Clinical trials: Prevention of Heart Disease
Coronary Arteriosclerosis
EARly Prevention of aTHeroma Progression
The purpose of this study is to compare standard therapy (risk factor control, life style modification) versus standard therapy plus low-dose rosuvastatin therapy (5mg/day) on progression of coronary atherosclerosis in statin…
- Trial name
- EARTH (NCT02105623)
- Testing
- Standard Therapy, Rosuvastatin
- Where
- South Korea
- Volunteers
- 111 people
- Sponsor
- CHEOL WHAN LEE, M.D., Ph.D
Cardiomyopathies
Assessment of Appropriate ICD Implantation for Primary Prevention of Sudden Cardiac Death
Prophylactic implant of an ICD (implantable cardioverter defibrillator) for prevention of sudden cardiac death from a life-threatening heart rhythm abnormality is a standard recommendation for patients with ejection fractions…
- Trial name
- NCT00926159
- Volunteers
- 549 people
- Sponsor
- University of Minnesota Physicians Heart at Fairview
Coronary Heart Disease
Trial of Lycopene/Ateronon for Secondary Prevention of Coronary Heart Disease
The purpose of this study is to determine whether Ateronon, a nutritional supplement that contains lycopene from tomatoes has a favorable effect on carotid atherosclerosis, lipid levels, and other biomarkers of coronary heart…
- Trial name
- NCT00939237
- Testing
- Ateronon
- Where
- United States
- Volunteers
- 213 people
- Sponsor
- Brigham and Women's Hospital
Atrial Fibrillation
Corticosteroids for the Prevention of Atrial Fibrillation After Cardiac Surgery
Atrial fibrillation is the most common arrhythmia to occur after cardiac surgery. Inflammatory response may be one etiological factor.
- Trial name
- NCT00442494
- Testing
- intravenous hydrocortisone
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Kuopio University Hospital
Acute Ischemic Stroke, Acute Renal Injury
Recombinant Human C1 Esterase Inhibitor (Conestat Alfa) in the Prevention of Acute Ischemic Cerebral and Renal Events After Transcatheter Aortic Valve Implantation
The aim of this trial is to assess the safety and efficacy of conestat alfa (Ruconest®, Pharming Technologies B.V.) on renal and cerebral ischemic events in patients undergoing TAVI for severe symptomatic aortic stenosis (AS)…
- Trial name
- PAIR-TAVI (NCT05145283)
- Testing
- Conestat alfa (Ruconest®), NaCl 0.9%)
- Where
- 2 sites in Switzerland
- Volunteers
- 141 people
- Sponsor
- University Hospital, Basel, Switzerland
Other Intraoperative Cardiac Functional Disturbances During Cardiac Surgery
Amiodarone for the Prevention of Reperfusion Ventricular Fibrillation
This was a prospective, randomized, double blinded study in which patients undergoing a cardiopulmonary bypass (CPB) with aortic cross clamping were randomly assigned to receive amiodarone, lidocaine, or saline placebo prior to…
- Trial name
- NCT00587483
- Testing
- Lidocaine, Amiodarone
- Where
- United States
- Volunteers
- 342 people
- Sponsor
- Mayo Clinic
Giant Cell Arteritis (GCA), Acute Coronary Syndrome (ACS)
Aspirin for the Prevention of Ischemic Complications in Giant Cell Arteritis
The ASPIRE-GCA Pilot trial will assess the feasibility of a future randomized controlled trial (RCT) evaluating the efficacy of low-dose ASA in preventing ischemic complications in patients with Giant Cell Arteritis (GCA).
- Conditions
- Giant Cell Arteritis (GCA), Acute Coronary Syndrome (ACS), Ishemic and Thrombotic Complications
- Trial name
- ASPIRE-GCA (NCT07908082)
- Testing
- Acetyl Salicylic Acid (ASA)
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Coronary Atherosclerosis, Coronary Restenosis
PIoglitazone for PrEvention of Restenosis in Diabetic Patients
Restenosis requiring reintervention is still a limitation of percutaneous coronary angioplasty. Despite the use of Drug eluting stent (DES), the rate of restenosis remains 7% to 16% in diabetic patients, making it a challenging…
- Conditions
- Coronary Atherosclerosis, Coronary Restenosis, Diabetes
- Trial name
- NCT00376870
- Testing
- Pioglitazone
- Where
- 2 sites in Italy
- Volunteers
- 160 people
- Sponsor
- University of Rome Tor Vergata
Cardiac Surgery Patients
HPI for Prevention of Hypotension During Cardiac Surgery
Hypotension prediction index (HPI) was applied in various types of non-cardiac surgery with convincing benefits of preventing hypotensive events and clinical sequelae.
- Trial name
- NCT06137547
- Testing
- Hypotension prediction index (HPI)
- Where
- Taiwan
- Volunteers
- 110 people
- Sponsor
- Mackay Memorial Hospital
Myocardial Infarction, Acute
Effect of INtravenous FERRic Carboxymaltose Onmortality and Cardiovascular Morbidity, and Quality of Life in Iron Deficient Patients With Recent Myocardial infarCTion
Non-commercial, multicentre, randomised, double-blind, parallel group, placebo-controlled clinical trial. Eligible patients were randomly assigned (1:1) using a secure, central, interactive, web-based response system, to…
- Trial name
- INFERRCT (NCT05759078)
- Testing
- Ferinject, Sodium Chloride 0.9% Inj
- Where
- 43 sites in Poland
- Volunteers
- 1,000 people
- Sponsor
- Wroclaw Medical University