Clinical trials: Prevention of Surgical Site Infections, open to volunteers
Thyroid Diseases, Wound Healing
Safety and Efficacy of NTP in Thyroid Surgery: Pilot Study on Morbidity Prevention and Adjuvant Oncological Control
The goal of this clinical trial is to evaluate the therapeutic efficacy and safety of non-thermal plasma (NTP) as an adjuvant treatment for surgical bed decontamination and accelerated tissue repair in patients undergoing total…
- Conditions
- Thyroid Diseases, Wound Healing, Thyroidectomy, Surgical Wound Infection
- Trial name
- NCT07382973
- Testing
- Atmospheric Pressure Non-Thermal Plasma, Standard Surgical Wound Care Protocol
- Where
- Mexico
- Volunteers
- 26 people
- Sponsor
- National Institute of Nuclear Research - Mexico
Infection
Intra-wound Vancomycin Powder for Prevention of Surgical Site Infection Following Spinal Surgery
Cefazolin is given routinely pre and intraoperatively for patients undergoing spinal surgery to reduce the rate of infection. Intra-wound admission of Vancomycin powder has been suggested to reduce wound infection rates.
- Trial name
- NCT05959603
- Testing
- Vancomycin
- Where
- Israel
- Volunteers
- 363 people
- Sponsor
- Rabin Medical Center
Surgical Site Infection (SSI)
Continuous Infusion Versus Intermittent IV Bolus of Cefazolin: Prevention of Surgical Site Infection During CABG Surgeries in Egyptian Patients.
A randomized controlled trial on adults who underwent coronary artery bypass grafting (CABG) surgery. To evaluate the effectiveness of intraoperative continuous infusion (CI) of cefazolin compared with intermittent (INT)…
- Trial name
- NCT07658378
- Testing
- Cefazolin 2 g Infusion, Cefazolin 2 GM Injection
- Volunteers
- 100 people
- Sponsor
- Helwan University
Surgical Site Infection (SSI)
Continuous Infusion Versus Intermittent IV Bolus of Cefazolin: Prevention of Surgical Site Infection During Orthopedic Surgeries in Egyptian Patients.
A randomized controlled trial on adults who underwent orthopedic surgery. To evaluate the effectiveness of intraoperative continuous infusion (CI) of cefazolin compared with intermittent (INT) cefazolin administration in…
- Trial name
- NCT07655596
- Testing
- Cefazolin 2 g Infusion, Cefazolin 2 GM Injection
- Volunteers
- 100 people
- Sponsor
- Helwan University
Breast Cancer, Breast Surgery
Evaluation of the Effect of Antibiotic Prophylaxis During Lumpectomy for Breast Cancer: Prospective Randomised Double-blind Noninferiority Study of Placebo vs Cefazolin
The goal of this clinical trial is to determine whether preoperative antibiotic prophylaxis with cefazolin is necessary to prevent surgical site infections in adult women undergoing breast-conserving surgery (lumpectomy or…
- Conditions
- Breast Cancer, Breast Surgery, Surgical Site Infection (SSI), Surgical Site Infection Prevention
- Trial name
- PROPHY-SEIN (NCT07898943)
- Testing
- Cefazolin 2 g Infusion
- Where
- 33 sites in France
- Volunteers
- 1,600 people
- Sponsor
- University Hospital, Clermont-Ferrand
Abdominal Aortic Aneurysm, Morbid Obesity
Pilot Study on the Effectiveness and Safety of OPTILENE® SILVER MESH ELASTIC in Prevention of Surgical Site Infection (SSI) and Incisional Hernia (IH)
The aim of the study is to describe the effectiveness of Optilene® Silver Mesh Elastic on prevention of surgical site infection (SSI) at 6 months follow-up in patients undergoing urgent laparotomy by collecting clinical data on…
- Trial name
- SSIHLVER (NCT06547138)
- Testing
- Prophylactic mesh
- Where
- 5 sites in Spain
- Volunteers
- 110 people
- Sponsor
- Aesculap AG
Surgical Site Infection
Duration of Cardiac Antimicrobial Prophylaxis Outcomes Study
This multicentre, adaptive, pragmatic, double-blind, three-arm, placebo-controlled, randomised, non-inferiority clinical trial will compare the incidence of surgical site infection and other healthcare associated infections…
- Trial name
- CALIPSO (NCT05447559)
- Testing
- Cefazolin, Water for injection
- Where
- 27 sites in United States, Australia and 3 more
- Volunteers
- 9,180 people
- Sponsor
- Monash University
Antibiotic Prophylaxis, Pancreatic Surgey
Perioperative Pharmacokinetic/Pharmacodynamic Target Attainment of Piperacillin During Major Hepatic and Pancreatic Surgery
Hepatic and pancreatic surgeries are associated with a high risk of surgical site infections, particularly in patients with preoperative biliary drainage, which is frequently associated with bacterial colonization of bile.
- Conditions
- Antibiotic Prophylaxis, Pancreatic Surgey, Hepatic Surgery
- Trial name
- PROPHTAZ (NCT07558681)
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- Central Hospital, Nancy, France
Surgical Site Infection
Local Subcutaneous Gentamicin for Prevention of Surgical Site Infection After Elective Cesarean Section
The goal of this clinical trial is to evaluate whether local subcutaneous administration of gentamicin reduces the incidence of surgical site infection (SSI) following elective cesarean section.
- Trial name
- NCT07311395
- Testing
- Gentamicin, Standard antibiotic prophylaxis
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Inguinal Hernia, Hydroceles
Prevention of Surgical Site Infection in Open Paediatric Groin Surgeries Using Intravenous Prophylactic Antibiotics and Antimicrobial-coated Sutures
The goal of this clinical trial is to learn if the use of prophylactic antibiotics and antimicrobial-coated sutures can prevent surgical site infection in children undergoing open groin surgeries.
- Conditions
- Inguinal Hernia, Hydroceles, Surgical Site Infection
- Trial name
- NCT07346742
- Testing
- Antimicrobial-coated sutures, Intravenous Cefuroxime
- Where
- Nigeria
- Volunteers
- 174 people
- Sponsor
- Olawumi Olajide
Surgical Site Infection
PRevention Of Trauma-related Infections Through an Embedded Clinical Trials Network
The purpose of this study is to compare the effectiveness of 2 prophylactic antibiotic regimens, ertapenem and cefazolin with metronidazole, in preventing organ space surgical site infections (OS-SSI) after emergency trauma…
- Trial name
- PROTECT (NCT06920147)
- Testing
- Ertapenem, Cefazolin and Metronidazole.
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- The University of Texas Health Science Center, Houston
Tooth Loss and Rehabillitation, Dental Implant Failure
Safety Assessment of Placing a Single Dental Implant Without Antibiotic Prophylaxis in Simple Cases: A Pilot Study
This pilot study will examine whether a single dental implant can be placed safely without giving antibiotics before or after surgery in patients with straightforward cases in Vietnam.
- Conditions
- Tooth Loss and Rehabillitation, Dental Implant Failure, Surgical Wound Infection
- Trial name
- NCT07920614
- Testing
- Single-Implant Placement Without Antibiotic Prophylaxis
- Where
- Vietnam
- Volunteers
- 39 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Incisional Hernia After Midline Laparotomy, Quality of Life (QOL)
NoPro - Norwegian Hernia Prophylaxis Study
A multicenter randomized controlled trial comparing midline laparotomy closures using the small-bite suture technique alone to those using the small-bite suture technique with an additional onlay prophylactic polypropylene mesh.
- Conditions
- Incisional Hernia After Midline Laparotomy, Quality of Life (QOL), Burst Abdomen, Surgical Site Infections
- Trial name
- NoPro (NCT06858020)
- Testing
- Prophylactic polypropylene onlay mesh
- Where
- Norway
- Volunteers
- 150 people
- Sponsor
- Sykehuset Innlandet HF
Hydrocephalus, Ventriculoperitoneal Shunt Infection
Efficacy and Cost-Effectiveness of Topical Vancomycin Powder in Preventing Pediatric Ventriculoperitoneal Shunt Infections Across Different Etiologies
Objectives Primary: To measure the reduction in VP shunt infection rates using topical vancomycin powder. Secondary: To compare efficacy across different Etiological Strata (Congenital, Post-hemorrhagic, post-inflammatory).
- Conditions
- Hydrocephalus, Ventriculoperitoneal Shunt Infection, Surgical Site Infection (SSI), Cerebrospinal Fluid Shunt Infection
- Trial name
- NCT07547826
- Testing
- Topical Vancomycin Powder, Standard Perioperative Care
- Where
- Egypt
- Volunteers
- 164 people
- Sponsor
- Assiut University
Colorectal Cancer, Incisional Hernia
Comparing Polypropylene Mesh and "Small Bites" Technique in Emergency Colorectal Surgery's Midline Laparotomy Closure. Study for Incisional Hernia Prevention.
The 2023 World Journal of Emergency Surgery guidelines couldn't provide a recommendation for emergency abdominal wall closure due to insufficient consensus (>80% required).
- Conditions
- Colorectal Cancer, Incisional Hernia, Wound Infection
- Trial name
- BITEME (NCT06220058)
- Testing
- Closure of the midline laparotomy using the "small bites" technique, Closure of the midline laparotomy using the "small bites" technique with an absorbable PP mesh
- Where
- Spain
- Volunteers
- 148 people
- Sponsor
- Fernandez Zamora
Site Infection
Incidence of Ssi After c.s
aim of the work is to evaluate adherence to preoperative , intraoperative, and postoperative infection preventive measures during cesarean section and to assess it s impact on the incidence of surgical site infection and maternal…
- Trial name
- NCT07476261
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- Assiut University
Surgical Site Infection, Vaginal Cuff Cellulitis
Prevention of Vaginal Cuff Infection After Hysterectomy by Addition of Vaginal Clindamycin
This study seeks to determine ways to reduce the hospitals surgical site infection rate during hysterectomy operations.
- Conditions
- Surgical Site Infection, Vaginal Cuff Cellulitis, Bacterial Vaginosis
- Trial name
- NCT07888101
- Testing
- Clindamycin Vaginal Gel
- Where
- United States
- Volunteers
- 900 people
- Sponsor
- Baylor Research Institute
Surgical Wound Infection
The Effect of Bacterial Decolonization Before Skin Cancer Surgery on Infection Rate of Lower Extremity Wounds Left Open to Heal
The goal of this clinical trial is to learn if reducing bacterial load on the skin and nostrils with topical antibacterial soap and ointment, respectively, reduces rate of infection in surgical sites on lower leg wounds left open…
- Trial name
- NCT07142408
- Testing
- Chlorhexidine gluconate (4%), Mupirocin 2% Ointment
- Where
- United States
- Volunteers
- 848 people
- Sponsor
- Cooper Norcross Health
Orthognathic Surgical Site Infection
Antibiotics for Prevention of Infection Following Orthognathic Surgery
Orthognathic surgery describes a group of procedures aimed at correcting developmental or acquired deformities of the jaws and facial skeleton.
- Trial name
- NCT05852158
- Testing
- Cefazolin 2 GM Injection, Cefazolin Injection
- Where
- Canada
- Volunteers
- 400 people
- Sponsor
- Abdul El-Rabbany
Surgical Site Infection (SSI), Spine Surgery
Investigation of the PREVENTIA® Irrigation Solution for Reducing Bacteria in Spinal Surgery With Implants - A Comparative Study
Spinal surgery carries a risk of surgical wound infections (i.e., the entry of bacteria). Despite various preventive measures, such infections continue to occur, particularly in operations involving implants.
- Conditions
- Surgical Site Infection (SSI), Spine Surgery, Surgical Site Infection Prevention
- Trial name
- PROTECT-SPINE (NCT07667036)
- Testing
- Preventia Surgical Solution, 0.9 % NaCl
- Where
- Switzerland
- Volunteers
- 114 people
- Sponsor
- Universität Luzern