Clinical trials: Prevention of Heart Disease
Atrial Fibrillation
Corticosteroids for the Prevention of Atrial Fibrillation After Cardiac Surgery
Atrial fibrillation is the most common arrhythmia to occur after cardiac surgery. Inflammatory response may be one etiological factor.
- Trial name
- NCT00442494
- Testing
- intravenous hydrocortisone
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Kuopio University Hospital
Ischemic Heart Disease
Telemonitoring During Phase 2-3 Cardiac Rehabilitation
In this study, 80 coronary artery disease patients with successful coronary revascularisation (by CABG or PCI) will be included.
- Trial name
- TeleRehabII (NCT01252030)
- Testing
- physical activity monitors, No physical activity monitors
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Jessa Hospital
Cardiovascular Diseases, Heart Diseases
Dietary Intervention to Improve Health of Cardiovascular Patients
Voed je Beter is a randomized, multicenter, controlled trial to examine whether personalized guidance to increase adherence to the Dutch dietary guidelines, compared to usual care, improves health of cardiovascular patients who…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Vascular Diseases
- Trial name
- NCT05071092
- Testing
- Dietary counselling
- Where
- Netherlands
- Volunteers
- 124 people
- Sponsor
- Wageningen University
Atrial Fibrillation, Cardiac Surgery
Prevention of Atrial Fibrillation by Low-dose Landiolol Administration After Cardiac Surgery
Postoperative atrial fibrillation (POAF) is a common complication that occurs in 30-50% of patients after cardiac surgery and increases morbidity and mortality and hospital length of stay.
- Trial name
- LANDIPROTEC (NCT04607122)
- Testing
- Landiolol, Saline
- Where
- 3 sites in France
- Volunteers
- 400 people
- Sponsor
- CMC Ambroise Paré
Thrombosis
A Study of the Safety and Pharmacokinetics of Apixaban Versus Vitamin K Antagonist (VKA) or Low Molecular Weight Heparin (LMWH) in Pediatric Subjects With Congenital or Acquired Heart Disease Requiring Anticoagulation
To investigate the safety and pharmacokinetics of apixaban in children with congenital or acquired heart disease who have a need for anticoagulation.
- Trial name
- NCT02981472
- Testing
- Apixaban, Vitamin K Antagonist (VKA), Low Molecular Weight Heparin (LMWH)
- Where
- 46 sites in United States, Argentina and 12 more
- Volunteers
- 192 people
- Sponsor
- Bristol-Myers Squibb
Diabetes, Myocardial Infarction
Prevention of Cardiovascular Complications in Diabetic Patients With Vitamin E Treatment
The purpose of this study is to determine whether Vitamin E treatment to Diabetic patients, who carry the Haptoglobin 2-2 Phenotype, prevents cardiovascular complications such as acute MI and Stroke.
- Conditions
- Diabetes, Myocardial Infarction, Cardiovascular Disease
- Trial name
- NCT00220831
- Testing
- Natural source Vitamin E 400IU/day
- Where
- Israel
- Volunteers
- 2,000 people
- Sponsor
- Technion, Israel Institute of Technology
Coronary Disease, Heart Valve Diseases
CTI-01 (Ethyl Pyruvate) Safety and Complication Prevention in Cardiac Surgery Patients on Cardiopulmonary Bypass (CPB)
Over 500,000 patients undergo cardiac surgery with CPB in the United States annually. Although mortality rates have decreased with advances in perioperative care, many patients are affected by postoperative organ dysfunction.
- Trial name
- NCT00107666
- Testing
- CTI-01 (ethyl pyruvate)
- Where
- 17 sites in United States
- Volunteers
- 150 people
- Sponsor
- Critical Therapeutics
Coronary Artery Disease
Community-based Precise Management for Patients With Coronary Artery Disease
The community-based precise management for patients with coronary artery disease study is a prospective, cluster-randomized, open-labeled trial.
- Trial name
- NCT05344053
- Testing
- Community-based precise management, Standard community-based management
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Atrial Fibrillation, Postoperative Complications
Landiolol for Prevention of Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery
Postoperative atrial fibrillation (POAF) is the most common arrhythmia after cardiac surgery with incidences ranging from 20% to 40% with the consequence of increasing mortality, morbidity, and hospital length of stay, as well as…
- Trial name
- LANDI-POAF (NCT05084118)
- Testing
- Landiolol HCl
- Where
- Austria
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Type2 Diabetes, Coronary Heart Disease
Coronary Artery Calcium-guided Primary Prevention of Major Coronary Heart Disease in Asymptomatic Diabetes
To evaluate benefits of primary prevention of major coronary heart disease for asymptomatic coronary artery disease in type 2 diabetes mellitus based on the coronary artery calcium score Our proposal 1.
- Trial name
- NCT05267990
- Testing
- Multi-Detector Computed Tomography
- Where
- Taiwan
- Volunteers
- 2,000 people
- Sponsor
- JuFeng, Hsiao
Coronary Artery Disease, Non-Obstructive Coronary Atherosclerosis
VIsualization of Coronary Artery Disease for Modification of RISK Factors
The VICAD-RISK study assesses if visualization of coronary CT angiography (CTA) images in participants with non-obstructive coronary artery disease will improve LDL lowering, reduce reporting of side effects by cholesterol…
- Trial name
- VICAD-RISK (NCT06413641)
- Testing
- Follow up at general practice, Consultation, Visualization of CTA images
- Where
- 5 sites in Denmark
- Volunteers
- 273 people
- Sponsor
- Aarhus University Hospital
Pericarditis, Recurrence
Study of Colchicine to Treat and Prevent Recurrent Pericarditis After Failure of Conventional Treatment.
The purpose of the study is to determine whether colchicine is safe and effective in treatment and prevention of recurrent pericarditis after failure of conventional treatment.
- Trial name
- CORP 2 (NCT00235079)
- Testing
- Colchicine
- Where
- 4 sites in Italy
- Volunteers
- 240 people
- Sponsor
- Azienda Sanitaria Locale 3, Torino
Hypertension, Coronary Artery Disease
Candesartan for Prevention of Cardiovascular Events After Cypher or Taxus Coronary Stenting (4C) Trial
Candesartan is effective in preventing cardiovascular events in patients without restenosis after coronary angioplasty. Therefore, the investigators hypothesized that candesartan after drug-eluting stent (DES) implantation was…
- Trial name
- NCT00139386
- Testing
- Candesartan
- Where
- Japan
- Volunteers
- 1,119 people
- Sponsor
- Kumamoto University
Acute ST-segment Elevation Myocardial Infarction (Patients Undergoing Emergency PCI)
Efficacy and Safety of Ultrasound Modulation of Stellate Ganglion for the Prevention of Ventricular Arrhythmia in Patients With ST-segment Elevation Myocardial Infarction
The goal of this multicenter, double-blind, randomized controlled trial is to evaluate the efficacy and safety of low-intensity focused ultrasound (LIFU) stellate ganglion modulation for preventing ventricular arrhythmias after…
- Trial name
- US-PRAY (NCT07587294)
- Testing
- Ultrasound modulation of the left stellate ganglion
- Where
- 7 sites in China
- Volunteers
- 100 people
- Sponsor
- Renmin Hospital of Wuhan University
Acute Kidney Injuries, Kidney Injuries, Acute
Short Term Spironolactone for Prevention of Acute Kidney Injury After Cardiac Surgery
Our aim is to test whether short term perioperative administration of oral spironolactone could reduce incidence of postoperative acute kidney injury (AKI) in cardiac surgical patients.
- Conditions
- Acute Kidney Injuries, Kidney Injuries, Acute, Kidney Injury, Acute, Acute Renal Injury
- Trial name
- NCT02417896
- Testing
- Spironolactone
- Where
- 2 sites in Mexico
- Volunteers
- 150 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Stroke, Ischemic, Atrial Fibrillation
Wearable Devices for Secondary Prevention of Ischemic Stroke
Ischemic stroke is an important cause of death and disability in Western countries. Different risk factors have been identified such as hypertension, diabetes, dyslipidemia, smoke, atrial fibrillation, obesity, and sedentary.
- Trial name
- NCT04282993
- Testing
- Wearable devices for identifying and measuring risk factors for ischemic stroke, Standard of care monitoring
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Campus Bio-Medico University
Acute Coronary Syndrome
A Web-Based Tailored Nursing Intervention to Increase Walking in Patients After an Acute Coronary Syndrome
Acute coronary syndromes (ACS) are one of the leading causes of coronary artery disease mortality, and among the top reasons for health care utilization in Canada.
- Trial name
- NCT02617641
- Testing
- TAVIEenM@RCHE, Publicly available websites
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Montreal Heart Institute
Atrial Fibrillation, Diet Therapy
Studies of the Prevention of Atrial Fibrillation by ALA
An alpha-linolenic acid (ALA) rich diet in the Lyon Heart Study reduced sudden cardiac deaths possibly by reducing cardiac arrhythmias and ventricular fibrillation (Lancet 1994).
- Trial name
- NCT00410839
- Testing
- ALA rich diet
- Where
- France
- Volunteers
- 130 people
- Sponsor
- University of Toronto
Atrial Fibrillation, Lung Cancer
Study of Amiodarone Given Before Lung Surgery to Prevent Atrial Fibrillation After Lung Resection
Atrial fibrillation is a very common complication of pulmonary resection. Patients who develop atrial fibrillation require additional treatment and are more likely to stay in the hospital for longer period of time increasing the…
- Trial name
- NCT00300495
- Testing
- Amiodarone, Control arm, standard care
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Beth Israel Deaconess Medical Center
Atherosclerosis, Coronary
Air Pollution (PM2.5) on Accelerated Atherosclerosis: A Montelukast Interventional Study in Modernizing China
Background: Longterm exposure to air pollution has been associated with cardiovascular events and mortality on top of traditional risk factors. Pulmonary inflammation and oxidative stress have been implicated.
- Trial name
- NCT04762472
- Testing
- Montelukast Oral Tablet
- Where
- Hong Kong
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong