birth, Preterm Birth Complication, Preterm Premature Rupture of Membrane
- Trial name
- MoL (NCT06074601)
- Testing
- Mirvie Predictive Test for Adverse Pregnancy Outcomes
- Where
- 10 sites in United States
- Volunteers
- 10,000 people
- Sponsor
- Mirvie
PROM, Preterm (Pregnancy)
Novel Use of Central Venous Pressure (CVP) Set With McDonald Cerclage Technique for Amnioinfusion in Preterm Premature Rupture of Membranes Improves Amniotic Fluid Index and Neonatal Outcomes
This prospective, two-arm, non-randomized comparative interventional study evaluated the effectiveness of amnioinfusion using a central venous pressure (CVP) set compared with conventional transabdominal amnioinfusion in pregnant…
- Trial name
- CAM-PPROM (NCT07774832)
- Testing
- CVP-Set Amnioinfusion With McDonald Cerclage, Conventional transabdominal amnioinfusion
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Herlambang Herlambang
Pregnancy, Pre-term Premature Rupture of Membranes
Preterm Premature Rupture of Membranes (PPROM): Bed Rest Versus Activity Trial
The objective of this study is to determine, through a randomized clinical trial, whether bed rest is helpful for the management of pregnancies complicated by preterm premature rupture of membranes (PPROM).
- Trial name
- BRAT (NCT01544387)
- Testing
- Bed Rest, Activity
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Preterm Birth, Preterm Premature Rupture of Membrane
Amniochorionic Membrane Cells in the Maternal Blood as a Biomarker for Preterm Birth
Globally, preterm birth (15 mill. per year) is the leading cause of under-5 child mortality (1 mill. per year) and morbidity. Important pathways include preterm labor contractions, Preterm Prelabor Rupture of the Fetal Membranes…
- Conditions
- Preterm Birth, Preterm Premature Rupture of Membrane, Preterm Labor
- Trial name
- NCT04705935
- Where
- Denmark
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Preterm Birth, PPROM
Antenatal Breastmilk Expression in Pregnant Women at High Risk of Preterm Birth
In this randomized controlled study, the investigators aim to examine if antenatal breastmilk expression (aBME) from week 28 in high-risk pregnancies is a safe and effective method to ensure early access to mother's own milk.
- Conditions
- Preterm Birth, PPROM, Preeclampsia, Previous Preterm Birth
- Trial name
- EXPRESSMOM2 (NCT07191366)
- Testing
- Handstimulation of breast
- Volunteers
- 250 people
- Sponsor
- Odense University Hospital
Fetal Membranes, Premature Rupture
Early Detection of Chorioamnionitis in Preterm Premature Rupture of Membranes
All included patients will have their fetal heart rate recording performed with an EDAN F3 fetal monitor that allowed the back up recording of the fetal heart rate beat to beat detection.
- Trial name
- AiRPM (NCT02901795)
- Where
- 4 sites in France
- Volunteers
- 120 people
- Sponsor
- Rennes University Hospital
Preterm Premature Rupture of Membrane
The Psychological Experience of Pathological Pregnancy. Study of the Case of Premature Rupture of Membranes and Evaluation of the Impact of Hypnosis Support
This research investigates the impact of a hypnosis-based intervention in alleviating state anxiety in Preterm Premature Rupture of Membranes (PPROM).
- Trial name
- HYPNOPROM (NCT05353153)
- Testing
- hypnosis, standart care
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Lille
Preterm Premature Rupture of the Membranes, Physical Activity
A Comparison of Bed Rest Versus Moderate Activity in Preterm Premature Rupture of Membranes (PPROM)
Bed rest has been a commonly prescribed intervention for high risk pregnancies, despite the lack of data to support its benefits, and increasing evidence pointing to potential harms.
- Trial name
- PACT (NCT02327637)
- Testing
- Moderate Activity
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of California, San Diego
Fetal Membranes, Premature Rupture
Removal Versus Retention of Cerclage in Preterm Premature Rupture of Membranes (PPROM)
The purpose of this study is to determine whether retention of cervical cerclage after PPROM improves latency (without a significant increase in chorioamnionitis) and lessens neonatal morbidity.
- Trial name
- PROMCerclage (NCT00201656)
- Testing
- Retention of Cerclage, Removal of Cerclage, Removal vs. Retention of Cervical Cerclage
- Where
- 23 sites in United States
- Volunteers
- 58 people
- Sponsor
- Obstetrix Medical Group
Preterm Premature Rupture of Membrane
Duration of Antibiotics Treatment With Cefazolin and Clarithromycin in Women With Preterm Premature Rupture of Membrane
The purpose of this study is to compare the neonatal outcome and infant neurologic outcome whose mother were treated with cefazolin plus clarithromycin for one week or until delivery after preterm premature rupture of membrane.
- Trial name
- NCT01503606
- Testing
- Cefazolin, Clarithromycin
- Where
- South Korea
- Volunteers
- 151 people
- Sponsor
- Samsung Medical Center
PPROM
Pro-omega-3, Reduction of Inflammation and Modulation of Prematurity
The aim of the project is to decrease the inflammatory status of pregnant women with preterm premature rupture of membranes to delay the initiation of labour that would inevitably lead to premature delivery.
- Trial name
- Pro-MEGA (NCT03739463)
- Testing
- MAG-DHA, Oleic acid
- Volunteers
- 70 people
- Sponsor
- Université de Sherbrooke
Preterm Premature Rupture of Membrane, Placenta Diseases
Biochemical and Histological Changes in Pregnant Women With Preterm Premature Rupture of Membrane
Although preterm premature rupture of membranes (PPROM) is one of the most common causes of preterm birth, it can also lead to serious maternal and neonatal complications.
- Trial name
- NCT06639919
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Manisa Celal Bayar University