Clinical trials: Prevention
COVID-19
Safety and Immunogenicity Study of Inactivated Vaccine for Prophylaxis of SARS CoV-2 Infection (COVID-19)
This study is a randomized, double-blinded, and placebo controlled phase Ⅰ/Ⅱ clinical trial of the SARS-CoV-2 inactivated vaccine manufactured by Sinovac Research \& Development Co., Ltd.
- Trial name
- NCT04352608
- Testing
- Two doses of medium dosage inactivated SARS-CoV-2 vaccine at the emergency vaccination schedule, Two doses of high dosage inactivated SARS-CoV-2 vaccine at the emergency vaccination schedule, Two doses of medium dosage inactivated SARS-CoV-2 vaccine at the routine vaccination schedule
- Where
- China
- Volunteers
- 744 people, healthy volunteers welcome
- Sponsor
- Sinovac Research and Development Co., Ltd.
Gun Violence Prevention, Adolescent Behavior
Supportive Hospital-Based Intervention for Firearm Trauma
This study is a quasi-experimental design, specifically a non-randomized controlled trial (NCT) designed to test the effects of gun violence reduction intervention including MI for youth ages 16-24 years old who present to the…
- Trial name
- SHIFT (NCT06712940)
- Testing
- Motivational Interviewing and Firearm Safety Training, with Case Management
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Tulane University
Post-Traumatic Headache
Multidisciplinary Translational Approach to Investigate Mechanisms Predictors & Prevention of Persistent PTH
This is a United States Department of Defense funded Focused Program study that aims to identify mechanisms and predictors for persistent of post-traumatic headache attributed to mild traumatic brain injury, and identify methods…
- Trial name
- NCT04098250
- Testing
- Erenumab
- Where
- 5 sites in United States
- Volunteers
- 6 people
- Sponsor
- Mayo Clinic
Radiographic Contrast Agent Nephropathy, Renal Failure
Prevention of Contrast Nephropathy During Diagnostic Coronary Angiogram or PCI With Hydratation Based on LEVDP
The goal is to determine if prehydration based on LEVDP is superior to a standard hydratation with NaCl 0.9% or NaHCO3 for the prevention of contrast nephropathy related to a diagnostic coronary angiogram or to PCI.
- Conditions
- Radiographic Contrast Agent Nephropathy, Renal Failure, Coronary Heart Disease
- Trial name
- NEPHRON (NCT00584350)
- Testing
- Hydratation according LVEDP + NaHCO3, normal saline, Sodium bicarbonate
- Where
- Canada
- Volunteers
- 330 people
- Sponsor
- Université de Sherbrooke
Foot Ulcer, Diabetic
Impact of Remote Foot Temperature Monitoring
One of the only evidence-based practices for the prevention of diabetic foot ulcer recurrence is once-daily foot temperature monitoring, which is recommended by multiple clinical practice guidelines for high-risk patients…
- Trial name
- NCT04345016
- Testing
- Once-daily remote foot temperature monitoring
- Where
- 3 sites in United States
- Volunteers
- 79 people
- Sponsor
- Kaiser Permanente
Breast Cancer, Chronic Myeloproliferative Disorders
Aprepitant, Granisetron, & Dexamethasone in Preventing Nausea & Vomiting in Pts. Receiving Cyclophosphamide Before a Stem Cell Transplant
RATIONALE: Antiemetic drugs, such as aprepitant, granisetron, and dexamethasone, may help lessen or prevent nausea and vomiting in patients treated with chemotherapy.
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Gestational Trophoblastic Tumor, Leukemia
- Trial name
- NCT00293384
- Testing
- Aprepitant, Cyclophosphamide, Dexamethasone
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Pregnancy, Preeclampsia
Abbreviated MgSO4 Therapy in Post-partum Preeclampsia
Magnesium sulfate is used for seizure prophylaxis in pregnancies complicated by preeclampsia. There is debate as to how long to continue this therapy after delivery of the pregnancy.
- Trial name
- NCT00344058
- Testing
- abbreviation of magnesium sulfate therapy (12 hours versus the traditional 24 hours after delivery)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Case Western Reserve University
Dental Caries in Children
The Effectiveness of Dental Health Home Visits on Caries Prevention in Young Children
Tooth decay affects 75% of Malaysian preschool children, most of which remain untreated. Untreated decay can cause pain, and impair nutritional status and physical growth.
- Trial name
- NCT04885348
- Testing
- Intervention Group (Dental Home Visits + Dental Home Education Leaflets), Control Group (Dental Home Education Leaflets)
- Volunteers
- 329 people, healthy volunteers welcome
- Sponsor
- Ministry of Education, Malaysia
Graft Versus Host Disease, Postbiotics
Intestinal Microbiome-based Research for the Prevention of Acute GVHD
Hematopoietic stem cell transplantation consists of preconditioning chemotherapy, stem cell infusion, and engraftment of hematopoietic stem cells.
- Conditions
- Graft Versus Host Disease, Postbiotics, Butyrate
- Trial name
- NCT05808985
- Testing
- sodium butyrate
- Where
- South Korea
- Volunteers
- 15 people
- Sponsor
- Soonchunhyang University Hospital
Stroke, Ischemic
A Personalized, Digital Coaching Program After Stroke
The Belgian Stroke Council initiated a project to improve risk factor control and medication adherence in ischemic stroke patients by developing an individualized in-hospital initiated and post- discharge, digital coaching…
- Trial name
- STROKECOACH (NCT03038685)
- Testing
- Strokecoach.be - digital coaching program for stroke patients
- Where
- 4 sites in Belgium
- Volunteers
- 148 people
- Sponsor
- University Hospital, Antwerp
Hemophilia A, Prophylaxis of Bleeding
An Observational Study Called JOIHA to Learn More About How Well the Treatment With Jivi Works to Prevent Problems With Joints in Adults With Hemophilia A.
This is an observational study in which data from people with hemophilia A who decide on their own or by recommendation of their doctors to take Jivi are collected and studied.
- Trial name
- JOIHA (NCT05643560)
- Testing
- Damoctocog alfa pegol (Jivi, BAY94-9027)
- Where
- Italy
- Volunteers
- 33 people
- Sponsor
- Bayer
STIs Prevention
Impact of the Daily Doxycycline Pre-exposure Prophylaxis (PrEP) on the Incidence of Syphilis, Gonorrhoea and Chlamydia
1. This study is a non-randomized observational cohort trial using before and after comparison to evaluate intervention 2. It would mimic the conditions that would occur outside a clinical trial. 2.
- Trial name
- Syphilaxis (NCT03709459)
- Testing
- Doxycycline
- Where
- 4 sites in Australia
- Volunteers
- 100 people
- Sponsor
- Kirby Institute
Aplastic Anemia, Myelodysplastic Syndromes
Posaconazole Prophylaxis During ATG Treatment for hMDS/AA Patients
To investigate the efficacy of posaconazole as prophylaxis antifungal agent in aplastic anemia / hypoplastic myelodysplastic syndrome (AA/hMDS) patients undergoing antithymocyte globulin (ATG) treatment
- Conditions
- Aplastic Anemia, Myelodysplastic Syndromes, Fungal Infection
- Trial name
- NCT03318159
- Testing
- Posaconazole
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Seoul National University Hospital
Smoking Reduction, Asthma in Children
Early Life Intervention in Pediatrics Supported by E-health - SMOKE
Unrestricted parental smoking habits are lifestyle risk behaviors associated with chronic, systemic inflammation, which promotes the pathogenesis of non-communicable diseases (NCDs).
- Conditions
- Smoking Reduction, Asthma in Children, Wheezing, Non-Communicable Disease
- Trial name
- ELIPSE-II (NCT06311162)
- Testing
- Life-Style app
- Where
- Switzerland
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Gestational Diabetes, Insulin Resistance
Pregnancy Outcomes: Effects of Metformin Study (POEM Study)
One approach to prevent the rising burden of diabetes is to address the issue of gestational diabetes mellitus (GDM). GDM has a growing prevalence up to 5-10% (and even higher in specific subgroups), with a pregnant population…
- Trial name
- POEM (NCT02947503)
- Testing
- Metformin TEVA 850 mg
- Where
- 4 sites in Netherlands
- Volunteers
- 500 people
- Sponsor
- Bethesda Diabetes Research Center
Food Insecurity, Obesity Prevention
Effects of an Urban-gardening Nutrition Intervention for Food Insecure College Students
The goal of this clinical trial is to learn if an urban gardening nutrition education program can have positive health effects on food insecure college students.
- Trial name
- UGNIFICS (NCT06822803)
- Testing
- Gardening Nutrition Education Program
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Florida International University
Hypertension, MTHFR 677 TT Genotype
China Stroke Primary Prevention Trial 2 for Participants With Hypertension and MTHFR 677 TT Genotype
This is a multi-center, randomized, double-blind, triple-dummy, controlled trial in 24,000 Chinese men and women with hypertension and MTHFR 677 TT genotype.
- Trial name
- CSPPT2-TT (NCT04974151)
- Testing
- Amlodipine besylate, Amlodipine besylate And Folic Acid, 5-methyltetrahydrofolate (5-MTHF)
- Where
- 20 sites in China
- Volunteers
- 24,000 people
- Sponsor
- Shenzhen Ausa Pharmed Co.,Ltd
Bronchiectasis, Pulmonary Disease
Bronchiectasis in Chronic Obstructive Pulmonary Disease (COPD) Patients: Role of Prophylaxis
Bronchiectasis is a chronic pulmonary disease characterized by an irreversible dilatation of the bronchi. The current view of the pathogenesis of bronchiectasis considers initial colonization of the lower respiratory tract by…
- Conditions
- Bronchiectasis, Pulmonary Disease, Chronic Bronchitis
- Trial name
- NCT00524095
- Testing
- azithromycin and fluticasone, fluticasone and azithromycin
- Where
- 4 sites in Italy
- Volunteers
- 210 people
- Sponsor
- University of Milan
Postinduction Hypotension
Intermittent Ephedrine Boluses for Prophylaxis Against Postinduction Hypotension
The aim of this work is to assess the efficacy of intermittent ephedrine boluses in prophylaxis against postinduction hypotension in high-risk patients undergoing major abdominal surgery, compared to standard care.
- Trial name
- NCT07722013
- Testing
- Normal Saline, Ephedrine
- Where
- Egypt
- Volunteers
- 124 people
- Sponsor
- Cairo University
Ileostomy - Stoma, Colorectal Surgery
Readmission and Dehydration Prevention in Patients With Elective Ileostomy
The goal of this prospective observational study is to evaluate the adherence to DRIP score calculation and the application rate of each proposed item to prevent dehydration and readmission in patients undergoing ileostomy…
- Conditions
- Ileostomy - Stoma, Colorectal Surgery, Dehydration
- Trial name
- PREDESTO (NCT06824623)
- Where
- 7 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Multidisciplinary Italian Study group for STOmas (MISSTO)