Clinical trials: Prevention of Heart Disease
Cardiac Death
Reduction of Inappropriate Implantable Cardioverter Defibrillator (ICD) Therapies in Primary Prevention Patients
The purpose of this study is to determine efficacy of a dedicated programming concept for avoidance of inappropriate implantable cardioverter defibrillator (ICD) therapies in patient with primary prevention ICD indication.
- Trial name
- DECREASE (NCT01217528)
- Testing
- device settings for group A, Device settings for group B
- Where
- 34 sites in Germany
- Volunteers
- 543 people
- Sponsor
- Abbott Medical Devices
Cardiovascular Diseases, Heart Diseases
Family Cardiac Caregiver Investigation to Evaluate Outcomes
The purpose of the FIT-O study was to estimate the prevalence of having a caregiver (paid and/or informal) among hospitalized cardiac patients by demographic factors such as patient age and race/ethnicity, and to link caregiver…
- Trial name
- FIT-O (NCT00990548)
- Where
- United States
- Volunteers
- 4,500 people
- Sponsor
- Columbia University
Altitude Hypoxia
Effect of Acetazolamide on Right Heart Function During Exercise in Lowlanders Older Than 40 Years at Altitude
Randomized, placebo controlled trial evaluating efficacy of acetazolamide on right heart function during exercise in lowlanders older than 40 years travelling from 760 m to 3'100 m.
- Trial name
- NCT03537924
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Cardiovascular Diseases, Heart Diseases
Behavior Change Family Counseling to Reduce Rate of Weight Gain in At-Risk Children
This study will train primary care providers to counsel families on behavior change that is aimed at reducing the rate of weight gain in at-risk children.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Obesity
- Trial name
- NCT00241891
- Testing
- Single behavior intervention, Multiple behavior interventions, Control Intervention unrelated to weight
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- Children's Hospital of Philadelphia
Cardiovascular Diseases, Myocardial Ischemia
Cardio-Cerebrovascular Co-Prevention and Co-Management Based on Internet+
Coronary heart disease and stroke are belong to the atherosclerotic vascular disease (ASCVD). When both occur at the same time, the mortality rate is 19%-37%.
- Conditions
- Cardiovascular Diseases, Myocardial Ischemia, Cerebrovascular Disorders, Stroke
- Trial name
- DEMO-CoCo (NCT04409210)
- Testing
- Establishment of individual health records, Cardiovascular risk assessment, Popularization of medical knowledge
- Where
- China
- Volunteers
- 8,840 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Atrial Fibrillation, Stroke Prevention
Atrial and Brain Natriuretic Peptide Secretion After Percutaneous Closure of the Left Atrial Appendage
To date there are no data suggesting substantial effects of hormonal interaction after percutaneous closure of the left atrial appendage (LAA).
- Conditions
- Atrial Fibrillation, Stroke Prevention, Left Atrial Appendage
- Trial name
- NCT01522911
- Testing
- WATCHMAN LAA system (Percutaneous left atrial appendage closure)
- Volunteers
- 50 people
- Sponsor
- University of Leipzig
Atrial Fibrillation, Risk Factors
Secondary Prevention of Atrial Fibrilation
Atrial fibrillation (AF) is the most common arrhythmia affecting over 3 million Americans and about 33.5 million individuals globally. The lifetime risk of developing AF is 1 in 4 for adults over age 40 years.
- Conditions
- Atrial Fibrillation, Risk Factors, Risk Reduction Behavior
- Trial name
- NCT03259893
- Testing
- AliveCor mobile ECG cardiac monitor, AF Program, Standard of care
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Boston Medical Center
Atrial Fibrillation
Amiodarone to Prevent Post-Operative Arrhythmias
Rapid heart rhythms originating from the upper heart chambers (atrial tachyarrhythmias) are very common after open-heart surgery.
- Trial name
- NCT00251706
- Testing
- amiodarone
- Where
- Canada
- Volunteers
- 600 people
- Sponsor
- University of Calgary
Cardiovascular Diseases, Heart Diseases
Stress Reduction and Prevention of Hypertension in Blacks
To examine the role of Transcendental Meditation in stress reduction and prevention of hypertension in Blacks.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension
- Trial name
- NCT00005748
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Nosocomial Pneumonia
High-dose Inhaled NO Therapy for the Prevention of Nosocomial Pneumonia After Cardiac Surgery With CPB
The primary aim of this single-center, prospective, randomized, controlled, pilot study is to test the hypothesis that inhalation of NO 200 ppm prevents the development of nosocomial pneumonia in patients at risk after cardiac…
- Trial name
- NCT06162455
- Testing
- 200- ppm NO
- Where
- Russia
- Volunteers
- 74 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Congestive Heart Failure
Sodium-glucose Cotransporter Type 2 Inhibitors for Acute Cardiorenal Syndrome Prevention
The effect of sodium-glucose cotransporter type 2 inhibitors (SGLT2i) on the parameters of renal function in acute decompensation of chronic heart failure (ADHF) compared to standard therapy will be analyzed.
- Trial name
- NCT04778787
- Testing
- Standard list of drugs used for acute decompensation of CHF (loop diuretics, vasodilators, digoxin, inotropic agents, vasopressors), plus dapagliflozin (Forxiga; MP-002596)
- Where
- 2 sites in Russia
- Volunteers
- 370 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Myocardial Infarction, Acute, Myocardial Infarction First
MSCs for Prevention of MI-induced HF
Results from recent clinical trials on bone marrow mononuclear cell (BM-MNC) transplantation show that this intervention can help reduce the incidence of heart failure (HF) after acute myocardial infarction (AMI).
- Conditions
- Myocardial Infarction, Acute, Myocardial Infarction First, Myocardial Infarction, Anterior Wall, Cardiac Remodeling, Ventricular
- Trial name
- PREVENT-TAHA8 (NCT05043610)
- Testing
- Umbilical Cord-Derived Wharton's Jelly Mesenchymal Stem Cells (WJ-MSCs), Conventional Treatment
- Where
- 3 sites in Iran
- Volunteers
- 420 people
- Sponsor
- Shiraz University of Medical Sciences
Patent Foramen Ovale, Cardiac Implantable Electronic Device
Patients With Patent Foramen Ovale and Endocardial Device Leads on Apixaban for Prevention of Paradoxical Emboli
Patients with a patent foramen ovale in the setting of endocardially placed cardiac implantable electronic devices such as pacemakers, defibrillators, or resynchronization therapies are likely at higher risk for paradoxical…
- Trial name
- PARADOX (NCT02378623)
- Testing
- Apixaban
- Where
- United States
- Sponsor
- Mayo Clinic
Surgery--Complications, Cardiac Valve Disease
Prevention of Acute Kidney Injury by N-Acetylcystein in Patients Undergone Cardiac Valve Replacement
This is a randomized clinical trial, double-blind, placebo-controlled study with the goal to assess the influence of using N-AcetylCysteyn (NAC) for prevention of AKI (Acute Kidney Injury) in post operatory of valve replacement…
- Conditions
- Surgery--Complications, Cardiac Valve Disease, Acute Kidney Injury, Oxygen Radical Damage
- Trial name
- NCT03440268
- Testing
- N Acetyl Cysteine
- Where
- Brazil
- Volunteers
- 154 people
- Sponsor
- University of Sao Paulo General Hospital
Ischemic Heart Disease
Diet and Prevention of Ischemic Heart Disease: a Translational Approach
The objective of this study is to test the effect of substitution dietary guidelines that are specifically aimed at the prevention of ischemic heart disease (IHD) on the dietary intake in the general Danish population.
- Trial name
- DIPI (NCT02062424)
- Testing
- DIPI
- Where
- Denmark
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- Technical University of Denmark
Congenital Heart Disease
Imaging by 4 DFlow in Patients With Tetralogy of Fallot
Conventionnal cadiac magnetic resonance (CMR) is the reference to assess changes in right heart flow and pulmonary artery hemodynamics in patients with repaired Tetralogy of Fallot.
- Trial name
- 4DFlowFallot (NCT03542968)
- Testing
- magnetic resonance imaging
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Atrial Fibrillation
GENERAL;GENeral Practitioners and Embolism pRevention in NVAF Patients Treated With RivAroxaban:reaL-life Evidence
In atrial fibrillation patients,anticoagulant therapy with warfarin has an excellent stroke preventive. Meantime,Warfarin may also increase the risk of hemorrhagic events.
- Trial name
- GENeRAL (NCT02633982)
- Where
- Japan
- Volunteers
- 5,000 people
- Sponsor
- Japan Cardiovascular Research Foundation
Cardiovascular Diseases, Heart Diseases
Health Promotion in the Elderly--Prevention of Cardiovascular Disorders
To develop an epidemiologic model to estimate the benefits, costs and risks of disease prevention in the elderly.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Cerebrovascular Disorders
- Trial name
- NCT00005450
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Coronary Syndrome
ALLiance for sEcondary PREvention After an Episode of Acute Coronary Syndrome (ALLEPRE)
The purpose of the ALLEPRE trial is to compare the benefit offered by a structured, intensive and fully nurse-led intensive secondary prevention intervention programme with that offered by standard of care in a high-risk…
- Trial name
- ALLEPRE (NCT02522182)
- Testing
- Nurse-led Intensive Secondary Prevention Programme, Usual Treatment
- Where
- 7 sites in Italy
- Volunteers
- 2,060 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
Atrial Fibrillation
New Formulations of Propafenone to Treat Atrial Fibrillation
Propafenone is a currently used medicine to treat atrial fibrillation and is a mixture of two compounds, (R)-propafenone and (S)-propafenone.
- Trial name
- NCT02710669
- Testing
- (R)-propafenone, (S)-Propafenone
- Where
- United States
- Volunteers
- 193 people
- Sponsor
- Vanderbilt University