Clinical trials: Preventive Intervention
Cystic Fibrosis, Prediabetes
Prevention of Cystic Fibrosis Diabetes
Acute systemic hyperglycemia causes oxidative stress and a pro-inflammatory response. The pro-inflammatory cytokines induced by hyperglycemia are toxic to islet insulin producing cells, and thus worsen glucose intolerance.
- Trial name
- Prevent (NCT00967798)
- Testing
- Sitagliptin
- Where
- 3 sites in United States
- Volunteers
- 33 people
- Sponsor
- Emory University
Asthma
Study Assessing the Long-term Effect of Dupilumab on Prevention of Lung Function Decline in Adult Patients With Uncontrolled Moderate to Severe Asthma
This is an interventional, randomized, parallel group, treatment, Phase 3b/4, double blind, 2-arm study to assess the effect of dupilumab compared to standard of care therapy on preventing or slowing the rate of lung function…
- Trial name
- ATLAS (NCT05097287)
- Testing
- Dupilumab
- Where
- 249 sites in United States, Belgium and 21 more
- Volunteers
- 1,339 people
- Sponsor
- Sanofi
Fatigue
Relationship Between Hip Abductor Strength and Ankle Stability
Ankle sprains are one of the most common injuries in sports. The analysis of risk factors is a priority in order to guide rehabilitation and prevention programs.
- Trial name
- HIAS (NCT05236816)
- Testing
- Fatigue (physical exercise)
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Safety and Efficacy
Prevention and Treatment of Differentiation Syndrome in Patients With Acute Promyelocytic Leukemia
With the introduction of all-trans-retinoic acid (ATRA) and arsenic,the outcome of patients with acute promyelocytic leukemia (APL)has been improved considerably over the last decades.However，early deaths (EDs), mainly due to…
- Trial name
- NCT04446806
- Testing
- Ruxolitinib
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital of Soochow University
HIV Prevention, Primary Care
Clinic-based HIV Identification and Prevention Project Using Electronic Resources
Hybrid Type II effectiveness-implementation trial to investigate whether electronic medical and sexual history data collection with HIV risk categorization/scoring will increase pre-exposure prophylaxis (PrEP) uptake among…
- Conditions
- HIV Prevention, Primary Care, PrEP
- Trial name
- CHIPPER (NCT05412433)
- Testing
- Patient Level, Multilevel, Control
- Where
- United States
- Volunteers
- 1,170 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
HIV Infections
Enema Use and Acceptability in HIV Negative Men Who Have Sex With Men
This study is looking at 3 different types of enemas used before receptive anal intercourse in men who have sex with men (MSM). We are investigating whether the enemas cause any damage to the lining of the colon, how far up the…
- Trial name
- NCT00696618
- Testing
- Fleet Enema, tap water enema, Normosol-R enema
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Coronary Artery Bypass Graft Redo, Heart Valve Diseases
SONOlysis in Risk REduction of Symptomatic and Silent Brain infarCtions dUring Cardiac surgEry
The aim of the project is to demonstrate a fibrinolytic effect of sonothrombolysis (continual transcranial Doppler monitoring) using 2 MHz diagnostic probe on the reduction of risk of brain infarctions due to the activation of…
- Trial name
- SONORESCUE (NCT01591018)
- Testing
- sonolysis, cardiac surgery
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- University Hospital Ostrava
Graft Versus Host Disease, Hematopoietic/Lymphoid Cancer
Donor Stem Cell Transplant Followed by Cyclophosphamide in Treating Patients With Hematological Diseases
This pilot clinical trial studies donor stem cell transplant followed by cyclophosphamide in treating patients with hematological diseases.
- Trial name
- NCT02248597
- Testing
- fludarabine phosphate, busulfan, cyclophosphamide
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Wake Forest University Health Sciences
EMERGENCY MEDICINE
Analysis and Improvising Working Practices in the ER
Analysis of electronic files of patients presenting to the emergency department to improve current practice
- Trial name
- NCT03943810
- Testing
- No intervention
- Volunteers
- 500,000 people
- Sponsor
- Sheba Medical Center
Human Immunodeficiency Virus
HIV Prevention in the Primary Care Setting
In the third decade of the HIV pandemic, what was once a uniformly and rapidly fatal disease has been transformed into a chronic illness by advances in the understanding of HIV pathogenesis and therapeutics.
- Trial name
- NCT00381524
- Testing
- Increase condom use
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- University of Alabama at Birmingham
Tuberculosis
A Study of Daily Rifapentine Combined With Isoniazid (1HP) for Tuberculosis Prevention in Children Less Than 13 Years of Age With and Without HIV
This study aims to find the proposed dose of Rifapentine (RPT) taken once daily with Isoniazid (INH) for 28 days to prevent tuberculosis (TB).
- Trial name
- NCT07124559
- Testing
- Rifapentine, Isoniazid, Dolutegravir
- Where
- 11 sites in Botswana, Haiti and 4 more
- Volunteers
- 144 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy
Adherence Dynamics for Whole Food Interventions in African-American Men
The purposes of this study are to explore the dynamics of adherence, using a simple whole food intervention strategy, both prior to and during the intervention period and to identify nutrient shifts in self-selected diets and to…
- Trial name
- DAPH (NCT01408459)
- Testing
- Tomato Product, Control
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
EUS Guided Cyanoacrylate Injection, Endoscopic Variceal Band Ligation
EUS Glue vs Endoscopic Variceal Band Ligation for Prevention of Rebleeding in Patients With HCC and EV Bleeding: a Retrospective Comparative Study
SP by EUS-CYA improves clinical outcomes (eg, EV rebleeding) in patients with HCC and prior EV bleeding when compared with SP by EGD-VBL
- Conditions
- EUS Guided Cyanoacrylate Injection, Endoscopic Variceal Band Ligation, Hepatocelular Carcinoma, Esophageal Variceal Bleeding
- Trial name
- EUSgluevsVBL (NCT04918459)
- Where
- Hong Kong
- Volunteers
- 70 people
- Sponsor
- Chinese University of Hong Kong
Enhanced Recovery After Surgery, Anesthesia
Enhanced Recovery After Surgery Protocol on Early Mobilization After Colorectal Surgery
Early mobilization is an important factor in increasing postoperative colorectal surgeries outcome. There are four components held by anesthesiologist in Enhanced Recovery After Surgery protocol for colorectal surgery in our…
- Conditions
- Enhanced Recovery After Surgery, Anesthesia, Surgery-Complications, Colorectal
- Trial name
- NCT06065696
- Testing
- Early mobilization, No early mobilization
- Where
- Indonesia
- Volunteers
- 343 people
- Sponsor
- Universitas Indonesia
Lower Extremity Chronic Venous Ulcers, Varicose Veins Leg
Intravenous Tramadol and Magnesium Sulphate for Prevention of Shivering
The aim of this work was to compare the efficacy of intravenous (IV) tramadol versus magnesium sulphate added to 100 ml saline for prevention of shivering associated with spinal anesthesia.
- Conditions
- Lower Extremity Chronic Venous Ulcers, Varicose Veins Leg, Hernia
- Trial name
- NCT06612996
- Testing
- Tramadol, Magnesium sulphate, Saline
- Volunteers
- 180 people
- Sponsor
- Al-Azhar University
Cytomegalovirus Infections
Maribavir Versus Oral Ganciclovir For The Prevention of Cytomegalovirus (CMV) Disease in Liver Transplant Recipients
The purpose of this research study is to investigate whether or not oral maribavir is safe and effective compared to oral ganciclovir for preventing CMV disease when administered for up to 14 weeks in patients who have had a…
- Trial name
- NCT00497796
- Testing
- maribavir, ganciclovir
- Where
- 55 sites in United States
- Volunteers
- 307 people
- Sponsor
- Shire
Fall, Motivation
Engaging Older Adults in Fall Prevention Using Motivational Interviewing (MI)
This mixed-methods, two-arm, randomized controlled trial will evaluate the impact of Motivational Interviewing (MI) as a follow-up care to patients who received fall prevention recommendations at Oregon Health \& Science…
- Conditions
- Fall, Motivation, Behavior, Coping Behavior
- Trial name
- NCT04612842
- Testing
- Motivational Interviewing
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Oregon Health and Science University
Post Traumatic Stress Disorder
Efficacy of Single Dose IV Hydrocortisone in Post Traumatic Stress Disorder (PTSD) Prevention
This study is designed to test the hypothesis that a single Hydrocortisone intra venous injection within 6 hours post-trauma facilitates physiological recovery thereby preventing the development of Post Traumatic Stress Disorder…
- Trial name
- NCT00855270
- Testing
- Hydrocortisone
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Risk Assessment, Parenting
Randomized Controlled Trial of a Risk Reframing Tool to Change Mothers' Parenting Associated With Children's Risky Play
Children's risky play is associated with a variety of positive developmental, physical and mental health outcomes, including greater physical activity, self-confidence and risk management skills.
- Trial name
- NCT03374683
- Testing
- RR Digital Tool, RR In-Person Workshop, Position Statement on Active Outdoor Play
- Where
- Canada
- Volunteers
- 451 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Cardiovascular Disease
Heart Attack Prevention Programme for You (HAPPY) London
Diseases of the heart and blood vessels, such as heart attacks and strokes, are very common and can lead to severe disability or death.
- Trial name
- HAPPYLondon (NCT01911910)
- Testing
- Electronic coaching plus standard care
- Where
- United Kingdom
- Volunteers
- 402 people
- Sponsor
- Queen Mary University of London
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