Clinical trials: Preventive Intervention
HIV
Implementation of the Pre-Exposure Prophylaxis (PrEP) to HIV: A Demonstrative Project.
A prospective, open, multicenter,demonstrative of PrEP, which aims to assess the acceptability, feasibility and safety from chemoprophylaxis co-formulated emtricitabine / tenofovir disoproxil fumarate (FTC / TDF) administered…
- Trial name
- PrEPBrasil (NCT01989611)
- Testing
- emtricitabine / tenofovir 200/300 mg
- Where
- 3 sites in Brazil
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Oswaldo Cruz Foundation
Migraine, Menopausal
Migraine Menopause Study
This study will assess whether the migraine medication eptinezumab (Vyepti) reduces migraine days in women who are in perimenopause and early menopause and who also experience night sweats and hot flashes.
- Conditions
- Migraine, Menopausal, Perimenopause
- Trial name
- NCT07916571
- Testing
- Eptinezumab 100 mg or Eptinezumab 300 mg administered intravenously in 100 mL saline solution
- Volunteers
- 120 people
- Sponsor
- Alberta Neurologic Centre
Schizophrenia, Bipolar Disorder
Development of a Mobile Heath Augmented Brief Suicide Prevention Intervention for People With SMI
Schizophrenia and bipolar disorder are associated with high risk for suicide, yet there are few brief interventions that directly target suicide prevention in this large population.
- Conditions
- Schizophrenia, Bipolar Disorder, Suicide and Self-harm
- Trial name
- NCT03198364
- Testing
- Safety and Recovery Therapy, Mobile Augmentation
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of California, San Diego
Endometriosis
Predictive Value of Preoperative Evaluation in Cases of Recurrent Endometriosis
To investigate the effect of preoperative evaluation parameters in predicting recurrent disease in women who have undergone cystectomy or unilateral salpingo-oophorectomy due to endometriosis.
- Trial name
- NCT06132009
- Testing
- Surgery of endometriosis
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Bagcilar Training and Research Hospital
Parastomal Hernia
Use of Resorbable Prosthetic Mesh "Ante Rectus" as Prevention of Parastomal Hernia.
The aim of this study was to assess feasibility, potential benefits and safety of a prophylactic biosynthetic mesh placed at the time of colostomy.
- Trial name
- NCT04749329
- Testing
- Mesh Group
- Where
- 2 sites in Italy
- Volunteers
- 110 people
- Sponsor
- Azienda Sanitaria Locale Napoli 2 Nord
Alzheimer Disease
Healthy Aging and Memory Study
This project will focus on the development and testing of efficient, cost effective measures that are specifically designed for use in Alzheimer's Disease (AD) primary prevention trials.
- Trial name
- NCT00034567
- Where
- 39 sites in United States
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Pancreatitis
Rectal Indomethacin to Prevent Post ESWL-pancreatitis
The purpose of the study is to determine whether rectal indomethacin reduces the incidence of post-ESWL pancreatitis.
- Trial name
- RIPEP (NCT02797067)
- Testing
- indomethacin suppository, Glycerin Suppository
- Where
- China
- Volunteers
- 1,370 people
- Sponsor
- Changhai Hospital
Peptic Ulcer, NSAID-Induced Peptic Ulcer
Fexuclue for Prevention of NSAIDs-Induced Peptic Ulcer in Real-World Practice
This study is a prospective, multi-center, observational study to evaluate the efficacy and safety of Fexuclue Tablet 20 mg in patients requiring prevention of NSAIDs-induced peptic ulcer in real-world clinical practice in Korea.
- Trial name
- NCT07558707
- Where
- South Korea
- Volunteers
- 7,000 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Colorectal Adenomatous Polyps
Calcium/Vitamin D, Biomarkers & Colon Polyp Prevention
The study team has developed a set of biomarkers of risk for colon cancer; this study tests 1) whether or not calcium and/or vitamin D supplementation can favorably affect these biomarkers in persons who are at higher than…
- Trial name
- PPS4B (NCT00399607)
- Testing
- Rectal biopsy during colonoscopy, Rectal biopsy at randomization, Rectal biopsy at 1 year
- Where
- 9 sites in United States
- Volunteers
- 264 people
- Sponsor
- Emory University
Morbid Obesity, Hypertension
Prevention of Coronary Heart Disease in Morbidly Obese Patients
The changes in risks of developing coronary heart disease in patients with morbid obesity after different weight loss interventions have not been extensively studied.
- Conditions
- Morbid Obesity, Hypertension, Type 2 DM, Obstructive Sleep Apnea
- Trial name
- SphCor (NCT00626964)
- Testing
- Bariatric Surgery, Conservative Treatment:
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- The Hospital of Vestfold
Pneumonia, Pneumocystis Carinii, HIV Infections
A Randomized, Comparative Study of Daily Dapsone and Daily Atovaquone for Prophylaxis Against PCP in HIV-Infected Patients Who Are Intolerant of Trimethoprim and/or Sulfonamides
To compare the efficacy and safety of dapsone versus atovaquone in preventing or delaying the onset of histologically proven or probable Pneumocystis carinii pneumonia in HIV-infected patients with CD4 counts <= 200 cells/mm3 or…
- Trial name
- NCT00000802
- Testing
- Atovaquone, Dapsone
- Where
- 44 sites in United States, Tanzania
- Volunteers
- 700 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Contraception, Bleeding
A Randomized Controlled Trial of Oral Naproxen and Transdermal Estradiol for Bleeding in LNG-IUC
We hypothesize that the addition of oral naproxen or transdermal estradiol will decrease the number of days of unscheduled bleeding experienced by first-time users of the levonorgestrel intrauterine system (LNG-IUC) during the…
- Trial name
- NCT00789802
- Testing
- transdermal estradiol, naproxen
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Adolescent Substance Use
Guiding Good Choices for Health
This study evaluates the feasibility and effectiveness of implementing Guiding Good Choices (GGC), an anticipatory guidance curriculum for parents of early adolescents, in three large, integrated healthcare systems.
- Trial name
- GGC4H (NCT04040153)
- Testing
- Guiding Good Choices
- Where
- 3 sites in United States
- Volunteers
- 3,636 people, healthy volunteers welcome
- Sponsor
- University of Washington
Surgical Wound Infection
Parenteral Antibiotics Compared to Combination of Oral and Parenteral Antibiotics in Colorectal Surgery Prophylaxis
Routine antibiotics for the intravenous and oral prophylaxis of colorectal surgery will be used. Experimental group: Patients undergoing elective colorectal surgery that involves, colonic resection.
- Trial name
- ORALEV (NCT02505581)
- Testing
- Extra dosage - cefuroxime (750mg) I.V, Colorectal Surgery, Ciprofloxacin 750 mg oral
- Where
- 3 sites in Spain
- Volunteers
- 536 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Chronic Kidney Disease
Prevention of Acute Kidney Injury - Molecular Mechanisms of Dietary Pre-conditioning in Human
The key objective of this pilot study is to assess the molecular mechanisms of renal pre-conditioning by a one-week low-calorie diet in humans.
- Trial name
- CR_LSP (NCT02745444)
- Testing
- low-calorie formula diet, protein-restricted diet
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Cologne
Iodine Deficiency
EUthyroid2: the Next Step Towards the Elimination of Iodine Deficiency and Preventable Iodine-related Disorders in Europe
In EUthyroid2 intervention measures are to be developed, implemented in ambulatory care settings and evaluated to effectively raise awareness for the risks of iodine deficiency among young women (18-24 years) in three European…
- Trial name
- EUthyroid2 (NCT06769009)
- Testing
- Educational intervention measures on iodine, iodine deficiency and iodine intake
- Where
- 6 sites in Bangladesh, Norway and 3 more
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- EUthyroid
Cesarean Section
Epidural Nalbuphine for Postcesarean Epidural Morphine Induced Pruritus
Can epidural nalbuphine reduce incidence or severity of epidural morphine induced pruritus in patient undergoing cesarean section?
- Trial name
- NCT00707824
- Testing
- nalbuphine, NSS
- Where
- Thailand
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Smoking Cessation
Enhancing Relapse Prevention for Smoking Cessation With Repetitive Transcranial Magnetic Stimulation
Tobacco use is one of the most significant cancer control and public health challenges in the US today. Half of all smokers in the US will attempt to quit tobacco each year, but fully 95% of those who attempt to quit will reverse…
- Trial name
- rTMS (NCT02822703)
- Testing
- rTMS Active 20Hz
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- The City College of New York
Covid19
BCG Against Covid-19 for Prevention and Amelioration of Severity Trial (BAC to the PAST)
The purpose of this study is to assess the efficacy of Bacille Calmette-Guérin (BCG) vaccination compared to placebo in reducing severe Covid-19 disease among elderly residents of skilled nursing facilities.
- Trial name
- NCT04534803
- Testing
- BCG Vaccine
- Volunteers
- healthy volunteers welcome
- Sponsor
- Harvard Medical School (HMS and HSDM)
Disorders of the Eye Following Cataract Surgery
Microbiological Evaluation of the Ocular Flora Before Cataract Surgery
The purpose of the present study is to elucidate the spectrum of ocular flora and their antimicrobial susceptibility profiles in patients undergoing routine cataract surgery.
- Trial name
- NCT02124603
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- SIFI SpA
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.