Clinical trials: Prevention of Heart Disease
PTSD, Acute Coronary Syndrome
Early EEG-NF Intervention for the Prevention of PTSD
12% of patients suffering from an acute crornary syndrome will develop long lasting anxiety symptoms. The object of this study is to lessen or prevent these symptoms by the use of neurofeed back (EEG-NF).
- Trial name
- NCT01729780
- Testing
- EEG-NF
- Volunteers
- 150 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Heart Failure
Evaluation of Patiromer Titration in Heart Failure Patients With Chronic Kidney Disease
The purpose of this study was to evaluate the feasibility of individualized titration of patiromer according to serum potassium.
- Trial name
- NCT01130597
- Testing
- patiromer, spironolactone
- Where
- 13 sites in Georgia, Slovenia
- Volunteers
- 63 people
- Sponsor
- Relypsa, Inc.
Diabetes Mellitus, Type 2
A Study Comparing Cardiovascular Effects of Ticagrelor Versus Placebo in Patients With Type 2 Diabetes Mellitus
The purpose of this study is to compare the effect of ticagrelor versus placebo in patients with Type 2 Diabetes Mellitus.
- Trial name
- THEMIS (NCT01991795)
- Testing
- Ticagrelor 60 mg
- Where
- 1,237 sites in United States, Argentina and 41 more
- Volunteers
- 19,271 people
- Sponsor
- AstraZeneca
Coronary Arterial Disease (CAD)
Reconsidering Long-Term Apirin in the Elderly in Secondary Prevention of Coronary Artery Disease Norway
Lifelong aspirin has been a cornerstone of secondary prevention after coronary artery disease (CAD), based on trials conducted 40-50 years ago.
- Trial name
- RELEASE-Norway (NCT07854795)
- Testing
- Discontinuation of aspirin (ATC-code B01AC06 and N02BA01)
- Where
- 9 sites in Norway
- Volunteers
- 7,000 people
- Sponsor
- Vestre Viken Hospital Trust
Atrial Fibrillation, Postoperative Atrial Fibrillation
SGB for Prevention of Postop A-Fib After Cardiac SurgeryTrial
This research study is being conducted to determine whether a stellate ganglion block, a small injection in the neck that temporarily reduces sympathetic nervous system activity, can help reduce the risk of developing…
- Trial name
- NCT07893275
- Testing
- Stellate Ganglion Block Injection with 10 mL 0.5% Bupivacaine, Stellate Ganglion Block Injection with 10 mL Normal Saline
- Volunteers
- 60 people
- Sponsor
- The Cleveland Clinic
Cardiovascular Diseases, Physical Inactivity
Integrating Exercise Into Lifestyle of Cardiac Outpatients
The purpose of the study is to investigate the long-term effects of a personalized physical activity program on exercise capacity and quality of life in patients with stable cardiovascular disease.
- Conditions
- Cardiovascular Diseases, Physical Inactivity, Aging, Quality of Life
- Trial name
- ITER (NCT05817305)
- Testing
- Medical history and functional evaluation, Health education
- Where
- Italy
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Università degli Studi di Ferrara
Contrast Induced Nephropathy
Oral Versus Intravenous Hydration to Prevent Contrast Induced Nephropathy
The increased risk for contrast-induced nephropathy (CIN) in patients with chronic kidney disease (CKD) undergoing coronary angiography (CAG) has been established.
- Trial name
- HYDRATE (NCT01093131)
- Testing
- Oral hydration, Oral sodium bicarbonate, Intravenous Hydration
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- The Western Pennsylvania Hospital
Acute Coronary Syndrome
Evaluation of Compliance With Management of Acute Coronary Syndrome on Discharge From Cardiac Intensive Care
To study compliance with secondary prevention during the first months following discharge from the cardiac intensive care unit (CIC) of patients experiencing a first episode of acute coronary syndrome : quantitative compliance…
- Trial name
- SCAVANCE (NCT01105325)
- Where
- 49 sites in France
- Volunteers
- 1,000 people
- Sponsor
- AstraZeneca
Cardiovascular Disease
Polypill Effects on Sub Clinical Atherosclerosis (PESCA) Trial
Medications that lower blood pressure and cholesterol are known to improve the shape and function of our blood vessels. These improvements include a reduction in the thickness of the wall of the carotid artery (the main artery…
- Trial name
- PESCA (NCT01326676)
- Testing
- Polypill: Red Heart Pill, Usual medication
- Where
- 3 sites in Ireland, Netherlands and 1 more
- Sponsor
- Imperial College London
Delirium, C.Surgical Procedure; Cardiac
Dexmedetomidine and Delirium in Patients After Cardiac Surgery
Postoperative delirium (POD) is a frequently occurring complication after cardiac surgery. Its occurrence is associated with worse outcomes of patients, including increased morbidity, prolonged hospital stay, increased medical…
- Conditions
- Delirium, C.Surgical Procedure; Cardiac, Postoperative Complications
- Trial name
- NCT02267538
- Testing
- dexmedetomidine hydrochloride for injection, 0.9% sodium chloride for injection
- Where
- China
- Volunteers
- 285 people
- Sponsor
- Peking University First Hospital
Atrial Fibrillation, Atrial Flutter
A Trial With Dronedarone to Prevent Hospitalization or Death in Patients With Atrial Fibrillation
To assess the efficacy of dronedarone in preventing cardiovascular hospitalization or death from any cause in a population of high-risk patients with atrial fibrillation/atrial flutter (AF/AFL).
- Trial name
- ATHENA (NCT00174785)
- Testing
- dronedarone (SR33589)
- Where
- 37 sites in United States, Argentina and 35 more
- Volunteers
- 4,628 people
- Sponsor
- Sanofi
Cardiovascular Disease
Role of Vitamin D in Secondary Prevention of Cardiovascular Events
The purpose of this study is to determine if Vitamin D supplementation helps prevent recurrent cardiovascular events, such as heart attack or stroke, in patients who have already experienced at least one cardiovascular event.
- Trial name
- NCT01018849
- Testing
- Cholecalciferol
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Creighton University
Hyperlipidemia
Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese(MEGA Study)
To evaluate the primary preventive effect of low-dose pravastatin against coronary heart disease (CHD) in Japanese hypercholesterolemic patients.
- Trial name
- NCT00211705
- Testing
- Diet, Diet+pravastatin
- Volunteers
- 8,000 people
- Sponsor
- Mitsukoshi Health and Welfare Foundation
HER2-positive Breast Cancer, HER2+ Breast Cancer
HER2HEART-US: Prevention of Cardiotoxicity in Breast Cancer Patients Receiving HER2-directed Therapy
Ten to 15% of patients with breast cancer are HER2 positive, with treatment focused on targeting the HER2 receptor. Although these treatments are generally well tolerated, they are associated with an increased risk of…
- Trial name
- NCT06844669
- Testing
- Carvedilol, Empagliflozin
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Washington University School of Medicine
Coronary Artery Disease,
Pathophysiology and Prevention of Perioperative Myocardial Injury: A Prospective Randomized Controlled Trial
Working hypothesis and aims: 1) To explore the pathophysiology of postoperative troponin elevations and 2) whether ranolazine, a new anti-ischemic drug that has no effect on blood pressure or heart rate, prevents postoperative…
- Trial name
- NCT01810796
- Testing
- Ranolazine
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Hadassah Medical Organization
Tricuspid Valve Insufficiency, Pacemaker Complication
Prevention of Pacemaker Lead Induced Tricuspid regurgitAtion by Transesophageal eCho guidEd Implantation Registry
Registry for patients undergoing pacemaker/ICD implantation including a transtricuspid lead with and without intraprocedural transesophageal echocardiography to evaluate risk factors for lead induced tricuspid regurgitation.
- Conditions
- Tricuspid Valve Insufficiency, Pacemaker Complication, Echocardiography, Transesophageal
- Trial name
- PLACE (NCT04945005)
- Testing
- Transesophageal guidance of lead implantation
- Where
- Germany
- Volunteers
- 124 people
- Sponsor
- LMU Klinikum
Acute Coronary Syndrome
A Web-Based Tailored Nursing Intervention to Increase Walking in Patients After an Acute Coronary Syndrome
Acute coronary syndromes (ACS) are one of the leading causes of coronary artery disease mortality, and among the top reasons for health care utilization in Canada.
- Trial name
- NCT02617641
- Testing
- TAVIEenM@RCHE, Publicly available websites
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Montreal Heart Institute
Anaesthesia, Toxicity
Sensitivity of ECG on Detection of Three Different Intravascular Applied Test Doses of Bupivacaine and Epinephrine
The purpose of this prospective randomised study is to investigate electrocardiographic alterations after intravascular injection of three different test solutions of bupivacaine and epinephrine in anaesthetised children up to 16…
- Trial name
- NCT01091766
- Testing
- intravenous injection of test solution
- Where
- Switzerland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Atrial Fibrillation
Optimizing Stroke Prophylaxis of Acute Atrial Fibrillation With an Electronic Clinical Decision Support Tool
Atrial fibrillation (AF) is the most common arrhythmia in the world, with significant morbidity and mortality. With appropriate oral anticoagulation, the risk of stroke due to atrial fibrillation decreases by 64%.
- Trial name
- AF SWCRT-CDS (NCT05341986)
- Testing
- Clinical Decision Support (CDS) tool
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Oregon Health and Science University
Myocardial Infarction, Peripheral Vascular Disease
Lowering the Risk of Operative Complications Using Atorvastatin Loading Dose
Patients submitted to noncardiac surgeries are at increased risk of serious cardiovascular complications. Statins have shown to lower cholesterol levels and reduce cardiovascular events in other scenarios.
- Conditions
- Myocardial Infarction, Peripheral Vascular Disease, Aortic Aneurism
- Trial name
- LOAD (NCT01543555)
- Testing
- Atorvastatin
- Where
- Brazil
- Volunteers
- 648 people
- Sponsor
- Hospital do Coracao