Clinical trials: Prevention of Heart Disease
Acute Kidney Injury, Cardiac Surgery
LSALT Peptide for Prevention or Attenuation of Acute Kidney Injury (AKI) in Patients Undergoing On-Pump Cardiac Surgery
To evaluate the percentage of subjects with AKI within 7 days following on-pump cardiac surgery defined by the KDIGO (Kidney Disease: Improving Global Outcomes) criteria: 1.
- Trial name
- NCT05879432
- Testing
- LSALT Peptide
- Where
- 9 sites in Canada, Turkey (Türkiye)
- Volunteers
- 240 people
- Sponsor
- Arch Biopartners Inc.
Atrial Fibrillation, AFib
Stroke Feasibility Study
This is a feasibility study to assess the safety and efficacy of the AtriCure AtriClip when placed via Minimally Invasive Surgical Deployment to the Left Atrial Appendage.
- Trial name
- NCT01997905
- Testing
- AtriClip LAA Exclusion Device
- Where
- 7 sites in United States
- Volunteers
- 13 people
- Sponsor
- AtriCure, Inc.
Coronary Atherosclerosis, Coronary Restenosis
PIoglitazone for PrEvention of Restenosis in Diabetic Patients
Restenosis requiring reintervention is still a limitation of percutaneous coronary angioplasty. Despite the use of Drug eluting stent (DES), the rate of restenosis remains 7% to 16% in diabetic patients, making it a challenging…
- Conditions
- Coronary Atherosclerosis, Coronary Restenosis, Diabetes
- Trial name
- NCT00376870
- Testing
- Pioglitazone
- Where
- 2 sites in Italy
- Volunteers
- 160 people
- Sponsor
- University of Rome Tor Vergata
Congenital Heart Disease in Children
BAX602 in Preventing the Adhesion Around Great Cardiac Vessels in Pediatric Patients With Congenital Heart Disease Undergoing Re-do Open Heart Surgery (Japan Trial)
Congenital heart disease occurs in about 1% of live births and can range from (1) naturally curable conditions that require no treatment to (2) conditions that require multiple immediate operations or refractory severe…
- Trial name
- NCT05647161
- Testing
- BAX602, No Intervention
- Where
- 6 sites in Japan
- Volunteers
- 34 people
- Sponsor
- Baxter Healthcare Corporation
Heart Surgery
Association Between S-LAAO and Adverse Cardiovascular Events Among Patients Undergoing Coronary Artery Bypass Grafting.
This is a prospective, single-center, randomized, active controlled, clinical trail to assess the efficacy and safety of surgical closure of left atrial appendage (LAA) in patients undergoing coronary artery bypass graft.
- Trial name
- NCT04108169
- Testing
- Left atrial appendage occlusion surgery
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Beijing Institute of Heart, Lung and Blood Vessel Diseases
Atherosclerosis, Ischemia
Trial to Assess the Effects of Vorapaxar (SCH 530348; MK-5348) in Preventing Heart Attack and Stroke in Patients With Atherosclerosis (TRA 2°P - TIMI 50) (P04737)
The study is designed to determine whether vorapaxar, when added to the existing standard of care (SOC) for preventing heart attack and stroke (eg, aspirin, clopidogrel) in participants with a known history of atherosclerosis…
- Conditions
- Atherosclerosis, Ischemia, Myocardial Infarction, Cerebrovascular Accident
- Trial name
- NCT00526474
- Testing
- Vorapaxar
- Volunteers
- 26,449 people
- Sponsor
- Merck Sharp & Dohme LLC
Vitamin D Deficiency, Thoracic Surgery
Prevention of Vitamin D Deficiency Following Pediatric CHD Surgery: a Phase II Dose Evaluation Randomized Controlled Trial Comparing Usual Care With a High Dose Pre-operative Supplementation Regimen Based on the Institute of Medicine Daily Upper Tolerable Intake Level
Our research group has shown that almost all children with congenital heart disease (CHD) are vitamin D deficient following heart surgery.
- Conditions
- Vitamin D Deficiency, Thoracic Surgery, Pediatric Disorders, Heart Defects, Congenital
- Trial name
- HICCUPS 2 (NCT01838447)
- Testing
- Cholecalciferol
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- Children's Hospital of Eastern Ontario
Coronary Artery Disease
Colchicine Use for Primary Prevention of Coronary Artery Disease
Colchicine has been widely used as an anti-gout medicine in the past decades. Some recent clinical trials have proved that low-dose colchicine can be used as a secondary prevention drug for coronary artery disease because of its…
- Trial name
- NCT05175274
- Testing
- Colchicine
- Where
- China
- Volunteers
- 6,792 people
- Sponsor
- Qingdao Central Hospital
Coronary Artery Disease, Class I Obesity
EFFECT OF PYRAMIDAL TRAINING ON EPICARDIAL FAT FOR CORONARY ARTERY DISEASE PREVENTION
To show the effect of pyramidal training for coronary artery disease prevention on: -Epicardial fat, BMI, Waist circumference (WC), Lipid profile, Quality of life and Mediterranean Diet Adherence.
- Trial name
- NCT06799104
- Testing
- Pyramidal training, Mediterranean diet
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Stroke, Prevention and Control
An Observational Cross-sectional Study Evaluating the Use of Re-sources and the Sociodemographic and Clinical Characteristics of Patients Diagnosed With Non-valvular Atrial Fibrillation With a Risk of Stroke or Systemic Embolism on Anticoagulant Therapy and Treated in Primary Care Centers
This is a retrospective observational study to describe the sociodemographic and clinical characteristics of patients diagnosed with non-valvular atrial fibrillation (NVAF) at risk of stroke or systemic embolism, who at least…
- Conditions
- Stroke, Prevention and Control, Atrial Fibrillation
- Trial name
- BRONCE-AP (NCT02559232)
- Testing
- Direct Oral Anticoagulant (DOAC)
- Where
- Spain
- Volunteers
- 247 people
- Sponsor
- Bayer
Coronary Disease
Non-Polymer-Based, Rapamycin-Eluting Stents to Prevent Restenosis
The purpose of the study is to evaluate the effectively of coating of coronary stents with two different doses of rapamycin for the prevention of coronary vessel re-blockage
- Trial name
- NCT00152308
- Testing
- 2% rapamycin-eluting YUKONdes PEARL-stent, 1% rapamycin-eluting YUKONdes PEARL-stent
- Where
- 10 sites in Austria, Germany and 1 more
- Volunteers
- 333 people
- Sponsor
- Translumina GmbH
Coronary Heart Disease, Hypercholesterolemia
Compliance With LDL-Lowering Therapy (Study P05467)(COMPLETED)
This observational study is being conducted in patients receiving statin treatment as secondary prevention of coronary heart disease under the current standard of care in compliance with European guidelines.
- Conditions
- Coronary Heart Disease, Hypercholesterolemia, Hyperlipidemia
- Trial name
- NCT00723723
- Testing
- Statin
- Volunteers
- 555 people
- Sponsor
- Organon and Co
Comorbidities and Coexisting Conditions, Ethics
eCardiacRehab - a Hybrid Patient-Centered eHealth Programme
The overall aim of eCardiacRehab trial is to meet rehabilitation needs of patients with coronary artery disease (CAD) regardless of their access to traditional place-based rehabilitation by developing and evaluating the efficacy…
- Conditions
- Comorbidities and Coexisting Conditions, Ethics, Continuity of Patient Care, Older Adults (65 Years and Older)
- Trial name
- eCardiacRehab (NCT07590635)
- Testing
- eCardiacRehab
- Where
- Norway
- Volunteers
- 1,000 people
- Sponsor
- Haukeland University Hospital
Chronic Heart Failure, Cardiovascular Diseases
AI-Based Monitoring System for Chronic Heart Failure With Advanced Wearable and Mini-Invasive Devices
The goal of this observational, multicenter study is to evaluate whether AI-driven remote monitoring using a mini-invasive wearable device can improve clinical outcomes in adult patients (≥18 years) with chronic heart failure…
- Conditions
- Chronic Heart Failure, Cardiovascular Diseases, Heart Failure With Reduced Ejection Fraction (HFrEF), Heart Failure With Preserved Ejection Fraction (HFPEF)
- Trial name
- SMART-CARE (NCT06909682)
- Testing
- Intervention Group (Device Group - AI-Based Remote Monitoring), Standard Clinical Follow-Up
- Where
- Italy
- Volunteers
- 205 people
- Sponsor
- University of Salerno
Atrial Fibrillation
COlchicine for the Prevention of Post Electrical Cardioversion Recurrence of AF
There is substantial evidence linking inflammation to the initiation and perpetuation of AF. Although the precise mechanism by which inflammation contributes to the development of AF remains unclear, it has been proposed that…
- Trial name
- COPPER-AF (NCT02582190)
- Testing
- Colchicine group
- Sponsor
- Elpen Pharmaceutical Co. Inc.
Diabetes, Heart Failure
A Pilot Study: Metformin Therapy in Heart Failure Patients With Early Diabetes or at High Risk of Developing Diabetes (Pre-Diabetes)
The Ahmanson-UCLA Cardiomyopathy Center is conducting a clinical research study that will assess the use of the medication metformin to improve quality of life, exercise capacity, and improved outcomes in heart failure patients…
- Trial name
- NCT01573949
- Testing
- Metformin
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of California, Los Angeles
Acute Kidney Injury, Percutaneous Coronary Intervention
Dapagliflozin in the Prevention of Post-Coronary Angioplasty Acute Kidney Injury
To compare the incidence of acute kidney injury (AKI) post percutaneous coronary intervention (PCI) in a Dapagliflozin treated group versus a group managed with the usual standard of care.
- Trial name
- DAPA-PCI-AKI (NCT05435235)
- Testing
- Dapagliflozin 10mg Tab
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Albert Einstein Healthcare Network
Atrial Fibrillation
Canakinumab for the Prevention of Recurrences After Electrical Cardioversion: CONVERT-AF
The purpose of this study is to test the efficacy of a single injection of Canakinumab on AF recurrences within 6 months after electrical cardioversion in patients with persistent AF.
- Trial name
- CONVERT-AF (NCT01805960)
- Testing
- Canakinumab
- Where
- 5 sites in Germany, Switzerland
- Volunteers
- 24 people
- Sponsor
- University Hospital, Basel, Switzerland
Atrial Fibrillation, Obstructive Sleep Apnea
Prevention of Atrial Fibrillation After Coronary Artery Bypass Grafting in Patients With Obstructive Sleep Apnea
Background. Atrial fibrillation is one of the most common complications in the postoperative period of coronary artery bypass grafting (CABG) surgery and usually associated with increased length of hospital stay and higher…
- Conditions
- Atrial Fibrillation, Obstructive Sleep Apnea, Coronary Artery Bypass Grafting
- Trial name
- PAFOS (NCT02737215)
- Testing
- CPAP
- Where
- 3 sites in Brazil
- Volunteers
- 144 people
- Sponsor
- Rodrigo Pinto Pedrosa
Heavy Smokers, Lung Cancer Screening
Akershus Cardiac Examination (ACE) 5 Study
Individuals with extensive smoking history have 2- to 3-fold increased risk of dying prematurely compared to age- and gender-matched peers.
- Conditions
- Heavy Smokers, Lung Cancer Screening, Cardiovascular Risk Profile, Cardiovascular Disease Prevention
- Trial name
- ACE5 (NCT07301489)
- Testing
- Lung Cancer Screening Plus Program, Standard of Care
- Where
- Norway
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Akershus