Clinical trials: Prevention of Heart Disease
Non-ST Segment Elevation Acute Coronary Syndrome
Comparison of Antiplatelet Effect of Ticagrelor vs Tirofiban in Patients With Non-ST Elevation Acute Coronary Syndrome
This is a single-center, open-label prospective randomized pharmacodynamic investigation of two anti platelet regimens in patients who are planned to undergo PCI for non-ST segment elevation acute coronary syndrome(NSTE-ACS) for…
- Trial name
- TE-CLOT (NCT01660373)
- Testing
- Tirofiban, Ticagrelor
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Pusan National University Yangsan Hospital
Obstructive Sleep Apnea, Hypertension
Antihypertensive and PAP Treatment in Obstructive Sleep Apnea Patients With Hypertension (AHPAP)
The investigators will perform a long term registry based prospective analysis on incidence of major cardiovascular events or death in hypertensive patients with obstructive sleep apnea .
- Conditions
- Obstructive Sleep Apnea, Hypertension, Death, Cardiac, Treatment Compliance
- Trial name
- AHPAP (NCT05115994)
- Testing
- Continous positive airway pressure
- Where
- Sweden
- Volunteers
- 10,000 people
- Sponsor
- Vastra Gotaland Region
Atrial Fibrillation, Atrial Appendage
Assessment of Dual Antiplatelet Therapy Versus Rivaroxaban In Atrial Fibrillation Patients Treated With Left Atrial Appendage Closure
Evaluation of 2 doses of rivaroxaban (10 and 15 mg) compared to dual anti platelet therapy (aspirin+clopidogrel) after left atrial appendage closure.
- Conditions
- Atrial Fibrillation, Atrial Appendage, Hemorrhage
- Trial name
- ADRIFT (NCT03273322)
- Testing
- Rivaroxaban 10 mg qd, Rivaroxaban 15 mg qd, DAPT
- Where
- France
- Volunteers
- 105 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bradycardia, Atrial Fibrillation
Atrial Pacing for Termination and Prevention of Atrial Fibrillation
Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with substantial morbidity and mortality. Present treatment strategies are aimed at termination of AF and prevention of AF recurrence using…
- Trial name
- NCT00123344
- Testing
- AT501 pacemaker
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University of Calgary
Impaired Glucose Tolerance
Rosiglitazone Therapy In The Prevention Of Coronary Artery Disease In Patients With Impaired Glucose Tolerance
Subjects with impaired glucose tolerance will be randomized to either rosiglitazone or placebo for a 18 month period. The study will look at baseline, 12 month and 18 month data for exercise tolerance, coronary artery…
- Trial name
- NCT00733174
- Testing
- Rosiglitazone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Denver Research Institute
Coronary Atherosclerosis and Other Heart Disease, Cardiovascular Diseases
The DANE-HEART Trial - Computed Tomography Coronary Angiography for Primary Prevention
The goal of this randomized controlled clinical trial in asymptomatic individuals with risk factors for cardiovascular disease is to investigate whether a preventive treatment strategy guided by computed tomography coronary…
- Trial name
- NCT05677386
- Testing
- Primary preventive treatment guided by CTCA, Cardiovascular risk Score
- Where
- 2 sites in Denmark
- Volunteers
- 6,000 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Pulmonary Disease, Chronic Obstructive
Beta-Blockers for the Prevention of Acute Exacerbations of Chronic Obstructive Pulmonary Disease
This is a multicenter, prospective, randomized, double-blind, placebo-controlled trial that will enroll 1028 patients with at least moderately severe COPD over a three year period and follow them at regular intervals for one…
- Trial name
- NCT02587351
- Testing
- Metoprolol succinate
- Where
- 27 sites in United States
- Volunteers
- 532 people
- Sponsor
- University of Minnesota
Stable or Unstable Angina Pectoris, Myocardial Ischemia
Efficiency of a New Therapy to Treat Stenosis of Coronary Vessels in Comparison With Two Already Admitted Therapies
The aim of the study is to examine the efficacy of Paclitaxel injection after a stent implantation in patients with stenosis in native coronary arteries to prevent restenosis in comparision with two admitted therapies.
- Trial name
- NCT00396929
- Testing
- local intracoronary dosis of Paclitaxel
- Where
- Germany
- Volunteers
- 204 people
- Sponsor
- University Hospital Tuebingen
Cardiovascular Diseases, Coronary Artery Disease
Optimising Secondary Prevention and Quality of Life in Early Cardiac Rehabilitation
The primary aim of this research is to explore the adherence and drop-out from early cardiac rehabilitation (CR), to inform interventions to support patient's adherence to CR and facilitate maintenance.
- Conditions
- Cardiovascular Diseases, Coronary Artery Disease, Myocardial Infarction, Acute Coronary Syndrome
- Trial name
- OSPREY-CR (NCT04781699)
- Where
- 6 sites in United Kingdom
- Volunteers
- 498 people, healthy volunteers welcome
- Sponsor
- Sheffield Hallam University
Patients With Coronary Artery Disease
Comparison Between HIIT and MICT on the Phase III of Cardiac Rehabilitation
The increase in the prevalence of cardiovascular diseases (CVD), directly associated with the aging of the population, is a concern for public health in Portugal.
- Trial name
- NCT03538119
- Testing
- High Intensity Interval Training Program, Moderate Intensity Continuous Training Program
- Where
- Portugal
- Volunteers
- 69 people
- Sponsor
- University of Évora
Gastric Ulcer Induced by Antiplatelet Agent, Ulcer of the Gastrointestinal Tract
Proton Pump Inhibitor Prevent Dual Antiplatelet Agents Induced Gastrointestinal Ulcer After Coronary Artery Bypass Graft
The purpose of this study is to determine whether 12-month prophylactic treatment with pantoprazole is superior to 1-month therapy without major cardiovascular events (MACE) increased significantly, in prevention of dual…
- Conditions
- Gastric Ulcer Induced by Antiplatelet Agent, Ulcer of the Gastrointestinal Tract, Proton Pump Inhibitor
- Trial name
- DACAB-GI-2 (NCT03038009)
- Testing
- Pantoprazole
- Where
- China
- Sponsor
- Ruijin Hospital
Heart Failure
Ability of L-carnitine to Prevent Heart Damage in Breast Cancer Patients Receiving Anthracycline Chemotherapy
Breast cancer is very common and afflicts 1 in 9 North American women. The treatment of breast cancer often requires the use of chemotherapy including "anthracyclines".
- Trial name
- NCT00247975
- Testing
- L-carnitine
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Atrial Fibrillation
Study to Learn More About the Benefits and Side-effects of Drugs Rivaroxaban and Apixaban Compared to the Drug Warfarin for Stroke Prevention in Patients With Rapid and Irregular Heartbeat Which is Not Due to a Heart-valve Fault (Non-valvular Atrial Fibrillation) in the UK Routine Clinical Practice
This population-based study will identify patients with rapid and irregular heartbeat which is not due to a fault with the heart valves (non-valvular atrial fibrillation) who initiate rivaroxaban, apixaban or warfarin as…
- Trial name
- SiERRA UK (NCT03847181)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), Apixaban (Eliquis), Warfarin
- Where
- United Kingdom
- Volunteers
- 45,164 people
- Sponsor
- Bayer
Diabetes Mellitus, Type 2, Coronary Artery Disease
POST-CABGDM: Empagliflozin in Perioperative CABG
Introduction: Diabetes Mellitus (DM) is a condition known to be associated with coronary artery disease (CAD) and its role as promoter of atherosclerosis is well stablished.
- Conditions
- Diabetes Mellitus, Type 2, Coronary Artery Disease, Coronary Artery Bypass Surgery, Acute Kidney Injury
- Trial name
- POST-CABGDM (NCT04523064)
- Testing
- Empagliflozin 25 MG
- Where
- Brazil
- Volunteers
- 155 people
- Sponsor
- University of Sao Paulo General Hospital
Cardioembolic Stroke, Atrial Fibrillation
Hirudin Plus Aspirin in the Secondary Prevention of Cardioembolic Stroke Due to Nonvalvular Atrial Fibrillation
To investigate the efficacy and safety of hirudin plus aspirin therapy compared with warfarin in the secondary prevention of cardioembolic stroke due to nonvalvular atrial fibrillation.
- Trial name
- NCT02181361
- Testing
- hirudin plus aspirin, Warfarin
- Where
- China
- Volunteers
- 239 people
- Sponsor
- Xijing Hospital
Cardiac Disease, Depression and Quality of Life
Evaluation of a Remote Behavioural Stress Recovery Intervention for Myocardial Infarction Patients Younger Than Fifty-five (BRIM-55): A Feasibility Study
The goal of this feasibility study is to learn if the randomised controlled trial evaluating the Remote-delivery Balance in Everyday Life (rBEL) programme for adults younger than 55 years who have experienced a myocardial…
- Conditions
- Cardiac Disease, Depression and Quality of Life, Cardiac Distress, Myocardial Infarction
- Trial name
- BRIM-55 (NCT07706816)
- Testing
- Remote-delivery Balance in Everyday Life (rBEL) Program for Myocardial Infarction Patients Younger Than 55 Years With Cardiac Distress
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Uppsala University
Eating Behavior Changes
Live Long, Heart Strong: A Digital Nutrition Intervention for Emerging Adults
Live Long, Heart Strong (LLHS) is a theory-guided, digital twin-supported nutrition intervention designed to promote cardiovascular health behaviors among emerging adults (18-25 years).
- Trial name
- LLHS (NCT07732569)
- Testing
- Live Long, Heart Strong (LLHS) Digital Nutrition Intervention, Static Digital Nutrition Education Toolkit
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Aortic Valve Stenosis
Anticoagulant Versus Dual Antiplatelet Therapy for Preventing Leaflet Thrombosis and Cerebral Embolization After Transcatheter Aortic Valve Replacement
This trial is to compare the efficacy of NOAC(Novel Oral Anticoagulants) with edoxaban vs. dual antiplatelet therapy (DAPT) for prevention of leaflet thrombosis (documented by cardiac CT imaging) and cerebral embolization…
- Trial name
- ADAPT-TAVR (NCT03284827)
- Testing
- NOAC, DAPT
- Where
- 5 sites in Hong Kong, South Korea and 1 more
- Volunteers
- 235 people
- Sponsor
- Duk-Woo Park, MD
Atrial Fibrillation, Intracranial Hemorrhages
A Pilot Study on the Prevention of the Vascular RISK Related to Atrial Fibrillation After Intracranial Hemorrhage by Closing the Left Auricle
Atrial fibrillation (AF) is a frequent heart rhythm disorder, responsible for the formation of cardiac thrombi, which can embolize in the systemic circulation, responsible for strokes (Cerebrovascular accidents).
- Trial name
- RIVAFAG (NCT03111654)
- Testing
- Compare the risk of a vascular event
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Atrial Fibrillation
Nifedipine vs Telmisartan on Prevention of Atrial Fibrillation (AF) Recurrence in Hypertensive Patients With AF
Different lowing blood pressure strategies have a different clinical efficacies. Blocking the angiotensin II type 1 receptor (Telmisartan) reduces the incidence of episodes of atrial fibrillation in hypertensive patients with…
- Trial name
- NCT01435161
- Testing
- Nifedipine,, Telmisartan
- Where
- China
- Volunteers
- 160 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University