Clinical trials: Prevention of Heart Disease
Delirium, Cognitive Decline
Dexmedetomidine or Clonidine Infusion for Prevention of Delirium After Open Heart Surgery
A parallel-group treatment, five-centre, participant and investigator masked, three-arm study to assess the safety and effectiveness of dexmedetomidine or clonidine infusion compared to placebo for the prevention of delirium and…
- Conditions
- Delirium, Cognitive Decline, Frailty
- Trial name
- ALPHA2PREVENT (NCT05029050)
- Testing
- Dexmedetomidine, Clonidine, Natriumchlorid
- Where
- 5 sites in Norway
- Volunteers
- 900 people
- Sponsor
- Oslo University Hospital
Coronary Heart Disease, Cardiovascular Disease
A Randomized Controlled Trial of Stress Reduction on Cardiovascular Morbidity and Mortality in African Americans
This randomized controlled clinical trial tests the hypothesis that a selected stress reduction approach, the Transcendental Meditation program will reduce all-cause mortality, myocardial infarction and stroke in African American…
- Trial name
- Milw (NCT01299935)
- Testing
- Transcendental Meditation, Health Education
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Maharishi International University
Coronary Artery Disease, Genetic Predisposition to Disease
Genetic Risk Stratification for Primary Prevention of CAD in Men and Pre & Post-menopausal Women
The investigators propose to genotype males and females at age 40 years and older, who are asymptomatic and without known heart disease (N=2000).
- Trial name
- NCT05169840
- Testing
- Genetic Risk Score for Coronary Artery Disease
- Where
- 3 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Atrial Fibrillation
Omega-3 Fatty Acids for Prevention of Post-Operative Atrial Fibrillation
This is a large multi-center study to examine whether peri-operative intake of n-3 polyunsaturated fatty acids (PUFA) will reduce the occurrence of post-operative atrial fibrillation or flutter (AF) in patients undergoing cardiac…
- Trial name
- OPERA (NCT00970489)
- Testing
- Omega -3 fatty acids
- Where
- United States
- Volunteers
- 1,516 people
- Sponsor
- Brigham and Women's Hospital
Periodontitis, Coronary Disease
Periodontal Therapy in a Primary Prevention of Cardiovascular Disease
Cardiovascular diseases (CVD) are still considered the main cause of mortality and morbidity all over the world. In the last years, efforts have been made to define more effective therapeutic and preventive strategies.Periodontal…
- Trial name
- NCT02081976
- Testing
- Integrated Care Group, Standard Care Group
- Where
- India
- Volunteers
- 57 people
- Sponsor
- Macmillan Research Group UK
Cardiovascular Diseases, Risk Reduction
Strategy for Cardiovascular Disease Prevention Through Tailored Health Management in Individuals With Elevated Risk
The China PEACE SMARTER trial is a cluster ramdomized trial aiming to assess the effectiveness of village doctor-led tailored health management on risk reduction of high-risk individuals for cardiovascular disease.
- Conditions
- Cardiovascular Diseases, Risk Reduction, Primary Prevention
- Trial name
- SMARTER (NCT05645640)
- Testing
- Village doctor-led tailored health management
- Where
- China
- Volunteers
- 4,533 people
- Sponsor
- China National Center for Cardiovascular Diseases
Delirium, Bypass Complication
Care Bundle's Impact on Delirium Prevention in CABG Patients
This research investigates the effectiveness of a care package used in the care of patients undergoing coronary artery bypass graft (CABG) surgery in preventing postoperative delirium.
- Conditions
- Delirium, Bypass Complication, Coronary Artery Bypass, Patient Care Bundles
- Trial name
- CareBundle (NCT06036017)
- Testing
- Earplugs, Music Therapy, Presence of Family After Extubation:
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- İslam Elagöz
Myocardial Infarction
Remote Exercise SWEDEHEART Study
The overall aim of the study is to evaluate if remote video exercise-based cardiac rehabilitation (exCR), offered as an alternative to centre-based exCR, can increase participation in exCR sessions post myocardial infarction (MI).
- Trial name
- NCT04260958
- Testing
- Exercise-based cardiac rehabilitation
- Where
- 25 sites in Sweden
- Volunteers
- 1,500 people
- Sponsor
- Sahlgrenska University Hospital
Acute Coronary Syndrome, Obstructive Sleep Apnea
Continuous Positive Airway Pressure (CPAP) in Patients With Acute Coronary Syndrome and Obstructive Sleep Apnea (OSA)
OSA may be a modifiable risk factor for cardiovascular disease due to its association with hypertension, stroke, heart attack and sudden death.
- Trial name
- ISAACC (NCT01335087)
- Testing
- Standard care, continuous positive airway pressure
- Where
- Spain
- Volunteers
- 1,864 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Cardiovascular Diseases, Prevention
Acute Effects of Beet Extract on Autonomic and Cardiovascular Recovery After Exercise
Dietary NO3 is found in high concentrations in green leafy vegetables and beets. Studies weighing the action of NO3 for ergogenic purposes have found metabolic improvement in skeletal muscle during exercise in hypoxia, lowering…
- Trial name
- NCT04094233
- Testing
- Beetroot extract
- Where
- Brazil
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Pernambuco
Pulmonary Disease, Chronic Obstructive, Heart Failure
Self-care Program in the Prevention of Admissions of Patients
One of the most cost effective intervention is to avoid unnecessary hospitalizations in the national health system. These unnecessary admissions are increasing for several years, reaching rates of over 30% in patients with…
- Trial name
- AUTOCUID (NCT01726244)
- Testing
- Multidisciplinary Intervention
- Where
- Spain
- Volunteers
- 144 people
- Sponsor
- Basque Health Service
Systemic Lupus Erythematosus, Lupus
Prevention of Atherosclerosis and Heart Disease in Patients With Systemic Lupus Erythematosis (SLE)
The purpose of this study is to find the best way to prevent heart disease and stroke in people with lupus (systemic lupus erythematosis, or SLE).
- Trial name
- NCT00054938
- Testing
- pravastatin, aspirin, ramipril
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Brigham and Women's Hospital
Atrial Fibrillation, Arrhythmias, Cardiac
Wearable Cardiac Monitor to Enhance Detection of Arrhythmia Recurrence After Catheter Ablation of Atrial Fibrillation
The WEAR-AF study is a prospective, multicenter clinical trial designed to evaluate the efficacy of wearable technology in the detection, monitoring, and management of atrial fibrillation (AF).
- Conditions
- Atrial Fibrillation, Arrhythmias, Cardiac, Heart Diseases, Cardiovascular Diseases
- Trial name
- WEAR-AF (NCT06564012)
- Volunteers
- 100 people
- Sponsor
- Sunnybrook Health Sciences Centre
Ventricular Tachycardia, Ischemic Cardiomyopathy
Impact of PREVENTIVE Substrate Ablation of Coronary Chronic Total Occlusion on Implantable cardioVerTer-Defibrillator Interventions
The aim of this study is to assess whether preventive substrate ablation of chronic total occlusion infarct-related artery (CTO-IRA) area in heart failure (HF) patients correlates with lower appropriate implantable cardiac…
- Trial name
- PREVENTIVE VT (NCT03421834)
- Testing
- Catheter ablation of ventricular tachycardia, Optimal medical treatment
- Where
- 5 sites in Croatia, Slovenia
- Volunteers
- 60 people
- Sponsor
- University Medical Centre Ljubljana
Coronary Heart Disease
Feasability of Collaborative Care in the Secondary Prevention of Coronary Heart Disease
The main focus of the pilot study is to evaluate the feasability and effectiveness of a collaborative care intervention for patients suffering from a coronary heart disease (CHD) with insufficient controlled health related risk…
- Trial name
- NCT02389153
- Testing
- collaborative care CHD
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Göttingen
Atrial Fibrillation
Esophageal Cooling for AF Ablation
The purpose of this study is to determine if esophageal cooling using the Attune Medical Esophageal Heat Transfer Device (EnsoETM) limits the number or seriousness of injury to the esophagus during atrial fibrillation ablation…
- Trial name
- eCoolAF (NCT03691571)
- Testing
- Esophageal Cooling, Control
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Pennsylvania
Intensive Care Unit Delirium, Postoperative Delirium
Role of Natural Light in the Prevention of Delirium After Cardiac Surgery: a Prospective Observational Study With Historical Control
Postoperative delirium is a common complication that usually occurs acutely within the first 24 hours after surgery and resolves within 72 hours; it is common in all medical areas and particularly affects patients over the age of…
- Conditions
- Intensive Care Unit Delirium, Postoperative Delirium, Cardiac Surgery
- Trial name
- iWOnDer (NCT05936944)
- Testing
- Exposure to totally artificial lighting
- Where
- Italy
- Volunteers
- 448 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
Acute Myocardial Infarction, ST Elevation Myocardial Infarction
A Polypill for Secondary Prevention of Ischemic Heart Disease
Cardiovascular diseases (CVD) are the leading cause of mortality and morbidity worldwide. The most important aspect of CVD secondary prevention is adherence to guideline-indicated pharmacological therapy which globally remains…
- Conditions
- Acute Myocardial Infarction, ST Elevation Myocardial Infarction, Non-ST Elevation Myocardial Infarction
- Trial name
- NCT03541109
- Testing
- Polypill
- Where
- 2 sites in Iran
- Volunteers
- 1,200 people
- Sponsor
- Isfahan University of Medical Sciences
Ischemic Heart Disease, Coronary Artery Disease
Electronic Letters to Improve Patient Activation in IHD: The NUDGE-IHD Trial
The goal of this clinical trial is to learn whether simple electronic information letters can increase patient activation and improve risk-factor monitoring in adults in Denmark with ischemic heart disease (IHD) who have LDL…
- Conditions
- Ischemic Heart Disease, Coronary Artery Disease, Hypercholesterolemia, Lipoprotein(a)
- Trial name
- NUDGE-IHD (NCT07382414)
- Testing
- LDL-C information letter, Lp(a) information letter
- Where
- Denmark
- Volunteers
- 123,000 people
- Sponsor
- Tor Biering-Sørensen
Doxorubicin Induced Cardiomyopathy
Role of Statin Therapy in Prevention of Anthracycline-Induced Cardiotoxicity
This study aims at evaluating the role of Atorvastatin in prevention of Anthracycline induced cardiotoxicity
- Trial name
- NCT05792293
- Testing
- Atorvastatin 40 Mg Oral Tablet
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University