Clinical trials: Preventive Cardiology
Lower Extremity Injuries, Venous Thromboembolism (VTE)
TRiP-cast Score Validation and Evaluation of Adherence to Preventive Anticoagulant Treatment in Patients With Lower Limb Trauma Requiring Immobilization
This is a prospective, multicenter, observational cohort study designed to externally validate the Trauma-Related Immobilization-related Prophylaxis (TRiP(cast)) score in Tunisian adults with acute lower-limb trauma requiring…
- Conditions
- Lower Extremity Injuries, Venous Thromboembolism (VTE), Deep Vein Thrombosis, Pulmonary Embolism
- Trial name
- TRiP-VALID (NCT07863115)
- Testing
- Low-Molecular-Weight Heparin (LMWH), Direct Oral Anticoagulants (DOACs), No Thromboprophylaxis Cohort
- Where
- Tunisia
- Volunteers
- 1,500 people
- Sponsor
- University of Monastir
Hemophilia A
Single-Arm Study To Evaluate The Efficacy and Safety of Valoctocogene Roxaparvovec in Hemophilia A Patients at a Dose of 4E13 vg/kg
This Phase III clinical study will assess the efficacy of BMN 270 defined as FVIII activity, during weeks 49-52 following intravenous infusion of BMN 270 and assess the impact of BMN 270 on usage of exogenous FVIII replacement…
- Trial name
- GENEr8-2 (NCT03392974)
- Testing
- Valoctocogene Roxaparvovec
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- BioMarin Pharmaceutical
Ischemic Stroke
Impact of a Pluriprofessional Intervention to Improve Medication Adherence (Secondary Preventive Medication) in Patients After Ischemic Stroke
Medication adherence is a major factor to prevent vascular recurrence after a first ischemic stroke. Nevertheless, it is suboptimal and the implementation of specific interventions are needed to improve it.
- Trial name
- ADMED-AVC (NCT02611440)
- Testing
- Pharmaceutical care
- Where
- 6 sites in France
- Volunteers
- 182 people
- Sponsor
- Hospices Civils de Lyon
Hemorrhage, Pneumonia
Oral Hygiene and Prophylactic Antibiotics to Prevent Intracerebral Hemorrhage Associated Pneumonia
Project Name: Randomized Controlled Clinical Study on oral hygiene and prophylactic antibiotics to prevent Intracerebral Hemorrhage associated pneumonia Research Objectives: To evaluate the effectiveness, safety and health…
- Trial name
- OCEAN (NCT07311343)
- Testing
- wether apply enhanced oral care combined with prophylactic antibiotics
- Where
- China
- Volunteers
- 440 people
- Sponsor
- Beijing Tiantan Hospital
Ischemic Stroke, Systemic Embolism
Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction Trial
This trial is a prospective, randomized, multicenter, multinational, blinded, superiority trial. The objective of this trial is to evaluate the effectiveness of left atrial appendage exclusion (LAAE) for the prevention of…
- Trial name
- LeAAPS (NCT05478304)
- Testing
- AtriClip LAA Exclusion System
- Where
- 138 sites in United States, Australia and 8 more
- Volunteers
- 6,573 people
- Sponsor
- AtriCure, Inc.
Diabetic Foot Ulcer, Type 2 Diabetes Mellitus With Complication
Implementation of a Preventive Diabetic Foot Care Program for Patients at Risk of Diabetic Foot
This study aims to evaluate the effect of a preventive diabetic foot care program on the knowledge, behavior, self-management, and glycemic control levels of type 2 diabetic patients at risk of diabetic foot.
- Trial name
- NCT06770829
- Testing
- DiaFOOTCare Program, Ministry of Health and Education
- Volunteers
- 78 people
- Sponsor
- Akdeniz University
Out-of-hospital Cardiac Arrest
Prophylactic Antibiotics in Comatose Survivors of Out-of-hospital Cardiac Arrest
The purpose of this study is to determine whether there is potential benefits of prophylactic antibiotic treatment in comatose survivors of out-of-hospital cardiac arrest (OHCA) treated in intensive care unit with therapeutic…
- Trial name
- NCT02899507
- Testing
- Amoxicillin-Clavulanic acid
- Where
- Slovenia
- Volunteers
- 60 people
- Sponsor
- University Medical Centre Ljubljana
Antibiotic Side Effect
Prevention of Cefoperazone-induced Coagulopathy
Evaluating the effect of prophylactic doses of vitamin K in preventing the adverse effect of cefoperazone/sulbactam induced coagulopathy in critically ill patients.
- Trial name
- NCT05742295
- Testing
- Vitamin K
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Helwan University
Fibrinogen, Spine Deformity
Effect of Prophylactic Fibrinogen Concentrate In Scoliosis Surgery
EFISS is a prospective, randomized, placebo-controlled trial testing the feasibility, safety and efficacy of prophylactic administration of fibrinogen in paediatric spinal surgery.
- Conditions
- Fibrinogen, Spine Deformity, Coagulopathy, Consumption, Bleeding
- Trial name
- EFISS (NCT05391412)
- Testing
- Fibrinogen Concentrate Human
- Where
- Czechia
- Volunteers
- 32 people
- Sponsor
- Brno University Hospital
Ventricular Tachycardia
Preventive aBlation of vEntricular tachycaRdia in Patients With myocardiaL INfarction
The BERLIN VT study is designed to evaluate the impact of prophylactic ventricular tachycardia (VT) ablation on all-cause mortality and unplanned hospital admission for congestive heart failure or symptomatic ventricular…
- Trial name
- BERLIN VT (NCT02501005)
- Testing
- VT ablation
- Where
- 5 sites in Germany
- Volunteers
- 163 people
- Sponsor
- Biotronik SE & Co. KG
Chemotherapeutic Agent Toxicity, Pancreatic Cancer
Chemotherapy With or Without Dalteparin in Treating Patients With Metastatic Pancreatic Cancer
RATIONALE: Drugs used in chemotherapy, such as gemcitabine and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Chemotherapeutic Agent Toxicity, Pancreatic Cancer, Thromboembolism
- Trial name
- PAM07 (NCT00662688)
- Testing
- daltéparine, Chemotherapy at the investigator's discretion
- Where
- 6 sites in France
- Volunteers
- 42 people
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Embryo Transfer, Hypertension, Pregnancy Induced
Treatment Preventive for Pre-eclampsia by Acetylsalicylic Acid in Women Who Underwent Frozen Embryo Transfer
Title: A prospective multicentric interventional randomized controlled trial to assess the effect of low dose acetylsalicylic acid as a preventive treatment of pre-eclampsia in pregnant women who underwent frozen embryo transfer
- Trial name
- TePPAFET (NCT05460416)
- Testing
- Acetylsalicylic acid
- Where
- Belgium
- Volunteers
- 276 people
- Sponsor
- Centre Hospitalier Universitaire de Liege
Peripheral Arterial Disease
A Usability Study of a Tele-health Service for Patients With Peripheral Arterial Disease.
The aim of the study is to analyze the applicability (usability) of a tele-health service as part of a potential disease management program for patients with peripheral arterial disease.
- Trial name
- NCT05619835
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University of Graz
Postpartum Period, Cesarean Section Surgery
Rivaroxaban vs Enoxaparin After Cesarean Section: Laboratory Thromboprophylaxis Outcomes
Pregnancy and the postpartum period increase venous thromboembolism (VTE) risk. After cesarean section, low-molecular-weight heparin (LMWH; enoxaparin) is commonly used for short-term thromboprophylaxis, but it requires daily…
- Conditions
- Postpartum Period, Cesarean Section Surgery, VTE (Venous Thromboembolism)
- Trial name
- NCT07820670
- Testing
- Rivaroxaban, Enoxaparin 40 mg
- Where
- Israel
- Volunteers
- 62 people
- Sponsor
- Wolfson Medical Center
Coronary Artery Disease
TIMELY-PrädiktoR Prospective Study
Brief Summary: Cardiac rehabilitation (CR) is a multi-factorial intervention, designed to limit the physiological and psychological effects of cardiovascular disease such as coronary artery disease (CAD), manage symptoms, and…
- Trial name
- NCT05461729
- Where
- Germany
- Volunteers
- 1,200 people
- Sponsor
- Dr. Boris Schmitz
Adverse Effect
Prophylactic Norepinephrine Infusion for Spinal Hypotension and Inferior Vena Cava Collapsibility Index
The purpose of this study is to investigate the preventive effect of norepinephrine on post-spinal hypotension and the effect of norepinephrine on inferior vena cava collapsibility index (IVC-CI).
- Trial name
- NCT03997500
- Testing
- normal saline, Norepinephrine
- Where
- China
- Volunteers
- 195 people
- Sponsor
- General Hospital of Ningxia Medical University
Postpartum Hemorrhage, Systemic Autoimmune Diseases
Prophylactic Tranexamic Acid Reduces Postpartum Hemorrhage
Postpartum hemorrhage (PPH) is the most significant leading cause of pregnancy-related mortality in high-risk cesarean delivery women.
- Trial name
- NCT06754371
- Testing
- tranexamic acid, normal saline
- Where
- China
- Volunteers
- 276 people
- Sponsor
- RenJi Hospital
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies
This pilot phase II trial studies how well giving donor T cells after donor stem cell transplant works in treating patients with hematologic malignancies.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q), Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)
- Trial name
- NCT01839916
- Testing
- therapeutic allogeneic lymphocytes, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- University of Chicago
Cancer Therapy-related Cardiovascular Toxicity
Correlation Between Myocardial Injury and Intestinal Flora Changes Associated With Oncology Drug Therapy and the Preventive of Probiotics
The purpose of this study was to explore the relationship between early myocardial injury caused by tumor drug therapy and intestinal microbial structure changes by echocardiographic two-dimensional speckle tracking technique and…
- Trial name
- NCT05730777
- Testing
- Bifidobacterium Bifidum Oral Capsule, Cisplatin, Carboplatin
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
Post Induction Hypotension, Sepsis
Prophylactic Noradrenaline Infusion and Its Impact on Post-induction Hypotension
researchers aim to evaluate the influence of prophylactic noradrenaline infusion on post-induction hypotension
- Trial name
- NCT07022730
- Testing
- Noradrenaline 0.2 mcg/kg/min at 5 minutes before induction
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University