Clinical trials: Prevention of Heart Disease
Heart Failure
Bioprofiling Response to Mineralocorticoid Receptor Antagonists for the Prevention of Heart Failure
Despite advances in care, prognosis remains poor once overt Heart Failure (HF) has developed. Prevention is most efficient when directed toward patients at risk and when mechanistically targeted to patients most likely to…
- Trial name
- Homage (NCT02556450)
- Testing
- Spironolacton
- Where
- 9 sites in France, Germany and 4 more
- Volunteers
- 528 people
- Sponsor
- ACS Biomarker
Coronary Artery Disease
Prevention of Coronary Microvascular Dysfunction Post-PCI by Intracoronary Nicardipine
This is a single-center double blind, placebo controlled study of patients undergoing a cardiac catheterization where the need for a percutaneous coronary intervention (PCI) is anticipated or will be determined during the early…
- Trial name
- NCT03184155
- Testing
- Nicardipine, Sterile Saline
- Where
- United States
- Sponsor
- Thomas Jefferson University
Heart Transplantation
Cell Therapy With Treg Cells Obtained From Thymic Tissue (thyTreg) to Prevent Rejection in Heart Transplant Children
The investigators developed a protocol to isolate Treg cells from thymic tissue (thyTreg) discarded in pediatric cardiac surgeries.
- Trial name
- THYTECH (NCT04924491)
- Testing
- Autologous thyTreg
- Where
- Spain
- Volunteers
- 11 people
- Sponsor
- Rafael Correa-Rocha
Venous Thrombosis, Pulmonary Embolism
Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (Netherlands)
This prospective cohort study will provide information about: characteristics of Rivaroxaban use in patients who are prescribed Rivaroxaban for the first time compared to patients who are prescribed Acenocoumarol for the first…
- Conditions
- Venous Thrombosis, Pulmonary Embolism, Atrial Fibrillation, Acute Coronary Syndrome
- Trial name
- NCT01947985
- Testing
- Rivaroxoban (Xarelto, Bay59-7939), Standard of care
- Where
- Netherlands
- Volunteers
- 208,958 people
- Sponsor
- Bayer
Myocardial Infarction
Remote Exercise SWEDEHEART Study
The overall aim of the study is to evaluate if remote video exercise-based cardiac rehabilitation (exCR), offered as an alternative to centre-based exCR, can increase participation in exCR sessions post myocardial infarction (MI).
- Trial name
- NCT04260958
- Testing
- Exercise-based cardiac rehabilitation
- Where
- 25 sites in Sweden
- Volunteers
- 1,500 people
- Sponsor
- Sahlgrenska University Hospital
Acute Kidney Injury
Effect of Darbepoetin in Contrast-induced Nephropathy
The purpose of this study is to determine whether the drug that produce red blood cells is effective in the prevention of kidney dysfunction after coronary angiography in patients with chronic kidney disease.
- Trial name
- NCT01197235
- Testing
- darbepoetin-α, isotonic saline
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Seoul National University Bundang Hospital
Atherosclerosis, Ischemia
Trial to Assess the Effects of Vorapaxar (SCH 530348; MK-5348) in Preventing Heart Attack and Stroke in Patients With Atherosclerosis (TRA 2°P - TIMI 50) (P04737)
The study is designed to determine whether vorapaxar, when added to the existing standard of care (SOC) for preventing heart attack and stroke (eg, aspirin, clopidogrel) in participants with a known history of atherosclerosis…
- Conditions
- Atherosclerosis, Ischemia, Myocardial Infarction, Cerebrovascular Accident
- Trial name
- NCT00526474
- Testing
- Vorapaxar
- Volunteers
- 26,449 people
- Sponsor
- Merck Sharp & Dohme LLC
Diabetes Mellitus, Type 2, Heart Failure
Prediction of Heart Failure and Cognitive Decline in Type 2 Diabetes
Type 2 diabetes is a risk factor of heart failure and cognitive decline. Heart failure at its early stage is often silent. At present, primary prevention for heart failure is not available.
- Conditions
- Diabetes Mellitus, Type 2, Heart Failure, Cognitive Decline
- Trial name
- PreciDIAB-H&B (NCT04583800)
- Where
- France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Lille
Atrial Fibrillation
Moxonidine for Prevention of Post-ablation AFib Recurrences
Hypothesis: Modulation of central nervous sympathetic activation by administration of moxonidine, a centrally acting medication which decreases the sympathetic nervous system activity, can lead to a decrease in atrial…
- Trial name
- NCT01791699
- Testing
- Moxonidine
- Where
- 3 sites in Greece
- Volunteers
- 150 people
- Sponsor
- Spyridon Deftereos
Acute Myocardial Infarction, ST Elevation Myocardial Infarction
A Polypill for Secondary Prevention of Ischemic Heart Disease
Cardiovascular diseases (CVD) are the leading cause of mortality and morbidity worldwide. The most important aspect of CVD secondary prevention is adherence to guideline-indicated pharmacological therapy which globally remains…
- Conditions
- Acute Myocardial Infarction, ST Elevation Myocardial Infarction, Non-ST Elevation Myocardial Infarction
- Trial name
- NCT03541109
- Testing
- Polypill
- Where
- 2 sites in Iran
- Volunteers
- 1,200 people
- Sponsor
- Isfahan University of Medical Sciences
Hyperlipidemia, Hypercholesterolemia
Patient and Provider Assessment of Lipid Management Registry
The purpose of the Patient and Provider Assessment of Lipid Management Registry (PALM) is to gain a better understanding of physicians' cholesterol medication prescribing practices, patient and physician attitudes and beliefs…
- Conditions
- Hyperlipidemia, Hypercholesterolemia, Cardiovascular Disease, Diabetes
- Trial name
- PALM (NCT02341664)
- Where
- 14 sites in United States
- Volunteers
- 7,658 people
- Sponsor
- Duke University
Heart Failure, Vasoplegia
Prevention of Low Blood Pressure After Cardiac Surgery in Heart Failure Patients With a Filter Called CytoSorb.
Vasoplegia is a common complication after heart surgery for heart failure. With vasoplegia, the blood vessels can no longer squeeze properly, causing low blood pressure that is sometimes difficult to treat with medication.
- Trial name
- CytoSorb-HF (NCT04812717)
- Testing
- CytoSorb device
- Where
- Netherlands
- Volunteers
- 36 people
- Sponsor
- Leiden University Medical Center
Atrial Fibrillation (AF)
BiodEgradable Soaked Amiodarone paTch Use for the Prevention of Atrial Fibrillation After Cardiac Surgery
The primary objective of the present prospective, randomized, double blind, controlled study is to assess whether the application of 2 oxidized regenerated cellulose (SurgicelTM FibrillarTM) patches soaked with amiodarone…
- Trial name
- BEAT-AF (NCT06722196)
- Testing
- topical amiodarone, saline solution patch
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Jilin Heart Hospital
Chagas Cardiomyopathy, Non-sustained Ventricular Tachycardia
Amiodarone Against ICD Therapy in Chagas Cardiomyopathy for Primary Prevention of Death
The primary objective is to compare the efficacy of the treatment using implantable cardioverter defibrillator (ICD) implantation to that of the treatment using amiodarone in the primary prevention of all-cause mortality in…
- Conditions
- Chagas Cardiomyopathy, Non-sustained Ventricular Tachycardia, At Least 10 Points in Rassi Risk Score for Death
- Trial name
- CHAGASICS (NCT01722942)
- Testing
- ICD implantation, amiodarone hydrochloride
- Where
- 20 sites in Brazil
- Volunteers
- 1,100 people
- Sponsor
- InCor Heart Institute
Acute Kidney Injury
Acute Post-cardiac Surgery Renal Failure: Prevention Through Individualized Intensive Hemodynamic Management
BACKGROUND: The incidence of acute kidney injury (AKI) in patients undergoing cardiac surgery can reach 35% and between 2 and 5% require kidney replacement therapy during the AKI episode.
- Trial name
- PrevHemAKI (NCT04005105)
- Testing
- Intensive management
- Where
- Spain
- Volunteers
- 98 people
- Sponsor
- Hospital Clinic of Barcelona
Contrast Induced Nephropathy
Efficacy of Alpha Tocopherol for Prevention of Contrast-induced Nephropathy in Chronic Kidney Disease (CKD) Patients
The purpose of this study is to demonstrate the efficacy of alpha tocopherol for prevention contrast-induced nephropathy in CKD patients undergoing elective coronary procedures.
- Trial name
- NCT01061320
- Testing
- alpha tocopherol
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Thammasat University
Atrial Fibrillation
Targeting Risk Interventions and Metformin for Atrial Fibrillation (TRIM-AF)
Prospective randomized open-label blinded endpoint (PROBE) 2x2 factorial study of metformin extended release up to 750 mg BID and lifestyle and risk factor modification (LRFM) in CIED patients with at least 1 ≥5 minute episode of…
- Trial name
- TRIM-AF (NCT03603912)
- Testing
- Metformin, Lifestyle/Risk Factor Modification
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- Mina Chung, MD
Atrial Fibrillation
Effect of 3 Years of Exercise on Development of Atrial Fibrillation
This is a substudy of "Generation 100". In that study, 4000 healthy persons between 70 and 75 will be randomised to a moderate intensity training group, a high intensity training group or control group, with 3 years of exercise.
- Trial name
- NCT01680302
- Testing
- High intensity exercise, Moderate intensity exercise, Control
- Where
- Norway
- Volunteers
- 1,567 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Atrial Fibrillation, Stroke
Improving Stroke Prevention in Atrial Fibrillation Through Pharmacist Prescribing
The purpose of this study is to compare the effectiveness of prescribing oral anticoagulation therapy by pharmacist intervention compared to enhanced usual care in participants with unrecognized AF and/or known AF but not taking…
- Trial name
- PIAAFRx (NCT03126214)
- Testing
- Anticoagulants
- Where
- Canada
- Volunteers
- 79 people
- Sponsor
- University of Alberta
Cancer, Heart Failure
A Multicenter Clinical Trial on DH001 Tablets in the Prevention of Doxorubicin-induced Cardiotoxicity in Cancer Patients
Purpose：1. Preliminary evaluation of the preventive effect of DH001 on doxorubicin-induced cardiotoxicity in cancer patients 2.To explore appropriate dosages to provide basis for dosages in subsequent confirmatory studies 3.To…
- Conditions
- Cancer, Heart Failure, Arrhythmia, Doxorubicin Induced Cardiomyopathy
- Trial name
- NCT06092606
- Testing
- Trial group: DH001 low-dose group, Trial group: DH001 high-dose group
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Monyan Pharmaceutical (Shanghai) Co., Ltd.