Clinical trials: Prevention Intervention
Gingivitis, Gingivitis; Chronic
A Multicentre Randomised Controlled Trial Evaluating the Efficacy of the SMILE™ Module for Improving Short-term Periodontal Outcomes, Compliance, and Acceptability Among Clinical Dental Students
This multicentre randomised controlled trial aims to evaluate the efficacy and safety of the SMILETM (Siwak Method for Integrated Lifestyle Enhancement) module in improving short-term periodontal outcomes, oral hygiene behaviour…
- Trial name
- SMILE (NCT07702383)
- Testing
- SMILE Module, Conventional Toothbrushing Module
- Where
- 4 sites in Malaysia
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Antimicrobial Prophylaxis, Asymptomatic Bacteriuria
"Peri-operative Antimicrobial Prophylaxis in Patients With Asymptomatic Bacteriuria of Enterobacteriacae ESBL+ Origin"
The aim of the study is to determine optimal safe duration of antibiotic prophylaxis in patients undergoing endourological procedures and ESWL, presenting with asymptomatic bacteriuria caused by multi-drug resistant bacterial…
- Trial name
- ESBL (NCT04152369)
- Testing
- Anti-microbial prophylaxis for an endourological procedure or ESWL
- Where
- Poland
- Volunteers
- 70 people
- Sponsor
- Military Institute od Medicine National Research Institute
Rheumatoid Arthritis
REU-stop - Effect of Intensive Smoking Cessation Intervention on Smoking Cessation and Disease Activity in Patients With Rheumatoid Arthritis.
This study aims to test the effect of an intensive smoking cessation intervention (motivational counseling combined with nicotine replacement) on smoking cessation and disease activity in patients with Rheumatoid Arthritis (RA).
- Trial name
- NCT02901886
- Testing
- Intensive smoking cessation intervention
- Where
- 2 sites in Denmark, Norway
- Volunteers
- 150 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Pediatric Obesity, Obesity
Family-centered Obesity Prevention: Communities for Healthy Living (CHL)
The Communities for Healthy Living (CHL) program is a family-focused intervention to promote healthy lifestyle behaviors including diet and physical activity among children (age 3-to 5-years) and their families, enrolled in Head…
- Trial name
- CHL (NCT03334669)
- Testing
- Parents Connect for Healthy Living (PConnect), Enhanced Nutrition Support, Media Resources
- Where
- United States
- Volunteers
- 4,999 people, healthy volunteers welcome
- Sponsor
- Boston College
HIV Infections
HIV Prevention Counseling for Men Who Have Sex With Men
The purpose of this study is to see if a behavioral intervention, a special kind of counseling, can reduce the risk of HIV infection in men who have sex with men.
- Trial name
- NCT00000931
- Testing
- Behavioral intervention, Risk-reduction counseling
- Where
- 6 sites in United States
- Volunteers
- 4,350 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Obesity
Can a Brief Primary Care Intervention Affect Healthy Weight Habits
Parents should receive anticipatory guidance about obesity prevention as part of the routine well child visit. Educational resources are needed to help physicians routinely provide these important anticipatory guidance messages.
- Trial name
- NCT01533896
- Testing
- Grow Nicely
- Where
- United States
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Risk Reduction Behavior, Interpersonal Relations
A Community-health Worker Delivered HIV/STI Prevention Intervention for Internally Displaced Women in Leogane, Haiti
The investigators will develop, deliver and evaluate a solar powered tablet-based individual and group focused HIV/STI prevention intervention with internally displaced women in Leogane, Haiti.
- Conditions
- Risk Reduction Behavior, Interpersonal Relations, Mental Disorders
- Trial name
- FASY (NCT01492829)
- Testing
- individual and group-based, community health worker delivered
- Where
- Haiti
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Women's College Hospital
Stress - Prevention of Sleep Disorders, PTSD and Depression
Solomiya App - CBT-based Self-help Intervention
The project aims to investigate the feasibility and acceptability of a smartphone intervention for depressive symptoms and insomnia in people living under prolonged stress due to the ongoing war in Ukraine.
- Trial name
- SOLOAPP-FAIT (NCT07104695)
- Testing
- Solomiya App - CBT-based self-help intervention
- Where
- Ukraine
- Volunteers
- 80 people
- Sponsor
- Solveig Kemna
Infectious Disease Prevention
Protection Motivation Theory-Based Education for Infectious Disease Prevention in Primary Care
This study aims to evaluate the effect of a Protection Motivation Theory-based educational intervention on infectious disease perception, risk awareness, and protective health behaviors among adults attending primary care…
- Trial name
- PMT-ID (NCT07790367)
- Testing
- Protection Motivation Theory-Based Educational Program
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Depression, Anxiety Disorders
The PredictPlusPrevent Study
Objective: To design, develop, and evaluate a personalized intervention for the universal prevention of depression and anxiety in the general population based on risk algorithms, ICTs, and decision support systems (DSS).
- Trial name
- NCT06351800
- Testing
- Predictplusprevent intervention, Psychoeducational intervention
- Volunteers
- 9,000 people, healthy volunteers welcome
- Sponsor
- The Mediterranean Institute for the Advance of Biotechnology and Health Research
HIV Infections
Affect Management Intervention for Early Adolescents Wtih Mental Health Problems
Adolescents are at risk for HIV because of sexual and drug use behavior initiated during early adolescence, and those with mental health problems appear to be particularly susceptible.
- Trial name
- Project TRAC (NCT00741975)
- Testing
- Affect Management, General Health Promotion
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Pediatric Obesity, Executive Function
Virtual Health Focused Acceptance-Based Program for Parents and Youth
The main purpose of vHAPPY is to pilot test a new type of virtual family-based healthy lifestyle program for children aged 8-14 with obesity and their caregivers.
- Trial name
- vHAPPY (NCT04634045)
- Testing
- Web Based Treatment
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Alabama at Birmingham
Mental Health Issue, Transdiagnostic Mechanisms
Efficacy of a Transdiagnostic Online Prevention Approach in Adolescents (EMPATIA)
The goal of this randomized controlled clinical trial is to investigate the efficacy of the internet-delivered intervention EMPATIA on general psychopathology of adolescents with subclinical symptoms compared to a Care As Usual…
- Conditions
- Mental Health Issue, Transdiagnostic Mechanisms, Adolescent Psychology, Prevention
- Trial name
- EMPATIA (NCT05934019)
- Testing
- EMPATIA 1
- Where
- Switzerland
- Volunteers
- 158 people
- Sponsor
- University of Bern
Alcohol Abuse
Brief Intervention for Heavy Drinkers
The purpose of the study is to determine whether a brief intervention (a short conversation build on the principles of motivational interviewing) is effective in lowering self reported alcohol use in heavy drinkers.
- Trial name
- NCT00728767
- Testing
- Brief intervention, Control group
- Where
- 9 sites in Denmark
- Volunteers
- 772 people
- Sponsor
- University of Southern Denmark
Pedophilia
ReDirection / Self-Guided ICBT to Reduce the Risk of Child Sexual Abuse Material (CSAM) Use
The creation and distribution of child sexual abuse material (CSAM) is a large-scale global problem. CSAM is sometimes referred to as child pornography.
- Trial name
- NCT06778044
- Testing
- ReDirection 1.0, ReDirection 2.0, Waitlist
- Where
- 2 sites in Canada, Finland
- Volunteers
- 300 people
- Sponsor
- The Royal Ottawa Mental Health Centre
Type 2 Diabetes, PreDiabetes
Promote Health With Digital Tools Among Adults With Type 2 Diabetes/Prediabetes and/or Hypertension
The goal of this hybrid type II effectiveness-implementation trial is to evaluate whether an intersectoral, digitally enabled, family-based intervention can prevent and manage type 2 diabetes mellitus (T2DM) and hypertension…
- Conditions
- Type 2 Diabetes, PreDiabetes, Hypertension, Obesity & Overweight
- Trial name
- DigiCare4You (NCT05648383)
- Testing
- mHealth self-management intervention, Standard care
- Where
- 4 sites in Albania, Bulgaria and 2 more
- Volunteers
- 1,215 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Asthma, Eczema
Fish Oil Supplementation During Pregnancy for Prevention of Asthma, Eczema and Allergies in Childhood
The aim of this study is to prevent asthma and allergies in childhood by supplementation with fish oil (n-3 fatty acids) to the mother during pregnancy.
- Conditions
- Asthma, Eczema, Allergy
- Trial name
- NCT00798226
- Testing
- n-3 fatty acid, olive oil
- Where
- 2 sites in Denmark
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Copenhagen Studies on Asthma in Childhood
Behavior, Risk
Come As You Are - Assessing the Efficacy of a Nurse Case Management HIV Prevention and Care Intervention Among Homeless Youth
The purpose of this study is to to determine the efficacy of the Nurse Case Management HIV (NCM4HIV) intervention on HIV prevention compared to usual care among Youth Experiencing Homelessness (YEH).
- Trial name
- NCT03910218
- Testing
- NCM4HIV, Usual Care
- Where
- United States
- Volunteers
- 474 people
- Sponsor
- The University of Texas Health Science Center, Houston
Testicular Germ Cell Tumor
Exercise in Testicular Germ Cell Cancer Survivors
Regular exercise is effective in prevention \& treatment of chronic diseases. Exercise can reduce late toxicity of chemotherapy, commonly found in cancer survivors, which is yet to be translated into clinical practice.
- Trial name
- ExCell (NCT05063760)
- Testing
- aerobic-strength exercise intervention (6-months)
- Where
- 2 sites in Slovakia
- Volunteers
- 60 people
- Sponsor
- Slovak Academy of Sciences
Primary Prevention
FIT FIRST Teen - School Intervention Study
The goal of this cluster randomised controlled trial is to investigate the effects of the FIT FIRST Teen program on adolescents' physical fitness, motivation, and well-being, as well as the implementation of such a program within…
- Trial name
- NCT06615791
- Testing
- FIT FIRST Teen
- Where
- Denmark
- Volunteers
- 912 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark